| biochemical and biological activities of the venom of the chinese pitviper zhaoermia mangshanensis, with the complete amino acid sequence and phylogenetic analysis of a novel arg49 phospholipase a2 myotoxin. | zhaoermia mangshanensis (formerly trimeresurus mangshanensis, ermia mangshanensis) represents a monotypic genus of pitviper known only from mt mang in china's hunan province, and is among the largest and most spectacular of asian venomous snakes. the venom of zhaoermia exhibits high coagulant activity on bovine and human fibrinogen and human plasma, high phosphodiesterase and arginine ester hydrolytic activity, and moderate to low l-amino acid oxidase, kallikrein, caseinolytic, phospholipase a(2 ... | 2006 | 16635500 |
| molecular evolution and structure-function relationships of crotoxin-like and asparagine-6-containing phospholipases a2 in pit viper venoms. | some myotoxic or neurotoxic pla2s (phospholipases a2) from pit viper venoms contain characteristic n6 substitutions. our survey of the venoms of more than ten pit viper genera revealed that n6-pla2s exist only in limited asian pit vipers of two genera, protobothrops and gloydius, and exist as either monomers or the basic subunits of heterodimers in some new world pit vipers. for the newly identified n6-pla2s, the neuromuscular blocking activities were assayed with the chick biventer cervicis neu ... | 2004 | 15032748 |
| exotic snake bites in the czech republic--epidemiological and clinical aspects during 15-year period (1999-2013). | only one natural venomous snake-the adder viper-lives in the central european region and its bite is usually associated only with mild course of envenoming. cases of envenoming caused by exotic snakes among their breeders are clinically more important. | 2014 | 24666339 |
| complete clinical course of envenomation by protobothrops mangshanensis: delayed coagulopathy and response to trimeresurus albolabris antivenom. | protobothrops mangshanensis, the mangshan pit viper, is a rare pit viper native to the area surrounding mount mang in china's hunan province. toxicity from envenomation is not well characterized. | 2016 | 26830495 |
| mitochondrial genome of protobothrops mangshanensis (squamata: viperidae: crotalinae). | protobothrops mangshanensis is a venomous pit viper species endemic to hunan province in china. in this study, the complete mitochondrial genome of p. mangshanensis had been determined. the circle genome with the 17,230 bp total length contained 13 protein-coding genes, 22 transfer rna genes, 2 ribosomal rna genes and 2 control regions. overall base composition of the complete mtdna was 32.27% a, 24.16% t, 30.34% c and 13.23% g. all the genes in p. mangshanensis were distributed on the h-strand, ... | 2014 | 23808922 |
| protobothrops mangshanensis bite: first clinical report of envenoming and its treatment. | this case report presents envenoming by the chinese pit viper protobothrops mangshanensis (formerly zhaoermia) and its treatment. | 2012 | 22660227 |
| crystal structure of a novel myotoxic arg49 phospholipase a2 homolog (zhaoermiatoxin) from zhaoermia mangshanensis snake venom: insights into arg49 coordination and the role of lys122 in the polarization of the c-terminus. | the venom of zhaoermia mangshanensis, encountered solely in mt mang in china's hunan province, exhibits coagulant, phosphodiesterase, l-amino acid oxidase, kallikrein, phospholipase a2 and myotoxic activities. the catalytically inactive pla2 homolog referred to as zhaoermiatoxin is highly myotoxic and displays high myonecrotic and edema activities. zhaoermiatoxin possesses a molecular weight of 13,972da, consists of 121 amino-acid residues cross-linked by seven disulfide bridges and shares high ... | 2008 | 18295812 |
| crystallization and preliminary x-ray diffraction analysis of a novel arg49 phospholipase a2 homologue from zhaoermia mangshanensis venom. | zhaoermiatoxin, an arg49 phospholipase a2 homologue from zhaoermia mangshanensis (formerly trimeresurus mangshanensis, ermia mangshanensis) venom is a novel member of the pla2-homologue family that possesses an arginine residue at position 49, probably arising from a secondary lys49-->arg substitution that does not alter the catalytic inactivity towards phospholipids. like other lys49 pla2 homologues, zhaoermiatoxin induces oedema and strong myonecrosis without detectable pla2 catalytic activity ... | 2007 | 17620723 |
| habitat association in the critically endangered mangshan pit viper (protobothrops mangshanensis), a species endemic to china. | habitat directly affects the population size and geographical distribution of wildlife species, including the mangshan pit viper (protobothrops mangshanensis), a critically endangered snake species endemic to china. we searched for mangshan pit viper using randomly arranged transects in their area of distribution and assessed their habitat association using plots, with the goals of gaining a better understanding of the habitat features associated with p. mangshanensis detection and determining i ... | 2020 | 32676224 |