| maporal virus as a surrogate for pathogenic new world hantaviruses and its inhibition by favipiravir. | pathogenic hantaviruses geographically distributed in the old world cause haemorrhagic fever with renal syndrome (hfrs), whereas new world hantaviruses are the aetiological agents of hantavirus cardiopulmonary syndrome (hcps). ribavirin, a drug associated with toxicities, is presently indicated for treatment of hfrs, whereas treatment of the more frequently lethal hcps is limited to supportive care. because of the need for safe and effective antivirals to treat severe hantaviral infections, we e ... | 2011 | 21566265 |
| the delicate pygmy rice rat (oligoryzomys delicatus) is the principal host of maporal virus (family bunyaviridae, genus hantavirus). | abstract choclo virus (chov) and maporal virus (mapv) are enzootic in panama and western venezuela, respectively. the results of previous studies suggested that the fulvous pygmy rice rat (oligoryzomys fulvescens) is the principal host of both viruses. the results of an analysis of nucleotide sequence data in this study indicated that the rodent associated with chov is the costa rican pygmy rice rat (oligoryzomys costaricensis) and that the rodent associated with mapv is the delicate pygmy rice ... | 2011 | 21548760 |
| natural host relationships of hantaviruses native to western venezuela. | strains of caño delgadito virus (cadv) and maporal virus (mapv) were isolated from 25 (8.9%) of the 280 rodents captured on farms in 1997 in western venezuela. the results of analyses of laboratory and zoographic data indicated that alston's cotton rat (sigmodon alstoni) is the principal host of cadv, horizontal virus transmission is the dominant mode of cadv transmission in alston's cotton rat in nature, a pygmy rice rat (oligoryzomys sp.) is the principal host of mapv, and the natural host rel ... | 2010 | 20055578 |
| maporal virus, a hantavirus associated with the fulvous pygmy rice rat (oligoryzomys fulvescens) in western venezuela. | oryzomine rodents in the southeastern united states, panama, and southern south america are natural hosts of 6 of the 13 viruses known to cause hantavirus pulmonary syndrome. the purpose of this study was to extend our knowledge of the geographical distribution and genetic diversity of the hantaviruses associated with oryzomine rodents in south america. an infectious hantavirus was isolated from two fulvous pygmy rice rats captured in western venezuela. analyses of complete nucleocapsid protein ... | 2004 | 15246651 |
| a lethal disease model for new world hantaviruses using immunosuppressed syrian hamsters. | hantavirus, the hemorrhagic causative agent of two clinical diseases, is found worldwide with variation in severity, incidence and mortality. the most lethal hantaviruses are found on the american continent where the most prevalent viruses like andes virus and sin nombre virus are known to cause hantavirus pulmonary syndrome. new world hantavirus infection of immunocompetent hamsters results in an asymptomatic infection except for andes virus and maporal virus; the only hantaviruses causing a le ... | 2017 | 29077702 |
| pneumonitis in syrian golden hamsters (mesocricetus auratus) infected with rio mamoré virus (family bunyaviridae, genus hantavirus). | rio mamoré virus is an etiological agent of hantavirus pulmonary syndrome in south america. the purpose of this study was to determine whether rio mamoré virus strain htn-007 in syrian golden hamsters is pathogenic. none of 37 adult hamsters infected by intramuscular injection of htn-007, including 10 animals killed on day 42 or 43 post-inoculation, exhibited any symptom of disease. histological abnormalities included severe or moderately severe pneumonitis in 6 (46.2%) of the 13 animals killed ... | 2014 | 25064267 |
| phylogenetic relationship of necoclí virus to other south american hantaviruses (bunyaviridae: hantavirus). | the results of a previous study suggested that cherrie's cane rat (zygodontomys cherriei) is the principal host of necoclí virus (family bunyaviridae, genus hantavirus) in colombia. bayesian analyses of complete nucleocapsid protein gene sequences and complete glycoprotein precursor gene sequences in this study confirmed that necoclí virus is phylogenetically closely related to maporal virus, which is principally associated with the delicate pygmy rice rat (oligoryzomys delicatus) in western ven ... | 2015 | 26186516 |
| maporal hantavirus causes mild pathology in deer mice (peromyscus maniculatus). | rodent-borne hantaviruses can cause two human diseases with many pathological similarities: hantavirus cardiopulmonary syndrome (hcps) in the western hemisphere and hemorrhagic fever with renal syndrome in the eastern hemisphere. each virus is hosted by specific reservoir species without conspicuous disease. hcps-causing hantaviruses require animal biosafety level-4 (absl-4) containment, which substantially limits experimental research of interactions between the viruses and their reservoir host ... | 2016 | 27763552 |
| unique interferon pathway regulation by the andes virus nucleocapsid protein is conferred by phosphorylation of serine 386. | andes virus (andv) causes hantavirus pulmonary syndrome (hps) and is the only hantavirus shown to spread person to person and cause a highly lethal hps-like disease in syrian hamsters. the unique ability of andv n protein to inhibit beta interferon (ifnβ) induction may contribute to its virulence and spread. here we analyzed ifnβ regulation by andv n protein substituted with divergent residues from the nearly identical maporal virus (mapv) n protein. we found that mapv n fails to inhibit ifnβ si ... | 2019 | 30867297 |