| identification and characterization of antimicrobial peptides from the skin of the endangered frog odorrana ishikawae. | the endangered anuran species, odorrana ishikawae, is endemic to only two small japanese islands, amami and okinawa. to assess the innate immune system in this frog, we investigated antimicrobial peptides in the skin using artificially bred animals. nine novel antimicrobial peptides containing the c-terminal cyclic heptapeptide domain were isolated on the basis of antimicrobial activity against escherichia coli. the peptides were members of the esculentin-1 (two peptides), esculentin-2 (one pept ... | 2010 | 21193000 |
| characterization of antimicrobial peptides from the skin secretions of the malaysian frogs, odorrana hosii and hylarana picturata (anura:ranidae). | peptidomic analysis of norepinephrine-stimulated skin secretions from hose's rock frog odorrana hosii (boulenger, 1891) led to the isolation of 8 peptides with differential antibacterial activities. structural characterization demonstrated that the peptides belonged to the esculentin-1 (1 peptide), esculentin-2 (1 peptide), brevinin-1 (2 peptides), brevinin-2 (2 peptides), and nigrocin-2 (2 peptides) families of antimicrobial peptides. similar analysis of skin secretions from the malaysian fire ... | 2008 | 18621071 |