| aaptamine, an alkaloid from the sponge aaptos suberitoides, functions as a proteasome inhibitor. | aaptamine (1), isoaaptamine (2), and demethylaaptamine (3) were isolated from the marine sponge aaptossuberitoides collected in indonesia as inhibitors of the proteasome. they inhibited the chymotrypsin-like and caspase-like activities of the proteasome with ic(50) values of 1.6-4.6 microg/ml, while they showed less inhibition of the trypsin-like activity of the proteasome. the three compounds showed cytotoxic activities against hela cells, but their cytotoxicity did not correlate with their pot ... | 2010 | 20451377 |