| anti-biofilm activity of an exopolysaccharide from a sponge-associated strain of bacillus licheniformis. | secondary metabolites ranging from furanone to exo-polysaccharides have been suggested to have anti-biofilm activity in various recent studies. among these, escherichia coli group ii capsular polysaccharides were shown to inhibit biofilm formation of a wide range of organisms and more recently marine vibrio sp. were found to secrete complex exopolysaccharides having the potential for broad-spectrum biofilm inhibition and disruption. | 2011 | 21951859 |
| optimization and production of pyrrolidone antimicrobial agent from marine sponge-associated streptomyces sp. maps15. | twenty-nine actinobacterial strains were isolated from marine sponge spongia officinalis and screened for antagonistic activity against various bacterial and fungal pathogens. the active antibiotic producer maps15 was identified as streptomyces sp. using 16s rrna phylogenetic analysis. the critical control factors were selected from plackett-burman (pb) factorial design and the bioprocess medium was optimized by central composite design (ccd) for the production of bioactive metabolite from strep ... | 2014 | 23917410 |
| bioactive terpenes from spongia officinalis. | the terpene metabolite pattern of mediterranean spongia officinalis was chemically investigated. this study resulted in the isolation of a series of sesterterpenes and c(21) furanoterpenes, according to the literature data on this sponge. four new oxidized minor metabolites (compounds 1, 2, 3, and 4) were isolated along with six known compounds of the furospongin series (compounds 5-8, 9, and 10) and three scalarane sesterterpenes (compounds 11-13). interestingly, tetrahydrofurospongin-2 (6) and ... | 2011 | 21548580 |
| polyprenyl-hydroquinones and -furans from three marine sponges inhibit the cell cycle regulating phosphatase cdc25a. | the cdc25 phosphatases regulate the cell division cycle by controlling the activity of cyclin-dependent kinases. while screening for inhibitors of phosphatases among natural products we repeatedly found that some polyprenyl-hydroquinones and polyprenyl-furans (furanoterpenoids) (furospongins, furospinosulins) were potent cdc25 phosphatase inhibitors. these compounds were extracted, isolated and identified independently from three sponge species (spongia officinalis, ircinia spinulosa, ircinia mu ... | 2004 | 14974610 |
| sponge-associated bacteria produce non-cytotoxic melanin which protects animal cells from photo-toxicity. | melanin is a photo-protective polymer found in many organisms. our research shows that the bacteria associated with darkly pigmented sponges (haliclona pigmentifera, sigmadocia pumila, fasciospongia cavernosa, spongia officinalis, and callyspongia diffusa) secrete non-cytotoxic melanin, with antioxidant activity that protects animal cells from photo-toxicity. out of 156 bacterial strains screened, 22 produced melanin and these melanin-producing bacteria (mpb) were identified as vibrio spp., prov ... | 2017 | 28315112 |