| the activator of human cerebroside sulphatase. activating effect on the acidic forms of the sulphatases from invertebrates. | 1) acidic forms of the sulphatase were partially purified from the following invertebrate species: tethya aurantium (porifera), patella vulgata (mollusca), maja squinado (arthropoda), marthasterias glacialis (echinodermata) and microcosmus sulcatus (tunicata). enzyme preparations thus obtained cleaved cerebroside sulphates (sulphatides) only in the presence of either specific detergents (e.g. taurodeoxycholate) or an activator protein isolated from human liver. this corresponds to the findings o ... | 1976 | 3465 |
| purification and characterization of a pore-forming protein from the marine sponge tethya lyncurium. | a pore-forming protein was detected and purified for the first time from a marine sponge (tethya lyncurium). the purified protein has a polypeptide molecular mass of 21 kda and a pi of 6.4. tethya pore-forming protein (also called tethya hemolysin) rapidly lysed erythrocytes from a variety of organisms. after binding to target membranes, the hemolysin resisted elution with edta, salt or solutions of low ionic strength and hence resembled an integral membrane protein. erythrocytes could be protec ... | 1992 | 1281099 |
| metabolism of some carcinogenic aromatic amines in four species of marine sponges. | postmitochondrial fractions from marine sponges geodia cydonium, tethya aurantium, verongia aerophoba and pellina semitubulosa activate precarcinogenic aromatic amine 2-aminoanthracene, but not precarcinogenic polycyclic aromatic hydrocarbon benzo(a)pyrene, to salmonella typhimurium ta 98 mutagens. all four sponge species lack a benzo(a)pyrene monooxygenase activity, but possesses the enzyme activity whose characteristics (selective activation of aromatic amines, nadph-dependency, ph optimum at ... | 1987 | 2881714 |
| biotransformation of genotoxic agents in marine sponges. mechanisms and modulation. | marine sponges do not appear to suffer from neoplastic diseases, in spite of possible high exposures resulting from their nature as sessile bottom filter feeders which pump large volumes of sea water. the assessment of several parameters related to the biotransformation of mutagens/carcinogens showed that the metabolic machinery of sponge medulla cells is mainly oriented towards detoxification, with some differences depending on species (geodia cydonium or tethya aurantium). glutathione (gsh) le ... | 1995 | 7476273 |
| cannabinoid receptors in invertebrates. | two cannabinoid receptors, cb1 and cb2, are expressed in mammals, birds, reptiles, and fish. the presence of cannabinoid receptors in invertebrates has been controversial, due to conflicting evidence. we conducted a systematic review of the literature, using expanded search parameters. evidence presented in the literature varied in validity, ranging from crude in vivo behavioural assays to robust in silico ortholog discovery. no research existed for several clades of invertebrates; we therefore ... | 2006 | 16599912 |
| spatial distribution of sponge-associated bacteria in the mediterranean sponge tethya aurantium. | the local distribution of the bacterial community associated with the marine sponge tethya aurantium pallas 1766 was studied. distinct bacterial communities were found to inhabit the endosome and cortex. clear differences in the associated bacterial populations were demonstrated by denaturing gradient gel electrophoresis (dgge) and analysis of 16s rrna gene clone libraries. specifically associated phylotypes were identified for both regions: a new phylotype of flexibacteria was recovered only fr ... | 2007 | 17059482 |
| scopularides a and b, cyclodepsipeptides from a marine sponge-derived fungus, scopulariopsis brevicaulis. | two novel cyclodepsipeptides, scopularides a and b, were found in the fungus scopulariopsis brevicaulis, which was isolated from the marine sponge tethya aurantium. in addition, the known fungal metabolite paxilline was identified. the structures of the scopularides were elucidated by nmr, ms, and chemical derivatization methods as cyclo-(3-hydroxy-4-methyldecanoyl-gly-l-val-d-leu-l-ala-l-phe) and cyclo-(3-hydroxy-4-methyloctanoyl-gly-l-val-d-leu-l-ala-l-phe) for scopularide a and b, respectivel ... | 2008 | 18412398 |
| phylogenetic identification of fungi isolated from the marine sponge tethya aurantium and identification of their secondary metabolites. | fungi associated with the marine sponge tethya aurantium were isolated and identified by morphological criteria and phylogenetic analyses based on internal transcribed spacer (its) regions. they were evaluated with regard to their secondary metabolite profiles. among the 81 isolates which were characterized, members of 21 genera were identified. some genera like acremonium, aspergillus, fusarium, penicillium, phoma, and trichoderma are quite common, but we also isolated strains belonging to gene ... | 2011 | 21731550 |
| helicusin e, isochromophilone x and isochromophilone xi: new chloroazaphilones produced by the fungus bartalinia robillardoides strain lf550. | microbial studies of the mediterranean sponge tethya aurantium led to the isolation of the fungus bartalinia robillardoides strain lf550. the strain produced a number of secondary metabolites belonging to the chloroazaphilones. this is the first report on the isolation of chloroazaphilones of a fungal strain belonging to the genus bartalinia. besides some known compounds (helicusin a (1) and deacetylsclerotiorin (2)), three new chloroazaphilones (helicusin e (3); isochromophilone x (4) and isoch ... | 2013 | 23481677 |
| natural products from marine fungi--still an underrepresented resource. | marine fungi represent a huge potential for new natural products and an increased number of new metabolites have become known over the past years, while much of the hidden potential still needs to be uncovered. representative examples of biodiversity studies of marine fungi and of natural products from a diverse selection of marine fungi from the author's lab are highlighting important aspects of this research. if one considers the huge phylogenetic diversity of marine fungi and their almost ubi ... | 2016 | 26784209 |
| de novo assembly and genome analyses of the marine-derived scopulariopsis brevicaulis strain lf580 unravels life-style traits and anticancerous scopularide biosynthetic gene cluster. | the marine-derived scopulariopsis brevicaulis strain lf580 produces scopularides a and b, which have anticancerous properties. we carried out genome sequencing using three next-generation dna sequencing methods. de novo hybrid assembly yielded 621 scaffolds with a total size of 32.2 mb and 16298 putative gene models. we identified a large non-ribosomal peptide synthetase gene (nrps1) and supporting pks2 gene in the same biosynthetic gene cluster. this cluster and the genes within the cluster are ... | 2015 | 26505484 |