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novel polyhydroxysterols from the red sea marine sponge lamellodysidea herbacea.chemical investigation of the dichloromethane extract of the red sea marine sponge lamellodysidea herbacea led to the isolation of four novel polyhydroxysteroids: cholesta-8-en-3beta,5alpha,6alpha,25-tetrol (1), cholesta-8(14)-en-3beta,5alpha,6alpha,25-tetrol (2), cholesta-8,24-dien-3beta,5alpha,6alpha-triol (3), and cholesta-8(14),24-dien-3beta,5alpha,6alpha-triol (4). their structures were identified through 1d and 2d nmr studies. relative stereochemistries were established by analysis of chem ...200516154169
investigation of oscillatoria spongeliae-dominated bacterial communities in four dictyoceratid sponges.certain species of marine sponges in the order dictyoceratida harbor large populations of the cyanobacterial symbiont oscillatoria spongeliae in the mesohyl (interior) of the sponge. we show that in four of these sponge species (lamellodysidea herbacea, lamellodysidea chlorea, lendenfeldia chondrodes, and phyllospongia papyracea) from palau there is a consistent community of alpha-proteobacteria in addition to o. spongeliae that fall within the rhodobacter group based on 16s rrna gene analysis. ...200516269779
polybrominated diphenyl ethers from the indonesian sponge lamellodysidea herbacea.four new (1-4) and 10 known polybrominated diphenyl ethers (5-14) have been isolated from the title sponge. the structures of the new entities were elucidated by interpretation of spectroscopic data and chemical transformations. these metabolites showed potent antimicrobial activity against bacillus subtilis and moderate/weak cytotoxicity against nbt-t2 rat bladder epithelial cells. the major constituent 14 was treated under debromination conditions to give eight derivatives, which were subjecte ...200717311456
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