| immunotherapeutic modification of escherichia coli peritonitis and bacteremia by tinospora cordifolia. | | 1992 | 1294124 |
| immunotherapeutic modification of escherichia coli peritonitis and bacteremia by tinospora cordifolia. | we present here the protective effects of an indian medicinal plant tinospora cordifolia as compared to gentamicin in e. coli induced peritonitis. pretreatment with tinospora cordifolia or gentamicin reduced mortality in mice injected with 1 x 10(8) e. coli intraperitoneally from 100% in controls to 17.8% and 11.1% respectively. this was associated with significantly improved bacterial clearance as well as improved phagocytic and intracellular bactericidal capacities of neutrophils in the tinosp ... | 1992 | 1512717 |
| effect of tinospora cordifolia on blood glucose and total lipid levels of normal and alloxan-diabetic rabbits. | the aqueous, alcoholic, and chloroform extracts of the leaves of tinospora cordifolia were administered in doses of 50, 100, 150 and 200 mg/kg body weight to normal and alloxan-diabetic rabbits. the blood glucose and total lipid levels were estimated before and 2, 4, 6, and 8 hours after administration of the extract. the extract exerted a significant (p less than 0.5) hypoglycaemic effect in normal as well as in alloxan-treated rabbits. the extracts, however, had no significant (p greater than ... | 1992 | 1529024 |
| modulation of immunosuppression in obstructive jaundice by tinospora cordifolia. | a clinical study was undertaken to determine the immune status of patients with obstructive jaundice. screening of 16 patients for phagocytic and microbicidal activity of polymorphonuclear cells (pmn) revealed a significant depression (21.2 +/- 3.7% phagocytosis and 20.85 +/- 4.5% intracellular killing) of these functions, as compared to normal values (30.37 +/- 5.1% and 26.41 +/- 4.3% respectively). an animal model of cholestasis was also established, using rats, in which a significant depressi ... | 1989 | 2697692 |
| comparative study of immunomodulating activity of indian medicinal plants, lithium carbonate and glucan. | the protective effects of asparagus racemosus (ar) and tinospora cordifolia (tc) against myelosuppression induced by single doses of cyclophosphamide (cp) have been previously reported. presented here are the results of a comparative study between ar, tc, glucan and lithium carbonate against the myelosuppressive effects of single and multiple doses of cyclophosphamide in mice. cyclophosphamide was administered as a single dose 200 mg/kg subcutaneously to one group of mice, while a second group r ... | 1988 | 3236938 |
| a comparative study of diuretic effects of tinospora cordifolia and hydrochlorothiazide in rats and a preliminary phase i study in human volunteers. | | 1988 | 3254990 |
| immunotherapeutic modification by tinospora cordifolia of abdominal sepsis induced by caecal ligation in rats. | | 1988 | 3338823 |
| antipyretic studies on some indigenous pakistani medicinal plants: ii. | eight pakistani medicinal plants were investigated for antipyretic activity in rabbits receiving subcutaneous yeast injections. hexane- and chloroform-soluble extracts of aconitum napellus stems, corchorus depressus whole plant and gmelina asiatica roots exhibited prominent oral antipyretic activity while insignificant antipyretic effects were found in the hexane- and chloroform-soluble portions of melia azadirachta seeds, tinospora cordifolia stems and vitex trifolia seeds. no antipyretic actio ... | 1987 | 3497307 |
| immunomodulating agents of plant origin. i: preliminary screening. | the immunobiological activity was investigated of certain medicinal plants widely used in the ayurvedic and unani systems of medicine for treatment of chronic infections and immunological disorders. the effect of an ethanolic extract of each drug was studied on delayed type hypersensitivity, humoral responses to sheep red blood cells, skin allograft rejection, and phagocytic activity of the reticuloendothelial system in mice. picrorhiza kurroa was found to be a potent immunostimulant, stimulatin ... | 1986 | 3560991 |
| the antiamoebic effect of a crude drug formulation of herbal extracts against entamoeba histolytica in vitro and in vivo. | the antiamoebic effect of a crude drug formulation against entamoeba histolytica was studied. in the traditional system of medicine in india, the formulation has been prescribed for intestinal disorders. it comprises of five medicinal herbs, namely, boerhavia diffusa, berberis aristata, tinospora cordifolia, terminalia chebula and zingiber officinale. the dried and pulverized plants were extracted in ethanol together and individually. in vitro amoebicidal activity was studied to determine the mi ... | 1995 | 7739226 |
| cordifolisides a, b, c: norditerpene furan glycosides from tinospora cordifolia. | several glycosides were isolated, as polyacetates, from the n-buoh fraction of the tinospora cordifolia stems. the structures of three new norditerpene furan glycosides cordifoliside a, b and c have been established by 1d and 2d nmr spectroscopy. | 1994 | 7765690 |
| quantitation of microbicidal activity of mononuclear phagocytes: an in vitro technique. | an in vitro assay technique was set up to determine the phagocytic and microbicidal activity of a monocyte-macrophage cell line using candida species as test organisms. the norms were determined for the activity of peritoneal macrophages of rats (24.69 +/- 2.6% phagocytosis and 35.4 +/- 5.22% ick) and human (27.89 +/- 3.63% phagocytosis and 50.91 +/- 6.3% ick). the assay technique was used to test the degree of activation of macrophages induced by metronidazole, tinospora cordifolia and asparaqu ... | 1993 | 8295140 |
| modulation of kupffer cell activity by tinospora cordifolia in liver damage. | kupffer cells are major determinants of outcome of liver injury. their activity was therefore studied in a model of chronic liver disease. the effect of tinospora cordifolia, an indigenous agent with proven hepatoprotective activity, was evaluated on kupffer cell function, using carbon clearance test as a parameter. rats were divided into two major groups. in gp i which served as normal control t1/2 of carbon was 9.48 +/- 4.14 min. gpii received horse-serum in a dose of 0.5 ml/100 gm b.w. i.p. f ... | 1994 | 8737554 |
| activity of a crude extract formulation in experimental hepatic amoebiasis and in immunomodulation studies. | the activity of a crude extract formulation was evaluated in experimental amoebic liver abscess in golden hamsters and in immunomodulation studies. the formulation comprises the following five plants-boerhavia diffusa, tinospora cordifolia, berberis aristata, terminalia chebula and zingiber officinale. the formulation had a maximum cure rate of 73% at a dose of 800 mg/kg/day in hepatic amoebiasis reducing the average degree of infection (adi) to 1.3 as compared to 4.2 for sham-treated controls. ... | 1996 | 8953425 |
| effect of some indian herbs on macrophage functions in ochratoxin a treated mice. | the effect of indian herbs namely, asparagus racemosus, tinospora cordifolia, withania somnifera and picrorhiza kurrooa on the functions of macrophages obtained from mice treated with the carcinogen ochratoxin a (ota) was investigated. the chemotactic activity of murine macrophages was significantly decreased by 17 weeks of treatment with ota compared with controls. production of interleukin-1 (il-1) and tumor necrosis factor (tnf) was also markedly reduced. treatment with asparagus racemosus, t ... | 1997 | 9324000 |
| effect of trasina, an ayurvedic herbal formulation, on pancreatic islet superoxide dismutase activity in hyperglycaemic rats. | diabetes mellitus was induced in male cf strain rats by streptozotocin (stz) and hyperglycaemia and superoxide dismutase (sod) activity of pancreatic islet cells was assessed on days 7, 14, 21 and 28. stz induced significant hyperglycaemia and a concomitant decrease in islet cell sod activity. transina (tr), an ayurvedic herbal formulation comprising of withania somnifera, tinospora cordifolia, eclipta alba, ocimum sanctum, picrorrhiza kurroa and shilajit, had little per se effect on blood sugar ... | 1997 | 9332177 |
| immunopotentiating compounds from tinospora cordifolia. | the active principles of tinospora cordifolia a traditional indian plant were found to possess anticomplementary and immunomodulatory activities. syringin (tc-4) and cordiol (tc-7) inhibited the in vitro immunohaemolysis of antibody-coated sheep erythrocytes by guinea pig serum. the reduced immunohaemolysis was found to be due to inhibition of the c3-convertase of the classical complement pathway. however, higher concentrations showed constant inhibitory effects. the compounds also gave rise to ... | 1997 | 9406896 |
| hypolipidaemic action of tinospora cordifolia roots in alloxan diabetic rats. | we undertook the present study to evaluate the hypolipidaemic effect of an aqueous extract of tinospora cordifolia roots, an indigenous plant used in ayurvedic medicine in india. administration of the extract of t. cordifolia roots (2.5 and 5.0 g/kg body weight) for 6 weeks resulted in a significant reduction in serum and tissue cholesterol, phospholipids and free fatty acids in alloxan diabetic rats. the root extract at a dose of 5.0 g/kg body weight showed highest hypolipidaemic effect. the ef ... | 1999 | 10075122 |
| antioxidant activity of tinospora cordifolia roots in experimental diabetes. | we made an attempt to study the antioxidant properties of tinospora cordifolia roots, an indigenous plant used in ayurvedic medicine in india in alloxan diabetic rats. oral administration of an aqueous t. cordifolia root extract (tcret) (2.5 and 5.0 g/kg) for 6 weeks resulted in a decrease in the levels of plasma thiobarbituric acid reactive substances, ceruloplasmin and alpha-tocopherol in alloxan diabetic rats. the root extract also causes an increase in the levels of glutathione and vitamin c ... | 1999 | 10404427 |
| adaptogenic properties of six rasayana herbs used in ayurvedic medicine. | plants from all over the world such as eleutherococcus senticosus, panax ginseng, raponticum carthamoides, rhodiola rosea, withania somnifera and ocimum sanctum have been extensively evaluated for their adaptogenic potential. however, none of them has been successfully introduced as an adaptogen in the clinic. this paper discusses some of the problems in evaluation of adaptogens which have precluded their inclusion as clinically useful drugs. we further discuss our results with six rasayana plan ... | 1999 | 10404532 |
| hypoglycaemic and other related actions of tinospora cordifolia roots in alloxan-induced diabetic rats. | tinospora cordifolia is widely used in indian ayurvedic medicine for treating diabetes mellitus. oral administration of an aqueous t. cordifolia root extract (tcret) to alloxan diabetic rats caused a significant reduction in blood glucose and brain lipids. the extract caused an increase in body weight, total haemoglobin and hepatic hexokinase. the root extract also lowers hepatic glucose-6-phosphatase and serum acid phosphatase, alkaline phosphatase, and lactate dehydrogenase in diabetic rats. t ... | 2000 | 10720784 |
| anti-hyperglycemic effect of eugenia jambolana and tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. | in india, the decoction of kernels of eugenia jambolana (ej) and extracts of tinospora cordifolia (tc) are used as a household remedy for diabetes. these also form constituents of many herbal formulations for diabetes that are marketed in this country. the anti-hyperglycemic effect of aqueous and alcoholic extracts as well as lyophilized powder of these two plants was evaluated in diabetic animals using different doses of diabetogenic agents for varying duration (21-120 days) so as to assess the ... | 2000 | 11091000 |
| antioxidant action of tinospora cordifolia root extract in alloxan diabetic rats. | tinospora cordifolia is widely used in indian ayurvedic medicine for the treatment of diabetes mellitus. oral administration of 2.5 g and 5.0 g/kg body weight of the aqueous extract of the roots for 6 weeks resulted in a significant reduction in thiobarbituric acid reactive substances (tbars) and an increase in reduced glutathione (gsh), catalase (cat) and superoxide dismutase (sod) in alloxan diabetic rats. the effect of tinospora cordifolia root extract (tcret) was most prominently seen in the ... | 2001 | 11351355 |
| traditional indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice. | the purpose of the study was to investigate the effects of daily oral feeding momordica charantia (mc) (200 mg/kg), eugenia jambolana (ej) (200 mg/kg), mucuna pruriens (mp) (200 mg/kg) and tinospora cordifolia (tc) extracts for 40 days on blood glucose concentrations and kidney functions in streptozotocin (stz)-diabetic rats. plasma glucose levels, body weight, urine volume and urinary albumin levels were monitored on every 10th day over a 40-day period while plasma creatinine levels were assess ... | 2001 | 11448544 |
| medicinal plants of india with anti-diabetic potential. | since ancient times, plants have been an exemplary source of medicine. ayurveda and other indian literature mention the use of plants in treatment of various human ailments. india has about 45000 plant species and among them, several thousands have been claimed to possess medicinal properties. research conducted in last few decades on plants mentioned in ancient literature or used traditionally for diabetes have shown anti-diabetic property. the present paper reviews 45 such plants and their pro ... | 2002 | 12020931 |
| antioxidant properties of a tinospora cordifolia polysaccharide against iron-mediated lipid damage and gamma-ray induced protein damage. | the antioxidant activity of an arabinogalactan polysaccharide (tsp) isolated from tinospora cordifolia, an indian medicinal plant, was studied. the polysaccharide showed good protection against iron-mediated lipid peroxidation of rat brain homogenate as revealed by the thiobarbituric acid reactive substances (tbars) and lipid hydroperoxide (looh) assays. tsp also provided significant protection to protein against gamma-ray induced damage. the protective action can possibly be explained by its ve ... | 2002 | 12189043 |
| hepatoprotective and immunomodulatory properties of tinospora cordifolia in ccl4 intoxicated mature albino rats. | effect of tinospora cordifolia extract on modulation of hepatoprotective and immunostimulatory functions in carbon tetrachloride (ccl4) intoxicated mature rats is reported here. administration of ccl4 (0.7 ml/kg body weight for 7 days) produces damage in the liver as evident by estimation of enzymes such as serum glutamate oxaloacetate transaminase (sgot), serum glutamate pyruvate transminase (sgpt) and alkaline phosphatase (alp) as well as serum bilirubin level. ccl4 administration also causes ... | 2002 | 12238138 |
| prevention of experimental diabetic cataract by indian ayurvedic plant extracts. | the efficacy of momordica charantia (mc), eugenia jambolana (ej), tinospora cordifolia (tc) and mucuna pruriens (mp) was assessed in the prevention of murine alloxan dibetic cataract. alloxan (120 mg/kg) was used as the diabetogenic agent. while controls and diabetic controls did not receive any plant extract, treated rats received lyophilized aqueous extract of mc and ej (200 mg/kg p.o.), alcohol extract of tc (400 mg/kg) and mp (200 mg/kg p.o.) every day until 4 months. serum glucose concentra ... | 2002 | 12458487 |
| comparative evaluation of hypoglycaemic activity of some indian medicinal plants in alloxan diabetic rats. | in our experiments 30 hypoglycaemic medicinal plants (known and less known) have been selected for thorough studies from indigenous folk medicines, ayurvedic, unani and siddha systems of medicines. in all the experiments with different herbal samples (vacuum dried 95% ethanolic extracts), definite blood glucose lowering effect within 2 weeks have been confirmed in alloxan diabetic albino rats. blood glucose values are brought down close to normal fasting level using herbal samples at a dose of 2 ... | 2003 | 12499084 |
| amelioration of experimental diabetic neuropathy and gastropathy in rats following oral administration of plant (eugenia jambolana, mucuna pruriens and tinospora cordifolia) extracts. | extract of m. charantia (200 mg/kg), e. jambolana (200 mg/kg), m. pruriens (200 mg/kg) and t. cordifolia (400 mg/kg) was administered for 50 days in stz induced diabetic mice, the plasma glucose concentration was reduced by 24.4, 20.84, 7.45 and 9.07% respectively. tail flick latency (tfl) and gastric transit percentage were significantly higher in diabetic controls versus normal controls. m. charantia and e. jambolana modified it favorably while m. pruriens and t. cordifolia did not exert any f ... | 2002 | 12635695 |
| hypoglycaemic and hypolipidaemic action of alcohol extract of tinospora cordifolia roots in chemical induced diabetes in rats. | the present investigation was undertaken to evaluate the hypoglycaemic and hypolipidaemic effects of an alcohol extract of tinospora cordifolia roots, an indigenous plant used in ayurvedic medicine in india. oral administration of the extract of tinospora cordifolia (tcret) roots for 6 weeks resulted in a significant reduction in blood and urine glucose and in lipids in serum and tissues in alloxan diabetic rats. the extract also prevented a decrease in body weight. thus our study clearly shows ... | 2003 | 12722152 |
| antiatherogenic effect of caps ht2, a herbal ayurvedic medicine formulation. | the antiatherogenic effect of a herbal formulation, caps ht2, was evaluated as antioxidant, anticoagulant, platelet antiaggregatory, lipoprotein lipase releasing, anti-inflammatory and hypolipidaemic activity in rats. the formulation contained the methanolic extracts of selected parts of plants, commiphora mukul, allium sativum, plumbago indica, semecarpus anacardium, hemidesmus indicus, terminalia arjuna, tinospora cordifolia, withania somnifera and ocimum sanctum. the formulation, caps ht2 was ... | 2003 | 13678230 |
| immunoprotection by botanical drugs in cancer chemotherapy. | most of the synthetic chemotherapeutic agents available today are immunosuppressants, cytotoxic, and exert variety of side effects that are particularly evident in cancer chemotherapy. botanical based immunomodulators are often employed as supportive or adjuvant therapy to overcome the undesired effects of cytotoxic chemotherapeutic agents and to restore normal health. total extract, polar and non-polar extracts, and their formulations, prepared from medicinal plants mentioned in ayurveda, namel ... | 2004 | 14698508 |
| glycosyl composition of polysaccharide from tinospora cordifolia. | polysaccharide from tinospora cordifolia was isolated, purified, hydrolysed, trimethylsilylated and then subjected to gc-mc studies. the polysaccharide composition was estimated as follows: glucose 98.0%, arabinose 0.5%, rhamnose 0.2%, xylose 0.8%, mannose 0.2% and galactose 0.3%. | 2003 | 14769254 |
| hepatocurative and antioxidant profile of hp-1, a polyherbal phytomedicine. | hp-1 a herbal formulation comprising of phyllanthus niruri and extracts of terminalia belerica, terminalia chebula, phyllanthus emblica and tinospora cordifolia has been evaluated for hepatoprotective activity against carbon tetrachloride (ccl4) induced toxicity. results show that hp-1 reversed the leakage of lactate dehydrogenase (ldh) and glutamate pyruvate transaminase (gpt) and prevented the depletion of glutathione (gsh) levels in a primary monolayer culture of rat hepatocytes (in vitro). h ... | 2003 | 14992325 |
| immunomodulatory and antitumor actions of medicinal plant tinospora cordifolia are mediated through activation of tumor-associated macrophages. | the present investigations were under taken to study whether the tumor-associated macrophages (tam) of dalton's lymphoma (dl), a spontaneous transplantable t cell lymphoma, can be activated by the alcoholic extract of medicinal plant tinospora cordifolia (altc). intraperitoneal administration of altc in dl-bearing mice not only augments the basic function of macrophages such as phagocytosis as well as their antigen presenting ability and secretion of il-1, tnf and rni. the results of the present ... | 2004 | 15106739 |
| radioprotective potential of an herbal extract of tinospora cordifolia. | a preparation of tinospora cordifolia (rtc) administered i.p. (200 mg/kg b.w.) to strain "a" male mice 1 h before whole body gamma-irradiation was evaluated for its radioprotective efficacy in terms of whole body survival, spleen colony forming units (cfu), hematological parameters, cell cycle progression, and micronuclei induction. preirradiation treatment with rtc rendered 76.3% survival (30 days), compared to 100% mortality in irradiated control and prevented radiation induced weight loss. on ... | 2004 | 15133291 |
| antifertility effect of tinospora cordifolia (willd.) stem extract in male rats. | oral administration of 70% methanolic extract of t. cordifolia stem to male rats at the dose level of 100 mg/rat/day for 60 days did not cause body weight loss but decreased the weight of testes, epididymis, seminal vesicle and ventral prostate in a significant manner. sperm motility as well as sperm density were reduced significantly which resulted in reduction of male fertility by 100%. the stem extract brought about an interference with spermatogenesis. the round spermatids were decreased by ... | 2003 | 15248490 |
| rubia cordifolia, fagonia cretica linn and tinospora cordifolia exert neuroprotection by modulating the antioxidant system in rat hippocampal slices subjected to oxygen glucose deprivation. | the major damaging factor during and after the ischemic/hypoxic insult is the generation of free radicals, which leads to apoptosis, necrosis and ultimately cell death. rubia cordifolia (rc), fagonia cretica linn (fc) and tinospora cordifolia (tc) have been reported to contain a wide variety of antioxidants and have been in use in the eastern system of medicine for various disorders. however, their mechanism of action was largely unknown. we therefore selected these herbs for the present study t ... | 2004 | 15310392 |
| the evaluation of nitric oxide scavenging activity of certain indian medicinal plants in vitro: a preliminary study. | the plant extracts of 17 commonly used indian medicinal plants were examined for their possible regulatory effect on nitric oxide (no) levels using sodium nitroprusside as an no donor in vitro. most of the plant extracts tested demonstrated direct scavenging of no and exhibited significant activity. the potency of scavenging activity was in the following order: alstonia scholaris > cynodon dactylon > morinda citrifolia > tylophora indica > tectona grandis > aegle marmelos (leaf) > momordica char ... | 2004 | 15383230 |
| effect of tinospora cordifolia on the cytokine profile of angiogenesis-induced animals. | the antiangiogenic activity of tinospora cordifolia was studied using in vivo as well as in vitro models. in vivo antiangiogenic activity was studied using b16f10 melanoma cell-induced capillary formation in animals. intraperitoneal administration of the extract at a concentration of 20 mg/kg significantly inhibited the tumour directed capillary formation induced by melanoma cells. analysis of the serum cytokine profile showed a drastic increase of proinflammatory cytokines such as il-1beta, il- ... | 2004 | 15454110 |
| immune stimulating properties of a novel polysaccharide from the medicinal plant tinospora cordifolia. | an alpha-d-glucan (rr1) composed of (1-->4) linked back bone and (1-->6) linked branches with a molecular mass of >550 kda and exhibiting unique immune stimulating properties is isolated and characterized from the medicinal plant tinospora cordifolia. this novel polysaccharide is noncytotoxic and nonproliferating to normal lymphocytes as well as tumor cell lines at 0-1000 microg/ml. it activated different subsets of the lymphocytes such as natural killer (nk) cells (331%), t cells (102%), and b ... | 2004 | 15454117 |
| effect of rubia cordifolia, fagonia cretica linn, and tinospora cordifolia on free radical generation and lipid peroxidation during oxygen-glucose deprivation in rat hippocampal slices. | the major damaging factor during and after the ischemic/hypoxic insult is the generation of free radicals, which leads to apoptosis, necrosis, and ultimately cell death. rubia cordifolia (rc), fagonia cretica linn (fc), and tinospora cordifolia (tc) have been reported to contain a wide variety of antioxidants and have been in use in the eastern system of medicine for various disorders. hippocampal slices were subjected to oxygen-glucose deprivation (ogd) and divided into three groups, control, o ... | 2004 | 15474468 |
| restoration of antioxidant defence by ethanolic tinospora cordifolia root extract in alloxan-induced diabetic liver and kidney. | the present study investigates the effect of oral administration of an alcoholic extract of tinospora cordifolia roots on antioxidant defence in alloxan-induced diabetes in rats. a significant increase in the concentration of thiobarbituric acid reactive substances (tbars) in liver and kidney was observed in diabetic rats. decreased concentration of glutathione (gsh) and decreased activities of superoxide dismutase (sod), and catalase in liver and kidney of diabetic rats were also noted. alcohol ... | 2004 | 15478189 |
| antihyperglycaemic and antioxidant effect of hyponidd, an ayurvedic herbomineral formulation in streptozotocin-induced diabetic rats. | hyponidd is a herbomineral formulation composed of the extracts of ten medicinal plants ( momordica charantia, melia azadirachta, pterocarpus marsupium, tinospora cordifolia , gymnema sylvestre, enicostemma littorale, emblica officinalis, eugenia jambolana, cassia auriculata and curcuma longa). we have investigated hyponidd for its possible antihyperglycaemic and antioxidant effect in diabetic rats. rats were rendered diabetic by streptozotocin (stz) (45 mg kg(-1) body weight). oral administrati ... | 2004 | 15525451 |
| restoration of antioxidants by ethanolic tinospora cordifolia in alloxan-induced diabetic wistar rats. | the present study investigates the effect of oral administration of an alcoholic extract of tinospora cordifolia roots on antioxidant defence in alloxan-induced diabetes in rats. a significant increase in the concentration of thiobarbituric acid reactive substances (tbars) in brain along with a decrease in heart was observed in diabetic rats. decreased concentration of glutathione (gsh) and decreased activities of superoxide dismutase (sod), catalase and glutathione peroxidase (gpx) in heart and ... | 2004 | 15575595 |
| effect of tinospora cordifolia on the antitumor activity of tumor-associated macrophages-derived dendritic cells. | we and others previously have reported that extract prepared from medicinal plant tinospora cordifolia shows a wide spectrum of immunoaugmentary effects. tinospora cordifolia was shown to upregulate antitumor activity of tumor-associated macrophages (tam). in this article we present evidence to show that an alcoholic extract of tinospora cordifolia (altc) enhances the differentiation of tam to dendritic cells (dc) in response to granulocyte/macrophage-colony-stimulating factor, interleukin-4, an ... | 2005 | 15803856 |
| anti-ulcer and anti-oxidant activity of pepticare, a herbomineral formulation. | pepticare, a herbomineral formulation of the ayurveda medicine consisting of the herbal drugs: glycyrrhiza glabra, emblica officinalis and tinospora cordifolia, was tested for its anti-ulcer and anti-oxidant activity in rats. effects of various doses (125, 250, 500 and 1000mg/kg, p.o.) of pepticare were studied on gastric secretion and gastric ulcers in pylorus-ligation and on ethanol-induced gastric mucosal injury in rats. the reduction in ulcer index in both the models along with the reduction ... | 2005 | 15898703 |
| antimicrobial activity of some medicinal plants from india. | the results of a preliminary antimicrobial screening of the methanol extracts of zingiber officinale, asteracantha longifolia, citrus acida, salacia microsperma and tinospora cordifolia are reported. | 2005 | 16229969 |
| effect of alcoholic extract of ayurvedic herb tinospora cordifolia on the proliferation and myeloid differentiation of bone marrow precursor cells in a tumor-bearing host. | the present study investigates the effect of in vivo administration of alcoholic extract of tinospora cordifolia whole plant (altc) on the proliferation and myeloid differentiation of bone marrow hematopoietic precursor cells in mice bearing a transplantable t cell lymphoma of spontaneous origin designated as dalton's lymphoma (dl). bmc obtained from altc administered dl-bearing mice showed an enhanced bmc proliferation and colony forming ability in vitro in response to l929 conditioned medium a ... | 2006 | 16326030 |
| cardioprotective activity of alcoholic extract of tinospora cordifolia in ischemia-reperfusion induced myocardial infarction in rats. | it has been suggested that the beneficial effects of reperfusing the myocardium might be in part reversed by the occurrence of reperfusion injury. oxidative stress was suggested to be implicating in the pathogenesis of ischemia-reperfusion (i/r) injury. many antioxidative plants were shown to be cardioprotective in experimental models of myocardial ischemia-reperfusion (i/r) injury. the present study was designed to investigate the effects of pretreatment with alcoholic extract of tinospora cord ... | 2005 | 16327173 |
| tinospora cordifolia induces enzymes of carcinogen/drug metabolism and antioxidant system, and inhibits lipid peroxidation in mice. | the present study is an effort to identify a potent chemopreventive agent against various diseases (including cancer) in which oxidative stress plays an important causative role. here, we investigated the effect of a hydroalcoholic (80% ethanol: 20% distilled water) extract of aerial roots of tinospora cordifolia (50 and 100mg/kg body wt./day for 2 weeks) on carcinogen/drug metabolizing phase-i and phase-ii enzymes, antioxidant enzymes, glutathione (gsh) content, lactate dehydrogenase and lipid ... | 2006 | 16360936 |
| restoration of thymic homeostasis in a tumor-bearing host by in vivo administration of medicinal herb tinospora cordifolia. | in vivo administration of alcoholic extract of medicinal plant tinospora cordifolia (tc) to mice bearing a spontaneous t cell lymphoma designated as dalton's lymphoma prevented tumor growth-dependent regression of thymus. tc was found to augment proliferation of thymocytes with a concomitant decrease in thymocyte apoptosis. it also resulted in a decrease in the number of hassal's corpuscles. restoration of thymus homeostasis was caused by tc-dependent augmentation in production of thymocyte grow ... | 2005 | 16435578 |
| evaluation of the antineoplastic activity of guduchi (tinospora cordifolia) in ehrlich ascites carcinoma bearing mice. | the anticancer activity of dichloromethane extract of guduchi [tinospora cordifolia (willd.) miers ex hook. f. & thoms. family: menispermaceae (tce)] in the mice transplanted with ehrlich ascites carcinoma (eac) was investigated. the eac mice receiving 25, 30, 40, 50 and 100 mg/kg, tce showed a dose dependent elevation in tumor-free survival and a highest number of survivors were observed at 50 mg/kg tce, which was considered as an optimum dose for its neoplastic action. the average survival tim ... | 2006 | 16508146 |
| influence of selected indian immunostimulant herbs against white spot syndrome virus (wssv) infection in black tiger shrimp, penaeus monodon with reference to haematological, biochemical and immunological changes. | immunostimulants are the substances, which enhance the non-specific defence mechanism and provide resistance against the invading pathogenic micro-organism. in order to increase the immunity of shrimps against the wssv, the methanolic extracts of five different herbal medicinal plants like cyanodon dactylon, aegle marmelos, tinospora cordifolia, picrorhiza kurooa and eclipta alba were selected and mixed thoroughly in equal proportion. the mixed extract was supplemented with various concentration ... | 2006 | 16698283 |
| modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. | modulation of cytokine secretion may offer novel approaches in the treatment of a variety of diseases. one strategy in the modulation of cytokine expression may be through the use of herbal medicines. a class of herbal medicines, known as immunomodulators, alters the activity of immune function through the dynamic regulation of informational molecules such as cytokines. this may offer an explanation of the effects of herbs on the immune system and other tissues. for this informal review, the aut ... | 2006 | 16813462 |
| screening of selected indian medicinal plants for acetylcholinesterase inhibitory activity. | seventy-six plant extracts including methanolic and successive water extracts from 37 indian medicinal plants were investigated for acetylcholinesterase (ache) inhibitory activity (in vitro). results indicated that methanolic extracts to be more active than water extracts. the potent ache inhibiting methanolic plant extracts included withania somnifera (root), semecarpus anacardium (stem bark), embelia ribes (root), tinospora cordifolia (stem), ficus religiosa (stem bark) and nardostachys jatama ... | 2007 | 16950584 |
| quantitative determination of four constituents of tinospora sps. by a reversed-phase hplc-uv-dad method. broad-based studies revealing variation in content of four secondary metabolites in the plant from different eco-geographical regions of india. | this paper describes the separation and quantitation of important markers, such as 20beta-hydroxyecdysone, tinosporaside, cordioside, and columbin, present in three species of tinospora viz, t. cordifolia, t. malabrica, and t. crispa. a reverse-phase (rp) high-performance liquid chromatography (hplc)-uv-diode array detection (dad) method employing gradient elution is thus developed. the marker compounds isolated from 70% ethanolic extract of t. cordfolia by repeated column chromatography are ide ... | 2006 | 16959127 |
| immunostimulatory effect of tinospora cordifolia miers leaf extract in oreochromis mossambicus. | immunostimulatory effect of leaf extract of t. cordifolia on (i) specific immunity (antibody response), (ii) non-specific immunity (neutrophil activity) and (iii) disease resistance against aeromonas hydrophila was investigated in o. mossambicus. ethanol and petroleum ether extracts of the leaves were used. both ethanol and petroleum ether extracts administered at doses of 0.8, 8 or 80 mg/kg body weight, prolonged the peak primary antibody titres upto one to three weeks. ethanol extract at the d ... | 2006 | 16999027 |
| mechanism of macrophage activation by (1,4)-alpha-d-glucan isolated from tinospora cordifolia. | the signaling mechanism of the novel (1,4)-alpha-d-glucan (rr1) isolated from the medicinal plant tinospora cordifolia was investigated in macrophages to evaluate its immunostimulating properties. when raw264.7 macrophages were incubated with rr1 at 4 degrees c, the novel glucan inhibited the phagocytosis of unopsonized zymosan a bioparticles in a dose-dependent manner. rr1 also inhibited the binding and internalization of opsonized zymosan a bioparticles, although at a lower level than laminari ... | 2006 | 17052672 |
| effect of tinospora cordifolia on gamma ray-induced perturbations in macrophages and splenocytes. | tinospora cordifolia (rtc) has already been reported to protect whole-body lethally irradiated mice. this study has focussed on certain aspects of immuno-competence, which are adversely affected by irradiation. this study included estimation of spleen size, cell count, dna fragmentation and apoptosis in splenocytes. the adherence, spreading and phagocytic activities of macrophages were also assessed. cytokines in serum and anti-oxidants in plasma were also estimated. administration of rtc (200 m ... | 2007 | 17548939 |
| effects of four indian medicinal herbs on isoniazid-, rifampicin- and pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs. | to evaluate and compare the hepatoprotective and immunomodulatory effects of curcuma longa (cl), ocimum sanctum (os), tinospora cordifolia (tc) and zizyphus mauritiana (zm) on liver injury and immunosuppression induced by isoniazid (inh), rifampicin (rif) and pyrazinamide (pza). | 2007 | 17589898 |
| antihyperglycaemic effect of 'ilogen-excel', an ayurvedic herbal formulation in streptozotocin-induced diabetes mellitus. | 'ilogen-excel', an ayurvedic herbal formulation is composed of eight medicinal plants (curcuma longa, strychnos potatorum, salacia oblonga, tinospora cordifolia, vetivelia zizanioides, coscinium fenestratum, andrographis paniculata and mimosa pudica). the present study evaluates the antihyperglycemic effect of 'ilogen-excel' in streptozotocin induced diabetic rats. rats were rendered diabetic by streptozotocin (stz) (45 mg/kg body weight). oral administration of 'ilogen-excel' (50 mg/kg and 100 ... | 2007 | 17665851 |
| g1-4a, an immunomodulatory polysaccharide from tinospora cordifolia, modulates macrophage responses and protects mice against lipopolysaccharide induced endotoxic shock. | pro-inflammatory cytokines are known to be the mediators of endotoxic shock and several immunomodulatory herbs can modulate the expression of these cytokines. therefore we have investigated the possibility of using an arabinogalactan polysaccharide, g1-4a, from the stem of tinospora cordifolia, for protection against endotoxin induced sepsis. there was 100% protection against lipopolysaccharide (lps) induced mortality in mice pretreated with g1-4a. to elucidate the mechanism of action, its effec ... | 2007 | 17673153 |
| the effects of spirulina on allergic rhinitis. | the prevalence of allergic rhinitis is increasing globally due to various causes. it affects the quality life of a large group of people in all around the world. allergic rhinitis still remains inadequately controlled with present medical means. the need of continuous medical therapy makes individuals anxious about the side effects of the drugs. so there is a need for an alternative strategy. effects of spirulina, tinospora cordifolia and butterbur were investigated recently on allergic rhinitis ... | 2008 | 18343939 |
| protective effect of tinospora cordifolia, phyllanthus emblica and their combination against antitubercular drugs induced hepatic damage: an experimental study. | this study investigated the hepatoprotective effect of two indian medicinal plants tinospora cordifolia (tc), phyllanthus emblica (pe), and their combination, in a rat model of isoniazid, rifampicin and pyrazinamide induced hepatic damage. hepatic damage was assessed using a composite score assigned to histopathological findings of degeneration, necrosis and fibrosis. the antituberculosis treatment (att), when given for 90 days, induced significant degeneration and necrosis (score: 7.5; p < 0.01 ... | 2008 | 18389486 |
| indian herbs and herbal drugs used for the treatment of diabetes. | traditional medicines derived from medicinal plants are used by about 60% of the world's population. this review focuses on indian herbal drugs and plants used in the treatment of diabetes, especially in india. diabetes is an important human ailment afflicting many from various walks of life in different countries. in india it is proving to be a major health problem, especially in the urban areas. though there are various approaches to reduce the ill effects of diabetes and its secondary complic ... | 2007 | 18398493 |
| evaluation of the antiosteoporotic potential of tinospora cordifolia in female rats. | the available courses of therapy to osteoporosis in menopausal women are limited by several side effects generated. a need therefore arises to explore herbal alternatives that are effective and safe. | 2008 | 18482809 |
| octacosanol isolated from tinospora cordifolia downregulates vegf gene expression by inhibiting nuclear translocation of nf-<kappa>b and its dna binding activity. | octacosanol is a long-chain aliphatic alcohol, which is the main component of policosanol used as a normolipidemic agent. it is known that angiogenesis is involved in tumor growth and metastasis. the present study identified octacosanol isolated from the plant tinospora cordifolia as a new antiangiogenic compound with inhibitory effects on in vivo angiogenesis assays. our results showed that octacosanol (i) inhibits proliferation of endothelial cells and ehrlich ascites tumor cells, (ii) inhibit ... | 2008 | 18513715 |
| chemopreventive potential of an indian medicinal plant (tinospora cordifolia) on skin carcinogenesis in mice. | tinospora cordifolia (guduchi), an indian medicinal plant, was used to explore antitumor promoting activity in a two-stage skin carcinogenesis model. for this purpose, mice were treated by single application of dmba (100 microg/100 microl of acetone) and two weeks later promoted by croton oil (1% in acetone three times a week) until the end of the experiment (i.e., 16 weeks). oral administration of the above extract at the preinitiational stage (i.e., seven days before and seven days after dmba ... | 2008 | 18652570 |
| preliminary investigation of the radiosensitizing activity of guduchi (tinospora cordifolia) in tumor-bearing mice. | the radiosensitizing activity of dichloromethane extract of guduchi [tinospora cordifolia (willd.) miers ex hook. f. & thoms. family: menispermaceae (tce)] in the mice transplanted with ehrlich ascites carcinoma (eac) was investigated. the eac mice received 0, 25, 30, 40, 50 or 100 mg/kg b.wt. tce 1 h before exposure to 6 gy hemi-body gamma-radiation and then once daily for another eight consecutive days after irradiation. the eac mice receiving tce for the above regimen showed a dose-dependent ... | 2008 | 18803246 |
| heavy metal accumulation in medicinal plants collected from environmentally different sites. | to estimate the heavy metal content in soil and selected medicinal plants procured from environmentally different sites of the same city. | 2008 | 18837296 |
| chemopreventive potential of epoxy clerodane diterpene from tinospora cordifolia against diethylnitrosamine-induced hepatocellular carcinoma. | medicinal plants are a promising source for identification of lead molecules for cancer therapy. in our continuous search to discover bioactive compounds from natural products, we isolated (5r, 10r)-4r, 8r-dihydroxy-2s, 3r:15, 16-diepoxycleroda-13(16), 17, 12s:18,1s-dilactone (ecd), a diterpenoid from tinospora cordifolia and studied its chemopreventive potential in diethylnitrosamine (den) induced hepatocellular carcinoma (hcc) rats. fifty male wistar rats were divided into five groups. group i ... | 2009 | 18853103 |
| hypoglycemic activity of the antioxidant saponarin, characterized as alpha-glucosidase inhibitor present in tinospora cordifolia. | tinospora cordifolia, used in anti-diabetic herbal drug preparations, was reported [12] to contain an alpha-glucosidase inhibitor, characterized as saponarin (apigenin-6-c-glucosyl-7-o-glucoside). the leaf extract had appreciable antioxidant and hydroxyl radical scavenging activities and contained the flavonoid in the range of 32.1 +/- 1.5-45.5 +/- 3.5 mg/g of dry solid. saponarin showed mixed competitive inhibition on activities of alpha-glucosidase and sucrase of different origins. ic(50), ki ... | 2009 | 18951283 |
| androgenic action of tinospora cordifolia ethanolic extract in prostate cancer cell line lncap. | recently, tinospora cordifolia (tc) was shown to affect prostate growth in rats. it is not known whether this is a direct effect of tc or whether it is induced by altered hormone release. to investigate the actions of tc on the prostate, human lncap cells were exposed to an ethanolic extract of tc. | 2009 | 19097771 |
| physiological effects of a novel immune stimulator drug, (1,4)-alpha-d-glucan, in rats. | the (1,4)-alpha-d-glucan (alpha-d-glucan), derived from medicinal plant, tinospora cordifolia, activates human lymphocytes with downstream synthesis of the pro- and anti-inflammatory cytokines, in vitro. we investigated physiological and immunological effects of a low and a high dose of alpha-d-glucan (0.5 and 10 mg/kg), in vivo, testing the hypothesis that intravenous administration of alpha-d-glucan does not affect haemodynamic, respiratory, haematological, and immune responses in normal rats. ... | 2009 | 19389049 |
| molecular events in the activation of b cells and macrophages by a non-microbial tlr4 agonist, g1-4a from tinospora cordifolia. | g1-4a, a polysaccharide from an indian medicinal plant tinospora cordifolia, was recently shown to protect mice against septic shock by modulating the proinflammatory cytokines. g1-4a also activated b cells polyclonally. the present report describes in detail the molecular events associated with g1-4a-induced immunomodulation in vitro and in vivo. g1-4a treatment led to an increase in the cd69 expression in lymphocytes. g1-4a-induced proliferation of b cells was completely inhibited by pi3k inhi ... | 2009 | 19428553 |
| preventive effect of tinospora cordifolia against high-fructose diet-induced insulin resistance and oxidative stress in male wistar rats. | high intake of dietary fructose exerts a number of adverse metabolic effects. the aim of the present study was to investigate whether aqueous extract of tinospora cordifolia stem (tcae) alleviates high-fructose diet-induced insulin resistance and oxidative stress in rats. high-fructose diet (66% of fructose) and tcae (400 mg/kg/day) were given simultaneously for a period of 60 days. fructose fed rats showed hyperglycemia, hyperinsulinemia, hypertriglyceridemia, impaired glucose tolerance and imp ... | 2009 | 19520137 |
| alpha glucosidase inhibition by stem extract of tinospora cordifolia. | inhibitors of alpha glucosidase have potential use in the treatment of diabetes mellitus. the stem extract of tinospora cordifolia was evaluated for inhibition of the enzyme. the extract was also found to inhibit the salivary and pancreatic amylase and therefore can effectively reduce an increase in postprandial glucose level. the crude ethyl acetate, dichloromethane (dcm), chloroform and hexane extracts of tinospora cordifolia were studied. 15 mg of the dcm extract was most effective in that sh ... | 2009 | 19555164 |
| trace element studies on tinospora cordifolia (menispermaceae), ocimum sanctum (lamiaceae), moringa oleifera (moringaceae), and phyllanthus niruri (euphorbiaceae) using pixe. | traditionally, tinospora cordifolia (willd.) hook. f. & thomson (menispermaceae), ocimum sanctum l. (lamiaceae), moringa oleifera lam. (moringaceae), and phyllanthus niruri l. (euphorbiaceae) are some of the commonly used medicinal plants in india for curing ailments ranging from common cold, skin diseases, and dental infections to major disorders like diabetes, hypertension, jaundice, rheumatism, etc. to understand and correlate their medicinal use, trace element studies on the aqueous extract ... | 2010 | 19588079 |
| immunological response to (1,4)-alpha-d-glucan in the lung and spleen of endotoxin-stimulated juvenile rats. | we investigated the effects of (1,4)-alpha-d-glucan (alpha-dg), a novel immune stimulatory drug from tinospora cordifolia, on the concentration of pro- and anti-inflammatory cytokines (interleukin [il]-1beta, il-6, tumour necrosis factor-alpha [tnf-alpha], gamma-interferon [ifn-gamma] and il-10) in the lung and spleen of endotoxin-stimulated juvenile rats. experimental groups (n = 16/group) included controls with an intraperitoneal injection of saline, endotoxaemic rats with a non-lethal dose of ... | 2009 | 19627280 |
| tinospora cordifolia, a safety evaluation. | tinospora cordifolia is one of the indispensable medicinal plants used in veterinary folk medicine/ayurvedic system of medicine for the treatment of diverse diseases and recommended for improving the immune system by means of body resistance. in the current study, we evaluated the genotoxic risk of the aqueous extract of t. cordifolia (tc) in a battery of four different genotoxicity tests viz., ames, in vitro chromosome aberration (ca), rodent bone marrow micronucleus (mn), and comet assay. expe ... | 2009 | 19651204 |
| antihyperglycemic, antihyperlipidemic and antioxidant effects of dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats. | present investigation was undertaken to evaluate antihyperglycemic, antihyperlipidemic and antioxidant activities of dihar, a polyherbal formulation containing drugs from eight different herbs viz., syzygium cumini, momordica charantia, emblica officinalis, gymnema sylvestre, enicostemma littorale, azadirachta indica, tinospora cordifolia and curcuma longa in streptozotocin (stz, 45 mg/kg iv single dose) induced type 1 diabetic rats. stz produced a significant increase in serum glucose, choleste ... | 2009 | 19761040 |
| beneficiary effect of tinospora cordifolia against high-fructose diet induced abnormalities in carbohydrate and lipid metabolism in wistar rats. | high intake of dietary fructose has been shown to exert a number of adverse metabolic eff ects in humans and experimental animals. the present study was designed to investigate the eff ect of the aqueous extract of tinospora cordifolia stem (tcae) on the adverse eff ects of fructose loading toward carbohydrate and lipid metabolism in rats. adult male wistar rats of body weight around 200 g were divided into four groups, two of which were fed with starch diet and the other two with high fructose ... | 2009 | 19764107 |
| evaluation of mammary gland immunity and therapeutic potential of tinospora cordifolia against bovine subclinical mastitis. | enhancement of the diseased mammary gland immunity and therapeutic potential of hydro-methanolic extract of tinospora cordifolia (t. cordifolia; stem) in bovine subclinical mastitis was investigated. somatic cell count (scc), total bacterial count (tbc), phagocytic activity, and leukocyte lysosomal enzymes like myeloperoxidase and acid phosphatase activity and interleukin-8 (il-8) level were evaluated after intramammary infusion of hydro-methanolic extract (stem) of t.cordifolia in diseased cows ... | 2010 | 19876755 |
| immunomodulatory effect of tinospora cordifolia extract in human immuno-deficiency virus positive patients. | to assess the safety and efficacy of tce in human immuno-deficiency virus positive patients. | 2008 | 20040936 |
| anti-tumor activity of four ayurvedic herbs in dalton lymphoma ascites bearing mice and their short-term in vitro cytotoxicity on dla-cell-line. | the anti-tumor activity and chemopreventive potential of four ayurvedic herbs viz. curcuma longa l., ocimum sanctum l., tinospora cordifolia (wild) miers ex hook.f & thomas and zizyphus mauritiana lam. were evaluated using dalton lymphoma ascites (dla) tumor model in swiss albino mice. the outcome was assessed using survival time, peritoneal ascitic fluid (tumor volume) and hematological indices as parameters. animals were divided into five groups (n = 6) viz. one dla control and four herb + dla ... | 2008 | 20161965 |
| beneficial effects of beta-ecdysone on the joint, epiphyseal cartilage tissue and trabecular bone in ovariectomized rats. | ecdysteroids are steroids found in invertebrates and plants. in mammals they have protein anabolic effects. we have recently published antiosteoporotic effects of tinospora cordifolia (tc) extract and the search for the possible active ingredients yielded the presence of beta-ecdysone (ecd). therefore, we investigated the effects of pure ecd in ovariectomized rats on morphological changes in joint, epiphyseal cartilage and trabecular tissue. following ovariectomy rats were fed for 1 month with e ... | 2010 | 20171072 |
| screening of antibacterial potentials of some medicinal plants from melghat forest in india. | cyperus rotundus, caesalpinia bonducella, tinospora cordifolia, gardenia gummifera, ailanthus excelsa, acacia arabica, embelia ribes and ventilago maderspatana from melghat forest were screened for their antibacterial potential against escherichia coli, staphylococcus aureus, klebsiella pneumoniae, proteus vulgaris, salmonella typhi, shigella flexneri, salmonella paratyphi, salmonella typhimurium, pseudomonas aeruginosa, enterobacter aerogenes by disc diffusion method. out of these medicinal pla ... | 2009 | 20448847 |
| beta-ecdysone has bone protective but no estrogenic effects in ovariectomized rats. | estrogens exert beneficial effects in the bone. their chronic use however bares several risks. therefore intensive search for non-estrogenic, bone protective compounds is going on. we observed that an extract of tinospora cordifolia has antiosteoporotic effects and identified 20-oh-ecdysone (beta-ecdysone=ecd) as a possible candidate for this action. ovariectomized (ovx) rats were treated orally over 3 months with no ecd (control) or 18, 57 or 121 mg ecd/day/animal. estradiol-17beta benzoate (e2 ... | 2010 | 20554186 |
| use of tinospora cordifolia in hiv infection. | | 2010 | 20606842 |
| water soluble fraction of tinospora cordifolia leaves enhanced the non-specific immune mechanisms and disease resistance in oreochromis mossambicus. | the present paper describes the effect of water-soluble fraction of the leaves of the indian medicinal plant, tinospora cordifolia (miers) on the non-specific immunity and disease resistance in oreochromis mossambicus (peters). fish were intraperitoneally injected with 0, 6, 60 or 600 mg kg(-1) body weight, of the water soluble fraction. the non-specific humoral (lysozyme, antiprotease and complement) and cellular (production of reactive oxygen and nitrogen species and myeloperoxidase) responses ... | 2010 | 20624469 |
| a comparative pharmacological investigation of three samples of 'guduchi ghrita' for adaptogenic activity against forced swimming induced gastric ulceration and hematological changes in albino rats. | this study was undertaken to investigate the impact of formulation factors and adjuvants on the expression of biological activity of tinospora cordifolia (willd.) miers. the adaptogenic effect of three samples of guduchi ghrita, prepared using plain ghee (clarified butter) obtained from three different sources was studied in albino rats and compared with expressed juice of stem of guduchi. the test preparations were evaluated against forced-swimming induced hypothermia, gastric ulceration and ch ... | 2010 | 20814518 |
| tinospora cordifolia ameliorates urotoxic effect of cyclophosphamide by modulating gsh and cytokine levels. | cyclophosphamide (cp) is a commonly used anti-cancer drug which causes toxicity by its reactive metabolites. in this study we investigated the effect of tinospora cordifolia on urotoxicity induced by acute dose of cp using swiss albino mice model. administration of an alcoholic extract of the plant t. cordifolia (family: menispermaceae) (200mg/kg i.p.) for 5 days reduced cp (1.5mmol/kg body wt. i.p.) induced urotoxicity as evident from the morphological analysis of bladder, decreased the relativ ... | 2010 | 20932729 |
| beneficial effects of tinospora cordifolia on blood profiles in male mice exposed to lead. | this study was carried out to evaluate in vivo protective role of aqueous extract of stem and leaves of tinospora cordifolia (tc) on the toxic effects of lead on the hematological values. the lead-treated (5 mg/kg body weight, intraperitonially, once daily) male albino mice concurrently received either t. cordifolia stem or leaves extracts (400 mg/kg body weight, orally, once daily) for the duration of 30 days. the animals exposed to lead showed significant decrease in rbc and hb level. signific ... | 2010 | 21042466 |
| protective role of tinospora cordifolia against lead-induced hepatotoxicity. | the importance of tinospora cordifolia stem and leaves extract was investigated for its possible hepatoprotective effect in swiss albino male mice against lead nitrate induced toxicity. oral administration of plant extracts prevented the occurrence of lead nitrate induced liver damage. the decreased level of tissue enzymes, i.e., superoxide dismutase (sod), catalase (cat) and increased level of aspartate aminotransferase (ast), alanine aminotransferase (alt), alkaline phosphatase (alp), and acid ... | 2010 | 21042467 |
| effects of supplementation of tinospora cordifolia to crossbred cows peripartum. | guduchi (tinospora cordifolia), a medicinal plant used in ayurveda, is well documented for its immunomodulatory properties. since the crossbred periparturient cow is highly susceptible to various diseases that effectively reduces its reproductive performance postpartum we explored the possibility of enhancing the reproductive performance of crossbred cows by guduchi supplementation peripartum. a total of 15 pregnant karan fries cows were selected and divided into two groups: treatment group of 8 ... | 2010 | 21163594 |
| synthesis of pediculocidal and larvicidal silver nanoparticles by leaf extract from heartleaf moonseed plant, tinospora cordifolia miers. | insecticide resistance and inadequate attention to the application instructions of topical pediculicides are common reasons for treatment failure. essential oils or plant extracts are good and safe alternatives due to their low toxicity to mammals and easy biodegradability. the present study was carried out to establish the pediculocidal and larvicidal activity of synthesized silver nanoparticles (agnps) using leaf aqueous extract of tinospora cordifolia miers (menispermaceae) against the head l ... | 2011 | 21212979 |
| potent α-amylase inhibitory activity of indian ayurvedic medicinal plants. | indian medicinal plants used in the ayurvedic traditional system to treat diabetes are a valuable source of novel anti-diabetic agents. pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post-prandial hyperglycemia via control of starch breakdown. in this study, seventeen indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for α-amylase inhibition, in order to assess and evaluate their inhibitory po ... | 2011 | 21251279 |
| radiation-induced testicular injury and its amelioration by tinospora cordifolia (an indian medicinal plant) extract. | the primary objective of this investigation is to determine the deleterious effects of sub lethal gamma radiation on testes and their possible inhibition by tinospora cordifolia extract (tce). for this purpose, one group of male swiss albino mice was exposed to 7.5?gy gamma radiation to serve as the irradiated control, while the other group received tce (75?mg/kg?b.?wt./day) orally for 5 consecutive days half an hr before irradiation to serve as experimental. exposure of animals to 7.5?gy gamma ... | 2011 | 21350610 |