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zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.three closely related fungal metabolites, zaragozic acids a, b, and c, that are potent inhibitors of squalene synthase have been isolated and characterized. zaragozic acids a, b, and c were produced from an unidentified sterile fungal culture, sporormiella intermedia, and leptodontium elatius, respectively. the structures of the zaragozic acids and their trimethyl esters were determined by a combination of physical and chemical techniques. the zaragozic acids are characterized by a novel 2,8-dio ...19938419946
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