| [hypoglycemic effects of siamese momordica charantia and phyllanthus urinaria extracts in streptozotocin-induced diabetic rats (the 1st report)]. | hypoglycemic effects of the extracts of two siamese plants, momordica charantia (m.c.) and phyllanthus urinaria (p.u.), were examined in streptozotocin-induced diabetic rats. oral administration of a 50% methanol extract (30 mg/kg) of m.c. and p.u. decreased the blood glucose levels (bgl) by 25% and 24%, respectively, at 3 hr after administration. among other fractions such as the ethyl ether or water soluble fractions, the 10 and 30 mg/kg n-butanol soluble fraction from m.c. extract was most ef ... | 1992 | 1464400 |
| retroviral reverse transcriptase inhibitory activity in thai herbs and spices: screening with moloney murine leukemia viral enzyme. | fifty-seven thai herbs and spices were examined for their retroviral reverse transcriptase inhibitory activity. all herbs and spices were extracted with hot-water and methanol. reverse transcriptase inhibitory activity of the extracts was determined by using moloney murine leukemia virus reverse transcriptase (m-mulv-rt) reacted with 3h-dttp and radioactivity measured with a scintillation counter. eighty-one per cent (46/57) of hot-water extracts and 54% (31/57) of methanol extracts showed inhib ... | 1993 | 7524165 |
| herbs of the genus phyllanthus in the treatment of chronic hepatitis b: observations with three preparations from different geographic sites. | it has been suggested that herbs of the phyllanthus family may have antiviral activity. we therefore tested the effects of three different phyllanthus extracts on the serologic status of 123 patients with chronic hepatitis b. eleven patients received an extract of phyllanthus amarus (l) provided by s.p. thyagarajan, madras, india. forty-two patients received phyllanthus niruri (l), gathered from hainan province in china, and 35 patients received an extract of phyllanthus urinaria (l), which had ... | 1995 | 7561442 |
| [experimental study on anti-duck hepatitis b viral effect of phyllanthus urinaria of different areas and combined therapy with other drugs]. | the duck hepatitis b virus model was treated with phyllanthus urinaria of different area and combined with sophora flavesceus as well as ciprofloxacin once a day for one month, the results indicated: guangxi and yunnan phyllanthus could lower the serum dhbv dna significantly (p < 0.05), but chongqing phyllanthus couldn't. and the amount of serum dhbv dna rose a week after stopping of yunnan phyllanthus. the antiviral effect of guangxi phyllanthus combined with ciprofloxacin seems to be strengthe ... | 1995 | 7647546 |
| [effects of extracts from phyllanthus urinaria l. on hbsag production in plc/prf/5 cell line]. | experiment on the effect of extracts from phyllanthus urinaria on hbsag production in plc/prf/5 human hepatoma cell line showed that the production was decreased markedly 48 hours after the treatment of cells with 2-4 mg/ml phyllanthus urinaria, especially in combination with 10(-5) mol/l of ara-a. the decrease of extracellular hb-sag excretion seems to stem from the inhibition of intracellular hbsag formation. | 1993 | 8011099 |
| analysis of the mechanisms underlying the contractile response induced by the hydroalcoholic extract of phyllanthus urinaria in the guinea-pig urinary bladder in-vitro. | the hydroalcoholic extract of phyllanthus urinaria (euphorbiaceae), substance p and substance p methyl ester all caused graded contractions in the guinea-pig urinary bladder. responses to hydroalcoholic extract and substance p were markedly inhibited in calcium-free krebs solution, this effect being reversed by reintroduction of calcium in the medium. the contraction in response to hydroalcoholic extract was unaffected by atropine, propranolol, prazosin, yohimbine, tetrodotoxin, w-conotoxin, nic ... | 1995 | 8583354 |
| mechanisms involved in the contractile responses induced by the hydroalcoholic extract of phyllanthus urinaria on the guinea pig isolated trachea: evidence for participation of tachykinins and influx of extracellular ca2+ sensitive to ruthenium red. | 1. the hydroalcoholic extract (he) of stems, leaves and roots from p. urinaria (euphorbiaceae) (1-3000 micrograms/ml), caused graded contraction in guinea pig trachea (gpt), being more effective in preparations without epithelium. 2. response to he was slightly affected by tetrodotoxin (0.3 microm) and nicardipine (1 microm), but was unaffected by w-conotoxin, atropine, mepyramine or staurosporine (all 1 microm). indomethacin (3 microm) greatly inhibited he contraction, but mk 571 (leukotriene d ... | 1996 | 8842681 |
| the relaxant effect of extract of phyllanthus urinaria in the guinea-pig isolated trachea. evidence for involvement of atp-sensitive potassium channels. | this study analyses the relaxation induced by the hydroalcoholic extract of stems, leaves and roots from phyllanthus urinaria (euphorbiaceae) in the guinea-pig trachea (gpt) pre-contracted by carbachol. the hydroalcoholic extract of p. urinaria (0.1-10 mg ml-1) caused a graded relaxation in gpt with or without epithelium, with mean ec50 values of 1.94 (1.41-2.67) and 2.00 (1.47-2.78) mg ml-1 and emax of 717 mg (+/- 16) and 627 mg (+/- 12), respectively. the relaxation in response to hydroalcohol ... | 1996 | 8961165 |
| the involvement of k+ channels and gi/o protein in the antinociceptive action of the gallic acid ethyl ester. | the anti-hyperalgesic action, antinociception, and also the possible mechanisms involved in the action of gallic acid ethyl ester (gaee) isolated from the aerial part of phyllanthus urinaria, have been investigated in different models of chemical, mechanical and thermal nociception in mice and rats. gaee given by intraperitoneal (i.p.), oral (p.o.), intrathecal (i.t.) or by intracerebroventricular (i.c.v.) routes produced dose-related antinociception when assessed against chemical nociception in ... | 1999 | 10499367 |
| the mechanisms underlying the relaxant effect of methyl and ethyl gallates in the guinea pig trachea in vitro: contribution of potassium channels. | the relaxant response and the possible contribution of k+ channels to the relaxation caused by both methyl and ethyl gallates, two compounds isolated from the brazilian medicinal plant phyllanthus urinaria, were investigated in the guinea pig trachea in vitro. both methyl and ethyl gallate (0.01-30 microm) caused graded and complete relaxation of the guinea pig trachea without epithelium, pre-contracted by histamine, with mean ec50 values of 1.8 (1.2-2.2) microm and 0.7 (0.6-0.8) microm, respect ... | 1999 | 10543436 |
| [mechanism of protective action of phyllanthus urinaria l. against injuries of liver cells]. | it has been found out that the carbon tetrachloride (ccl4)-induced increase of serum glutamic-pyruvic transaminase (alt) and elevation of mda in liver of mice are significantly lowered by phyllanthus urinaria in vivo, and the coincubation of isolated rat hepatocytes with phyllanthus urinaria in vitro significantly inhibits ccl4-induced decrease of mobility of membrane of liver cells and increase of intracellular free ca2+ ([ca2+]i) concentrations of liver cells. these results suggest that the an ... | 1997 | 10743206 |
| [chemical constituents of phyllanthus urinaria l. and its antiviral activity against hepatitis b virus]. | studies on the chemical constituents of phyllanthus urinaria and its antiviral activity against hepatitis b virus were completed. eleven compounds have been isolated. two of them are new compounds methyl ester dehydrochebulic acid and methyl brevifolin carboxylate. antiviral experiments on hbsag in vitro and liver damage caused by ccl4 have shown that. phyllanthus urinaria possesses antiviral activities against hbv. | 1998 | 11601301 |
| medicinal and ethnoveterinary remedies of hunters in trinidad. | ethnomedicines are used by hunters for themselves and their hunting dogs in trinidad. plants are used for snakebites, scorpion stings, for injuries and mange of dogs and to facilitate hunting success. | 2001 | 11737880 |
| novel substituted methylenedioxy lignan suppresses proliferation of cancer cells by inhibiting telomerase and activation of c-myc and caspases leading to apoptosis. | conventional solvent fractionation and bioactivity based target assays were used to identify a new anti-cancer molecule from phyllanthus urinaria, a herbal medicinal plant used in south india. at each step of the purification process the different fractions that were isolated were tested for specific anti-proliferative activity by assays measuring the inhibition of [(3)h]thymidine incorporation, and trypan blue drug exclusion. the ethyl acetate fraction that contained the bioactivity was further ... | 2002 | 12085264 |
| phyllanthus urinaria triggers the apoptosis and bcl-2 down-regulation in lewis lung carcinoma cells. | phyllanthus urinaria (p. urinaria), a widely used herb medicine, was tested for the anticancer effect in its water extract for the first time. the water extract of p. urinaria significantly decreased the number of lewis lung carcinoma cells in a dose-and time-dependent manner as determined by mtt assay. however, the water extract of p. urinaria did not exert any cytotoxic effect on normal cells such as endothelial cells and liver cells. result from flow cytometry revealed a dose-dependent increa ... | 2003 | 12559392 |
| frontal immunoaffinity chromatography with mass spectrometric detection: a method for finding active compounds from traditional chinese herbs. | frontal affinity chromatography (fac) using immobilized polyclone antibodies of compound a coupled with mass spectrometry was used for the screening of affinity compounds from an extract of phyllanthus urinaria l. mass spectrometry was used as an analyzer of fac. it can analyze the frontal affinity chromatogram of each compound of the extract in one program. the extract was dissolved in 2 mm nh4oac at a concentration of 10 microg/ ml, then loaded on the immobilized antibody column, and data were ... | 2003 | 14632110 |
| modulation of pai-1 and tpa activity and thrombolytic effects of corilagin. | in this study, charlton's and tomihisa's methods were modified to investigate the thrombolytic effect of corilagin from the chinese herbal plant phyllanthus urinaria l., as well as its effect on carotid artery patency status. the activity of type 1 plasminogen activator inhibitor (pai-1) in rat plasma or platelet-released substances and tissue-type plasminogen activator (tpa) in rat plasma was assayed by use of a chromogenic substrate. the results showed that corilagin had a dose-dependent throm ... | 2003 | 14750026 |
| phyllanthus urinaria induces the fas receptor/ligand expression and ceramide-mediated apoptosis in hl-60 cells. | phyllanthus urinaria (p. urinaria), a widely used herb medicine, was tested for the anticancer effect on human myeloid leukemia cells in this study. the water extract of p. urinaria induced the apoptosis of hl-60 cells as demonstrated by morphological change, dna fragmentation and increased caspase-3 activity. however, normal human peripheral mononuclear cells remained viable under the same treatment. the p. urinaria-induced apoptosis of hl-60 cells was associated with the increased bax gene exp ... | 2004 | 15135654 |
| aqueous extract of phyllanthus urinaria induces apoptosis in human cancer cells. | cell apoptosis is now known to play an important role in the maintenance of cellular homeostasis and anti-carcinogenesis. the anticancer effect of aqueous extract prepared from phyllanthus urinaria (p. urinaria) was investigated by analyzing its potential to induce apoptosis in human cancer cells. we showed that the aqueous extract of p. urinaria could reduce the viability by inducing the apoptosis in human cancer cells derived from several different origins as demonstrated by morphological chan ... | 2004 | 15315256 |
| chemopreventive action of phyllanthus urinaria linn on dmba-induced skin carcinogenesis in mice. | the inhibition of tumor incidence by hydro-alcoholic extract of the whole plant of p. urinaria was evaluated in 6-7 weeks old female albino mice on two-stage process of skin carcinogenesis induced by a single application of 7,12-dimethylbenz(a)anthracene (50 microg/50 microl of acetone), and 2 weeks later, promoted by repeated application of croton oil (1% in acetone/three times a week) till the end of the experiment (15 weeks). topical application of the extract at a dose of 5 mg/kg body weight ... | 2003 | 15332506 |
| [effects of fraction from phyllanthus urinaria on thrombosis and coagulation system in animals]. | to investigate the effects of puw (a fraction containing 60% corilagin from a chinese herbal plant phyllanthus urinaria) on thrombosis and coagulation system. | 2004 | 15339469 |
| acetone, ethanol and methanol extracts of phyllanthus urinaria inhibit hsv-2 infection in vitro. | phyllanthus urinaria linnea (euphorbiaceae) is one of the traditional medicinal plants that are widely applied by oriental people, especially by chinese and indian, to ameliorate various kinds of ailments. many biological activities, including anti-hepatitis b virus, anti-epstein-barr virus and anti-retroviral reverse transcriptase, of p. urinaria have been reported, but not against herpes simplex virus (hsv). in this study, the anti-hsv-1 and hsv-2 activities of different solvents extracted fro ... | 2005 | 15885815 |
| antioxidative and cardioprotective effects of phyllanthus urinaria l. on doxorubicin-induced cardiotoxicity. | cardiac toxicity is a major adverse effect caused by doxorubicin (dox) therapy. many recent studies have shown that dox toxicity involves generation of reactive oxygen species (ros). although protection or alleviation of dox toxicity can be achieved by administration of antioxidant vitamins such as ascorbic acid and vitamin e, their cardioprotective effect remains controversial. thus alternative naturally occurring antioxidants may potentially be candidates for antioxidant therapy. in this study ... | 2005 | 15997091 |
| a flavonoid from medicinal plants blocks hepatitis b virus-e antigen secretion in hbv-infected hepatocytes. | a flavonoid molecule that showed a unique anti-hbv function was isolated from phyllanthus urinaria. the molecular formula was determined as c14h6o8 based on fam-ms analysis and the structure was determined by nmr. the identified flavonoid molecule, ellagic acid, showed unique anti-hbv functions. ellagic acid did not inhibit either hbv polymerase activity, hbv replication or block hbsag secretion. rather, ellagic acid blocks effectively hbeag secretion in hepg2 2.2.15 cells (ic50=0.07 microg/ml). ... | 2005 | 16118024 |
| screening of selected indigenous plants of cambodia for antiplasmodial activity. | the in vitro antiplasmodial activity of 117 aqueous, methanol and dichloromethane extracts derived from different parts of 28 indigenous wild plant species was studied. these plants are commonly used in cambodian traditional medicine. the plant extracts were tested for in vitro activity against a chloroquine resistant plasmodium falciparum strain (w2). nine extracts were moderately active with ic(50) values ranging between 5 and 10 microg/ml, 17 extracts were active with ic(50) values ranging be ... | 2006 | 16546336 |
| anti-tumor and anti-angiogenic effects of phyllanthus urinaria in mice bearing lewis lung carcinoma. | phyllanthus urinaria, a widely used herb medicine in asia, was tested for its anti-tumor effect in vivo for the first time. the anti-tumor activity in p. urinaria extract was evaluated by its effect on tumor developed in c57bl/6j mice with implantation of lewis lung carcinoma cells. the oral administration of p. urinaria to mice caused significant inhibition of tumor development with lower occurrence rate and markedly reduced tumor size. neither the total body weight of mouse nor the weights of ... | 2006 | 16644472 |
| ethnomedicines used in trinidad and tobago for urinary problems and diabetes mellitus. | this paper is based on ethnobotanical interviews conducted from 1996-2000 in trinidad and tobago with thirty male and female respondents. | 2006 | 17040567 |
| the in vitro activity of geraniin and 1,3,4,6-tetra-o-galloyl-beta-d-glucose isolated from phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection. | phyllanthus urinaria linnea (euphorbiaceae) is a widely used traditional medicinal plant by oriental countries and has been reported to possess various biological activities. previously, the acetone extract from phyllanthus urinaria was found to inhibit herpes simplex virus (hsv) infection. in this study, geraniin and 1,3,4,6-tetra-o-galloyl-beta-d-glucose (1346togdg), both of which were isolated from the acetone extract of phyllanthus urinaria, were examined for their activity against hsv-1 and ... | 2007 | 17113739 |
| hippomanin a from acetone extract of phyllanthus urinaria inhibited hsv-2 but not hsv-1 infection in vitro. | phyllanthus urinaria linnea (euphorbiaceae) is a commonly used traditional medicinal plant in oriental countries and has been reported to possess various biological activities. previously, the acetone extract and some pure compounds from p. urinaria were found to suppress herpes simplex virus (hsv). in this study, another two pure compounds were isolated from acetone extract of p. urinaria and were tested for their in vitro anti-hsv-1 and hsv-2 activities. the results showed that hippomanin a im ... | 2007 | 17661333 |
| phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivo. | hepatic oxidative stress plays a critical role in metabolic forms of steatohepatitis. phyllanthus urinaria, an herbal medicine, has been reported to have potential antioxidant properties. we tested the effects of p. urinaria on nutritional steatohepatitis both in vitro and in vivo. immortalized normal hepatocytes (aml-12) or primary hepatocytes were exposed to control, the methionine-and-choline-deficient (mcd) culture medium, in the presence or absence of p. urinaria for 24 hours. hepatocyte tr ... | 2008 | 18157836 |
| antioxidant, anti-semicarbazide-sensitive amine oxidase, and anti-hypertensive activities of geraniin isolated from phyllanthus urinaria. | the wrinkle-fruited leaf flower (phyllanthus urinaria l.) (euphorbiaceae) is widely used as a traditional folk medicine for inflammatory relief. geraniin, the hydrolysable tannin, was purified by a series of chromatographic processes from the 70% aqueous acetone extracts of p. urinaria and identified by nmr [1h (500 mhz) and 13c nmr (126 mhz)] spectra and mass spectroscopy. the scavenging activities of geraniin against dpph radicals (half-inhibition concentration, ic50, were 0.92 and 1.27 microm ... | 2008 | 18495318 |
| [phyllanthus urinaria extract promotes n-cadherin expression in nitrogen mustard-disrupted testicular tissues in vivo]. | to explore the protective effect of the phyllanthus urinaria (pu) extract on the n-cadherin expression in the testicular tissues disrupted by nitrogen mustard (hn2) in vivo. | 2008 | 18572855 |
| inhibition of helicobacter pylori-induced inflammation in human gastric epithelial ags cells by phyllanthus urinaria extracts. | helicobacter pylori is linked to a majority of peptic ulcers and to some types of gastric cancer, and its resistance to antibiotic treatment is now found worldwide. this study is aimed at evaluating the antimicrobial activity of phyllanthus urinaria linnea (euphorbiaceae), chloroform (puc) and methanol (pum) extracts, and its eight isolates on h. pylori-infected human gastric epithelial ags cells. | 2008 | 18602230 |
| phyllanthus urinaria increases apoptosis and reduces telomerase activity in human nasopharyngeal carcinoma cells. | this study was designed to obtain the chemical fingerprint and to investigate the effect of phyllanthus urinaria on telomerase activity and apoptotic pathways in the human nasopharyngeal carcinoma cell line (npc-bm1). | 2009 | 19295228 |
| phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome p450 cyp2e1. | acetaminophen is a commonly used drug for the treatment of patients with common cold and influenza. however, an overdose of acetaminophen may be fatal. in this study we investigated whether mice, administered intraperitoneally with a lethal dose of acetaminophen, when followed by oral administration of phyllanthus urinaria extract, may be prevented from death. histopathological analysis of mouse liver sections showed that phyllanthus urinaria extract may protect the hepatocytes from acetaminophe ... | 2009 | 19386480 |
| heterapoderopsis bicallosicollis (coleoptera: attelabidae): a potential biological control agent for triadica sebifera. | native to china, chinese tallow, triadica sebifera l. small (euphorbiaceae), is an invasive plant in the southeastern united states. the leaf-rolling weevil, heterapoderopsis bicallosicollis voss, is a common herbivore attacking this plant in china. to evaluate its potential as a biological control agent of t. sebifera, biology and host specificity of this weevil were studied in china. h. bicallosicollis occurs over a wide, native, geographic range and its immatures successfully develop at 15-35 ... | 2009 | 19689892 |
| cytoprotective role of phyllanthus urinaria l. and glutathione-s transferase pi in doxorubicin-induced toxicity in h9c2 cells. | to examine cytoprotective effect of phyllanthus urinaria (pu) ethanolic extract in doxorubicin (dox)-induced toxicity. the research focus was on the mechanism of action in association with the expression and localization of glutathione-s transferase (gst) in cardiac h9c2 cells. | 2009 | 19705546 |
| excoecarianin, isolated from phyllanthus urinaria linnea, inhibits herpes simplex virus type 2 infection through inactivation of viral particles. | phyllanthus urinaria linnea (euphorbiaceae) is one of the traditional medicinal plants widely used by oriental people to treat various diseases. we have previously demonstrated that the acetone extract of p. urinaria inhibits herpes simplex virus type 2 (hsv-2) but not hsv-1 infection. in a continuing effort to clarify the antiviral mechanisms of p. urinaria, we isolated the pure compound excoecarianin from the whole plant of p. urinaria through acetone extraction, and investigated its anti-hsv- ... | 2009 | 19808846 |
| ellagic acid, the active compound of phyllanthus urinaria, exerts in vivo anti-angiogenic effect and inhibits mmp-2 activity. | this study aimed to assess the potential anti-angiogenic mechanism of phyllanthus urinaria and characterize the major compound in p. urinaria that exerts anti-angiogenic effect. the water extract of p. urinaria and ellagic acid were used to evaluate the anti-angiogenic effect in chorioallantoic membrane (cam) in chicken embryo and human vascular endothelial cells (huvecs). the matrix metalloproteinase-2 (mmp-2) activity was determined by gelatin zymography. the mrna expressions of mmp-2, mmp-14 ... | 2009 | 20007260 |
| anti-angiogenic and cytotoxicity studies of some medicinal plants. | angiogenesis plays an important role in tumor formation and proliferation. the development of anti-angiogenic agents to block new blood vessel growth will inhibit metastasis and induce apoptosis of the cancer cells. nine medicinal plants, strobilanthes crispus, phyllanthus niruri, phyllanthus pulcher, phyllanthus urinaria, ailanthus malabarica, irvingia malayana, smilax myosotiflora, tinospora crispa and blumea balsamifera were screened for anti-angiogenic properties using the rat aortic ring as ... | 2010 | 20112179 |
| antimicrobial activity of some indian medicinal plants. | the antimicrobial potential of seventy-seven extracts from twenty-four plants was screened against eight bacteria and four pathogenic fungi, using microbroth dilution assay. lowest concentration of the extract, which inhibits any visual microbial growth after treatment with p-iodonitrotetrazolium violet, was considered to be minimum inhibitory concentration (mic). water extracts of acacia nilotica, justicia zelanica, lantana camara and saraca asoca exhibited good activity against all the bacteri ... | 2007 | 20161895 |
| assessing species admixtures in raw drug trade of phyllanthus, a hepato-protective plant using molecular tools. | phyllanthus (euphorbiaceae) species are well known for their hepato-protective activity and are used in several ethno-medicines in indigenous health care systems in india. | 2010 | 20435119 |
| effects of phyllanthus urinaria extract on hepg2 cell viability and oxidative phosphorylation by isolated rat liver mitochondria. | phyllanthus urinaria is widely used as anti-inflammatory, anti-diarrheal and hepatoprotective medicines in asian countries such as india, china and thailand. in thailand, phyllanthus urinaria is traditionally used as an adjuvant or alternative medicine for cancer patients, including liver cancer. however, there is limited scientific evidence supporting its use in cancer particularly hepatocellular carcinoma. | 2010 | 20488238 |
| novel use of silymarin as delayed therapy for acetaminophen-induced acute hepatic injury. | recently, we have demonstrated that silymarin has a comparable pharmaceutical activity as phyllanthus urinaria extract when used to rescue mice from acetaminophen-induced acute liver injury. in the present study, we further compared the therapeutic action of silymarin with n-acetyl cysteine (commonly used in clinical practice for emergency treatments) as a rescuer in mice after administering a lethal dose of acetaminophen for 24 h. | 2010 | 20829599 |
| anti-cancer effects of phyllanthus urinaria and relevant mechanisms. | phyllanthus urinaria (p. urinaria), a widely used herbal medicine, has been reported to possess various biological activities. this report aimed to characterize the whole p. urinaria plant, present the anticancer effects of p. urinaria both in vivo and in vitro, and explore relevant mechanisms. the water extract of p. urinaria not only significantly reduces the cell viability of various cancer cell lines from different origins but also suppresses tumor development in c57bl/6j mice after implanta ... | 2010 | 20979698 |
| hepatoprotective activity of the phyllanthus species on tert-butyl hydroperoxide (t-bh)-induced cytotoxicity in hepg2 cells. | phyllanthus (euphorbiaceae) species have long been used in folk medicine to treat various pathological conditions including liver diseases. some species of phyllanthus were found to exhibit hepatoprotective activity against drugs or toxins and this property was majorly attributed to phyllanthin and hypophyllanthin. in this study, we examined the hepatoprotective activity of five different species of phyllanthus, namely, phyllanthus amarus, phyllanthus fraternus, phyllanthus maderaspatensis, phyl ... | 2011 | 21969794 |
| comparison of plants used for skin and stomach problems in trinidad and tobago with asian ethnomedicine. | this paper provides a preliminary evaluation of fifty-eight ethnomedicinal plants used in trinidad and tobago for skin problems, stomach problems, pain and internal parasites for safety and possible efficacy. thirty respondents, ten of whom were male were interviewed from september 1996 to september 2000 on medicinal plant use for health problems. the respondents were obtained by snowball sampling, and were found in thirteen different sites, 12 in trinidad and one in tobago. the uses are compare ... | 2007 | 17207273 |
| in vitro antimicrobial activity of traditional plant used in mestizo shamanism from the peruvian amazon in case of infectious diseases. | our survey was performed near iquitos (peruvian amazon) and its surroundings and leads us to consider mestizo ethnomedical practices. the plant species reported here are traditionally used for ailments related to microbial infections. inhabitants of various ethnic origins were interviewed, and 52 selected plants extracts were evaluated for their antimicrobial properties against a panel of 36 sensitive and multi-resistant bacteria or yeast. the study aimed at providing information on antimicrobia ... | 2015 | 27013805 |
| a novel green gelatin-agar microencapsulation system with p. urinaria as an improved anti-a. niger model. | in this study, a novel green microencapsulation system was used to develop phyllanthus urinaria (pu) extract containing microcapsules. agar was used with gelatin as the wall matrix materials of microcapsules to prevent the use of toxic crosslinker formaldehyde. microencapsulated pu extract was developed to improve the potential antifungal activities of pu water extracts. the active components and surface morphology of pu extract containing microcapsules were analyzed by liquid chromatography/mas ... | 2013 | 23218379 |
| antiviral effects of phyllanthus urinaria containing corilagin against human enterovirus 71 and coxsackievirus a16 in vitro. | human enterovirus 71 (ev71) and coxsackievirus a16 (ca16) are major causative agents of hand, foot, and mouth disease (hfmd) especially in infants and children under 5 years of age. despite recent outbreaks of hfmd, there are no approved therapeutics against ev71 and ca16 infection. moreover, in a small percentage of cases, the disease progression can lead to serious complications of the central nervous system. in this study, we investigated the antiviral effect of corilagin and phyllanthus urin ... | 2015 | 24752860 |
| inhibitory effect of phyllanthus urinaria l. extract on the replication of lamivudine-resistant hepatitis b virus in vitro. | long-term treatment of chronic hepatitis b (chb) with nucleos(t)ide analogs results in the emergence of drug-resistant hepatitis b virus (hbv) harboring mutations in the polymerase (p) gene. the phyllanthus extract has anti-hbv activity; however, its antiviral activity against lamivudine (lmv)-resistant mutants has not been examined. | 2015 | 26220282 |
| extract from phyllanthus urinaria l. inhibits hepatitis b virus replication and expression in hepatitis b virus transfection model in vitro. | to explore the effects of the extract from phyllanthus urinaria l. on hepatitis b virus (hbv) replication and expression in hbv transient transfection model in vitro. | 2015 | 25869593 |
| efficacy of early treatment on 52 patients with preneoplastic hepatitis b virus-associated hepatocellular carcinoma by compound phyllanthus urinaria l. | to observe the change in the number of antibodies of preneoplastic hepatocellular carcinoma (hcc) using early treatment by compound phyllanthus urinaria l. (cpul) on patients with preneoplastic hepatitis b virus (hbv)-associated hcc. | 2014 | 23529834 |
| activity-based and fraction-guided analysis of phyllanthus urinaria identifies loliolide as a potent inhibitor of hepatitis c virus entry. | without a vaccine, hepatitis c virus (hcv) remains a global medical and socio-economic burden, predisposing about 170 million carriers worldwide to end-stage liver diseases including cirrhosis and hepatocellular carcinoma. although the recently developed direct-acting antivirals (daas) have revolutionized hepatitis c treatment, most of them are unsuitable for monotherapy due to risks of resistance, thus necessitating combination with interferon (ifn)-alpha, ribavirin, or additional daas. more im ... | 2016 | 27012176 |
| in vitro antiplasmodial activity, macronutrients and trace metals in the medicinal plants: phyllanthus spp. and alpinia conchigera griff. | an antiplasmodial screening of phyllanthus debilis and phyllanthus urinaria was carried out. the medicinal plants were extracted and evaluated for in vitro antiplasmodial activity against d10 (chloroquine-sensitive, cqs) and gombak a (chloroquine-resistant, cqr) strains of plasmodium falciparum. the methanolic crudes from the soxhlet extraction were active against both strains however, p. urinaria (ic50 8.9 μg/ml with cqr strain) exhibited better anti-malarial activity compared to p. debilis (ic ... | 2015 | 25801263 |
| an ethnopharmacological survey and in vitro confirmation of the ethnopharmacological use of medicinal plants as anthelmintic remedies in the ashanti region, in the central part of ghana. | infections with helminths are still a big problem in many parts of the world. the majority of the people in west africa treat such infections with medicinal plants related to the local traditional medicine. the present study aims at identifying medicinal plants traditionally used for worm infections in the ashanti region, ghana. in vitro screening of selected extracts from plants on which scientific knowledge is limited was to be performed. | 2014 | 25446638 |
| a survey of herbal weeds for treating skin disorders from southern thailand: songkhla and krabi province. | skin diseases are common health problems which affecting to all ages. in thailand, the number of patients diagnosed with skin diseases is increasing every year. nowadays, the ministry of public health is supporting and promoting herbs for treating various disorders, including disorders of the skin to reduce the problem of antibiotic resistance and adverse drug reactions. this study aimed to: (1) enumerate the herbal weeds for treating skin disorders; (2) study local knowledge of weed utilization ... | 2016 | 27693346 |
| eare-1, a transcriptionally active ty1/copia-like retrotransposon has colonized the genome of excoecaria agallocha through horizontal transfer. | long terminal repeat (ltr) retrotransposons constitute the majority of the content of angiosperm genomes, but their evolutionary dynamics remain poorly understood. here, we report the isolation and characterization of a putative full-length (~9550 bp) ty1/copia-like retrotransposon in excoecaria agallocha and its evolution in euphorbiaceae. the so-called eare-1 is phylogenetically closely related to rire-1 from oryza australiensis, and has proliferated recently (~7.19 mya) in the e. agallocha ge ... | 2017 | 28174588 |
| screening for potential α-glucosidase and α-amylase inhibitory constituents from selected vietnamese plants used to treat type 2 diabetes. | the 18 plant species investigated in this study have been used as herbal antidiabetic remedies in vietnamese traditional medicines. this study aimed to evaluate their ability to inhibit α-glucosidase and α-amylase, two key enzymes involved in serum glucose regulation. | 2016 | 27041401 |
| phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-pa via erk and akt signaling pathways. | phyllanthus urinaria is widely used as anti-inflammatory, antiviral, antibacterial, and anti-hepatotoxic medicines in almost every tropical country. however, scientific evidence supporting its use in cancer metastasis is limited, particularly osteosarcoma. we investigated the effect of p. urinaria extract (pue) on cell viability, invasion, and migration in the human osteosarcoma saos-2 cell line, and looked at the impact of pue on several relevant proteases and signaling pathways. this study dem ... | 2013 | 23201449 |