| antiviral activities of medicinal herbs traditionally used in southern mainland china. | the aqueous extracts from 21 medicinal herbs traditionally used in southern mainland china were screened for antiviral activities against human herpes simplex virus type 1 (hsv-1) and human respiratory syncytial virus (rsv) using a cytopathic effect (cpe) reduction assay. three extracts from agrimonia pilosa, pithecellobium clypearia and punica granatum, respectively, showed anti-hsv-1 activity, which was possibly contributed by the polyphenolic compounds in the herbal extracts. six of the extra ... | 2004 | 15478204 |
| evaluation of antiinflammatory activity of the total flavonoids of laggera pterodonta on acute and chronic inflammation models. | the antiinflammatory effect of the total flavonoids of laggera pterodonta (tflp) was evaluated with various in vivo models of both acute and chronic inflammation. in the acute inflammation tests, tflp significantly inhibited xylene-induced mouse ear oedema, carrageenan-induced rat paw oedema and acetic acid-induced mouse vascular permeability. in the carrageenan-induced rat pleurisy model, tflp efficiently suppressed inflammatory exudate and leukocyte migration, reduced the serum levels of lysoz ... | 2006 | 16673449 |
| inhibition of enterovirus 71 replication by chrysosplenetin and penduletin. | in recent years, enterovirus 71 (ev71) infections have caused an increasing epidemic in young children, accompanying with more severe nervous system disease and more deaths. unfortunately, there is no specific medication for it so far. here we investigated the anti-ev71 activity of chrysosplenetin and penduletin, two o-methylated flavonols isolated from the leaves of laggera pterodonta. these two compounds were found to have strong activity in vitro against ev71 with low cytotoxicity. in the cyt ... | 2011 | 21914477 |
| [effect of yunnan herb laggera pterodonta against influenza a (h1n1) virus in vitro]. | laggera pterodonta is commonly used for treating influenza in southwest china, especially in yunnnan province. the main clinical effects of l. pterodonta include anti-influenza, anti-microbial, anti-inflammatory. to investigate the anti-influenza a (h1n1) virus effect of l. pterodonta, neutralization inhibition and proliferation inhibition tests were performed. mdck culture method was used to observe the cytopathic effect (cpe) of extracts from l. pterodonta in inhibiting influenza a (h1n1) viru ... | 2015 | 26983222 |
| purification and identification of antiviral components from laggera pterodonta by high-speed counter-current chromatography. | although laggera pterodonta, a folk medicine has been widely used for several centuries as an antiviral agent, there have been no studies to identify its antiviral components. a bioassay-guided phytochemical examination of l. pterodonta disclosed that its aqueous extract, which was made up of three dicaffeoylquinic acids showed significant inhibitory activity of virus replication. then a simple and efficient preparative high-speed counter-current chromatography (hsccc) method was successfully es ... | 2007 | 17920342 |
| terpenoids and flavonoids from laggera pterodonta. | to study the chemical constituents of aerial parts of laggera pterodonta (dc.) benth., the air-dried aerial parts of this plant were powered and extracted with boiling water and purified by silica gel column chromatography and recrystallized. eleven compounds were obtained from l. pterodonta. they were identified as to be 6-o-beta-d-glucopyranosyl-carvotanacetone (1), pterodontic acid (2), 1beta-hydroxy pterondontic acid (3), pterodontoside a (4), pterodondiol (5), pterodontriol b (6), 5-hydroxy ... | 2007 | 17703774 |
| sesquiterpenoids from hedychium yunnanense and porana discifera, and the structural revision of two sesquiterpenoids from laggera pterodonta. | a new eudesmane-type sesquiterpenoid, hedytriol (1), was isolated from hedychium yunnanense (zingiberaceae). by means of chemical and spectroscopic methods, the structure of 1 was determined as ( - )-7ah-eudesmane-1beta, 4alpha, 11-triol. a new ent-eudesmane sesquiterpenoid, disciferitriol (2), was isolated from porana discifera (convolvulaceae), which was exactly the enantiomer of hedytriol (1). the structures of pterodondiol (3a) and pterodontriol b (3), previously isolated from laggera pterod ... | 2007 | 17566922 |
| hepatoprotective and antioxidative effects of total phenolics from laggera pterodonta on chemical-induced injury in primary cultured neonatal rat hepatocytes. | although laggera pterodonta as a folk medicine has been widely used for several centuries to ameliorate some inflammatory ailments as hepatitis in china, there have been no studies of the hepatoprotective and antioxidative effects of this plant. in this paper, the hepatoprotective effect of total phenolics from l. pterodonta (tplp) against cci4-, d-galn-, taa-, and t-bhp-induced injury was examined in primary cultured neonatal rat hepatocytes. tplp inhibited the cellular leakage of two enzymes, ... | 2007 | 17329003 |