| elevated concentrations in serum immunoglobulins due to infection by ovine progressive pneumonia virus. | sixty-seven serum samples were obtained from 2 sheep flocks. agar gel immunodiffusion (agid) was used to separate progressive pneumonia virus (ppv)-infected sheep from noninfected sheep by the presence of precipitating antibodies. immunoglobulin (ig), total protein, and albumin concentrations were then measured from all 67 sera to determine whether differences existed between ppv-infected and non-infected sheep. a significant difference (p less than 0.0005) was found in both total protein and ig ... | 1979 | 110182 |
| detection of antibodies to ovine lentivirus using a recombinant antigen derived from the env gene. | the western blot assay was performed to characterize antibodies to the transmembrane glycoprotein (tgp) of ovine progressive pneumonia virus (oppv) by using glutathione-s-transferase-tgp (gst-tgp) protein. the gst-tgp protein was efficiently expressed in escherichia coli (e. coli) and was highly immunoreactive in the western blot assay. this assay detected antibodies in 97% (103/106) of the sera from agarose gel immunodiffusion (agid) positive opp animals. like human aids patients, antibodies to ... | 1992 | 1314572 |
| seroprevalence of ovine progressive pneumonia virus in sheep in the united states as assessed by analyses of voluntarily submitted samples. | ovine progressive pneumonia (opp) is a lentivirus-induced disease of sheep in the united states that is similar, if not identical, to maedi/visna in many other countries. prevalence estimates of seropositivity to this virus in sheep in the united states have been confined to limited groups or flocks of sheep and have varied from 1 to 90%. in this study of detection of antibodies against opp virus, we found a lower general prevalence of antibodies to opp virus in sheep than was previously reporte ... | 1992 | 1320816 |
| seroprevalence of ovine progressive pneumonia virus in various domestic and wild animal species, and species susceptibility to the virus. | ovine progressive pneumonia is caused by a lentivirus of known infectivity only for sheep and goats. virus susceptibility of 11 other species of animals was examined. species included cattle, chickens, deer, dogs, goats, hamsters, horses, mice, pigs, rabbits, and rats. of these species, only goats and rabbits could be experimentally infected with the virus. the infection in rabbits was acute, and virus did not persist or induce antibody production as it does in sheep and goats. sera obtained fro ... | 1991 | 2012329 |
| prevalence and effect of subclinical ovine progressive pneumonia virus infection on ewe wool and lamb production. | the prevalence of infection with ovine progressive pneumonia (opp) virus and its effects on ewe wool and lamb production were investigated in a flock of 2,976 ewes of 6 breed types (rambouillet, targhee, columbia, polypay, 1/4 cross finnsheep, and 1/2 cross finnsheep). prevalence of seropositivity was significantly (p less than or equal to 0.01) lower among rambouillet and targhee breeds (44 and 42%, respectively), intermediate in polypay, columbia, and 1/4 cross finnsheep (approximately 53%), a ... | 1990 | 2170310 |
| prevalence of antibodies to seven viruses in a flock of ewes in minnesota. | blood samples were collected from a flock of healthy ewes at a university of minnesota research station. sera from these blood samples were tested for antibodies against 7 viruses, using 3 tests (eg, virus-neutralization test for bovine viral diarrhea virus, infectious bovine rhinotracheitis virus, bovine adenovirus type 3, and bovine respiratory syncytial virus; hemagglutination inhibition test for parainfluenza virus type 3; and agar-gel immunodiffusion test for lentivirus of ovine progressive ... | 1988 | 2837112 |
| development of an enzyme-linked immunosorbent assay for caprine arthritis-encephalitis virus. | because relatively few caprine arthritis-encephalitis virus (caev)-infected animals exhibit clinical signs of illness, efforts to control and eradicate this virus will depend heavily on a sensitive diagnostic test that can be easily carried out. the currently utilized tests are of limited usefulness because of relatively low sensitivity or because of incomplete cross-reactivity of goat sera with heterologous test antigens. an enzyme-linked immunosorbent assay (elisa) with purified caev antigen a ... | 1988 | 2838510 |
| mastitis associated with ovine progressive pneumonia virus infection in sheep. | eighteen ewes were experimentally infected with ovine progressive pneumonia virus and their mammary glands were examined for lesions and virus at 2.5 to 10 years postinoculation. lesions were seen in 14 of 18 sheep; virus was isolated from 4 of 8 sheep. lesion consisted of an interstitial accumulation of lymphocytes with periductal lymphoid nodules, and epithelial vacuolation and necrosis at the site of the lymphoid nodules. | 1985 | 2986491 |
| appearance of ovine progressive pneumonia virus outside the united states. | a recently isolated israeli retrovirus from a sheep with maedi-visna was compared with other retroviruses, using cdna-rna hybridization in solution. the israeli isolate was shown to have close, if not identical, genetic homologic features with the ovine progressive pneumonia virus reported in the united states, rather than with those of the maedivisna viruses of european origin. | 1985 | 2998239 |
| ultrastructure and frequency of mastitis caused by ovine progressive pneumonia virus infection in sheep. | twenty-five sheep, experimentally (n = 15) or naturally (n = 6) infected with ovine progressive pneumonia virus and noninfected controls (n = 4), were evaluated for histological and ultrastructural lesions of mastitis. histologically, nine of 15 experimentally infected sheep and all six naturally infected sheep had lympho-plasmacytic mastitis. severity of the lesion increased with length of time after infection. periductal lymphatic nodules were seen in five sheep experimentally infected for 2.8 ... | 1986 | 3008404 |
| caprine arthritis-encephalitis in the basque country, spain. | a goat herd severely affected by arthritis was studied. the most representative clinical signs consisted of articular swelling, mainly of the carpal joints, and the subsequent locomotor disorders. some goats also showed signs of central nervous system involvement. examinations of joint fluid revealed an increased number of mononuclear blood cells, mostly lymphocytes. gross and microscopic articular lesions were of inflammatory and degenerative types. periarticular connective tissue, synovial bur ... | 1987 | 3037762 |
| seroreactivity of peruvian sheep and goats to small ruminant lentivirus-ovine progressive pneumonia virus. | sera from 3,369 sheep and 1,394 goats in peru were examined by agar-gel immunodiffusion for antibodies to ovine progressive pneumonia virus (oppv). the point prevalence rates for antibodies to oppv in sheep were 1.7% to 40.6% (mean, 19.02%) in the 7 flocks studied, whereas for goats, the point prevalence rates for antibodies that cross-reacted with oppv in 12 herds were 0.0% to 45.1%. for sheep, a direct association between increasing age and increasing seroreactivity to oppv was established, an ... | 1987 | 3105369 |
| evidence of decreased concanavalin a induced suppressor cell activity in the peripheral blood and pulmonary lymph nodes of sheep with ovine progressive pneumonia. | concanavalin a (con a) induced suppressor cell activity was evaluated in a group of ovine progressive pneumonia virus-antibody positive sheep (oppv+). decreased levels of suppressor activity were observed in the peripheral blood and regional pulmonary lymph nodes of animals with clinical and pathological evidence of ovine progressive pneumonia (opp) when compared to animals with no lesions and animals with caseous lymphadenitis involving the lungs and pulmonary lymph nodes. decreased levels of c ... | 1985 | 3156446 |
| ovine interleukin-2: partial purification and assay in normal sheep and sheep with ovine progressive pneumonia. | interleukin-2 (il-2), a t cell derived lymphokine, acts in nonspecific hormone-like fashion to maintain proliferation of activated lymphocytes in vitro and is believed to play a key role in cell-mediated immune function in vivo. the parameters of induction and assay of factors with il-2 activity were examined in a group of clinically normal sheep seronegative for antibodies to ovine progressive pneumonia virus (oppv-). supernatants from cultures of concanavalin a (con a) stimulated mononuclear l ... | 1985 | 3871987 |
| immunomorphologic and morphometric changes in pulmonary lymph nodes of sheep with progressive pneumonia. | morphologic, immunohistochemical, and morphometric studies were conducted on the posterior mediastinal lymph nodes of eleven sheep with naturally occurring ovine progressive pneumonia and four apparently healthy sheep with no pulmonary lesions (three seropositive, one seronegative for antibody to ovine progressive pneumonia virus). compared with lesion-free sheep, sheep with ovine progressive pneumonia had a seven-fold increase in b lymphocyte areas and a 21/2-fold increase in t lymphocyte areas ... | 1985 | 3883634 |
| vasculitis associated with ovine progressive pneumonia virus infection in sheep. | vasculitis, involving small muscular arteries and arterioles, was found in 5 of 18 sheep naturally infected with ovine progressive pneumonia (opp) virus and in 5 of 11 sheep experimentally infected with opp virus. in order of frequency, arterial lesions were seen in carpal joint capsules, kidneys, meninges, brains, lungs, and tracheas. the lesions were intramural edema and hemorrhage, mononuclear cell infiltration, fibrinoid necrosis of media, and thrombosis. the vascular lesions were frequently ... | 1985 | 3970444 |
| firm udder in periparturient ewes with lymphocytic accumulations, retrovirus infection, and milk unavailable at the teat. | a condition of firm udders in periparturient ewes, with little or no milk available at the teat, was associated with negative bacterial cultures of mammary tissue, isolation of ovine progressive pneumonia virus from mammary tissue, lymphocytic accumulations in mammary tissue, especially around ducts, and antibody to ovine progressive pneumonia virus in sera. milk was present in the glands, but was not adequately transported through the duct system. the cull rate of ewes with this condition was r ... | 1985 | 3972701 |
| preparation of sheep and cattle immunoglobulins with antibody activity by high-performance liquid chromatography. | high-performance anion-exchange chromatography (hpiec) and high-performance size-exclusion chromatography (hpsec) were used to purify serum igm and igg from sheep and cattle. pooled serum from normal cattle and sheep and serum from sheep, infected with two different viruses, were prepared for hpiec by chromatography on cm-affi-gel blue. after hpiec, fractions containing igg and igm were pooled and concentrated and further purified by hpsec. the purity of fractions from hpiec and hpsec were evalu ... | 1985 | 4030943 |
| intrauterine transmission of ovine progressive pneumonia virus. | ovine fetuses, newborn lambs, and ovine colostrum were examined for ovine progressive pneumonia virus. the lambs and colostrum were also examined for specific antibody. virus was isolated from 1 fetus, from 2 newborn lambs, and from most samples of colostrum. the fetus was about 100 days old and was carried by a seronegative ewe in contact with seropositive sheep. both newborn lambs were carried by seropositive ewes. one lamb was dead at birth; the other lamb was normal and had not nursed. antib ... | 1981 | 6275749 |
| effects on ovine fetuses of exposure to ovine progressive pneumonia virus. | fetuses of 20 pregnant ewes at 4 gestational periods (45, 55, 85, and 100 days) were inoculated with ovine progressive pneumonia virus. fourteen of 16 fetuses exposed to virus before gestational day 80 were either resorbed or expelled, whereas 10 of 15 fetuses exposed to virus after day 80 were normal at birth. three of the 9 expelled fetuses and 1 of 2 newborn lambs had accumulations of lymphoid cells in the lungs. virus was readily isolated from the tissues of expelled fetuses and newborn lamb ... | 1982 | 6283954 |
| sheep pulmonary adenomatosis (jaagsiekte) in the united states. | morphologic features of 8 cases of sheep pulmonary adenomatosis in the united states are described. all cases were studied by light microscopy and 1 case, by electron microscopy. the common finding in all sheep was an adenoma composed of fetal type ii alveolar epithelial cells. the stroma closely resembled interalveolar septa in most areas. in other areas, there was excessive collagenous or myxomatous tissue. metastatic tumor in mediastinal lymph nodes of 2 sheep closely resembled tumor in the l ... | 1982 | 7165156 |
| analysis and pcr detection of antigen compositions of ovine progressive pneumonia virus. | ovine progressive pneumonia virus (oppv) was proliferated utilizing sheep foetal lung cells, and the cytopathic effect (cpe) of the virus was investigated. oppv was purified with a 10%-sucrose cushion and then with 20%-55% discontinuous sucrose density gradient centrifugation. the structural proteins and antigen compositions of oppv were analysed by sds-page and western blotting. besides, the opp proviral cdnas of the virus-infected cell cultures and the peripheral blood monocytes from sheep inf ... | 1995 | 7626198 |
| oligopeptide-based enzyme immunoassay for ovine lentivirus antibody detection. | ovine progressive pneumonia virus (oppv) is a lentivirus which causes a progressive disease in sheep. immunodominant epitopes have been identified in the envelope gp40 glycoprotein. synthetic peptides representing these regions are able to detect the presence of oppv antibodies in 96% of infected sheep. | 1994 | 7929780 |
| evaluation of agar gel immunodiffusion serology using caprine and ovine lentiviral antigens for detection of antibody to caprine arthritis-encephalitis virus. | the sensitivity of the agar gel immunodiffusion (agid) test for the detection of antibody to caprine arthritis-encephalitis virus (caev) was investigated with caev or ovine progressive pneumonia virus (oppv) as the source of antigen. a total of 218 goat serum specimens were tested for anti-caev antibody by agid and immunoprecipitation of [35s]methionine-labeled caev. in comparison with that of immunoprecipitation, the sensitivity of the caev agid test was 0.91, and that of the oppv agid test was ... | 1994 | 8126191 |
| antigenic relatedness between ovine progressive pneumonia virus (oppv) and hiv-1. | the antigenic relatedness between ovine progressive pneumonia virus (oppv), a lentivirus that infects sheep, and human immunodeficiency virus (hiv-1) was examined by immunoblot analysis. fourteen of 20 sheep sera, that were positive for oppv antibodies on an immunodiffusion test, reacted with hiv-1 p24 on a commercial blot of hiv-1 and cell lysate proteins (virostat, portland, maine). sheep oppv antisera did not bind to cellular antigens on a negative control blot of cellular proteins. there was ... | 1993 | 8391410 |
| effect of fiv infection on lung inflammatory cell populations recovered by bronchoalveolar lavage. | human immunodeficiency virus (hiv) and ovine progressive pneumonia virus have been associated with lymphocytic pneumonitis. pulmonary cell populations in cats infected with feline immunodeficiency virus (fiv) were evaluated by bronchoalveolar lavage (bal) to identify changes associated with lentivirus infection in this species. bronchoalveolar lavage was performed through an endotracheal tube using 15 ml kg-1 body weight of sterile 0.9% sodium chloride solution. results of bal fluid cytologic an ... | 1996 | 8797273 |
| early detection of maedi-visna (ovine progressive pneumonia) virus seroconversion in field sheep samples. | the aim of this work was to investigate whether an enzyme-linked immunosorbent assay (elisa) was useful for early detection of maedi-visna virus (mvv) infection in sheep under field conditions. an elisa based on p25 recombinant protein and a gp46 synthetic peptide was used. sequentially obtained serum samples (n = 1,941) were studied for 4 years. elisa results were compared with those of the agar gel immunodiffusion (agid) test, and results of both tests were compared with a reference result est ... | 2001 | 11478601 |
| detection of serum antibodies to ovine progressive pneumonia virus in sheep by using a caprine arthritis-encephalitis virus competitive-inhibition enzyme-linked immunosorbent assay. | a competitive-inhibition enzyme-linked immunosorbent assay (celisa) for detection of antibodies to the surface envelope (su) of caprine arthritis-encephalitis virus (caev) was recently reported (l. m. herrmann, w. p. cheevers, t. c. mcguire, d. scott adams, m. m. hutton, w. g. gavin, and d. p. knowles, clin. diagn. lab. immunol. 10:267-271, 2003). the celisa utilizes caev-63 su captured on microtiter plates using the monoclonal antibody (mab) f7-299 and measures competitive displacement of bindi ... | 2003 | 12965917 |
| seven new ovine progressive pneumonia virus (oppv) field isolates from dubois idaho sheep comprise part of oppv clade ii based on surface envelope glycoprotein (su) sequences. | seven new ovine progressive pneumonia virus (oppv) field isolates were derived from colostrum and milk of 10 naturally oppv-infected sheep from the us sheep experiment station in dubois, idaho, usa. sixteen sequences of the surface envelope glycoprotein (su) from these seven dubois oppv field isolates and su sequence from oppv wlc1 were obtained, aligned with published srlv su sequences, and analyzed using phylogenetic analysis using parsimony (paup). percent nucleotide identity in su was greate ... | 2004 | 15084404 |
| surface envelope glycoprotein is b-lymphocyte immunodominant in sheep naturally infected with ovine progressive pneumonia virus. | the b-lymphocyte-immunodominant antigen involved in naturally ovine progressive pneumonia virus (oppv)-infected mature sheep remains unknown. therefore, the amount of antibody in sera from 10 naturally oppv-infected sheep was evaluated by immunoprecipitation (ip) of the major viral proteins in [(35)s]methionine/cysteine-labeled oppv (whole virus) lysate. using an excess of oppv proteins in whole-virus lysate, 8 out of 10 sheep had the highest serum antibody ip endpoint titers to the gp135 surfac ... | 2005 | 15939757 |
| ovine progressive pneumonia virus capsid is b-cell immunodominant using western blot analysis: a comparison of sensitivity between western blot analysis and immunoprecipitation. | a western blot assay was developed and analyzed against the comparable standard, immunoprecipitation of (35)[s]-methionine/cysteine-labeled ovine progressive pneumonia virus (oppv) proteins, for its ability to detect anti-oppv antibodies using endpoint titers. western blot analysis is 12-fold more sensitive in detecting endpoint anti-capsid antibody titers than ip, and the capsid is the b-cell immunodominant oppv protein when utilizing western blot analysis. since the surface envelope glycoprote ... | 2006 | 16879880 |
| evidence of proviral clearance following postpartum transmission of an ovine lentivirus. | lentiviral transmission by transfer of infected colostrum and/or milk is considered to be highly efficient. in this study, postpartum transmission of ovine progressive pneumonia virus (oppv) from 10 naturally infected ewes to their 23 lambs was followed from the perinatal period throughout a four-year period. the lambs were allowed to suckle from their dam from birth through 32 weeks of age. virus was tracked by virus isolation, quantitative pcr (qpcr), and anti-oppv antibody responses as measur ... | 2007 | 17267002 |
| development and validation of an ovine progressive pneumonia virus quantitative pcr. | ovine progressive pneumonia virus (oppv) infects at least one sheep in 81% of u.s. sheep flocks, as determined by serology, and can cause viral mastitis, arthritis, dyspnea, and cachexia. diagnostic tests that quantify oppv proviral load in peripheral blood leukocytes (pbl) provide an additional method for identification of infected sheep and may help to further understanding of the pathogenesis of oppv-induced disease. in this study, we compared a new oppv real-time quantitative pcr (qpcr) assa ... | 2007 | 17699832 |
| ovine progressive pneumonia provirus levels associate with breed and ovar-drb1. | previous studies initiated defining the role of host genetics in influencing the outcome of exposure to ovine progressive pneumonia virus. however, specific genes influencing host control of virus replication and disease progression have not been identified. this study, using 383 ewes of the columbia, polypay, and rambouillet breeds, tested the hypothesis that host control of oppv as measured by provirus levels in the peripheral blood associates with certain breeds and mhc class ii ovis aries (o ... | 2008 | 18797863 |
| minimum intravenous infectious dose of ovine progressive pneumonia virus (oppv). | the minimum intravenous infectious dose for ovine progressive pneumonia virus (oppv) wlc1 was determined using twenty-four 6month-old lambs. twelve groups of two 6month-old lambs were inoculated intravenously (i.v.) with tissue culture fluid containing ovine progressive pneumonia virus (oppv) wlc1 titers ranging from 10(7.6) tcid(50)/lamb down to 10(-3.4) tcid(50)/lamb and were monitored for seroconversion using the oppv agar gel immunodiffusion assay (agid). fifteen of the 16 lambs given equal ... | 2009 | 19246063 |
| peripheral ovine progressive pneumonia provirus levels correlate with and predict histological tissue lesion severity in naturally infected sheep. | studies were undertaken to determine whether anti-ovine progressive pneumonia virus (oppv) antibody responses in serum or opp provirus levels in peripheral blood associate with the degree of histologically measured tissue lesions in naturally oppv-infected sheep. sections of formalin-fixed, paraffin-embedded, and hematoxylin- and eosin-stained lung, mammary gland, carpal synovial membrane, and brain tissues from 11 oppv-infected ewes (mean age of 8.6 years) and 5 oppv-uninfected ewes (mean age o ... | 2009 | 19261772 |
| common promoter deletion is associated with 3.9-fold differential transcription of ovine ccr5 and reduced proviral level of ovine progressive pneumonia virus. | chemokine (c-c motif) receptor 5 (ccr5) is a chemokine receptor that regulates immune cell recruitment in inflammation and serves as a coreceptor for human immunodeficiency virus (hiv). a human ccr5 coding deletion (termed delta-32) results in strong resistance to hiv infection, and sequence variants in ccr5 regulatory regions have been implicated in delayed progression to acquired immune deficiency syndrome. both ovine progressive pneumonia virus (oppv), also known as maedi-visna, and hiv are m ... | 2009 | 19397512 |
| evaluation of a caprine arthritis-encephalitis virus/maedi-visna virus indirect enzyme-linked immunosorbent assay in the serological diagnosis of ovine progressive pneumonia virus in u.s. sheep. | a caprine arthritis-encephalitis virus (caev)/maedi-visna virus (mvv) indirect enzyme-linked immunosorbent assay (ielisa) was validated with samples from u.s. sheep and by the use of radioimmunoprecipitation as the standard for comparison. the sensitivity and the specificity were 86.0% (+ or - 5.8%) and 95.9% (+ or - 2.9%), respectively. the ielisa format and phylogenetic differences based on the mvv gag sequence contribute to the reduced sensitivity. | 2010 | 20016044 |
| ovine progressive pneumonia virus capsid antigen as found in cd163- and cd172a-positive alveolar macrophages of persistently infected sheep. | in situ detection of ovine progressive pneumonia virus (oppv) and the phenotypic identification of the cells that harbor oppv have not been described for the oppv-affected tissues, which include lung, mammary gland, synovial membranes of the carpal joint, and choroid plexus of the brain. in this study, the authors first developed a single enzyme-based automated immunohistochemical (ihc) analysis for detection of oppv capsid antigen (ca) on oppv-affected tissues, using 2 anti-caev ca monoclonal a ... | 2010 | 20382821 |
| non-maternal transmission is the major mode of ovine lentivirus transmission in a ewe flock: a molecular epidemiology study. | transmission of ovine progressive pneumonia virus (oppv), a lentivirus of sheep, occurs through both maternal and non-maternal means. currently, the contribution of each route to the overall flock oppv prevalence is poorly understood since previous serological epidemiologic studies lacked the ability to accurately track routes of transmission within an infected flock. in this study, the amount of maternal opp transmission was assessed in a naturally infected ewe flock by applying molecular analy ... | 2010 | 20601169 |
| genome-wide search for host association factors during ovine progressive pneumonia virus infection. | ovine progressive pneumonia virus (oppv) is an important virus that causes serious diseases in sheep and goats with a prevalence of 36% in the usa. although oppv was discovered more than half of a century ago, little is known about the infection and pathogenesis of this virus. in this report, we used rna-seq technology to conduct a genome-wide probe for cellular factors that are associated with oppv infection. a total of approximately 22,000 goat host genes were detected of which 657 were found ... | 2016 | 26950733 |
| mutations in ovis aries tmem154 are associated with lower small ruminant lentivirus proviral concentration in one sheep flock. | small ruminant lentivirus (srlv), also called ovine progressive pneumonia virus or maedi-visna, is present in 24% of us sheep. like human immunodeficiency virus, srlv is a macrophage-tropic lentivirus that causes lifelong infection. the production impacts from srlv are due to a range of disease symptoms, including pneumonia, arthritis, mastitis, body condition wasting and encephalitis. there is no cure and no effective vaccine for preventing srlv infection. however, breed differences in prevalen ... | 2014 | 24934128 |
| expanding possibilities for intervention against small ruminant lentiviruses through genetic marker-assisted selective breeding. | small ruminant lentiviruses include members that infect sheep (ovine lentivirus [ovlv]; also known as ovine progressive pneumonia virus/maedi-visna virus) and goats (caprine arthritis encephalitis virus [caev]). breed differences in seroprevalence and proviral concentration of ovlv had suggested a strong genetic component in susceptibility to infection by ovlv in sheep. a genetic marker test for susceptibility to ovlv has been developed recently based on the tmem154 gene with validation data fro ... | 2013 | 23771240 |
| incidence of infection in 39-month-old ewes with tmem154 diplotypes "1 1," "1 3," and "3 3" after natural exposure to ovine progressive pneumonia virus. | production and well-being of sheep and goats in many countries are harmfully impacted by small ruminant lentiviruses (srlv) that cause incurable, progressive diseases. susceptibility to ovine progressive pneumonia virus (oppv), the north american form of srlv, is influenced by variants of the ovine transmembrane protein 154 gene (tmem154). the experimental objective was to estimate additive and dominance effects of tmem154 haplotypes 1 and 3 on susceptibility of breeding ewes to infection after ... | 2015 | 25568355 |
| genetic testing for tmem154 mutations associated with lentivirus susceptibility in sheep. | in sheep, small ruminant lentiviruses cause an incurable, progressive, lymphoproliferative disease that affects millions of animals worldwide. known as ovine progressive pneumonia virus (oppv) in the u.s., and visna/maedi virus (vmv) elsewhere, these viruses reduce an animal's health, productivity, and lifespan. genetic variation in the ovine transmembrane protein 154 gene (tmem154) has been previously associated with oppv infection in u.s. sheep. sheep with the ancestral tmem154 haplotype encod ... | 2013 | 23408992 |
| effects of tmem154 haplotypes 1 and 3 on susceptibility to ovine progressive pneumonia virus following natural exposure in sheep. | small ruminant lentiviruses (srlv) adversely affect production and well-being of sheep and goats throughout much of the world. the srlv, including ovine progressive pneumonia virus (oppv) in north america, cause lifetime infections, and management procedures to eradicate or reduce disease prevalence are costly. variants of ovine transmembrane protein 154 gene (tmem154) affect susceptibility to oppv. the primary experimental objective was to estimate additive and dominance effects of tmem154 hapl ... | 2013 | 23989875 |