| mouse fibroblast l929 cells are less permissive to infection by nelson bay orthoreovirus compared to other mammalian cell lines. | in recent years, bats have been identified as a natural reservoir for a diverse range of viruses. nelson bay orthoreovirus (nbv) was first isolated from the heart blood of a fruit bat (pteropus poliocephalus) in 1968. while the pathogenesis of nbv remains unknown, other related members of this group have caused acute respiratory disease in humans. thus the potential for nbv to impact human health appears plausible. here, to increase our knowledge of nbv, we examined the replication and infectivi ... | 2015 | 25748429 |
| pteropine orthoreovirus infection among out-patients with acute upper respiratory tract infection in malaysia. | this study aims to assess the incidence rate of pteropine orthreovirus (prv) infection in patients with acute upper respiratory tract infection (urti) in a suburban setting in malaysia, where bats are known to be present in the neighborhood. using molecular detection of prvs directly from oropharyngeal swabs, our study demonstrates that prv is among one of the common causative agents of acute urti with cough and sore throat as the commonest presenting clinical features. phylogenetic analysis on ... | 2015 | 26106066 |
| evolutionary relationship of the l- and m-class genome segments of bat-borne fusogenic orthoreoviruses in malaysia and australia. | we previously described three new malaysian orthoreoviruses designated pulau virus, melaka virus and kampar virus. melaka and kampar viruses were shown to cause respiratory disease in humans. these viruses, together with nelson bay virus, isolated from australian bats, are tentatively classified as different strains within the species pteropine orthoreovirus (prv), formerly known as nelson bay orthoreovirus, based on the small (s) genome segments. here we report the sequences of the large (l) an ... | 2011 | 21849518 |
| a previously unknown reovirus of bat origin is associated with an acute respiratory disease in humans. | respiratory infections constitute the most widespread human infectious disease, and a substantial proportion of them are caused by unknown etiological agents. reoviruses (respiratory enteric orphan viruses) were first isolated from humans in the early 1950s and so named because they were not associated with any known disease. here, we report a previously unknown reovirus (named "melaka virus") isolated from a 39-year-old male patient in melaka, malaysia, who was suffering from high fever and acu ... | 2007 | 17592121 |
| pulau virus; a new member of the nelson bay orthoreovirus species isolated from fruit bats in malaysia. | after the outbreak of nipah virus (niv) in 1998-99, which resulted in 105 human deaths and the culling of more than one million pigs, a search was initiated for the natural host reservoir of niv on tioman island off the east coast of malaysia. three different syncytia-forming viruses were isolated from fruit bats on the island. they were nipah virus, tioman virus (a novel paramyxovirus related to menangle virus), and a reovirus, named pulau virus (puv), which is the subject of this study. puv di ... | 2006 | 16205863 |
| irf7 in the australian black flying fox, pteropus alecto: evidence for a unique expression pattern and functional conservation. | as the only flying mammal, bats harbor a number of emerging and re-emerging viruses, many of which cause severe diseases in humans and other mammals yet result in no clinical symptoms in bats. as the master regulator of the interferon (ifn)-dependent immune response, ifn regulatory factor 7 (irf7) plays a central role in innate antiviral immunity. to explore the role of bat irf7 in the regulation of the ifn response, we performed sequence and functional analysis of irf7 from the pteropid bat, pt ... | 2014 | 25100081 |
| emerging and re-emerging viruses in malaysia, 1997-2007. | over the past decade, a number of unique zoonotic and non-zoonotic viruses have emerged in malaysia. several of these viruses have resulted in significant morbidity and mortality to those affected and they have imposed a tremendous public health and economic burden on the state. amongst the most devastating was the outbreak of nipah virus encephalitis in 1998, which resulted in 109 deaths. the culling of more than a million pigs, identified as the amplifying host, ultimately brought the outbreak ... | 2009 | 19010076 |