| pleiotropic effects of the lpxm mutation in yersinia pestis resulting in modification of the biosynthesis of major immunoreactive antigens. | deletion mutants in the lpxm gene in two yersinia pestis strains, the live russian vaccine strain ev niieg and a fully virulent strain, 231, synthesise a less toxic penta-acylated lipopolysaccharide (lps). analysis of these mutants revealed they possessed marked reductions in expression and immunoreactivity of numerous major proteins and carbohydrate antigens, including f1, pla, ymt, v antigen, lps, and eca. moreover, both mutants demonstrated altered epitope specificities of the antigens as det ... | 2009 | 19428838 |