| multigenic evasion of inflammation by poxviruses. | analyses of different cowpox virus (brighton red strain [cpv-br]) mutants indicate that there is a minimum of three genes encoded by cpv-br that are nonessential for virus replication in tissue culture but are involved in inhibiting the generation of an inflammatory response in the chicken embryo chorioallantoic membrane (cam) model. the cpv-br-encoded anti-inflammatory genes include the gene encoding the 38-kda protein (also called 38k, crma, spi-2, or vv-wr-orf-b13r), a tumor necrosis factor r ... | 1994 | 8107235 |
| cowpox virus infection of cynomolgus macaques as a model of hemorrhagic smallpox. | hemorrhagic smallpox was a rare but severe manifestation of variola virus infection that resulted in nearly 100% mortality. here we describe intravenous (iv) inoculation of cowpox virus brighton red strain in cynomolgus macaques (macaca fascicularis) which resulted in disease similar in presentation to hemorrhagic smallpox in humans. iv inoculation of macaques resulted in a uniformly lethal disease within 12days post-inoculation in two independent experiments. clinical observations and hematolog ... | 2011 | 21840027 |
| exposure of rhesus monkeys to cowpox virus brighton red by large-particle aerosol droplets results in an upper respiratory tract disease. | we previously demonstrated that small-particle (0.5-3.0 µm) aerosol infection of rhesus monkeys (macaca mulatta) with cowpox virus (cpxv)-brighton red (br) results in fulminant respiratory tract disease characterized by severe lung parenchymal pathology but only limited systemic virus dissemination and limited classic epidermal pox-like lesion development (johnson et al., 2015). based on these results, and to further develop cpxv as an improved model of human smallpox, we evaluated a novel large ... | 2016 | 27166137 |