| 11-oxoaerothionin: a cytotoxic antitumor bromotyrosine-derived alkaloid from the caribbean marine sponge aplysina lacunosa. | a new cytotoxic bromotyrosine-derived secondary metabolite, 11-oxoaerothionin [3], was isolated from the caribbean sea sponge aplysina lacunosa. the structure of 3 was argued on the basis of detailed spectroscopic analysis and by chemical conversion to the known antibiotic compound 11-hydroxyaerothionin [2]. when screened against a panel of four human cell lines, 11-oxoaerothionin [3] showed pronounced as well as selective antitumor activity toward the human colon (hct 116) cell line within the ... | 1992 | 1402952 |
| isolation and characterization of novel 2-hydroxy fatty acids from the phospholipids of the sponge smenospongia aurea. | the caribbean sponge smenospongia aurea revealed the presence of six novel branched alpha-hydroxy fatty acids: 2-hydroxy-17-methyloctadecanoic acid, 2-hydroxy-21-methyldocosanoic acid, 2-hydroxy-22-methyltricosanoic acid, and 2-hydroxy-22-methyltetracosanoic acid, 2-hydroxy-24-methylpentacosanoic acid, and 2-hydroxy-23-methylpentacosanoic acid. these novel alpha-hydroxy fatty acids were associated with phosphatidylethanolamine. the sponges aplysina lacunosa and aplysina fistularis also contained ... | 1992 | 1487966 |
| its-2 and 18s rrna gene phylogeny of aplysinidae (verongida, demospongiae). | 18s ribosomal dna and internal transcribed spacer 2 (its-2) full-length sequences, each of which was sequenced three times, were used to construct phylogenetic trees with alignments based on secondary structures, in order to elucidate genealogical relationships within the aplysinidae (verongida). the first poriferan its-2 secondary structures are reported. altogether 11 aplysina sponges and 3 additional sponges (verongula gigantea, aiolochroia crassa, smenospongia aurea) from tropical and subtro ... | 2005 | 15871043 |
| bromotyrosine-derived alkaloids from the caribbean sponge aplysina lacunosa. | three new bromotyrosine-derived alkaloids 14-debromo-11-deoxyfistularin-3 (1), aplysinin a (2), and aplysinin b (3), together with 15 known compounds (4-18) were isolated from the sponge aplysina lacunosa collected from stirrup cay, bahamas. the structures of the isolated compounds were identified on the basis of ms and nmr data analysis. the (13)c nmr assignment of spirocyclohexadienylisoxazoline moieties of 1 and 2 were confirmed by an 1,1-adequate experiment. compounds 1 and 2 showed a mild t ... | 2015 | 26734082 |