| human parvovirus 4 in the bone marrow of italian patients with aids. | human parvovirus 4 (parv4) is a recently discovered member of the parvoviridae. we investigated the presence of this virus in bone-marrow aspirates of 35 italian patients with aids. viral dna was detected by polymerase chain reaction in over 40% of patients (16/35). the infection was most prevalent in injection drug users (idu; 12/18; 66.7%) as opposed to non-idu (4/17; 23.5%). parv4 infection is widespread in italian patients with aids. | 2007 | 17589196 |
| persistence of novel human parvovirus parv4 in liver tissue of adults. | human parvovirus 4 (parv4) is a recently identified virus whose biology, epidemiology and pathogenic potential have yet to be determined. recently, it was reported that parv4 dna persists in tissues of some hiv-infected individuals, whilst parv4 dna was not detected in tissues of subjects not infected with hiv. in the present study, liver tissue from 87 individuals, none of who were infected with hiv, with the exception of a single subject, was analyzed for the presence of parv4 dna. overall, pa ... | 2008 | 18098166 |
| identification of novel porcine and bovine parvoviruses closely related to human parvovirus 4. | human parvovirus 4 (parv4), a recently discovered parvovirus found exclusively in human plasma and liver tissue, was considered phylogenetically distinct from other parvoviruses. here, we report the discovery of two novel parvoviruses closely related to parv4, porcine hokovirus (phov) and bovine hokovirus (bhov), from porcine and bovine samples in hong kong. their nearly full-length sequences were also analysed. parv4-like viruses were detected by pcr among 44.4 % (148/333) of porcine samples (i ... | 2008 | 18632954 |
| human parvovirus 4 in kidney transplant patients, france. | | 2008 | 18976581 |
| detection of parv4, genotypes 1 and 2, in healthy and pathological clinical specimens. | the molecular epidemiology and tissue distribution of human parvovirus 4 (parv4) and its variant parv5 (parvoviridae family) are poorly known. the aim of this study was to investigate the epidemiological role and prevalence of parv4/5 by a nested-pcr on different clinical specimens, including blood samples from healthy donors, healthy and pathological skin samples, and bronchoalveolar lavages (bal). among blood specimens, 2/53 were positive; 3/37 and 23/105 of healthy and pathological skin speci ... | 2009 | 19579698 |
| human parvovirus 4 in recipients of cellular products and in blood donors: epidemiologic similarity with b19 parvovirus. | | 2009 | 19732407 |
| novel human parvovirus 4 genotype 3 in infants, ghana. | human parvovirus 4 has been considered to be transmitted only parenterally. however, after novel genotype 3 of parvovirus 4 was found in 2 patients with no parenteral risks, we tested infants in ghana. a viremia rate of 8.6% over 2 years indicates that this infection is common in children in africa. | 2010 | 20587191 |
| changing epidemiology of human parvovirus 4 infection in sub-saharan africa. | human parvovirus 4 infections are primarily associated with parenteral exposure in western countries. by elisa, we demonstrate frequent seropositivity for antibody to parvovirus 4 viral protein 2 among adult populations throughout sub-saharan africa (burkina faso, 37%; cameroon, 25%; democratic republic of the congo, 35%; south africa, 20%), which implies existence of alternative transmission routes. | 2010 | 20875290 |
| prevalence of nucleic acid sequences specific for human parvoviruses, hepatitis a and hepatitis e viruses in coagulation factor concentrates. | due to their high resistance to inactivation procedures, nonenveloped viruses such as parvovirus b19, human bocavirus (hbov), human parvovirus 4 (parv4), hepatitis a (hav) and hepatitis e virus (hev) pose a particular threat to blood products. virus transmission to patients treated with blood products presents an additional burden to disease. we determined the frequency and the amount of nucleic acid specific for nonenveloped viruses in recently manufactured preparations of commercial coagulatio ... | 2010 | 21133933 |
| serodiagnosis of primary infections with human parvovirus 4, finland. | to determine the prevalence of parvovirus 4 infection and its clinical and sociodemographic correlations in finland, we used virus-like particle-based serodiagnostic procedures (immunoglobulin [ig] g, igm, and igg avidity) and pcr. we found 2 persons with parvovirus 4 primary infection who had mild or asymptomatic clinical features among hepatitis c virus-infected injection drug users. | 2011 | 21192859 |
| parvovirus 4 in french in-patients: a study of hemodialysis and lung transplant cohorts. | the epidemiology and the clinical implication of human parvovirus 4 (parv4) in human populations is still under evaluation. the distribution of parv4 dna was determined in cohorts of french hemodialysis and lung transplant patients. plasma samples (n=289) were tested for parv4 by real-time pcr assay (orf2), and amplification products selected at random were sequenced. analysis of available serological and biological markers was also undertaken. fifty-seven samples out of 185 (30.8%) were positiv ... | 2011 | 21328388 |
| immunoglobulin g and m antibodies to human parvovirus 4 (parv4) are frequently detected in patients with hiv-1 infection. | the transmission routes of parv4 are not completely understood. the first parv4 serological study suggested that parv4 is transmitted predominantly through parenteral route. | 2011 | 21353629 |
| human parvovirus 4 as potential cause of encephalitis in children, india. | to investigate whether uncharacterized infectious agents were associated with neurologic disease, we analyzed cerebrospinal fluid specimens from 12 children with acute central nervous system infection. a high-throughput pyrosequencing screen detected human parvovirus 4 dna in cerebrospinal fluid of 2 children with encephalitis of unknown etiology. | 2011 | 21801629 |
| discovery and genomic characterization of a novel ovine partetravirus and a new genotype of bovine partetravirus. | partetravirus is a recently described group of animal parvoviruses which include the human partetravirus, bovine partetravirus and porcine partetravirus (previously known as human parvovirus 4, bovine hokovirus and porcine hokovirus respectively). in this report, we describe the discovery and genomic characterization of partetraviruses in bovine and ovine samples from china. these partetraviruses were detected by pcr in 1.8% of bovine liver samples, 66.7% of ovine liver samples and 71.4% of ovin ... | 2011 | 21980506 |
| placental transmission of human parvovirus 4 in newborns with hydrops, taiwan. | in studying the epidemiology of parvovirus 4 (parv4) in taiwan, we detected dna in plasma of 3 mothers and their newborns with hydrops. in 1 additional case, only the mother had parv4 dna. our findings demonstrate that parv4 can be transmitted through the placenta. | 2011 | 22000381 |
| porcine hokovirus in wild boar in portugal. | porcine hokovirus (phov), also referred to as porcine parvovirus 4 (p-parv4), a recently discovered parvovirus of swine that is closely related to human parvovirus 4/5 (h-parv4/5), was first described in hong kong. to evaluate the occurrence of p-parv4 in portuguese wild boars in the hunting season of 2011/2012, liver and serum samples were tested. p-parv4 was detected in 24 % of the wild boars analyzed. phylogenetic analysis showed a close relationship between the p-parv4 isolates and other p-p ... | 2016 | 26711454 |
| parv4 found in wild chimpanzee faeces: an alternate route of transmission? | human parvovirus 4 (parv4, family parvoviridae, genus tetraparvovirus) displays puzzling features, such as uncertain clinical importance/significance, unclear routes of transmission, and discontinuous geographical distribution. the origin, or the general reservoir, of human parv4 infection is unknown. we aimed to detect and characterize parv4 virus in faecal samples collected from two wild chimpanzee populations and 19 species of captive non-human primates. we aimed to investigate these species ... | 2019 | 30343383 |
| Molecular characterization of the newly identified human parvovirus 4 in the family Parvoviridae. | Human parvovirus 4 (PARV4) is an emerging human virus, and little is known about the molecular aspects of PARV4 apart from its incomplete genome sequence, which lacks information of the termini. We analyzed the gene expression profile of PARV4 using a nearly full-length HPV4 genome in a replication competent system in 293 cells. We found that PARV4 utilizes two promoters to transcribe non-structural protein- and structural protein-encoding mRNAs, respectively, which were polyadenylated at the ri ... | 2012 | 22044541 |
| Virologic and clinical features of primary infection with human parvovirus 4 in subjects with hemophilia: frequent transmission by virally inactivated clotting factor concentrates. | BACKGROUND: Human parvovirus 4 (PARV4) is a newly discovered parvovirus prevalent in injecting drug users and other groups with histories of parenteral exposure including persons with hemophilia exposed to non-virally inactivated clotting factor concentrates. To investigate its potential ongoing transmission to persons with hemophilia treated with plasma-derived, virally inactivated clotting factors, we screened a large cohort of persons with hemophilia for antibody seroconversion to PARV4 over ... | 2011 | 22043925 |