| identification and characterization of a novel tospovirus species using a new rt-pcr approach. | a novel tospovirus serologically distinct from all established tospovirus species was found in thailand in physalis minima l. the s rna of this virus was cloned by a new rt-pcr approach revealing a nucleotide sequence of 3257 nucleotides. the ambisense rna segment encoded a nonstructural protein (nss) of 469 amino acids, with a predicted mr of 53.2 kda, and a nucleoprotein (n) of 279 amino acids and a mr of 31.0 kda, so far the largest n protein known for any tospovirus species. n protein sequen ... | 2001 | 11315637 |
| cytotoxicity of plants from malaysia and thailand used traditionally to treat cancer. | the srb cytotoxicity assay was used to screen extracts and isolated constituents of some traditional medicinal plants from malaysia and thailand against two human cancer cell lines, cor l23 lung cancer cell line and mcf7 breast cancer cell line and the non-cancer mcf5 cell line. five out of the seven species tested, i.e. thai alpinia galanga, alpinia officinarum, cayratia japonica, physalis minima, tabernaemontana divaricata, exhibited interesting cytotoxicity activity and this is the first repo ... | 2005 | 15888378 |
| antileishmanial physalins from physalis minima. | three new physalins (1-3) and a new withanolide 7 have been isolated from the whole plant of physalis minima, along with three known physalins: physalin h (4), isophysalin b (5), and 5beta,6beta-epoxyphysalin b (6). their structures were deduced on the basis of in-depth spectroscopic analyses. compounds 1-6 showed significant in vitro leishmanicidal activities (0.92-19.4 microg/ml) against promastigotes of leishmania major. | 2005 | 17193198 |
| new leishmanicidal physalins from physalis minima. | two new physalins, 16,24-cyclo-13,14-secoergosta-2-ene-18,26-dioic acid-14 : 17,14 : 27-diepoxy-11beta,13,20,22-tetrahydroxy-5alpha-methoxy-1,15-dioxo-gamma-lactone delta-lactone (1), and 16,24-cyclo-13,14-secoergosta-2-ene-18,26-dioic acid-14 : 17,14 : 27-diepoxy-5alpha,11beta,13,20,22-pentahydroxy-1,6,15-trioxo-gamma-lactone delta-lactone (2), have been isolated from the whole plant of physalis minima linn. (var. indica). their structures were deduced on the basis of spectroscopic analysis. bo ... | 2007 | 17680497 |
| anti-inflammatory, analgesic and antipyretic activities of physalis minima linn. | in our present investigation, the crude methanol extract and chloroform fraction of the whole plant of physalis minima linn (solanaceae) was investigated for anti-inflammatory, analgesic and antipyretic activities in nmri mice and wistar rats of either sex at 200 and 400 mg/kg, respectively. various established in-vivo model's were used during the study. both crude extract and chloroform fraction showed marked anti-inflammatory and analgesic activities as compared to a control at tested doses. t ... | 2009 | 18825533 |
| growth arrest and induction of apoptotic and non-apoptotic programmed cell death by, physalis minima l. chloroform extract in human ovarian carcinoma caov-3 cells. | the decoction of the whole plant of physalis minima l. is traditionally consumed to treat cancer. its anticancer property has been previously verified (using in vitro cytotoxicity assays) against nci-h23 lung, corl23 lung and mcf7 breast cancer cell lines but the mechanism underlying the anticancer potency towards ovarian carcinoma cells remain unclear. | 2010 | 20045455 |
| interaction studies of coumaroyltyramine with human serum albumin and its biological importance. | n-trans-p-coumaroyltyramine (ct) isolated from physalis minima is a phenolic substance exhibiting many pharmacological activities like potent inhibition of acetyl cholinesterase, cell proliferation, platelet aggregation, and also antioxidant activity. here, we have studied the binding of ct with hsa at physiological ph 7.2 by using fluorescence, circular dichroism spectroscopy, mass spectrometry, and molecular docking methods. from the fluorescence emission studies, the number of binding sites a ... | 2010 | 20136105 |
| apoptotic effects of physalis minima l. chloroform extract in human breast carcinoma t-47d cells mediated by c-myc-, p53-, and caspase-3-dependent pathways. | the chloroform extract of physalis minima produced a significant growth inhibition against human t-47d breast carcinoma cells as compared with other extracts with an ec(50) value of 3.8 microg/ml. an analysis of cell death mechanisms indicated that the extract elicited an apoptotic cell death. mrna expression analysis revealed the coregulation of apoptotic genes, that is, c-myc , p53, and caspase-3. the c-myc was significantly induced by the chloroform extract at the earlier phase of treatment, ... | 2010 | 20150224 |
| ethnobotanical survey of medicinal plants commonly used by kani tribals in tirunelveli hills of western ghats, india. | for thousands of years, medicinal plants have played an important role throughout the world in treating and preventing a variety of diseases. kani tribal people in tirunelveli hills still depend on medicinal plants and most of them have a general knowledge of medicinal plants which are used for first aid remedies, to treat cough, cold, fever, headache, poisonous bites and some simple ailments. | 2011 | 21291981 |
| anti lipid peroxidation activity of piper trioicum roxb. and physalis minima l. extracts. | attempt has been made to evaluate free radical scavenging activity of ethanolic extract of piper trioicum roxb. and physalis minima l. individually. in this study goat liver has been used as lipid source. this in vitro evaluation was done by measuring the malondialdehyde (mda) of tissue homogenates. the results suggest that the ethanolic extract of the piper trioicum roxb. and physalis minima l. has the ability to suppress the lipid peroxidation and it was also found that piper trioicum roxb. ex ... | 2011 | 21715277 |
| steroidal constituents of physalis minima (solanaceae). | | 1975 | 1172507 |
| differential expression of antioxidant enzymes during degradation of azo dye reactive black 8 in hairy roots of physalis minima l. | the enzymes involved in the protection of plant metabolism in presence of azo dye was characterized by studying activities of the role of antioxidant enzymes in the hairy roots (hrs) of physalis minima l. during degradation of an azo dye, reactive black 8 (rb8). when the hrs were exposed to rb8 (30 mg l(-1)), a nine fold increase in sod activity was observed after 24 h, while 22 and 50 fold increase in activity was observed for pox and apx respectively after 72 h, whereas there was no significa ... | 2015 | 25409242 |
| shoot regeneration of mesophyll protoplasts transformed by agrobacterium tumefaciens, not achievable with untransformed protoplasts. | alternative methods for shoot regeneration in protoplast derived cultures were developed in nicotiana paniculata and physalis minima. in both species protoplast derived callus is not regeneratable to shoots by conventional methods, e.g. hormone treatment. leaf discs and stem segments of n. paniculata and p. minima were incubated with agrobacterium tumefaciens "shooter" strains harbouring pgv 2215 or pgv 2298 or wildtype strain b6s3. after 36 h of co-incubation protoplasts were prepared. (leaf di ... | 1986 | 24247786 |
| cytotoxic activities of physalis minima l. chloroform extract on human lung adenocarcinoma nci-h23 cell lines by induction of apoptosis. | physalis minima l. is reputed for having anticancer property. in this study, the chloroform extract of this plant exhibited remarkable cytotoxic activities on nci-h23 (human lung adenocarcinoma) cell line at dose- and time-dependent manners (after 24, 48 and 72 h of incubation). analysis of cell-death mechanism demonstrated that the extract exerted apoptotic programed cell death in nci-h23 cells with typical dna fragmentation, which is a biochemical hallmark of apoptosis. morphological observati ... | 2009 | 19541726 |
| solasodine glycoside production by hairy root cultures of physalis minima linn. | hairy root cultures of physalis minima l. were developed using agrobacterium rhizogenes, strain atcc 15834 mediated transformation and grown in half strength of murashige and skoog medium containing 8% (w/v) sucrose. media supplementation with 1 mg naphthalenacetic acid l(-1) and 1 mg benzyladenine increased solasodine glycoside up to 900 g dry wt, which was 20 times higher than that in the native root. | 2004 | 15168852 |