| cell-mediated immune responses to copv early proteins. | cell-mediated immunity plays a key role in the regression of papillomavirus-induced warts and intra-epithelial lesions but the target antigens that induce this response are not clear. canine oral papillomavirus (copv) infection of the oral cavity in dogs is a well-characterized model of mucosal papillomavirus infection that permits analysis of the immune events during the infectious cycle. in this study we show that during the copv infectious cycle, systemic t cell responses to peptides of sever ... | 2006 | 16949120 |
| an epidermotropic canine papillomavirus with malignant potential contains an e5 gene and establishes a unique genus. | a novel canine papillomavirus, cfpv-2, was cloned from a footpad lesion of a golden retriever. unlike the known canine oral papillomavirus (copv), which has a double-stranded dna genome size of 8607 bps, the genome of cfpv-2 is 8101 bps. some of this size difference is due to an abbreviated early-late region (elr), which is 1200 bps shorter than that of copv. however, cfpv-2 has other differences from copv, including the presence of an e5 orf between the e2 gene and the elr and an enlarged e4 or ... | 2007 | 17034826 |
| amplicon-plus targeting technology (aptt) for rapid production of a highly unstable vaccine protein in tobacco plants. | high-level expression of transgenes is essential for cost-effective production of valuable pharmaceutical proteins in plants. however, transgenic proteins often accumulate in plants at low levels. low levels of protein accumulation can be caused by many factors including post-transcriptional gene silencing (ptgs) and/or rapid turnover of the transgenic proteins. we have developed an amplicon-plus targeting technology (aptt), by using novel combination of known techniques that appears to overcome ... | 2007 | 17221361 |
| ancient papillomavirus-host co-speciation in felidae. | estimating evolutionary rates for slowly evolving viruses such as papillomaviruses (pvs) is not possible using fossil calibrations directly or sequences sampled over a time-scale of decades. an ability to correlate their divergence with a host species, however, can provide a means to estimate evolutionary rates for these viruses accurately. to determine whether such an approach is feasible, we sequenced complete feline pv genomes, previously available only for the domestic cat (felis domesticus, ... | 2007 | 17430578 |
| detection of canine oral papillomavirus dna in conjunctival epithelial hyperplastic lesions of three dogs. | papillomavirus infections are responsible for plaques and papillomas in various locations on the skin and in mucous membranes. the aim of this report was to describe morphologic features of a viral pigmented conjunctival plaque and 2 conjunctival squamous papillomas in 3 dogs, and to investigate these lesions for the presence of papillomavirus dna by polymerase chain reaction (pcr), dna sequence analysis, and in situ hydridization (ish). histopathology revealed in all neoplasms various degrees o ... | 2009 | 19112112 |
| genomic characterization of the first insectivoran papillomavirus reveals an unusually long, second non-coding region and indicates a close relationship to betapapillomavirus. | knowledge about biological diversity is the prerequisite to reliably reconstruct the evolution of pathogens such as papillomaviruses (pv). however, complete genomes of non-human pv have only been cloned and sequenced from 8 out of 18 orders within the placentalia, although the host-specific variety of pv is considered much larger. we isolated and sequenced the complete genome of the first insectivoran pv type from hair follicle cells of the european hedgehog (erinaceus europaeus), designated ehp ... | 2009 | 19218207 |
| canine inverted papillomas associated with dna of four different papillomaviruses. | inverted papillomas are uncommon papillomavirus (pv)-induced canine skin lesions. they consist of cup- to dome-shaped dermal nodules with a central pore filled with keratin. histologically they are characterized by endophytic projections of the epidermis extending into dermis. cytopathic effects of pvs infection include the presence of clumped keratohyalin granules, koilocytes and intranuclear inclusion bodies. different dna hybridization studies carried out with a canine oral papillomavirus (co ... | 2010 | 20042038 |
| characterization of canine oral papillomavirus by histopathological and genetic analysis in korea. | in august 2008, forty dogs out of 400 developed oral warts in a breeding farm in korea. canine oral papilloma infection is a common disease in dogs. however, there has been no report of an outbreak of canine oral papillomavirus (copv) in a group of dogs or in dog breeding farms in korea, and the genetic analysis of copv in korea has yet to be performed. this study diagnosed canine oral papilloma from the oral samples of these dogs based on histopathological examination and immunohistochemistry. ... | 2010 | 20195061 |