Publications

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crassin acetate, the principal antineoplastic agent in four gorgonians of the pseudoplexaura genus.crassin acetate, a lactonic cembrane diterpene, has been shown to be the principal antineoplastic agent present in the marine invertebrates (gorgonians) pseudoplexaura porosa, p. flagellosa, p. wagenaari and p. crucis.1975578
minor and trace sterols in marine invertebrates. 1. general methods of analysis.3beta-hydroxy sterols occurring at a concentration of at least 0.001% of the sterol mixtures of pseudoplexaura porosa and plexaura homomalla have been fractionated using a series of refined techniques and subsequently analyzed using combined gas chromatography-mass spectrometry (gc-ms) in the development of a procedure for examining the minor and trace components of marine sterol mixtures. a total of 49 sterols were found which spanned a molecular weight range of 274 to 440. in addition delta4-3 ...197613520
gorgosterol biosynthesis: localization of squalene formation in the zooxanthellar component of various gorgonians.four species of gorgonians: three related pseudoplexaurids pseudoplexaura porosa, p. flagellosa and p. wagenaari; and the unrelated pseudopterogorgia americana, are sources of zooxanthellae capable, in purified broken cell preparations, of converting [14c]labeled farnesyl pyrophosphate into squalene. more extensive studies with p. porosa and p. americana zooxanthellae preparations characterize the conversion as enzymatic and demonstrate farnesyl pyrophosphate and reduced pyridine nucleotide as s ...19852861942
discovery of an arachidonic acid c-8 lipoxygenase in the gorgonian coral pseudoplexaura porosa.the gorgonian coral pseudoplexaura porosa contains a lipoxygenase capable of converting exogenous arachidonic acid into (8r)-8-hydroperoxy-5,9,11,14-eicosatetraenoic acid. the (8r)- (or 8-l-) configuration in this product, opposite to that observed in previously reported 8-lipoxygenase products, was determined unambiguously by comparison of oxidative ozonolysis fragments with authentic malic acid-derived standards. extracts from the coral contained no detectable prostaglandins (pgas, pgbs, pges, ...19862867091
isolation, localization and biosynthesis of crassin acetate in pseudoplexaura porosa (houttuyn). 19704393527
unsaturated fatty acid-dependent oxidation of epinephrine in homogenates of the gorgonian, pseudoplexaura porosa.a novel epinephrine oxidation system in homogenates of the gorgonian pseudoplexaura porosa was discovered. the enzymatic reaction required an unsaturated fatty acid and molecular oxygen or hydrogen peroxide. diphenylisobenzofuran was also oxidized by ps. porosa homogenates in the presence of an unsaturated fatty acid. hydroxyl radical and superoxide anion did not appear to be involved in either of these oxidative reactions. the production of lipid hydroperoxides was not necessary for epinephrine ...19826129928
marine antitumor agents: 14-deoxycrassin and pseudoplexaurol, new cembranoid diterpenes from the caribbean gorgonian pseudoplexaura porosa.two new cytotoxic antitumor diterpenoids of the cembrane class, named 14-deoxycrassin (3) and pseudoplexaurol (4), have been isolated from the caribbean gorgonian octocoral pseudoplexaura porosa. the structure of lactone 3, possessing the infrequently encountered alpha-methylene-delta-lactone ring, has been established from spectral and chemical data and that of alcohol 4 has been established from spectral data.19938095027
natural prey preferences and spatial variability of predation pressure by cyphoma gibbosum (mollusca: gastropoda) on octocoral communities off la parguera, puerto rico.this study evaluated the natural prey preferences and spatial variability of predation pressure (pp = proportion of colonies with snails and/or clear predation signs) by the gastropod cyphoma gibbosum on octocoral communities off the la parguera natural reserve, puerto rico. all octocoral colonies were checked for presence of c. gibbosum and/or clear predation signs in four permanent band-transects (2 × 10 m), along three depth intervals (0-5, 7-12, >15 m deep) in each of six reefs along an insh ...201427433523
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