| diagnostic bioluminescent phage for detection of yersinia pestis. | yersinia pestis is the etiological agent of the plague. because of the disease's inherent communicability, rapid clinical course, and high mortality, it is critical that an outbreak, whether it is natural or deliberate, be detected and diagnosed quickly. the objective of this research was to generate a recombinant luxab ("light")-tagged reporter phage that can detect y. pestis by rapidly and specifically conferring a bioluminescent signal response to these cells. the bacterial luxab reporter gen ... | 2009 | 19828743 |
| the genome sequence of yersinia pestis bacteriophage phia1122 reveals an intimate history with the coliphage t3 and t7 genomes. | the genome sequence of bacteriophage phia1122 has been determined. phia1122 grows on almost all isolates of yersinia pestis and is used by the centers for disease control and prevention as a diagnostic agent for the causative agent of plague. phia1122 is very closely related to coliphage t7; the two genomes are colinear, and the genome-wide level of nucleotide identity is about 89%. however, a quarter of the phia1122 genome, one that includes about half of the morphogenetic and maturation functi ... | 2003 | 12923098 |
| 'bioluminescent' reporter phage for the detection of category a bacterial pathogens. | yersinia pestis and bacillus anthracis are category a bacterial pathogens that are the causative agents of the plague and anthrax, respectively (1). although the natural occurrence of both diseases' is now relatively rare, the possibility of terrorist groups using these pathogens as a bioweapon is real. because of the disease's inherent communicability, rapid clinical course, and high mortality rate, it is critical that an outbreak be detected quickly. therefore methodologies that provide rapid ... | 2011 | 21775956 |