| picornavirus non-structural proteins as targets for new anti-virals with broad activity. | picornaviridae is one of the largest viral families and is composed of 14 genera, six of which include human pathogens. the best known picornaviruses are enteroviruses (including polio, pv, and rhinoviruses), foot-and-mouth disease virus (fmdv), and hepatitis a virus (hav). although infections often are mild, certain strains may cause pandemic outbreaks accompanied with meningitis and/or paralysis. vaccines are available for pv, hav and fmdv. when the oral vaccines are given to immunocompromised ... | 2011 | 21236302 |
| the complete genome sequence of an enterovirus 76 isolate in china reveals a recombination event. | enterovirus 76 (ev76) is a new member of species human enterovirus a (hev-a). so far, the only complete genome sequence of the prototype strain from france has been available. in this study, we determined the complete nucleotide sequence of strain 04360, isolated from an acute flaccid paralysis patient in shandong province, china in 2004. sequence analysis revealed 80.7-94.7% vp1 nucleotide identity to other ev76 strains and provided evidence of recombination with other types of hev-a in the p2 ... | 2011 | 21755310 |
| molecular epidemiological study of enteroviruses associated with encephalitis in children from india. | enteroviruses have been reported in encephalitis cases. however, clinical and epidemiological characteristics of enteroviruses in encephalitis are not fully established. we prospectively investigated 204 children with encephalitis over a period of 2 years (2009 to 2010) for enterovirus. enterovirus was detected in 45 specimens (22.1%); of these, 40 were typed by seminested reverse transcription-pcr (rt-pcr) and sequencing of the vp1 gene. molecular typing of enterovirus revealed the predominance ... | 2012 | 22895040 |
| changing clinico-laboratory profile of encephalitis patients in the eastern uttar pradesh region of india. | a cross-sectional study was done on 100 consecutive paediatric patients presenting with acute encephalitis syndrome. the clinico-laboratory features of all patients were recorded in a prestructured performa. cerebrospinal fluid and serum samples were tested for: japanese encephalitis (je) virus; chandipura virus; coxsackie virus; dengue virus; enterovirus 76; and west nile virus. twenty-two (22.0%) patients were confirmed je cases and 17% had parasitic or bacteriological aetiology. the remaining ... | 2012 | 22431829 |
| characterization of enteroviruses from non-human primates in cameroon revealed virus types widespread in humans along with candidate new types and species. | enteroviruses (evs) infecting african non-human primates (nhp) are still poorly documented. this study was designed to characterize the genetic diversity of evs among captive and wild nhp in cameroon and to compare this diversity with that found in humans. stool specimens were collected in april 2008 in nhp housed in sanctuaries in yaounde and neighborhoods. moreover, stool specimens collected from wild nhp from june 2006 to october 2008 in the southern rain forest of cameroon were considered. r ... | 2014 | 25079078 |