| isolation and immunomodulatory effect of flavonoids from syzygium samarangense. | sixteen flavonoids were isolated from the acetone extract of the leaves of syzygium samarangense merr. et perry. the isolated flavonoids were evaluated for immunopharmacological activity. human peripheral blood mononuclear cells (pbmc) were used as target cells, and cell proliferation was determined by 3h-thymidine uptake. among them, (-)-strobopinin (2), myricetin 3-o-(2''-o-galloyl)-alpha-rhamnopyranoside (8), (-)-epigallocatechin 3- o-gallate (10) and myricetin 3-o-alpha-rhamnopyranoside (11) ... | 2004 | 15643565 |
| spasmolytic flavonoids from syzygium samarangense (blume) merr. & l.m. perry. | the hexane extract of syzygium samarangense (ss.hex) dose-dependently (10-1000 microg/ ml) relaxed the spontaneously contracting isolated rabbit jejunum. four rare c-methylated flavonoids with a chalcone and a flavanone skeleton were isolated from ss.hex and were subsequently tested for spasmolytic activity. all flavonoids, identified as 2'-hydroxy-4',6'-dimethoxy-3'-methylchalcone (1), 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone (2), 2',4'-dihydroxy-6'-methoxy-3'-methylchalcone (3), and 7 ... | 2005 | 15787247 |
| antihyperglycaemic flavonoids from syzygium samarangense (blume) merr. and perry. | 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone 1, its isomeric flavanone 5-o-methyl-4'-desmethoxymatteucinol 2 and 2'4'-dihydroxy-6'-methoxy-3'-methylchalcone 3 were isolated from the leaves of s. samarangense using a bioassay-directed scheme. in an oral glucose tolerance test, at a dosage of 1.0 mg/20 g mouse, 1 and 2 significantly (alpha = 0.05) lowered the blood glucose levels (bgls) in glucose-hyperglycaemic mice when administered 15 min after a glucose load. when co-administered with glu ... | 2005 | 15934025 |
| presence of calcium antagonist activity explains the use of syzygium samarangense in diarrhoea. | syzygium samarangense (family; myrtaceae) or 'makopa', as it is commonly known, is native to malaysia, some islands of indonesia and to far east in general. this study was undertaken to rationalize the use of this plant in hypermotility states of the gut. the hexane extract of s. samarangense (ss.hex) was found to dose-dependently (10-3000 microg/ml) relax the spontaneously contracting isolated rabbit jejunum. when tested for a possible calcium channel blocking (ccb) activity, the extract (10-10 ... | 2006 | 16397921 |
| antioxidant activities of some local bangladeshi fruits (artocarpus heterophyllus, annona squamosa, terminalia bellirica, syzygium samarangense, averrhoa carambola and olea europa). | in the present study, antioxidant activities of the fruits of a. heterophyllus, a. squamosa, t. bellirica, s. samarangense, a. carambola and o. europa were investigated. for this, at first matured fruits of them were sliced into small pieces and dried in the sun and finally crushed in a grinder to make powder. ethanolic extracts of fruit powder were prepared using 99.99% ethanol. the antioxidative activities of these extracts were determined according to their abilities of scavenging 1, 1-diphen ... | 2007 | 17460898 |
| stercurensin inhibits nuclear factor-?b-dependent inflammatory signals through attenuation of tak1-tab1 complex formation. | we identified a chalcone, 2',4'-dihydroxy-6'-methoxy-3'-methylchalcone (stercurensin), as an active compound isolated from the leaves of syzygium samarangense. in the present study, the anti-inflammatory effects and underlying mechanisms of stercurensin were examined using lipopolysaccharide (lps)-stimulated raw264.7 cells and mice. to determine the effects of stercurensin in vitro, inducible nitric oxide synthase (inos) and cyclooxygenase-2 (cox-2) expression were analyzed by rt-pcr and immunob ... | 2011 | 21268076 |
| induction of autophagy by dimethyl cardamonin is associated with proliferative arrest in human colorectal carcinoma hct116 and lovo cells. | dimethyl cardamonin (2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone; dmc) is a naturally occurring chalcone, and it is the major compound isolated from the leaves of syzygium samarangense (blume) merr. & l.m. perry (myrtaceae). experiments were conducted to determine the effects of dmc on cell proliferation, cell-cycle distribution and programmed cell death in cultures of human colorectal carcinoma hct116 and lovo cells. results showed that dmc inhibited hct116 and lovo cell proliferation and ... | 2011 | 21538483 |
| inhibitory effects of aurentiacin from syzygium samarangense on lipopolysaccharide-induced inflammatory response in mouse macrophages. | aurentiacin is a chalcone isolated from syzygium samarangense. in the present study, we examined the anti-inflammatory effects of aurentiacin in lipopolysaccharide (lps)-stimulated mouse macrophages. aurentiacin significantly inhibited lps-induced nitric oxide (no) production in raw264.7 cells concomitantly with the suppression of inducible nitric oxide synthase (inos) expression. aurentiacin also reduced the mrna levels of pro-inflammatory cytokines such as tumor necrosis factor-α (tnf-α) and i ... | 2011 | 22155221 |
| contribution to in vitro screening of egyptian plants for schistosomicidal activity. | context: this study is a continuation of our previous work in which a bioassay screening of 346 methanol extracts from 281 egyptian plant species was carried out for in vitro schistosomicidal activity. objective: another 309 methanol extracts from 278 plant species were subjected to the bioassay screening using the same technique on viable schistosoma mansoni sambon (schistosomatidae) mature worms in specialized culture medium (roswell park memorial institute medium 1640) in a trial to discove ... | 2011 | 22133013 |
| chemical profiling of the essential oils of syzygium aqueum, syzygium samarangense and eugenia uniflora and their discrimination using chemometric analysis. | the essential oil compositions of the leaves of three related myrtaceae species, namely syzygium aqueum, syzygium samarangense and eugenia uniflora, were investigated using glc/ms and glc/fid. altogether, 125 compounds were identified: α-selinene (13.85%), β-caryophyllene (12.72%) and β-selinene constitute the most abundant constituents in s. aqueum. germacrene d (21.62%) represents the major compound in s. samarangense whereas in e. uniflora, spathulenol (15.80%) represents the predominant comp ... | 2016 | 27447784 |
| effects of 20 selected fruits on ethanol metabolism: potential health benefits and harmful impacts. | the consumption of alcohol is often accompanied by other foods, such as fruits and vegetables. this study is aimed to investigate the effects of 20 selected fruits on ethanol metabolism to find out their potential health benefits and harmful impacts. the effects of the fruits on ethanol metabolism were characterized by the concentrations of ethanol and acetaldehyde in blood, as well as activities of alcohol dehydrogenase and acetaldehyde dehydrogenase in liver of mice. furthermore, potential hea ... | 2016 | 27043608 |
| antihyperglycemic activities of leaves of three edible fruit plants (averrhoa carambola, ficus hispida and syzygium samarangense) of bangladesh. | averrhoa carambola l. (oxalidaceae), ficus hispida l.f. (moraceae), and syzygium samarangense (blume) merr. & l.m. perry (myrtaceae) are three common plants in bangladesh, the fruits of which are edible. the leaves and fruits of a. carambola and f. hispida are used by folk medicinal practitioners for treatment of diabetes, while the leaves of s. samarangense are used for treatment of cold, itches, and waist pain. since scientific studies are absent on the antihyperglycemic effects of the leaves ... | 2012 | 23983348 |
| antioxidant and α-glucosidase inhibitory activities of 40 tropical juices from malaysia and identification of phenolics from the bioactive fruit juices of barringtonia racemosa and phyllanthus acidus. | the present study compared ph, total soluble solids, vitamin c, and total phenolic contents, antioxidant activities, and α-glucosidase inhibitory activities of 40 fresh juices. the juice of baccaurea polyneura showed the highest yield (74.17 ± 1.44%) and total soluble solids (32.83 ± 0.27 °brix). the highest and lowest ph values were respectively measured from the juices of dimocarpus longan (6.87 ± 0.01) and averrhoa bilimbi (1.67 ± 0.67). the juice of psidium guajava gave the highest total phe ... | 2014 | 25198055 |