| thottapalayam virus: a presumptive arbovirus isolated from a shrew in india. | | 1971 | 5169031 |
| serological relationships among viruses in the hantavirus genus, family bunyaviridae. | we examined the serological relationships among 32 hantavirus isolates collected from numerous geographic regions and hosts. we prepared rat immune sera to each virus and used these sera in hemagglutination inhibition (hai) tests, enzyme-linked immunosorbent assays (elisa), and plaque-reduction neutralization tests to establish the antigenic relationships among the isolates. our studies included viruses that had been partially characterized previously, as well as isolates for which little or no ... | 1994 | 8259655 |
| phylogenetic analyses of virus isolates in the genus hantavirus, family bunyaviridae. | we constructed a phylogenic tree by pairwise comparison of the deduced amino acid sequences encoded in the medium (m) genome segments of 13 hantaviruses. five distinct branches were identified, four of which are represented by hantaan, seoul, puumala, and prospect hill viruses. these groups corresponded to those previously established by serological and genetic means. in addition, we present sequence information for the m segment of thailand virus and demonstrate that it represents a unique, fif ... | 1994 | 8259656 |
| development of serological assays for thottapalayam virus, an insectivore-borne hantavirus. | thottapalayam virus (tpmv), a member of the genus hantavirus in the family bunyaviridae, was isolated from an insectivore, suncus murinus (musk shrew), captured in southern india in 1964. while the isolation of tpmv predates the discovery of the prototype hantaan virus, little is known about its genetics and biology. to date, preliminary evidence suggests that tpmv differs significantly, both antigenically and genetically, from all known rodent-borne hantaviruses. however, since detailed epizoot ... | 2007 | 17182762 |
| thottapalayam virus is genetically distant to the rodent-borne hantaviruses, consistent with its isolation from the asian house shrew (suncus murinus). | thottapalayam (tpm) virus belongs to the genus hantavirus, family bunyaviridae. the genomes of hantaviruses consist of three negative-stranded rna segments (s, m and l) encoding the virus nucleocapsid (n), glycoprotein (gn, gc), and polymerase (l) proteins, respectively. the genus hantavirus contains predominantly rodent-borne viruses, with the prominent exception of tpm virus which was isolated in india in 1964 from an insectivore, suncus murinus, commonly referred to as the asian house shrew o ... | 2007 | 17711577 |
| thottapalayam virus, a prototype shrewborne hantavirus. | thottapalayam virus (tpmv) has been placed in the genus hantavirus of the family bunyaviridae by virtue of its morphologic features and overall genetic similarities to well-characterized rodentborne hantaviruses. this virus has been isolated from the asian house shrew (suncus murinus); however, whether tpmv is naturally harbored by an insectivore host or represents spillover from a rodent reservoir host is unknown. our analysis of published and unpublished data on the experimental host range, ge ... | 2007 | 18214168 |
| hantaviruses: an emerging public health threat in india? a review. | the emerging viral diseases haemorrhagic fever with renal syndrome (hfrs) and hantavirus cardiopulmonary syndrome (hcps) are a cause of global concern as they are increasingly reported from newer regions of the world. the hantavirus species causing hfrs include hantaan virus,seoul virus, puumala virus, and dobrava-belgrade virus while sin nombre virus was responsible for the 1993 outbreak of hcps in the four corners region of the us. humans are accidental hosts and get infected by aerosols gener ... | 2008 | 19208975 |
| characterization of imjin virus, a newly isolated hantavirus from the ussuri white-toothed shrew (crocidura lasiura). | until recently, the single known exception to the rodent-hantavirus association was thottapalayam virus (tpmv), a long-unclassified virus isolated from the asian house shrew (suncus murinus). robust gene amplification techniques have now uncovered several genetically distinct hantaviruses from shrews in widely separated geographic regions. here, we report the characterization of a newly identified hantavirus, designated imjin virus (mjnv), isolated from the lung tissues of ussuri white-toothed s ... | 2009 | 19357167 |
| a new subtype of thottapalayam virus carried by the asian house shrew (suncus murinus) in china. | recently, many novel hantavirus species carried by insectivore had been found. in order to know whether the insectivore-associated hantaviruses exist in china, asian house shrew (suncus murinus) were analyzed for the presence of hantaviruses. 362 asian house shrews were captured in wenzhou of zhejiang province. hantavirus-specific rna was detected by rt-pcr in lung tissue samples of six shrews. the complete hantavirus s and m segment sequences and also partial l segment sequences were successful ... | 2011 | 21801855 |
| molecular evolution of azagny virus, a newfound hantavirus harbored by the west african pygmy shrew (crocidura obscurior) in cote d'ivoire. | abstract: background: tanganya virus (tgnv), the only shrew-associated hantavirus reported to date from sub-saharan africa, is harbored by the therese's shrew (crocidura theresae), and is phylogenetically distinct from thottapalayam virus (tpmv) in the asian house shrew (suncus murinus) and imjin virus (mjnv) in the ussuri white-toothed shrew (crocidura lasiura). the existence of myriad soricid-borne hantaviruses in eurasia and north america would predict the presence of additional hantaviruses ... | 2011 | 21798050 |
| comparison of innate immune responses to pathogenic and putative non-pathogenic hantaviruses in vitro. | hantaviruses are human pathogens that cause hemorrhagic fever with renal syndrome or hantavirus cardiopulmonary syndrome. the mechanisms accounting for the differences in virulence between pathogenic and non-pathogenic hantaviruses are not well known. we have examined the pathogenesis of different hantavirus groups by comparing the innate immune responses induced in the host cell following infection by pathogenic (sin nombre, hantaan, and seoul virus) and putative non-pathogenic (prospect hill, ... | 2011 | 21820021 |
| Short report: Genetic diversity of Thottapalayam virus, a Hantavirus harbored by the Asian house shrew (Suncus murinus) in Nepal. | Despite the recent discovery of genetically divergent hantaviruses in shrews of multiple species in widely separated geographic regions, data are unavailable about the genetic diversity and phylogeography of Thottapalayam virus (TPMV), a hantavirus originally isolated from an Asian house shrew (Suncus murinus) captured in southern India more than four decades ago. To bridge this knowledge gap, the S, M, and L segments of hantavirus RNA were amplified by reverse transcription polymerase chain rea ... | 2011 | 21896819 |
| novel serological tools for detection of thottapalayam virus, a soricomorpha-borne hantavirus. | we developed serological tools for the detection of hantavirus-specific antibodies and hantavirus antigens in shrews. the work was focussed to generate thottapalayam virus (tpmv)-specific monoclonal antibodies (mabs) and anti-shrew immunoglobulin g (igg) antibodies. the mabs against tpmv nucleocapsid (n) protein were produced after immunization of balb/c mice with recombinant tpmv n proteins expressed in escherichia coli, baculovirus and saccharomyces cerevisiae-mediated expression systems. in t ... | 2012 | 22828778 |
| studies on hantavirus infection in small mammals captured in southern and central highland area of vietnam. | to investigate the distribution of hantaviruses among animals in southern and central highland area of vietnam, a total of 1311 serum samples were obtained from rats and asian house shrews (suncus murinus) captured at 11 locations between 2006 and 2009. a total of 1066 serum samples from rats were examined for igg antibodies against hantaan virus, and there were 30 antibody-positive serum samples from rats that had been captured mainly in a port area and urban area in ho chi minh city (hcmc) (2. ... | 2012 | 22673720 |
| distinct innate immune responses in human macrophages and endothelial cells infected with shrew-borne hantaviruses. | although hantaviruses have been previously considered as rodent-borne pathogens, recent studies demonstrate genetically distinct hantaviruses in evolutionarily distant non-rodent reservoirs, including shrews, moles and bats. the immunological responses to these newfound hantaviruses in humans are unknown. we compared the innate immune responses to imjin virus (mjnv) and thottapalayam virus (tpmv), two shrew-borne hantaviruses, with that toward two rodent-borne hantaviruses, pathogenic hantann vi ... | 2012 | 22944108 |
| biodiversity and evolution of imjin virus and thottapalayam virus in crocidurinae shrews in zhejiang province, china. | the recent discovery of numerous hantaviruses in insectivores has provided a new view of hantavirus biodiversity and evolution. to determine the presence and genetic diversity of imjin virus (mjnv) and thottapalayam virus (tpmv) in insectivores in zhejiang province, china, we captured and performed virus screening of 32 ussuri white-toothed shrews (crocidura lasiura) and 105 asian house shrews (suncus murinus) in different coastal regions. hantavirus genome (s, m, and l segments) sequences were ... | 2014 | 24874196 |
| discovery of hantaviruses in bats and insectivores and the evolution of the genus hantavirus. | hantaviruses are among the most important zoonotic pathogens of humans, causing either hemorrhagic fever with renal syndrome (hfrs) or hantavirus pulmonary syndrome (hps). from the period 1964-2006 almost all hantaviruses had been identified in rodents, with the exception of thottapalayam virus (tpmv) isolated from shrews sampled in india. as a consequence, rodents were considered as the natural reservoir hosts. however, over the past seven years, most of the newly found hantavirus genotypes hav ... | 2014 | 24509342 |
| the n-terminus of the montano virus nucleocapsid protein possesses broadly cross-reactive conformation-dependent epitopes conserved in rodent-borne hantaviruses. | the hantavirus nucleocapsid (n) protein is an important immunogen that stimulates a strong and cross-reactive immune response in humans and rodents. a large proportion of the response to n protein has been found to target its n-terminus. however, the exact nature of this bias towards the n-terminus is not yet fully understood. we characterized six monoclonal antibodies (mabs) against the n protein of montano virus (mtnv), a mexican hantavirus. five of these mabs recognized eight american hantavi ... | 2012 | 22520837 |