| comparative genetic analysis of genomic dna sequences of two human isolates of tanapox virus. | members of the genus yatapoxvirus, which include tanapox virus (tpv) and yaba monkey tumor virus, infect primates including humans. two strains of tpv isolated 50 years apart from patients infected from the equatorial region of africa have been sequenced. the original isolate from a human case in the tana river valley, kenya, in 1957 (tpv-kenya) and an isolate from an infected traveler in the republic of congo in 2004 (tpv-roc). although isolated 50 years apart the genomes were highly conserved. ... | 2007 | 17574698 |
| deerpox virus encodes an inhibitor of apoptosis that regulates bak and bax. | poxviruses encode numerous proteins that inhibit apoptosis, a form of cell death critical to the elimination of virally infected cells. sequencing of the deerpox virus genome revealed dpv022, a protein that lacks obvious homology to cellular members of the bcl-2 family but shares limited regions of amino acid identity with two unique poxviral inhibitors of apoptosis, m11l and f1l. given the limited homology, we sought to determine whether dpv022 could inhibit apoptosis. here we show that dpv022 ... | 2010 | 21159883 |
| serosurvey for antibody to deerpox virus in five cervid species in oregon, usa. | five cervid species in oregon, usa were tested with a serum neutralization assay for antibody to deerpox virus (dpv). none of the 50 elk (cervus elaphus ssp. roosevelti and nelsonii) had detectable antibody. prevalence of antibody to dpv in the remaining species was: 52% (n=55) in black-tailed deer (odocoileus hemionus columbianus), 32% (n= 59) in mule deer (o. hemionus hemionus), and 36% (n=50) in columbian white-tailed deer (o. virginianus leucurus), with an overall antibody prevalence of 40.2 ... | 2013 | 23307387 |
| molecular and biological characterization of a cervidpoxvirus isolated from moose with necrotizing dermatitis. | cervidpoxvirus is one of the more recently designated genera within the subfamily chordopoxvirinae, with deerpox virus (dpv) as the only recognized species to date. in this study, the authors describe spontaneous disease and infection in the north american moose (alces americanus) by a novel cervidpoxvirus, here named moosepox virus (mpv). three 4-month-old moose calves developed a multifocal subacute-to-chronic, necrotizing, suppurative-to-granulomatous dermatitis that affected the face and the ... | 2020 | 32096438 |
| isolation and characterization of a cervidpoxvirus from a goitered gazelle (gazella subgutturosa) from a zoologic park in minnesota. | deerpox virus (dpv) is the sole member of the newly ratified cervidpoxvirus genus in the subfamily chordopoxvirinae. presented here is the first diagnostic report of isolation of dpv from a goitered gazelle (gazella subgutturosa). a tissue homogenate was submitted by a zoologic park to the minnesota veterinary diagnostic laboratory at the university of minnesota for poxvirus diagnostic investigation and then referred to plum island foreign animal disease diagnostic laboratory for confirmation. p ... | 2013 | 24063086 |
| genome of deerpox virus. | deerpox virus (dpv), an uncharacterized and unclassified member of the poxviridae, has been isolated from north american free-ranging mule deer (odocoileus hemionus) exhibiting mucocutaneous disease. here we report the genomic sequence and comparative analysis of two pathogenic dpv isolates, w-848-83 (w83) and w-1170-84 (w84). the w83 and w84 genomes are 166 and 170 kbp, containing 169 and 170 putative genes, respectively. nucleotide identity between dpvs is 95% over the central 157 kbp. w83 and ... | 2005 | 15613325 |
| characterization of mule deerpox virus in florida white-tailed deer fawns expands the known host and geographic range of this emerging pathogen. | infections caused by mule deerpox virus (mdpv) have been sporadically reported in north american cervids. white-tailed deer (odocoileus virginianus) fawns from a farm located in south central florida presented with ulcerative and crusting lesions on the coronary band as well as the mucocutaneous tissues of the head. evaluation of the crusted skin lesions was undertaken using microscopic pathology and molecular techniques. a crusted skin sample was processed for virus isolation in four mammalian ... | 2019 | 30238163 |
| characterization of cervidpoxvirus isolates from oregon, california, and eastern canada. | the present report describes the analysis of 4 deerpox virus isolates from california, oregon, and ontario, canada. all 4 isolates were associated with cutaneous crusting lesions. examination of selected samples by electron microscopy demonstrated that the viruses were morphologically similar to orthopoxviruses. phylogenetic analysis of the a21 gene, which is found in all poxviruses, indicated that the 4 isolates form a lineage distinct from other members except for those belonging to the genus ... | 2009 | 19564496 |
| experimental deerpox infection in black-tailed deer (odocoileus hemionus columbianus). | the pathogenic potential of deerpox virus was investigated via an experimental study utilizing seven black-tailed deer fawns (odocoileus hemionus) between june and august of 2007. successful transmission was achieved via intracutaneous and intravenous routes, and by commingling an uninoculated animal with experimentally infected fawns. one fawn became depressed and reluctant to eat but systemic clinical signs in the other fawns were confined to mild transient pyrexia. typical multifocal poxviral ... | 2010 | 20090016 |
| diagnosis of deerpox virus infection in a white-tailed deer (odocoileus virginianus) fawn. | a 3-month-old fawn from a group of 12 captive white-tailed deer (odocoileus virginianus) displaying cutaneous lesions was presented to the mississippi veterinary research & diagnostic laboratory for necropsy. postmortem examination identified multiple discrete, round, alopecic, flat, proliferative dermal lesions scattered along the skin of the lips, muzzle, pinna, ventral thorax, medial limbs, and most notably the abdomen. multiple ulcers were present on the commissures of the lips, dorsal surfa ... | 2011 | 21908356 |
| structural basis of deerpox virus-mediated inhibition of apoptosis. | apoptosis is a key innate defence mechanism to eliminate virally infected cells. to counteract premature host-cell apoptosis, poxviruses have evolved numerous molecular strategies, including the use of bcl-2 proteins, to ensure their own survival. here, it is reported that the deerpox virus inhibitor of apoptosis, dpv022, only engages a highly restricted set of death-inducing bcl-2 proteins, including bim, bax and bak, with modest affinities. structural analysis reveals that dpv022 adopts a bcl- ... | 2015 | 26249341 |