| effect of phyllanthus amarus on chronic carriers of hepatitis b virus. | in a preliminary study, carriers of hepatitis b virus were treated with a preparation of the plant phyllanthus amarus for 30 days. 22 of 37 (59%) treated patients had lost hepatitis b surface antigen when tested 15-20 days after the end of the treatment compared with only 1 of 23 (4%) placebo-treated controls. some subjects have been followed for up to 9 months. in no case has the surface antigen returned. clinical observation revealed few or no toxic effects. the encouraging results of this pre ... | 1988 | 2901611 |
| herbs of the genus phyllanthus in the treatment of chronic hepatitis b: observations with three preparations from different geographic sites. | it has been suggested that herbs of the phyllanthus family may have antiviral activity. we therefore tested the effects of three different phyllanthus extracts on the serologic status of 123 patients with chronic hepatitis b. eleven patients received an extract of phyllanthus amarus (l) provided by s.p. thyagarajan, madras, india. forty-two patients received phyllanthus niruri (l), gathered from hainan province in china, and 35 patients received an extract of phyllanthus urinaria (l), which had ... | 1995 | 7561442 |
| inhibition of signal-regulated protein kinases by plant-derived hydrolysable tannins. | a variety of hydrolysable tannins purified from phyllanthus amarus are potent inhibitors of rat liver cyclic amp-dependent protein kinase catalytic subunit (cak) with ic50 values (concentrations for 50% inhibition) in the range 0.2-1.7 microm. the three most effective compounds of this series of hydrolysable tannins have five phenolic substituents. these three compounds are also the most effective inhibitors of wheat embryo ca(2+)-dependent protein kinase (cdpk), rat brain ca(2+)- and phospholip ... | 1995 | 7772301 |
| effect of an extract from phyllanthus amarus on hepatitis b surface antigen gene expression in human hepatoma cells. | it has been suggested that phyllanthus amarus may be helpful in the treatment of hepatitis b virus infection. we studied the effect of an aqueous extract of p. amarus on the cultured hepatoma cell line hepa2. this cell line had been transfected with tandemly arranged hbv dna and continued to synthesize and secrete both hbsag and hbeag. extract of p. amarus reversibly inhibited cellular proliferation and suppressed hbsag production but not hbeag production in hepa2 cells. we also found that p. am ... | 1993 | 8470882 |
| a comparative study of phyllanthus amarus compound and interferon in the treatment of chronic viral hepatitis b. | fifty-five patients with chronic viral hepatitis b were randomly divided into two groups. thirty patients were treated with phyllanthus amarus compound (pa co) for three months in the treatment group, another 25 patients were treated with domestic recombinant human interferon alpha-1b (ifn-alpha 1b) for three months as controls. the total effective rate in the treatment group was 83.3%, showing no significant difference from the control (p>0.05). the normalization rates of alt, a/g and sb in the ... | 2001 | 11485076 |
| herbal medicines for liver diseases in india. | the use of natural remedies for the treatment of liver diseases has a long history, starting with the ayurvedhic treatment, and extending to the chinese, european and other systems of traditional medicines. the 21st century has seen a paradigm shift towards therapeutic evaluation of herbal products in liver diseases by carefully synergizing the strengths of the traditional systems of medicine with that of the modern concept of evidence-based medicinal evaluation, standardization of herbal produc ... | 2002 | 12472966 |
| anti-mutagenic activity of phyllanthus amarus schum & thonn in vitro as well as in vivo. | methanolic extract of phyllanthus amarus was tested for its anti-mutagenic activity in salmonella typhimurium strains ta1535, ta100, and ta102 (ames test). p. amarus extract was able to inhibit the activation and mutagenicity of 2-acetaminofluorene (2-aaf) and aflatoxinb(1) at concentrations of 0.25-2 mg/plate. it was also found to inhibit mutagenicity induced by direct acting mutagens sodium azide (nan(3)), n-methyl-n-nitro-n-nitrosoguanidine (mnng), and 4-nitro-0-phenylenediamine (npd), at con ... | 2002 | 12111712 |
| antitumour and anticarcinogenic activity of phyllanthus amarus extract. | aqueous extract of phyllanthus amarus (p. amarus) treatment exhibited potent anticarcinogenic activity against 20-methylcholanthrene (20-mc) induced sarcoma development and increased the survival of tumour harboring mice. the extract administration (p.o) was also found to prolong the life span of dalton's lymphoma ascites (dla) and ehrlich ascites carcinoma (eac) bearing mice and reduced the volume of transplanted solid tumours. the extract inhibited aniline hydroxylase, a p-450 enzyme. the conc ... | 2002 | 12020923 |
| antimutagenic and anticarcinogenic effects of phyllanthus amarus. | this study aimed to examine the antimutagenic and anticarcinogenic potential of phyllanthus amarus schum. et thonn. using the bacterial preincubation mutation assay and an in-vivo alkaline elution method for dna single-strand breaks in hamster liver cells. the aqueous extract of the entire plant showed an antimutagenic effect against induction by 2-aminofluorene (af2), 2-aminoanthracene (2aa) and 4-nitroquinolone-1-oxide (4-nqo) in salmonella typhimurium strains ta98 and ta100, and in escherichi ... | 2002 | 11924760 |
| chinese medicinal herbs for asymptomatic carriers of hepatitis b virus infection. | about 350 million people are chronically infected carriers of hepatitis b virus and are at a higher risk of serious illness and death from cirrhosis of the liver and liver cancer. chinese medicinal herbs have been used widely for more than 2000 years to treat chronic liver disease. | 2001 | 11406038 |
| morphometric and histopathological studies on the effects of some chromatographic fractions of phyllanthus amarus and euphorbia hirta on the male reproductive organs of rats. | the aqueous crude extracts of p. amarus and e. hirta were administered to thirty eight-week old sexually mature male albino to determine the effects of these extracts on the male reproductive organs of these animals. the results from this study revealed that the aqueous crude extracts of p. amarus and e. hirta caused varying degrees of testicular degeneration as well as reduction in the mean seminiferous tubular diameter (std) in the treated rats. it thus shows that the aqueous crude extracts of ... | 2003 | 14610373 |
| protective effect of an extract of phyllanthus amarus against radiation-induced damage in mice. | the radioprotective effect of an extract of the plant phyllanthus amarus (p. amarus) was investigated in adult balb/c mice. p. amarus extract (750 mg/kg b.wt and 250 mg/kg b.wt) was administered orally to mice for five days prior to whole body radiation (6 gy) and for one month after radiation. the animals were sacrificed on days 3, 9, 12, and 30 after radiation. p. amarus significantly increased the total w.b.c count, bone marrow cellularity, and alpha-esterase activity as compared to untreated ... | 2004 | 15133301 |
| chinese medicinal herbs for chronic hepatitis b. | hepatitis b virus infection is a serious health problem worldwide. traditional chinese medicinal herbs have been widely used to treat chronic liver diseases, and many controlled trials have been done to investigate their efficacy. | 2001 | 11279742 |
| phyllanthus amarus extract administration increases the life span of rats with hepatocellular carcinoma. | the effect of phyllanthus amarus extract administration after induction of hepatocellular carcinoma (hcc) by n-nitrosodiethylamine (ndea) was studied in wistar rats. administration of an aqueous extract of p. amarus was found to significantly increase the survival of hepatocellular carcinoma harboring animals. all the untreated rats died of tumour burden by 33.7+/-1.6 weeks. administration of p. amarus extract (150 mg/kg b.w.) after tumour development increased the survival of animals to an aver ... | 2000 | 11025159 |
| evaluation of inhibitory effect of the plant phyllanthus amarus against dermatophytic fungi microsporum gypseum. | the antifungal activity of various solvent extracts (such as ether, chloroform, ethyl acetate and ethyl alcohol) of the plant phyllanthus amarus against dermatophytic fungi microsporum gypseum was observed. | 2004 | 15602834 |
| treatment of chronic liver diseases with traditional chinese medicine. | traditional chinese medicine is still being extensively used for treatment of liver disease in china. the anti-viral herbs, phyllanthus amarus, p. niruri and p urninaria, and oxymatrine extracted from sophora flavecientis and s. subprostratae, have been shown to have a remarkable hbv suppressing effect with a serum conversion rate for hbeag and hbv dna around 45%, similar to that of ifn-alpha. the anti-inflammatory compound, stronger neominophagen c (snmc), is a japanese preparation of glycerrhi ... | 2000 | 10921385 |
| effect of emblica officinalis, phyllanthus amarus and picrorrhiza kurroa on n-nitrosodiethylamine induced hepatocarcinogenesis. | extracts of emblica officinalis (eo), phyllanthus amarus (p. amarus) and picrorrhiza kurroa (p. kurroa) significantly inhibited hepatocarcinogenesis induced by n-nitrosodiethylamine (ndea) in a dose dependent manner. the anticarcinogenic activity of these extracts were evaluated by their effect on tumour incidence, levels of carcinogen metabolizing enzymes, levels of liver cancer markers and liver injury markers. animals treated with ndea alone showed 100% tumour incidence and significantly elev ... | 1999 | 10211933 |
| phyllanthus amarus suppresses hepatitis b virus by interrupting interactions between hbv enhancer i and cellular transcription factors. | the phyllanthus amarus plant suppresses hbv mrna transcription in vitro and exhibits therapeutic potential in chronic hbv carriers, although further work is necessary to define its mechanism of action. analysis in huh-7 cells with transfected plasmids using a luciferase reporter showed that p. amarus specifically inhibited hbv enhancer i activity. to identify the mechanism of this hbv enhancer i inhibition, liver-enriched cellular transcription factors were co-expressed in huh-7 cells. the c/ebp ... | 1997 | 9395786 |
| phyllanthus amarus down-regulates hepatitis b virus mrna transcription and replication. | the phyllanthus amarus plant shows potential for treating hepatitis b virus. to define the mechanism of action of p. amarus, we used hepg2 2.2.15 cells, which support hepatitis b virus replication. p. amarus inhibited hepatitis b virus polymerase activity, decreased episomal hepatitis b virus dna content and suppressed virus release into culture medium. to examine transcriptional control mechanisms, we used g26 hepatitis b virus transgenic mice, which produce serum hbsag but neither hbcag nor vi ... | 1996 | 9013081 |
| inhibition of hbsag secretion from alexander cell line by phyllanthus amarus. | alexander cell line, an human hepatocellular carcinoma derived cell line which has the property of secreting hbsag in the supernatant was used to study the antiviral property of phyllanthus amarus. aquous extract of phyllanthus amarus was evaluated for its in vitro ability to inhibit hbsag secretion on a dose dependent manner. it was seen that p. amarus at 1mg/ml concentration on a single dose inhibited the secretion of hbsag for a period of 48 hours. this experiment proved the anti hepatitis b ... | 1996 | 8972151 |
| diuretic, hypotensive and hypoglycaemic effect of phyllanthus amarus. | diuretic, hypotensive and hypoglycaemic effects of phyllanthus amarus (syn. phyllanthus niruri) on human subjects were assessed. nine mild hypertensives (four of them also suffering from diabetes mellitus) were treated with a preparation of the whole plant of p. amarus for 10 days. suitable parameters were studied in the blood and urine samples of the subjects, along with physiological profile and dietary pattern before and after the treatment period. significant increase in 24 hr urine volume, ... | 1995 | 8786163 |
| evaluation of phyllanthus amarus and phyllanthus maderaspatensis as agents for postexposure prophylaxis in neonatal duck hepatitis b virus infection. | the therapeutic potential of plant extracts of phyllanthus amarus and phyllanthus maderas patensis for postexposure prophylaxis against infection by hepadnaviruses was studied in ducklings infected by the duck hepatitis b virus (dhbv). forty-four pekin ducklings were inoculated intraperitoneally with dhbv at 24 hr post-hatch. they were treated by intraperitoneal injection of phyllanthus amarus (aqueous extract) (100 mg/kg body weight) or phyllanthus mad eraspatensis (alcoholic extract) (100 mg/k ... | 1993 | 8515247 |
| a two-stage clinical trial of phyllanthus amarus in hepatitis b carriers: failure to eradicate the surface antigen. | there have been conflicting data in literature about the value of phyllanthus amarus in treating hepatitis b virus-related disorders. | 1994 | 8119752 |
| evaluation of anti-hepadnavirus activity of phyllanthus amarus and phyllanthus maderaspatensis in duck hepatitis b virus carrier pekin ducks. | extracts of the two traditional indian herbs, phyllanthus amarus (p. amarus) and phyllanthus maderaspatensis (p. maderaspatensis), described by others as useful in the treatment of chronic hepatitis b virus infection were studied for antiviral properties on duck hepatitis b virus infection. one hundred and fourteen ducks infected posthatch with the duck hepatitis b virus (dhbv) were divided into groups at three months of age and treated intraperitoneally with the aqueous, butanol, and alcoholic ... | 1993 | 8106861 |
| [efficacy of phyllanthus spp. in treating patients with chronic hepatitis b]. | the efficacy of phyllanthus amarus produced in india, p. niruri gathered from hainan province and p. urinaria from henan province was assessed in a total of 88 cases of chronic hepatitis b with 11.42 and 35 each. it was shown that p. urinaria had the effect of seroconversion on hbeag from positive to negative as well as on hbeab from negative to positive, while the other two herbs had not. in addition none of these three herbs had similar effect on hbsag. | 1994 | 7718142 |
| effect of phyllanthus amarus on chronic carriers of hepatitis b virus. | | 1988 | 2902445 |
| hepatoprotective effect of ethanolic extract of phyllanthus amarus schum. et thonn. on aflatoxin b1-induced liver damage in mice. | phyllanthus amarus schum. et thonn. (bhuia amla; euphorbiacae) is a herb common to central and southern india. it is an ayurvedic herb and has a wide range of traditional uses in different diseases. the aim of this work was to evaluate the hepatoprotective effect of ethanolic extract of phyllanthus amarus (phyllanthus amarus) on aflatoxin b(1)-induced liver damage in mice using different biochemical parameters and histopathological studies. aflatoxin was administered orally (66.6 microg kg(-1)bw ... | 2007 | 17720339 |
| hepatitis b virus and hepatocellular carcinoma--treatment of hbv carriers with phyllanthus amarus. | extracts of phyllanthus amarus inhibit the dna polymerase of hbv and related viruses. woodchuck carriers of woodchuck hepatitis virus (whv) were treated intraperitoneally with p. amarus extract. three of four animals which had been recently infected lost the virus. animals infected for about 3 months or more had a decrease in virus levels. human carriers of hbv were treated orally for 1 month. about 60% of the carriers lost hbv, which did not return during the observation period. fractions conta ... | 1989 | 2559794 |
| hepatitis b virus and primary hepatocellular carcinoma: treatment of hbv carriers with phyllanthus amarus. | a viricide capable of eliminating hepatitis b virus (hbv) from chronic carriers should, theoretically, decrease the risk of primary hepatocellular carcinoma. extracts of phyllanthus amarus have been shown to inhibit the dna polymerase of hbv and woodchuck hepatitis virus (whv) in vitro. three of four recently infected whv carriers treated i.p. with p. amarus extract lost whv, animals infected for greater than or equal to 3 months showed a decrease in virus levels. preliminary results in human ca ... | 1990 | 2158192 |
| nacl as a physiological modulator of proline metabolism and antioxidant potential in phyllanthus amarus. | some medicinal plants need to be cultivated commercially in order to meet the ever-increasing demand for medicinal plants for the indigenous systems of medicine as well as for the pharmaceutical industry; in this regard, it seems significant to test the important medicinal plants for their salt-tolerance capacity, with a view to exploiting the saline lands for medicinal plant cultivation. phyllanthus amarus plants were grown in the presence of nacl in order to study the effect of nacl (80 mm nac ... | 2007 | 17923374 |
| effect of phyllanthus amarus on duck hepatitis b virus replication in vivo. | nine ducks congenitally infected with the duck hepatitis b virus (dhbv) were treated either orally (four ducks for 10 weeks) or intraperitoneally (five ducks for 12 weeks) with the indian traditional herbal remedy phyllanthus amarus. compared to placebo-treated control ducks, these treatments did not result in a reduction of circulating viral dna in the serum or in the level of viral dna replication in the liver. in two of the five intraperitoneal-treated ducks, a reduction in the levels of duck ... | 1990 | 2081970 |
| larvicidal activity of some euphorbiaceae plant extracts against aedes aegypti and culex quinquefasciatus (diptera: culicidae). | larvicidal activity of ethyl acetate, butanol, and petroleum ether extracts of five species of euphorbiaceae plants, jatropha curcas, pedilanthus tithymaloides, phyllanthus amarus, euphorbia hirta, and euphorbia tirucalli, were tested against the early fourth instar larvae of aedes aegypti l. and culex quinquefasciatus (say). the larval mortality was observed after 24 h of exposure. all extracts showed low larvicidal effects; however, the highest larval mortality was found in petroleum ether ext ... | 2008 | 18163189 |
| phyllanthus amarus and hepatitis b. | | 1990 | 1976968 |
| failure of phyllanthus amarus to eradicate hepatitis b surface antigen from symptomless carriers. | | 1990 | 1972525 |
| in vitro effect of phyllanthus amarus on hepatitis b virus. | to evaluate the effects of p. amarus on hepatitis b virus (hbv) antigens and hbv-dna, initial ethanolic extract and subsequent fractions of the plants were prepared. the whole plant material was dried, powdered and extracted with alcohol and subsequently fractionated in hexane, chloroform, butanol and finally in water. all the material were tested for in vitro effects on hbsag, hbeag and hbv-dna in serum samples positive for hbv antigens followed by the screening of respective antigens by elisa. ... | 1991 | 1855821 |
| hepatoprotective potentials of phyllanthusamarus against ethanol-induced oxidative stress in rats. | the hepatoprotective effect of methanolic extract of the leaf of phyllanthus amarus (p. amarus) against ethanol-induced oxidative damage was investigated in adult male wistar albino rats. p. amarus (250 and 500 mg/kg/day) and ethanol (5 g/kg/day, 20% w/v) were administered orally to animals for 4 weeks and 3 weeks, respectively. ethanol treatment markedly decreased the level of reduced glutathione (gsh), superoxide dismutase (sod), and catalase (cat) in the liver, which were significantly enhanc ... | 2008 | 18524448 |
| efficacy of phyllanthus amarus for eradication of hepatitis b virus in chronic carriers. | sixty-five adult asymptomatic chronic carriers of hepatitis b virus were enrolled to the randomized controlled efficacy study of phyllanthus amarus. thirty-four received phyllanthus amarus 600 mg per day for 30 days and 31 received placebo in identical capsules. the conversion rate of hbsag was 6 per cent in the study group at day 30. when 20 subjects in the phyllanthus amarus group were given a further 30-day treatment and 22 placebo recipients given phyllanthus amarus 1,200 mg per day for 30 d ... | 1991 | 1791391 |
| phyllanthus amarus has anti-inflammatory potential by inhibition of inos, cox-2, and cytokines via the nf-kappab pathway. | phyllanthus amarus is a herbal medicine traditionally applied in the treatment of viral hepatitis. aim of this study was to investigate potential anti-inflammatory properties of standardized p. amarus extracts concerning a potential influence of p. amarus on endotoxin-induced nitric oxide synthase (inos), cyclooxygenase (cox-2), and cytokine production in vivo and in vitro. | 2003 | 12586294 |
| interactions between cytochromes p450, glutathione s-transferases and ghanaian medicinal plants. | inhibition of cytochrome p450s (cyps) is a major cause of adverse drug-drug interactions. alternatively, inhibition of glutathione s-transferases (gsts) may increase harmful effects of electrophilic compounds or metabolites. in the present study, aqueous extracts of seven ghanaian medicinal plants were investigated for their inhibitory potential towards recombinant human cyp1a2, cyp2c9, cyp2d6 and cyp3a4, heterologously expressed in escherichia coli. effects of these extracts on recombinant huma ... | 2008 | 18822337 |
| hypoglycemic effect of methanol extract of phyllanthus amarus schum & thonn on alloxan induced diabetes mellitus in rats and its relation with antioxidant potential. | methanolic extract of p. amarus was found to have potential anti-oxidant activity as it could inhibit lipid peroxidation, and scavenge hydroxyl and superoxide radicals in vitro. the amount required for 50% inhibition of lipid peroxide formation was 104 microg/ml and the concentrations needed to scavenge hydroxyl and superoxide radicals were 117 and 19 microg/ml respectively. the extract was found to reduce the blood sugar in alloxan diabetic rats at 4th hr by 6% at a dose level of 200 mg/kg body ... | 2002 | 12597020 |
| inhibition of wild-type human immunodeficiency virus and reverse transcriptase inhibitor-resistant variants by phyllanthus amarus. | substantial progress has been made in research on natural products which effectively inhibit hiv-1 replication. many active compounds were isolated from traditionally used medicinal plants including phyllanthus species. this study shows that aqueous as well as alcohol-based phyllanthus amarus extracts potently inhibit hiv-1 replication in hela cd4(+) cells with 50% effective concentration (ec(50)) values ranging from 0.9 to 7.6 microg/ml. a gallotannin enriched fraction showed enhanced activity ... | 2003 | 12742578 |
| inhibition of experimental gastric lesion and inflammation by phyllanthus amarus extract. | methanolic extract of phyllanthus amarus shum & thonn (euphorbiaceae) 50, 200, and 1000 mg/kg body weight significantly inhibited gastric lesions, induced by intragastric administration of absolute ethanol (8 ml/kg). mortality, increased stomach weight, ulcer index, and intraluminal bleeding were reduced significantly by phyllanthus amarus. biochemical analysis indicated that reduced glutathione (gsh) of gastric mucosa produced by ethanol administration was significantly elevated by treatment wi ... | 2003 | 12860307 |
| concerted inhibitory activities of phyllanthus amarus on hiv replication in vitro and ex vivo. | phyllanthus amarus derived preparations were previously shown to inhibit rt inhibitor-resistant hiv variants as efficiently as wild-type strains. the drugs target different steps of the hiv life cycle, thereby presenting multiple antiviral activities. here we show that a water/alcohol extract blocks hiv-1 attachment and the hiv-1 enzymes integrase, reverse transcriptase and protease to different degrees. a gallotannin containing fraction and the isolated ellagitannins geraniin and corilagin were ... | 2004 | 15498604 |
| efficacy of herbal remedies used by herbalists in oyo state nigeria for treatment of plasmodium falciparum infections--a survey and an observation. | in the course of evaluating the contribution of phytomedicine to possible drug discovery of antimalarial drugs, an ethnomedical survey of specialized children traditional clinics was done. in the observational multi center study, efficacy of eight different herbal remedies, each consisting of 3-8 ingredients and administered by herbalists were investigated in clients enrolled in the six traditional clinics in oyo (urban center) and otu (rural center) of oyo state, nigeria. the clients, aged betw ... | 2004 | 15565927 |
| antibacterial screening of some peruvian medicinal plants used in callería district. | nine ethanol extracts of brunfelsia grandiflora (solanaceae), caesalpinia spinosa (caesalpiniaceae), dracontium loretense (araceae), equisetum giganteum (equisetaceae), maytenus macrocarpa (celastraceae), phyllanthus amarus (euphorbiaceae), piper aduncum (piperaceae), terminalia catappa (combretaceae), and uncaria tomentosa (rubiaceae), medicinal plants traditionally used in calleria district for treating conditions likely to be associated with microorganisms, were screened for antimicrobial act ... | 2005 | 15894143 |
| effect of cadmium on growth, ultramorphology of leaf and secondary metabolites of phyllanthus amarus schum. and thonn. | the pollution is increasing in the environment by different kinds of human activities, which results in the accumulation of heavy metals including cadmium in the soil and water and it causes different types of problems to living beings. as the plants are utilized by human being as food and medicine, therefore, it is mandatory to see the effect of metals on plants. in this context, efforts have been made to observe the effect of different concentration of cadmium (cd) on phyllanthus amarus schum. ... | 2005 | 15992855 |
| chemoprotective activity of an extract of phyllanthus amarus against cyclophosphamide induced toxicity in mice. | the effect of 75% methanolic extract of the plant phyllanthus amarus (p. amarus) was studied against cyclophosphamide (ctx) induced toxicity in mice. administration of ctx (25 mg/kg b.wt, i.p.) for 14 days produced significant myelosuppression as seen from the decreased wbc count and bone marrow cellularity. administration of p. amarus extract at doses 250 and 750 mg/kg b.wt significantly reduced the myelosuppression and improved the wbc count, bone marrow cellularity as well as the number of ma ... | 2005 | 16008127 |
| tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in leishmania major-infected macrophage-like raw 264.7 cells. | some polyphenol-containing extracts (pelargonium sidoides, phyllanthus amarus) and representatives of simple phenols (shikimic acid 3- and 5-o-gallate), flavan-3-ols (epigallocatechin 3-gallate), proanthocyanidins (a hexamer) and hydrolysable tannins (corilagin, casuariin, geraniin) were studied for gene expressions (inos, il-1, il-10, il-12, il-18, tnf-alpha, ifn-alpha/gamma) by rt-pcr. all extracts and compounds were capable of enhancing the inos and cytokine mrna levels in parasitised cells w ... | 2005 | 16143535 |
| toxic effects of chromatographic fractions of phyllanthus amarus on the serum biochemistry of rats. | chromatographic fractions obtained from phyllanthus amarus were tested for toxicity on the serum biochemistry of rats. the results revealed that some fractions of p. amarus had potentially deleterious effects on the blood and therefore caution should be exercised in the use of p. amarus as a medicinal plant. | 2005 | 16220579 |
| two new lignans from phyllanthus amarus. | two new lignans, 3-(3,4-dimethoxy-benzyl)-4-(7-methoxy-benzo[1,3]dioxol-5-yl-methyl)-dihydrofuran-2-one (1) and 4-(3,4-dimethoxy-phenyl)-1-(7-methoxy-benzo[1,3]dioxol-5-yl)-2,3-bis-methoxymethyl-butan-1-ol (2), were isolated from the leaves of phyllanthus amarus and their structures were established by spectral analysis. additionally, eight known lignans were also isolated and characterized. | 2009 | 20183291 |
| antioxidant potential of aqueous extract of phyllanthus amarus in rats. | increased levels of oxidative stress may be implicated in the etiology of many pathological conditions. protective antioxidant action imparted by many plant extracts and plant products make them promising therapeutic drugs for free radical induced pathologies. in this study we assessed the antioxidant potential of phyllanthus amarus (euphorbiaceae). | 2009 | 20336219 |
| some clinico-pathological changes associated with the aqueous extract of the leaves of phyllanthus amarus in rats. | the pathological changes of the aqueous crude extract of the leaves of phyllanthus amarus were studied in 32 male rats over a period of 30 days. the animals were divided into four groups of eight animals per group. the aqueous crude extract was prepared and administered orally using a cannula to rats in three groups receiving doses of 400 mg/kg, 800 mg/kg and 1,000 mg/kg but the fourth group served as a control and received distilled water only. blood samples were collected for haematological an ... | 2005 | 16317655 |
| inhibition of drug metabolizing enzymes (cytochrome p450) in vitro as well as in vivo by phyllanthus amarus schum & thonn. | an alcoholic extract of phyllanthus amarus (p. amarus) was found to inhibit cytochrome p450 (p450) enzymes both in vivo as well as in vitro. this was studied using specific resorufin derivatives, as substrate for isoenzymes in the p450 super family. concentration needed for 50% inhibition of 7-ethoxyresorufin-o-deethylase (erod), cyp1a1 was 4.6 microg/ml while concentration needed for 7-methoxyresorufin-o-demethylase (mrod) cyp1a2 was 7.725 microg/ml and 7-pentoxyresorufin-o-depentylase (prod), ... | 2006 | 16819159 |
| inhibition of n-methyl n'-nitro-n-nitrosoguanidine (mnng) induced gastric carcinogenesis by phyllanthus amarus extract. | chemopreventive activity of phyllanthus amarus schum & thonn (euphorbiaceae) extract was studied with regard to n-methyl n'-nitro-n-nitrosoguanidine (mnng) induced stomach cancer in wistar rats. administration of the extract with mnng significantly reduced the incidence of gastric neoplasms in rats (44%) as well as their numbers. moreover, elevated levels of enzymes in the stomach were found to be reduced by p. amarus administration. for example, gamma-glutamyl transpeptidase activity was decrea ... | 2006 | 16839226 |
| hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of phyllanthus amarus in mice. | the effect of the aqueous leaf and seed extracts of phyllanthus amarus at oral dose of 150, 300 and 600 mg/kg was investigated for their antidiabetic and anti-lipidemic potentials. the extract produced a dose-dependent decrease in the fasting plasma glucose and cholesterol, and reduction in weights in treated mice. the results suggest that the extract could be enhancing peripheral utilization of glucose but the mechanisms on how this works remain unclear. | 2006 | 16905277 |
| antiinflammatory and antiallodynic actions of the lignan niranthin isolated from phyllanthus amarus. evidence for interaction with platelet activating factor receptor. | previous studies have shown that the extracts obtained from phyllanthus amarus, and some of the lignans isolated from it, exhibit pronounced antiinflammatory properties. in the present study, we have assessed whether the antiinflammatory actions of these lignans can be mediated by interaction with platelet activating factor (paf) receptor or interference with the action of this lipid. the local administration of nirtetralin, phyltetralin or niranthin (30 nmol/paw), similar to web2170 (a paf rece ... | 2006 | 16925995 |
| the cytotoxic effect and the multidrug resistance reversing action of lignans from phyllanthus amarus. | multidrug resistance (mdr) constitutes the major obstacle to the successful treatment of cancer. in several cancer cells, mdr is thought to be mediated by the super-expression of p-glycoprotein (pgp). pgp extrudes drugs from the cells, therefore reducing their cytotoxicity, and its activity inhibition may reverse the mdr phenotype. the present study evaluated the possible cytotoxic effect and mdr reversing properties of the extract and compounds isolated from phyllanthus amarus. to this purpose, ... | 2006 | 17054045 |
| hepatoprotective activity of phyllanthus amarus schum. et. thonn. extract in ethanol treated rats: in vitro and in vivo studies. | the present study was undertaken to investigate the protective effect and possible mechanism of aqueous extract from phyllanthus amarus schum. et. thonn. (pa) on ethanol-induced rat hepatic injury. in the in vitro study, pa (1-4 mg/ml) increased %mtt reduction assay and decreased the release of transaminases (ast and alt) in rat primary cultured hepatocytes being treated with ethanol. hepatotoxic parameters studied in vivo included serum transaminases (ast and alt), serum triglyceride (stg), hep ... | 2007 | 17870264 |
| the antiplasmodial effect of the extracts and formulated capsules of phyllanthus amarus on plasmodium yoelii infection in mice. | to investigate the antiplasmodial activity of the extracts of phyllanthus amarus (p. amarus) on plasmodium yoelii (p. yoelii) (a resistant malaria parasite strain used in animal studies) infection in mice. | 2011 | 21771471 |
| analgesic activity of aqueous leaf extract of phyllanthus amarus. | various doses of the aqueous extract of phyllanthus amarus (aepa) were investigated for analgesic and anti-inflammatory activities using both thermal and chemical models of pain assessment in rats. the extract caused a significant (p < 0.05) dose related increase inhibition of the carrageenan-induced paw oedema in the rats. the inhibition produced by 200 mg/kg aepa (70.20%) was significantly higher than that of the reference drug (acetylsalicylic acid). the extract produced a marked analgesic ac ... | 2011 | 21834261 |
| an extract of phyllanthus amarus protects mouse chromosomes and intestine from radiation induced damages. | we reported earlier on our preliminary study of the radioprotective effect of phyllanthus amarus (p.amarus) in mice. p.amarus was found to inhibit the myelosuppression and elevated the levels of antioxidant enzymes in the blood and liver. in the present study we have evaluated the protective effect of p.amarus against radiation-induced changes in the intestine and mouse chromosomal damage. p.amarus at concentrations of 250 & 750 mg/kg. b. wt were found to elevate the antioxidant enzymes in the i ... | 2007 | 17917369 |
| protective effects of phyllanthus amarus aqueous extract against renal oxidative stress in streptozotocin -induced diabetic rats. | in the present study, we have evaluated the antihyperglycemic, hypolipidemic and antioxidant activities of aqueous extract of phyllanthus amarus (paaet) in streptozotocin (stz)-induced diabetic rats. | 2011 | 21844996 |
| in vitro and in vivo antiplasmodial activity of 'saye', an herbal remedy used in burkina faso traditional medicine. | 'saye', a traditional medicine used in burkina faso, which consists of extracts of cochlospermum planchonii (rhizome), cassia alata (leaf) and phyllanthus amarus (whole plant), showed a significant effect against plasmodium falciparum and plasmodium berghei parasites grown in vivo (ic(50) = 80.11 +/- 3.40 microg/ml; ed(50) = 112.78 +/- 32.32 mg/kg). in vitro the activity was lower. | 2008 | 17926335 |
| radioprotective potential of plants and herbs against the effects of ionizing radiation. | ionizing radiations produce deleterious effects in the living organisms and the rapid technological advancement has increased human exposure to ionizing radiations enormously. there is a need to protect humans against such effects of ionizing radiation. attempts to protect against the deleterious effects of ionizing radiations by pharmacological intervention were made as early as 1949 and efforts are continued to search radioprotectors, which may be of great help for human application. this revi ... | 2007 | 18188408 |
| hypotensive effect of aqueous extract of the leaves of phyllanthus amarus schum and thonn (euphorbiaceae). | the plant of phyllanthus amarus is used as diuretic and to lower blood pressure in traditional medicine practice. the effect of the aqueous extract of the leaves of phyllanthus amarus on blood pressure was evaluated in normotensive male rabbits. intravenously administered aqueous doses (5 mg to 80 mg/kg) of the extract to anaesthesized normotensive male rabbits produced a significant fall in mean diastolic, systolic and mean arterial pressures in a graded dose response manner. the dose of 5 mg/k ... | 2007 | 18323250 |
| synergistic effect of silymarin and standardized extract of phyllanthus amarus against ccl4-induced hepatotoxicity in rattus norvegicus. | in search of the effective and standardized hepatoprotective combination therapy, silymarin and standardized extract of phyllanthus amarus has been evaluated against ccl(4)-induced hepatotoxicity in rats. eight groups of rats were used. the animals of group a served as normal and were given only vehicle. the animals of group b served as toxin control and were administered with ccl(4) (50% solution of ccl(4) in liquid paraffin, 2 ml/kg b.w., intraperitoneally). the animals of groups c-h received ... | 2008 | 18848770 |
| phyllanthus amarus inhibits cell growth and induces apoptosis in dalton's lymphoma ascites cells through activation of caspase-3 and downregulation of bcl-2. | the authors found in an earlier study that phyllanthus amarus extract could significantly inhibit the solid and ascites tumor development in mice induced by dalton's lymphoma ascites (dla) cells. in the present study, the apoptotic effects of p. amarus against dla cells in culture was evaluated. p. amarus produced significant reduction in cell viability as determined by the mtt assay. it also induces the formation of apoptotic bodies with characteristic features like plasma membrane invagination ... | 2009 | 19223368 |
| radioprotective properties of polyphenols from phyllanthus amarus linn. | radioprotective activity of pure compounds isolated from the plant phyllanthus amarus was studied using rat liver mitochondria and pbr322 plasmid dna as an in vitro model system. these compounds were ellagitannins namely amariin, 1-galloyl-2,3-dehydrohexahydroxydiphenyl (dhhdp)-glucose, repandusinic acid, geraniin, corilagin, phyllanthusiin d, and flavonoids namely rutin, and quercetin 3-o-glucoside. the activity was then correlated with their hydroxyl and superoxide radical scavenging activity. ... | 2009 | 19461166 |
| isolation, characterization and antioxidative effect of phyllanthin against ccl4-induced toxicity in hepg2 cell line. | the present study was an attempt to investigate the hepatoprotective and antioxidative property of phyllanthus amarus (p. amarus) extract and phyllanthin. phyllanthin, one of the active lignin present in this plant species was isolated from the aerial parts, by silica gel column chromatography employing gradient elution with hexane-ethyl acetate solvent mixture. it was obtained in high yields (1.23%), compared to reported procedures and the purity was ascertained by hptlc and reversed-phase hplc ... | 2009 | 19576190 |
| clonal propagation of phyllanthus amarus: a hepatoprotector. | the micropropagation protocol for phyllanthus amarus, an important medicinal herb used widely for the treatment of hepatitis in ethnomedicinal systems, was standardized with shoot tip and single node explants. | 0 | 22438668 |
| ethno-medicinal application of plants in the eastern region of shimoga district, karnataka, india. | the present paper aimed to document and study the role of traditional herbal drugs in the treatment of human and veterinary ailments by communities residing in the eastern part of shimoga district of karnataka in india and to determine the consensus of informant's knowledge on different category of ailments and fidelity level of plant species in treating particular disease. | 2009 | 19686831 |
| antifungal activity of securinine against some plant pathogenic fungi. | the alkaloid securinine was assessed against spore germination of some plant pathogenic and saprophytic fungi (alternaria alternata, alternaria brassicae, alternaria brassicicola, curvularia lunata, curvularia maculans, curvularia pallenscens, colletotrichum musae, colletotrichum sp., erysiphe pisi, helminthosporium echinoclova, helminthosporium spiciferum, heterosporium sp.). spore germinations of all the tested fungi were inhibited. alternaria brassicicola, c. lunata, c. pallenscens and h. spi ... | 2008 | 23990741 |
| mitigation of carbon tetrachloride-induced damage by phyllanthus amarus in liver of mice. | liver disease has become a global concern worldwide. in absence of reliable liver protective drugs in modem medicine, a large number of medicinal preparations are recommended for the treatment of liver disorders as they are believed to be harmless based on their natural origin. the aim of the present study was to determine the hepatoprotective activity of phyllanthus amarus plant extract against carbon tetrachloride (ccl4-induced liver damage in female mice. carbon tetrachloride administration c ... | 2009 | 19702178 |
| inhibition of viral carcinogenesis by phyllanthus amarus. | friend murine leukemia virus (fmulv) is an acutely oncogenic retrovirus, and its infection leads to erythroblastosis and leukemia in mice. this infection model is used in the search for new antiviral agents. in the present study, the authors have evaluated the potential of an extract of phyllanthus amarus against fmulv-induced erythroleukemia in balb/c mice. injection of newborn mice with fmulv resulted in leukemia and animals died due to splenomegaly. oral administration of p.amarus was found t ... | 2009 | 19815595 |
| inhibitory effects of the standardized extract of phyllanthus amarus on cellular and humoral immune responses in balb/c mice. | phyllanthus amarus has been shown to have strong inhibitory effects on phagocytic activity of human neutrophils and on cellular immune responses in wistar-kyoto rats. in this study, we investigated the effects of daily treatment of standardized extract of p. amarus at 50, 100 and 200 mg/kg for 14 days in balb/c mice by measuring the myeloperoxidase activity (mpo), nitric oxide (no) release, macrophage phagocytosis, swelling of footpad in delayed type hypersensitivity (dth), and serum immunoglobu ... | 2016 | 27137750 |
| aqueous extract of phyllanthus amarus inhibits chromium(vi)-induced toxicity in mda-mb-435s cells. | cr(vi) (hexavalent) is a very strong oxidant which causes high cytotoxicity through oxidative stress in tissue systems. its abundance in groundwater and drinking water in several parts of the world has been noted to cause severe toxicity to both flora and fauna. this study evaluated the effects of aqueous extract of phyllanthus amarus schum. & thon. against cr(vi)-induced oxidative toxicity in vitro in mda-mb-435s human breast carcinoma cells, along with an estimation of its antioxidant potentia ... | 2010 | 19874864 |
| protective activity of phyllanthin in ethanol-treated primary culture of rat hepatocytes. | to investigate the protective effect of phyllanthin (a known principal constituent of phyllanthus amarus schum. et thonn.) on ethanol-induced rat liver cell injury. | 2010 | 20064596 |
| in vitro inhibitory effect of west african medicinal and food plants on human cytochrome p450 3a subfamily. | in africa, medicinal plants are used intensively and concomitantly with allopathic medicines in the treatment of opportunity diseases by many patients or by healthy person to prevent diseases. however, there is little information about the interactions between medicines and botanical products used currently in west africa area. therefore, the aim of the present investigation is to study the effect of some plant products on cyp3a4, cyp3a5 and cyp3a7, three individual enzymes of cyp3a subfamily, i ... | 2010 | 20109542 |
| assessing species admixtures in raw drug trade of phyllanthus, a hepato-protective plant using molecular tools. | phyllanthus (euphorbiaceae) species are well known for their hepato-protective activity and are used in several ethno-medicines in indigenous health care systems in india. | 2010 | 20435119 |
| antidiabetic screening of commercial botanical products in 3t3-l1 adipocytes and db/db mice. | numerous botanicals are purported to improve glucose metabolism and diabetic risk factors with varying degrees of supportive evidence. we investigated 203 commercially available botanical products representing 90 unique botanical species for effects on lipogenic activity in differentiating 3t3-l1 adipocytes. anti-inflammatory activity of 21 of these products was further assessed in tumor necrosis factor alpha (tnfalpha)-stimulated, mature 3t3-l1 adipocytes. from these results, rho-isoalpha acids ... | 2010 | 20521979 |
| protective effects of phyllanthus amarus on fibrotic markers during alcohol and polyunsaturated fatty acid-induced toxicity. | alcoholic liver disease (ald) remains a major problem, with significant morbidity and mortality worldwide. one of the serious consequences of ald is hepatic fibrosis. this happens when the matrix synthesis rate exceeds that of matrix degradation. matrix metalloproteinases (mmps) and tissue inhibitors of matrix metalloproteinases (timps) play a key role in matrix remodeling. disruption of mmp/timp balance can lead to excessive accumulation of extracellular matrix components resulting in severe li ... | 2010 | 21047178 |
| effects of orthosiphon grandiflorus, hibiscus sabdariffa and phyllanthus amarus extracts on risk factors for urinary calcium oxalate stones in rats. | we evaluated the antilithic effect of orthosiphon grandiflorus, hibiscus sabdariffa and phyllanthus amarus extracts on known risk factors for calcium oxalate stones in rats. | 2011 | 21075390 |
| inhibitory effects of phyllanthus amarus and its major lignans on human microsomal cytochrome p450 activities: evidence for cyp3a4 mechanism-based inhibition. | phyllanthus amarus has long been used as a herbal medicine in several countries. phytochemicals in herbal medicine may interact with cytochromes p450 (cyp) and thus raise the potential of herb-drug interactions; therefore, the inhibitory effects of p. amarus and its major phytochemicals phyllanthin and hypophyllanthin on cyp isoforms were determined using human liver microsomes and selective substrates. both ethanolic and aqueous extracts of p. amarus inhibited cyp1a2, cyp2d6, cyp2e1 and cyp3a4 ... | 2010 | 21178301 |
| inhibition of chemiluminescence and chemotactic activity of phagocytes in vitro by the extracts of selected medicinal plants. | the methanol extracts of 20 selected medicinal plants were investigated for their effects on the respiratory burst of human whole blood, isolated human polymorphonuclear leukocytes (pmns) and isolated mice macrophages using a luminol/lucigenin-based chemiluminescence assay. we also tested the effect of the extracts on chemotactic migration of pmns using the boyden chamber technique. the extracts of curcuma domestica l., phyllanthus amarus schum & thonn and c. xanthorrhiza roxb. were the samples ... | 2010 | 21184195 |
| inhibition of hepatitis c virus replication by herbal extract: phyllanthus amarus as potent natural source. | hepatitis c virus infection is a major health problem worldwide. developing effective antiviral therapy for hcv is the need of the hour. the viral enzymes ns3 protease and ns5b rna dependent rna polymerase are essential enzymes for polyprotein processing and viral rna replication and thus can be potential targets for screening anti-hcv compounds. a large number of phytochemicals are present in plants, which are found to be promising antiviral agents. in this study, we have screened inhibitory ef ... | 2011 | 21440018 |
| documentation and quantitative analysis of the local knowledge on medicinal plants among traditional siddha healers in virudhunagar district of tamil nadu, india. | india has a population with high degree of medical pluralism. siddha system of indian traditional medicine is practiced dominantly by the people in tamil nadu. the traditionally trained siddha healers still play an important role in the rural health care. their knowledge is comparatively more vulnerable than the documented traditional knowledge. thus, the present study was aimed to document and quantitatively analyze the local knowledge of the traditional siddha healers in virudhunagar district ... | 2011 | 21718779 |
| ethnomedicinal and ecological status of plants in garhwal himalaya, india. | the northern part of india harbours a great diversity of medicinal plants due to its distinct geography and ecological marginal conditions. the traditional medical systems of northern india are part of a time tested culture and honored still by people today. these traditional systems have been curing complex disease for more than 3,000 years. with rapidly growing demand for these medicinal plants, most of the plant populations have been depleted, indicating a lack of ecological knowledge among c ... | 2011 | 22011477 |
| indian herbs and herbal drugs used for the treatment of diabetes. | traditional medicines derived from medicinal plants are used by about 60% of the world's population. this review focuses on indian herbal drugs and plants used in the treatment of diabetes, especially in india. diabetes is an important human ailment afflicting many from various walks of life in different countries. in india it is proving to be a major health problem, especially in the urban areas. though there are various approaches to reduce the ill effects of diabetes and its secondary complic ... | 2007 | 18398493 |
| protective effect of the aqueous leaf and seed extract of phyllanthus amarus on gentamicin and acetaminophen-induced nephrotoxic rats. | in african traditional medicine, different parts of phyllanthus amarus schum. and thonn. (family: euphorbiaceae) are highly valued for the treatment of array of human diseases including hepatic and urolithic and/or other renal diseases. in the present study, single oral 100-400mg/kg/day of the leaf and seed aqueous extract of phyllanthus amarus (pa) were studied for their protective effects in acetaminophen- and gentamicin-induced nephrotoxic wistar rats for 14 days. | 2008 | 18554830 |
| larvicidal potential of some plants from west africa against culex quinquefasciatus (say) and anopheles gambiae giles (diptera: culicidae). | mosquitoes increased resistance to insecticides, and environmental concerns about the use of insecticides, pose a major challenge in the search for new molecules to deplete and incapacitate mosquito populations. plants are the valuable source as practices consisting in exploiting plant materials as repellents, and are still in wide use throughout developing countries. the aim of the present study was to screen plants from cτte d'ivoire for larvicidal activity against mosquitoes. | 2013 | 23995311 |
| antioxidant activity of some polyphenol constituents of the medicinal plant phyllanthus amarus linn. | phyllanthus amarus linn is a widely distributed tropical medicinal plant highly valued for its therapeutic properties. the antioxidant activity of some of its principal constituents, namely amariin, 1-galloyl-2,3-dehydrohexahydroxydiphenyl (dhhdp)-glucose, repandusinic acid, geraniin, corilagin, phyllanthusiin d, rutin and quercetin 3-o-glucoside were examined for their ability to scavenge free radicals in a range of systems including 2,2-diphenyl-2-picrylhydrazyl (dpph), 2,2-azobis-3-ethylbenzt ... | 2008 | 18796238 |
| antiplasmodial activity of extracts of tridax procumbens and phyllanthus amarus in in vitro plasmodium falciparum culture systems. | aqueous extracts of tridax procumbens (tp) (compositae) and phyllanthus amarus (pa) (euphorbiaceae) are used in traditional medicine in ghana to treat malaria. previous studies have demonstrated the anti-trypanosoma, anti-bacterial and anti-hiv effects of tp and pa. | 2011 | 22359419 |
| in vitro antiplasmodial effect of ethanolic extracts of coastal medicinal plants along palk strait against plasmodium falciparum. | to identify the possible antiplasmodial compounds from achyranthes aspera (a. aspera), acalypha indica (a. indica), jatropha glandulifera (j. glandulifera) and phyllanthus amarus (p. amarus). | 2012 | 23569931 |
| anti-quorum sensing activity of the traditional chinese herb, phyllanthus amarus. | the discovery of quorum sensing in proteobacteria and its function in regulating virulence determinants makes it an attractive alternative towards attenuation of bacterial pathogens. in this study, crude extracts of phyllanthus amarus schumach. & thonn, a traditional chinese herb, were screened for their anti-quorum sensing properties through a series of bioassays. only the methanolic extract of p. amarus exhibited anti-quorum sensing activity, whereby it interrupted the ability of chromobacteri ... | 2013 | 24169540 |
| preliminary phytochemical investigation and antibacterial activity of phyllanthus amarus schum & thorn. | the aqueous extract of phyllanthus amarus schum & thorn, was selected for preliminary phytochemical and antibacterial activity against human pathogens. minimum inhibitory concentration was performed by broth dilution method and the zone of inhibition was studied by agar disc diffusion method at concentrations of 10 and 20 mg/ml in dmso (dimethyl sulfoxide). the results revealed the antimicrobial activity of extract against the the strains of microorganisms concentrations in ranges of 60 and 500 ... | 2007 | 22557251 |
| antimicrobial, antioxidant activities and total phenolic content of thai medicinal plants used to treat hiv patients. | opportunistic infections in aids patients is the leading cause of death in among them. hiv infection was reported as causes of increasing oxidative stress which may lead to progress of many syndrome. thus medicinal plants as demonstrated antimicrobial and antioxidant activities would be therapeutic values to treat opportunistic infections of aids patients. | 2012 | 23964459 |
| phyllanthin from phyllanthus amarus inhibits cellular and humoral immune responses in balb/c mice. | phyllanthin found in many phyllanthus species has various biochemical and pharmacological properties especially on its hepatoprotective effects. however, its effect on the immune system has not been well documented. | 2016 | 27765364 |
| immunosuppressive effects of the standardized extract of phyllanthus amarus on cellular immune responses in wistar-kyoto rats. | phyllanthus amarus (family: euphorbiaceae) is of immense interest due to its wide spectrum of biological activities. in the present study, the standardized 80% ethanol extract of p. amarus was investigated for its modulatory activity on various cellular immune parameters, including chemotaxis of neutrophils, engulfment of escherichia coli by neutrophils, and mac-1 expression, in leukocytes isolated from treated/nontreated wistar-kyoto rats. the detailed cell-mediated activity of p. amarus was al ... | 2015 | 26347462 |
| ethnopharmacology guided screening of traditional indian herbs for selective inhibition of plasmodium specific lactate dehydrogenase. | medicinal plants traditionally used to treat malaria can provide quality leads towards identifying novel anti-malarial drugs. here we combined this approach with target based drug discovery and explored plasmodium specific lactate dehydrogenase (ldh) inhibitory activity of 8 indian plants which are ethnically used to treat malaria. | 2012 | 22982392 |
| phyllanthin of standardized phyllanthus amarus extract attenuates liver oxidative stress in mice and exerts cytoprotective activity on human hepatoma cell line. | phyllanthus amarus, a traditional herbal liver-protecting medicine, is known to contain an active ingredient phyllanthin. many research studies and clinical trials performed in the past using this plant have given contentious results which clearly accentuates the need for the standardization of the extracts. | 2011 | 25755316 |