| [the effect of salvia miltiorrhiza on the ischemic injury of the intercalated disc of heart in rabbits (author's transl)]. | | 1979 | 532638 |
| the effect of ih764-3 on fibroblast proliferation and function. | the effect of ih764-3, a potent component isolated from salvia miltiorrhiza, on the proliferation and function of cultured fibroblasts was studied. it was found that the fibroblast growth curve had a dose-dependent relationship with ih764-3 concentration. the incorporation of 3h-tdr and 3h-proline into fibroblasts was significantly inhibited by ih764-3, and calmodulin, fibronectin and thrombospondin contents in the test group were obviously lower than those in the control group. flow cytometry s ... | 1992 | 1286182 |
| [prevention of reperfusion injury of an ischemic flap: an experimental study]. | oxygen-derived free radicals are important mediators of tissue injury in experimental island skin flaps that have been subjected to prolonged ischemia (vascular occlusion) followed by reperfusion. in this study, the role of oxygen free radical scavenger, sod, and a herb, salvia miltiorrhiza, in the protection of cellular damages during total ischemia and reperfusion was study in the epigastric island skin flaps in experimental rats with electron microscopy and the assessment of survival of the f ... | 1992 | 1298539 |
| the effects of danshen (salvia miltiorrhiza) on pharmacokinetics and pharmacodynamics of warfarin in rats. | danshen is a chinese folk medicine commonly used in the chinese population. the effects of danshen on the pharmacokinetics and pharmacodynamics of warfarin were studied in rats. in the pharmacokinetic study, single oral doses of warfarin were administered to rats or after 3 days treatment with danshen intraperitoneally twice daily. plasma warfarin concentrations were measured for 48 after each of two warfarin doses by high performance liquid chromatography (hplc). in the pharmacodynamic study, t ... | 1992 | 1301354 |
| [effects of salvia miltiorrhiza bunge on isolated perfused liver and portal vein of rats]. | the experiment results showed that salvia miltiorrhiza (smb) had a protective effect on the isolated perfused liver injured by ccl4 of rats, made the activity of gpt in perfusate of smb group lower than that of intoxicated groups and relieved the hepato-pathohistologic lesions of smb group as compared to the intoxicated group. smb had no significant effects on both the activities of sgpt in vitro and the portal vein of rats. | 1992 | 1304759 |
| modulating effect of tanshinones on mutagenic activity of trp-p-1 and benzo[a]pyrene in salmonella typhimurium. | the modulating effects of the chinese medicinal plant 'tan-shen', the radix of salvia miltiorrhiza bunge, on the mutagenic activities of trp-p-1 (3-amino-1,4-dimethyl-5h-pyrido[4,3-b]indole) and b(a)p (benzo[a]pyrene) were investigated using salmonella typhimurium ta98. ether- and hot water-extracted 'tan-shen' enhanced both mutagens at low concentrations, but suppressed them at high concentrations. extracts by ether treatment were more effective than those extracted by hot water. dihydrotanshin ... | 1992 | 1370713 |
| [preliminary study of rose shu-xin oral liquid in the treatment of angina pectoris in coronary heart disease]. | 200 cases with the qi stagnation and blood stasis type of coronary heart disease were divided into two groups randomly. group a used rose shu-xin (heart comforting) oral liquid which is mainly made from the local natural resources-rose compound products. while group b used salvia miltiorrhiza (co.) tablet. the results showed that in group a, the total effective rate was 98% and the ecg improving rate was 75%, while in group b, it was 50% and 40% respectively. there was significant difference bet ... | 1992 | 1392493 |
| [effect of salvia miltiorrhiza on the cardial ischemia in rats induced by ligation]. | i.p. injection (5 g crude drug/kg) of water extract of salvia miltiorrhiza to s.d. rats can prevent the acute cardial ischemia induced by the ligation of the coronary artery. the elevation of s-t segment in the electrocardiogram caused by the ischemia was greatly reduced in animals treated with salvia miltiorrhiza compared with control group. the ischemia area in the left ventricle was significantly reduced and survival rate of the rats increased. | 1992 | 1392496 |
| [antioxidative effect of three water-soluble components isolated from salvia miltiorrhiza in vitro]. | the antioxidative effect of three water-soluble components isolated from salvia miltiorrhiza has been investigated. all the three components were found to inhibit both nadph-vit c and fe(2+)-cysteine induced lipid peroxidation (malondialdehyde formation) in rat brain, liver and kidney microsomes in vitro. the order of their inhibitory effect is as follows: salvianolic acid a, salvianolic acid b and rosmarinic acid. the inhibitory effect on lipid peroxidation induced by nadph-vit c was more than ... | 1992 | 1414377 |
| multiple organ injuries after abdominal high energy wounding in animals and the protective effect of antioxidants. | multiple organ injuries caused by high energy abdominal wounds were studied in 8 pigs and 24 dogs, and at the same time the protective effect of antioxidants in 14 dogs with multiple organ injuries was also studied. the experimental results showed that: 1) more than two organs (six organs at most) were wounded in each of the animals studied; 2) the injuries were characterized by hemorrhaging, tissue rupture and hematoma, and the main pathologic changes were local edema and necrosis; 3) the marke ... | 1992 | 1450398 |
| an application of hplc for identification of abietane-type pigments from salvia miltiorrhiza and their effects on post-hypoxic cardiac contractile force in rats. | | 1992 | 1484900 |
| [effects of chinese materia medica in activating blood and stimulating menstrual flow on the endocrine function of ovary-uterus and its mechanisms]. | effects of salvia miltiorrhiza (sm), ligusticum chuanxiong (lc) and artemisia anomale (aa) on the endocrine function of ovary-uterus were studied. in immature wistar rats, sm increased the level of estradiol (e2) in plasma (131.8 +/- 7.4 pg/ml, p less than 0.01), the weight of uterus (35.3 +/- 4.5 mg, p less than 0.05) and the ovarian pgf2 alpha content (495.0 +/- 41.7 pg/ova., p less than 0.05), but the ovarian pge2 content was reduced (2198.3 +/- 139.0 pg/ova, p less than 0.01), as compared wi ... | 1992 | 1504535 |
| protective action of seven natural phenolic compounds against peroxidative damage to biomembranes. | the effects of seven phenolic compounds isolated from salvia miltiorrhiza on peroxidative damage to liver microsomes, hepatocytes and erythrocytes of rats were studied. the results show that the seven compounds inhibited lipid peroxidation of rat liver microsomes induced by iron/cysteine and vitamin c/nadph. the hemolysis of rat erythrocytes induced by hydrogen peroxide was also inhibited. the degree of inhibition varied with different compounds. among the seven compounds, the action of salviano ... | 1992 | 1739402 |
| [prevention and treatment of isoproterenol induced ventricular fibrillation in rats by aqueous extract of salvia miltiorrhiza]. | acute fatal ventricular fibrillation (vf) in male sprague-dawley rats was induced by subcutaneous injection of isoproterenol (1 mg or 5 mg/kg body weight) to two groups of rats of different body weights (525 +/- 21 g or 387 +/- 11 g) respectively. vf occurred in all control rats resulting in 96% death with only 4% spontaneously reverted and survived. pretreatment of animals, with or without pentobarbital anaesthesia, with an aqueous extract of salvia miltiorrhiza (sm-h, i.p., 5 g herb/kg body we ... | 1991 | 1773471 |
| [effect of salvia miltiorrhiza co. on angiotensin ii and atrial natriuretic polypeptide in rabbits]. | both angiotensin ii (aii) and atrial natriuretic polypeptide (anp) are related to the function of blood vessels, but differ in their actions. the authors observed the effect of salvia miltiorrhiza co. (smc) on the activities of aii and anp in rabbits by radioimmunoassay. it was found that the concentration of aii and anp in plasma were significantly lower (p less than 0.05), and slightly lower in brain and atrial (p greater than 0.05) in smc group than in control group. it indicated that the eff ... | 1991 | 1833082 |
| structure-activity relationship of miltirone, an active central benzodiazepine receptor ligand isolated from salvia miltiorrhiza bunge (danshen). | twenty one o-quinonoid-type compounds and one coumarin-type compound related to miltirone (1) have been synthesized with the aim to identify the key structural elements involved in miltirone's interaction with the central benzodiazepine receptor. on the basis of their inhibition of [3h]flunitrazepam binding to bovine cerebral cortex membranes, it is apparent that ring a of miltirone is essential for affinity. although increasing the size of ring a from six-membered to seven- and eight-membered i ... | 1991 | 1851844 |
| effect of abietane- type pigments from salvia miltiorrhiza on post-hypoxic recovery of cardiac contractile force in rats. | | 1991 | 1896526 |
| [chemical studies of salvia miltiorrhiza f. alba]. | fourteen constituents were isolated from the roots of salvia miltiorrhiza f. alba. two of them were new compounds and were named 1,2,15,16-tetrahydrotanshiquinone (i) and tanshinaldehyde (ii). the others were identified as ro-090680 (iii), dihydroisotanshone i (iv), danshexinkun b (v), miltirone (vi), nortanshinone (vii), hydroxytanshinone ii-a (viii), tanshinone i (ix), dihydrotanshinone i (x), tanshinone ii-a (xi), cryptotanshinone (xii), methylenetanshiquinone (xiii), methyltanshinonate (xiv) ... | 1991 | 1957662 |
| [protective mechanism of salvia miltiorrhiza and paeonia lactiflora for experimental liver damage]. | experimental model of acute liver damage with d-galactosamine was made. thereafter, salvia miltiorrhiza (sm) and paeonia lactiflora (pl) were given to the rats. survival rate of rats and liver coefficient (liver weight/body weight) were observed. changes of alt and bilirubin in serum were detected. level of plasma fibronectin (pfn) was determined at various times. changes of pathological histology under microscope and electron-microscope were observed. the results showed that sm and pl could inc ... | 1991 | 2060049 |
| [experimental study on myocardial protection with verapamil and salvia miltiorrhiza bunge cardioplegia]. | myocardial 45ca sequestration was studied in dogs during 60 minutes of global ischemia and 30 minutes of reperfusion using cardiopulmonary bypass (cpb) and myocardial function was studied before and after cpb. group a (n = 5), as a control, received cold hyperkalemic cardioplegic solution, group b (n = 5) received the same solution plus verapamil (150 micrograms/kg/l) and group c plus specific activity (tsa = dpm x 10(4)/g) and plasma specific activity (psa = dpm x 10(4)/ml) were determined by b ... | 1990 | 2163818 |
| effect of salvianolic acid a, a depside from roots of salvia miltiorrhiza, on gastric h+,k(+)-atpase. | salvianolic acid a, a depside from the roots of salvia miltiorrhiza, inhibited pig gastric h+,k(+)-atpase and pnppase with 50% inhibition values (ic50) of 5.2 x 10(-7) m and 1.7 x 10(-6) m, respectively. kinetic studies revealed that the inhibition patterns induced by salvianolic acid a were competitive with respect to atp and noncompetitive with respect to k+. salvianolic acid a (25 mg/kg, i.p.) significantly inhibited acid secretion in pylorus-ligated rats. at the same dose it also showed a si ... | 1990 | 2173008 |
| [protective action of salvia miltiorrhiza aqueous extract on chemically induced acute myocardial ischemia in rats]. | aqueous extract of salvia miltiorrhiza (sm-h) can protect the acute myocardial ischemia and arrhythmia of sprague-dawley rats induced by isoproterenol (iso) or bacl2 with the following results: (1) intraperitoneal injection (i.p.) of sm-h for 3 to 5 days or intravenously (i.v.) just once significantly reduced the death rate of the animals, (2) i.v. sm-h pretreatment significantly increased the lethal dose of bacl2 infusion, (3) i.p. sm-h significantly decreased premature ventricular contraction, ... | 1990 | 2268921 |
| hypotensive action of salvia miltiorrhiza cell culture extract. | salvia miltiorrhiza cell culture extract (sce) was shown to produce dose-dependent hypotensive response in normo-tensive rats. the mode of this hypotensive action was studied both in vivo and in vitro. this vasodepressor effect was not due to the presence of cations (potassium, calcium and magnesium) in the extract. in pharmacological antagonist studies, the hypotensive effect was shown not being mediated via the alpha-, beta-adrenoceptors, histamine receptors and autonomic ganglion; nor via dir ... | 1990 | 2270850 |
| [effect of salvia miltiorrhiza on the left ventricular diastolic function in coronary artery stenosis]. | in 24 open-chest mongrel dogs, coronary artery critical stenosis were produced by a micrometer constriction on left circumflex coronary artery. it was reduction about 87% in lumen area. cbf, -vce, -dp/dt max were decreased, t was increased (p less than 0.01). 15 minutes after stenosis, the salvia miltiorrhiza injection was injected into left atrium. cbf, -dp/dt max, -vce were increased and t was decreased after the injection of salvia miltiorrhiza. moreover, the change of cbf was the earliest. t ... | 1990 | 2292121 |
| [inhibition of aldose reductase from rat lens by some chinese herbs and their components]. | nearly 20 herbs or herbal components were screened for the inhibitory effect of rat lens aldose reductase(ar) with a fluorometric assay of ar activity. among these glycyrrhiza uralensis, salvia miltiorrhiza, radix astragali, gentiana scabra, silybin, puerarin and baicalin were found to exhibit markedly inhibitory effects on ar comparable to sorbinil. the authors suggest that some of the chinese herbs used in the control of diabetic complications may act through the pharmacologic action of inhibi ... | 1989 | 2511877 |
| [clinical and laboratory studies of the effect of an antilupus pill on systemic lupus erythematosus]. | an effort was made to get a clear understanding of antilupus pill (alp) action on systemic lupus erythematosus (sle) and to evaluate its therapeutic effect. alp was originated from a notable efficacious recipe by an expert physician of tcm. it was prepared with the decoction of 17 chinese medical herbs (such as flos lonicerae, salvia miltiorrhiza etc.) to dispell noxious heat from blood, replenish the vital essence, invigorate blood circulation and resolve the stagnation. the effective rate of 9 ... | 1989 | 2598347 |
| isolation of inhibitors of adenylate cyclase from dan-shen, the root of salvia miltiorrhiza. | the effect of dan-shen extract, the root of salvia miltiorrhiza, on adenylate cyclase was investigated in both rat brain and rat erythrocytes. the etoac fraction of the meoh extract was proved to have significant inhibitory activity. potent inhibitory principles in the etoac fraction were isolated and identified as 4 polyphenolic acids, rosemarinic acid, lithospermic acid, and their methyl ester derivatives. | 1989 | 2630095 |
| possible active components of tan-shen (salvia miltiorrhiza) for protection of the myocardium against ischemia-induced derangements. | extract of tan-shen (salvia miltiorrhiza, labiatae), a chinese traditional crude drug, was reported to show beneficial activity for heart disease. chemical examination on the extract was performed on the basis of screening for protective action on the ischemic myocardium. isolated hearts were subjected to hypoxic perfusion for 20 min, followed by 45 min reoxygenation, and the recovery of cardiac contractile force and changes in uv absorbance of the perfusate were examined. among the components i ... | 1989 | 2717690 |
| [dilative effect of injection of radix angelicae, salvia miltiorrhiza and ligustrazin on the pulmonary vessels in rats]. | | 1988 | 2968176 |
| studies on cardiovascular actions of salvia miltiorrhiza. | cardiovascular actions of s. miltiorrhiza (sm) were studied on systemic blood pressure in the rat. langendorff cardiac preparation in the guinea pig, and four types of vasculature in the dog, including coronary, renal, femoral, and mesenteric arteries. sm induced dose-related hypotension without changing heart rate. the hypotension was antagonized by atropine, propranolol, and chlorpheniramine plus cimetidine. in the isolated whole-heart preparation, sm increased coronary blood flow significantl ... | 1986 | 3008548 |
| [the protective effects of salvia miltiorrhiza on the warm ischemic kidney: experimental study in animals]. | | 1988 | 3248477 |
| [clinical and experimental study on the effect of salvia miltiorrhiza on microcirculation and 2,3 diphosphoglyceric acid in patients with coronary heart disease]. | | 1988 | 3255538 |
| [platelet aggregation inhibitors from salvia miltiorrhiza bunge]. | | 1988 | 3257038 |
| [effect of salvia miltiorrhiza on the survival time of a heart allograft in experimental animals]. | | 1988 | 3289765 |
| cardiovascular pharmacology of panax notoginseng (burk) f.h. chen and salvia miltiorrhiza. | the cardiovascular pharmacology of two chinese herbs, salvia miltiorrhiza (sm) and panax notoginseng (burk) f. h. chen (png) were studied both in vivo and in vitro. extracts of both herbs suppressed systemic blood pressure in albino rats and rabbits, an effect which was blocked or reversed by atropine, propranolol, and chlorpheniramine plus cimetidine. this reversed hypertension was blocked by phenoxybenzamine. these results indicate that these herbs have multiple effector sites in the cardiovas ... | 1986 | 3799531 |
| [effect of salvia miltiorrhiza on experimental hepatic regeneration]. | | 1983 | 6193898 |
| [the relationship between root growth and the cryptotanshinone content of salvia miltiorrhiza]. | | 1983 | 6220832 |
| [effect of salvia miltiorrhiza on mesenteric microcirculatory blood flow in the dog measured by the doppler effect of laser light]. | | 1984 | 6240347 |
| [pharmacology of salvia miltiorrhiza]. | | 1984 | 6544558 |
| preliminary observation of 131cs distribution in experimental acute myocardial infarction and coronary insufficiency treated with root of salvia miltiorrhiza, flower of chrysanthemum morifolium and chrysanthemum indicum. | | 1983 | 6562297 |
| new platelet aggregation inhibitors from tan-shen; radix of salvia miltiorrhiza bunge. | | 1983 | 6616715 |
| [studies on the chemical components of dan-shen (salvia miltiorrhiza bunge) (author's transl)]. | | 1980 | 7211394 |
| the effects of danshen (salvia miltiorrhiza) on warfarin pharmacodynamics and pharmacokinetics of warfarin enantiomers in rats. | the effects of danshen (salvia miltiorrhiza), a popular traditional chinese medicinal herb on the pharmacokinetics and pharmacodynamics of r- and s-warfarin stereoisomers were studied in rats. after a single oral dose of racemic warfarin (2 mg kg-1), treatment with oral danshen extract (5 g kg-1, twice daily) for 3 days significantly altered the overall pharmacokinetics of both r- and s-warfarin and increased the plasma concentrations of both enantiomers over a period of 24 h and the prothrombin ... | 1995 | 7494191 |
| experimental study of the effect of ih764-3 on pulmonary fibrosis. | ih764-3 is a potent component isolated from salvia miltiorrhiza. we have studied the effect of ih764-3 on experimental pulmonary fibrosis in rats and mice treated with a single intratracheal instillation of bleomycin-a6. three groups of animals were assigned as blm+saline, blm+ih764-3 and normal control. the results indicated that in the treated group, lung coefficient, surfactant, hydroxyproline content and fgf activity were significantly lower than those in the control group (p < 0.05, 0.05, 0 ... | 1993 | 7506074 |
| [effect of salvia miltiorrhiza on lipid peroxidation antioxidant enzymes activity in patients with chronic cor pulmonale]. | this paper studied the effect of salvia miltiorrhiza (sm) on plasma lipid peroxidation (lpo), rbc superoxide dismutase (sod), glutathione peroxidase (gsh-px) and catalase (cat) activity in patients with chronic cor pulmonale. 30 patients were randomly divided into two treatment groups (routine and sm). the four parameters have been measured in 22 healthy subjects as control and patients of two treatment groups. the results showed: (1) before treatment both treatment groups had significantly high ... | 1994 | 7841755 |
| [influence of combined salvia miltiorrhiza and ligusticum wallichii on pharmacokinetics of tetramethylpyrazine in rats]. | influence of salvia miltiorrhiza (sm) and/or ligusticum wallichii (lw) on pharmacokinetics of tetramethylpyrazine (tmp) was observed in rats. the content of tmp in lw and lw-sm decoctions were 375.8 and 236.2 micrograms/ml respectively. the rat serum components after oral administration of lw were analyzed by modified hplc. one of 3 compounds was detected, which was identified as tmp by the comparison of the parameters of 4 spectrums (uv, ir, ms and nmr) with those of tmp in literature. pharmaco ... | 1994 | 7950215 |
| [effect of acetylsalvianolic acid a on platelet function]. | acetylsalvianolic acid a (asaa) is an semisynthetic analogue of salvianolic acid a, isolated from danshen (salvia miltiorrhiza bunge). in in vitro experiments, asaa showed marked inhibitory effect on rat and rabbit platelet aggregation induced by adp, collagen, arachidonic acid (aa) and thrombin. in ex vivo experiments with adp, collagen, and aa as inducers, asaa was also shown to inhibit platelet aggregation remarkably. the effect lasted more than two hours. in addition, asaa was found to have ... | 1994 | 7992621 |
| [inhibition of oxygen free radicals in potassium channels of cardiac myocytes and the action of salvianolic acid a]. | by using the patch clamp technique, the effect of oxygen free radicals on the single potassium channels of cardiac papillary muscle cells were studied, as well as the action of salvianolic acid a. it was found that xanthane-xanthane oxidase generated oxygen free radicals could apparently inhibited the unitary currents of the single potassium channel activity. this inhibition was reversed by salvianolic acid a, which is an effective component extracted from salvia miltiorrhiza. | 1993 | 8168213 |
| [effect of naomaitong on basilar artery rings and portal vein strips]. | both naomaitong and single salvia miltiorrhiza inhibit the contraction of rabbit basilar artery rings evoked by cacl2 and kc1 and have nonspecific antagonism against the quantity effect curve of cacl2. naomaitong and single salvia miltiorrhiza also inhibit the contraction of rabbit basilar artery rings evoked by kc1. clearly the inhibitory function of the former is greater than that of the latter. but on the myogenic activity of portal vein strips in rats naomaitong has light inhibitive effect w ... | 1993 | 8267860 |
| effect of sodium tanshinone iia sulfonate in the rabbit myocardium and on human cardiomyocytes and vascular endothelial cells. | sodium tanshinone iia sulfonate (sts) is a derivative of tanshinone iia. the latter is a pharmacologically active component isolated from the rhizome of the chinese herb salvia miltiorrhiza. liquid chromatographically pure sts was found to reduce myocardial infarct size by 53.14 +/- 22.79% relative to that in the saline control in a rabbit 1 hr-ischemia and 3 hr-reperfusion model. this effect was comparable to that of trolox (a better characterized antioxidant serving as a reference cytoprotecto ... | 1993 | 8274165 |
| demonstration of the myocardial salvage effect of lithospermic acid b isolated from the aqueous extract of salvia miltiorrhiza. | lithospermic acid b has been isolated to > 95% purity by high performance liquid chromatography from the aqueous extract of the roots of salvia miltiorrhiza. when infused at 5.5 mumoles/kg into the post-ischemic rabbit heart, it reduced by 62 +/- 10% (n = 8) the myocardial damage found in the saline control in a rabbit ischemia-reperfusion model. | 1993 | 8492636 |
| crown gall culture and production of tanshinone in salvia miltiorrhiza. | crown galls were induced by direct infection of sterile seedlings with agrobacterium tumefaciens c58, and the transformation was proved by opine identification. the crown galls grew well in a hormone-free medium. b5 and ms basic media were good for the growth of crown galls (strain ca), which increased up to 102 and 90 times in a month, respectively. however, 67-v and wp basic media are good for tanshinone production. it has been shown that crown galls can be utilized as a culture system to prod ... | 1995 | 8562850 |
| [the effects of salvia miltiorrhiza and polysaccharide sulphate on the adhesion of erythrocytes of the patients with cerebral thrombosis to cultured endothelial cells]. | salvia miltiorrhiza and polysaccharide sulphate are commonly prescribed for curing cerebral vascular diseases. in this study, we found that the adhesion of erythrocytes of the patients with cerebral thrombosis to cultured human umbilical vein endothelial cells was decreased in number and intensity after the erythrocytes were treated with salvia miltiorrhiza and polysaccharide sulphate in flow field. moreover we found that polysaccharide sulphate was more effective than salvia miltiorrhiza in pre ... | 1995 | 8732056 |
| scavenging effects of salvia miltiorrhiza on free radicals and its protection for myocardial mitochondrial membranes from ischemia-reperfusion injury. | using low temperature electron spin resonance (esr) technique, we found that salvia miltiorrhiza injection could scavenge the oxygen free radicals generated from ischemia-reperfusion injury in the myocardium as effectively as sod. using esr spin trapping technique we found that one of its effective components, danshensu, could scavenge superoxide anion free radicals generated from the reaction system of xanthine and xanthine oxidase, and that lipid free radicals generated from lipid peroxidation ... | 1996 | 8739039 |
| [development and utilization of medicinal plant resources of salvia in anhui]. | in this paper, twenty species (including three forma) of salvia produced and distributed in anhui, together with a key for their identification are presented. development and utilization of these plant resources, as well as the cause for poor quality of salvia miltiorrhiza at present are also discussed. | 1996 | 8758754 |
| [beneficial effects of acetylsalvianolic acid a on focal cerebral ischemic rats subjected to middle cerebral artery thrombosis]. | acetylsalvianolic acid a (asaa) is a semisynthetic analogue of salvianolic acid a isolated from danshen (salvia miltiorrhiza bunge). a rat middle cerebral artery thrombosis model was made by adding fecl3 to the surface of the right middle cerebral artery (mca). using this model, the protective effects of asaa on focal cerebral ischemic injury were studied. the neurologic status of each rat was carefully evaluated at 4, 8 and 24 h after surgery. the cerebral infarction and the morphological chang ... | 1996 | 8762456 |
| effect of 764-3 on aggregation and calcium movements in aequorin-loaded human platelets. | washed human platelets were loaded with the ca(2+)-sensitive photoprotein, aequorin, using hypoosmotic shock treatment-technique. then aggregation and cytoplasmic ionized calcium concentration ([ca2+]i) changes in response to collagen or thrombin were measured simultaneously in the aequorin-loaded human platelets with a platelet ionized calcium aggregometer. 764-3, an active component isolated from the chinese medicinal herb salvia miltiorrhiza bge, inhibited platelet [ca2+]i rise as well as agg ... | 1996 | 9206120 |
| inhibition of farnesyl protein transferase by monoterpene, curcumin derivatives and gallotannin. | ras proteins must be isoprenylated at a conserved cysteine residue near the carboxyl terminus (cys-186 in mammalian ras p21 proteins) in order to extend their biological activity. previous studies have indicate an intermediate in the mevalonate pathway, most likely farnesyl pyrophosphate, is the donor of this isoprenyl group, and that using inhibitors of the mevalonate pathway could block the transforming properties of ras oncogene. unfortunately, mevalonate is a precursor of various end product ... | 1997 | 9252680 |
| in vitro cytotoxicity of tanshinones from salvia miltiorrhiza. | the cytotoxicity-guided fractionation of the roots of salvia miltiorrhiza b. (labiatae) extracts led to the isolation of eighteen active principles 1-18, responsible for the cytotoxicity against five cultured human tumor cell lines, i.e., a549 (non-small cell lung), sk-ov-3 (ovary), sk-mel-2 (melanoma), xf498 (central nerve system) and hct-15 (colon), using the srb (sulfrhodamine-b) method in vitro. all active compounds 1-18 including two novel components 5 and 11 were comprised of tanshinone pi ... | 1997 | 9270379 |
| [experimental study of the protective effects of astragalus and salvia miltiorrhiza bunge on glycerol induced acute renal failure in rabbits]. | the astragalus and salvia miltiorrhiza bunge alcohol extracts were used in preventive treatment of glycerol induced acute renal failure (arf) in rabbits. the experimental rabbits were divided: astragalus group (ab), salvia miltiorrhia bunge group (sm), two extracts mixture group (absm), and normol saline control group (c). the extracts, mixtures and normol saline were administrated before and after the induced arf. the counts of na, k, creatinine in urine and blood and urinary aap, nag were dete ... | 1996 | 9387712 |
| [experimental study of salvia miltiorrhiza on prevention of restenosis after angioplasty]. | for evaluating the possibility of salvia miltiorrhiza (sm) on the prevention of arterial restenosis after angioplasty, we investigated the effect of sm on the intimal thickening of air-injured carotid artery of rats. the results showed that the maximal intimal thickness of the injured arteries was much thinner in the treatment group than that in the control group, indicated that sm could prevent experimental restenosis in rat model. furthermore, we examined the effect of sm on the proliferation ... | 1996 | 9387749 |
| selection of a high tanshinone-producing crown gall strain and production of tanshinone in the strain. | crown galls were induced by direct infection of sterile seedlings of salvia miltiorrhiza with agrobacterium tumefaciens c58 and subcultured on a 67-v hormone-free medium by successively selecting red cell aggregates. a high tanshinone-producing crown gall strain c1 was obtained after 12 months in a subculture. it grows well and retains its high tanshinone-producing characteristic in liquid stationary cultures. it is obvious that the yeast extract and fermentation extract of armillaria mellea as ... | 1997 | 9429783 |
| tanshinone production in ti-transformed salvia miltiorrhiza cell suspension cultures. | transformed cell cultures of salvia miltiorrhiza were established by infecting sterile plantlets with agrobacterium tumefaciens strain c58. the transformed cells in suspension formed macroscopic clumps of cell aggregates up to 2-3 cm in size rather than homogeneous cell suspensions. these transformed cells grew well in hormone-free media. it was found that the b5 mediums supported the best growth while the 6,7-v medium promoted tanshinone production in the transformed cell suspension cultures. t ... | 1997 | 9470220 |
| increase of vitamin e content in ldl and reduction of atherosclerosis in cholesterol-fed rabbits by a water-soluble antioxidant-rich fraction of salvia miltiorrhiza. | antioxidants that prevent ldl from oxidation may reduce atherosclerosis. salvia miltiorrhiza bunge is a chinese herb widely used for the treatment of atherosclerosis-related disorders. salvianolic acid b (sal b), a water-soluble polyphenolic antioxidant isolated from the roots of this plant, was found to scavenge 1,1-diphenyl-2-picrylhydrazyl radicals and inhibit ldl oxidation more effectively than probucol. in order to evaluate the antiatherogenic potential, new zealand white rabbits were fed f ... | 1998 | 9514418 |
| drug interactions as a cause of overanticoagulation and bleedings in chinese patients receiving warfarin. | little is known about the incidence and consequences of drug interactions in patients receiving warfarin. hence, drug interactions as a cause of overanticoagulation and bleedings were determined in chinese patients admitted to our medical unit during a 9-month period in 1994/95. only patients with an admission international normalized ratio (inr) of > 3.0 (target range 2.0-2.5) were included since the drug interactions, if present, were more likely to be of clinical significance. of 35 patients ... | 1998 | 9707357 |
| salvia miltiorrhiza reduces experimentally-induced hepatic fibrosis in rats. | hepatic fibrosis occurs as a result of injury to the liver parenchyma and biliary system. we have studied the effect of the traditional chinese medicinal herb, salvia miltiorrhiza, in an experimental model of hepatic fibrosis and evaluated its effect on various paradigms involved in hepatic fibrosis. | 1998 | 9833914 |
| [observation of therapeutic effect by combined administration of salvia miltiorrhiza, ligustrazine and panax notoginseng on late hemorrhagic shock of rabbits]. | to explore the therapeutic mechanism of salvia miltiorrhize, ligustrazine and panax notoginseng in treating late hemorrhagic shock in rabbit. | 1997 | 9863115 |
| [actions of salvianolic acid a on ccl4-poisoned liver injury and fibrosis in rats]. | to study the actions of salvianolic acid a (sa-a) on liver injury and liver fibrosis. | 1997 | 10322948 |
| salvia miltiorrhiza extract inhibits alcohol absorption, preference, and discrimination in sp rats. | experiment 1 of the present study investigated the ability of a standardized extract of salvia miltiorrhiza in reducing voluntary ethanol intake in ethanol-preferring rats of the sp line. ethanol intake occurred under the two-bottle free-choice regimen between 10% (v/v) ethanol and water in daily 4-h scheduled access periods; water was present 24 h/day. intragastric administration of 200 mg/kg salvia miltiorrhiza extract resulted in approximately 40% reduction in ethanol intake and preference th ... | 1999 | 10386667 |
| tanshinone iia isolated from salvia miltiorrhiza bunge induced apoptosis in hl60 human premyelocytic leukemia cell line. | apoptosis is a new therapeutic target of cancer research. tanshinone iia isolated from salvia miltiorrhiza bunge, a traditional oriental medical herb, was observed to induce apoptosis in hl60 human premyelocytic leukemia cell line. tanshinone iia induced dna fragmentation into the multiples of 180 bp and increased the percentage of hypodiploid cells in flow cytometry after propidium iodide (pi) staining. tanshinone iia-induced apoptosis is accompanied by the specific proteolytic cleavage of poly ... | 1999 | 10624871 |
| tanshinone iia, an ingredient of salvia miltiorrhiza bunge, induces apoptosis in human leukemia cell lines through the activation of caspase-3. | tanshinone ii-a is a derivative of phenanthrene-quinone isolated from salvia miltiorrhiza bunge, a traditional herbal medicine that is known to induce antiinflammatory, anti-oxidative and cytotoxic activity. we have examined cellular effects of tanshione ii-a on hl60 human promyelocytic leukemic cells and k562 human erythroleukemic cells. tanshione ii-a induced a dose- and time-dependent dna fragmentation into the multiples of 180 bp and specific proteolytic cleavage of poly(adp-ribose) polymera ... | 1999 | 10630370 |
| effect of salvia miltiorrhiza on aflatoxin b1-induced oxidative stress in cultured rat hepatocytes. | recent findings have suggested that oxidative damage might contribute to the cytotoxicity and carcinogenicity of aflatoxin b1 (afb1). salvia miltiorrhiza (sm), a herbal plant that has been used extensively in traditional chinese medicine for treating cardiovascular and liver diseases, is believed to have some antioxidative capabilities. in this study, the protective effect of sm against afb1-induced cytotoxicity was investigated in cultured primary rat hepatocytes. afb1-induced cytotoxicity and ... | 1999 | 10630680 |
| antibacterial activities of cryptotanshinone and dihydrotanshinone i from a medicinal herb, salvia miltiorrhiza bunge. | cryptotanshinone and dihydrotanshinone i, constituents of a medicinal plant, salvia miltiorrhiza bunge, had antibacterial activity against a broad range of gram positive bacteria. these compounds generated superoxide radicals in bacillus subtilis lysates. a recombination-deficient mutant strain of b. subtilis was 2- to 8-fold more sensitive than a wild strain, and this hypersensitivity was reduced in the presence of dithiothreitol as an antioxidant. dna, rna, and protein syntheses in b. subtilis ... | 1999 | 10664860 |
| herb-drug interactions. | concurrent use of herbs may mimic, magnify, or oppose the effect of drugs. plausible cases of herb-drug interactions include: bleeding when warfarin is combined with ginkgo (ginkgo biloba), garlic (allium sativum), dong quai (angelica sinensis), or danshen (salvia miltiorrhiza); mild serotonin syndrome in patients who mix st john's wort (hypericum perforatum) with serotonin-reuptake inhibitors; decreased bioavailability of digoxin, theophylline, cyclosporin, and phenprocoumon when these drugs ar ... | 2000 | 10675182 |
| salvia miltiorrhiza inhibits cell growth and induces apoptosis in human hepatoma hepg(2) cells. | salvia miltiorrhiza (sm) is a traditional chinese herbal medicine, commonly used to treat liver diseases in china for centuries. several earlier studies have indicated that sm exhibits anti-tumor properties, but its mechanism remains to be elucidated. in this study, we evaluated the molecular mechanism of sm in a human hepatoma cell line, hepg(2). our results show that sm exerted clear cytotoxic effects, and strongly inhibited the proliferation of hepg(2) cells. it was also observed that sm trea ... | 2000 | 10779635 |
| [oral anticoagulants and medicinal plants. an emerging interaction]. | the consumption of herbal medicines is increasing steadily throughout the world, although to our knowledge there are neither studies on their effectiveness nor controls over the quality and safety of these preparations. considered "food integrators", these preparations are marketed without restriction. it is a common notion that natural therapy has neither side nor toxic effects: allergic reactions, direct toxic effects or those due to contamination, carcinogenicity, mutagenicity, and heavy meta ... | 2000 | 10920504 |
| treatment of chronic liver diseases with traditional chinese medicine. | traditional chinese medicine is still being extensively used for treatment of liver disease in china. the anti-viral herbs, phyllanthus amarus, p. niruri and p urninaria, and oxymatrine extracted from sophora flavecientis and s. subprostratae, have been shown to have a remarkable hbv suppressing effect with a serum conversion rate for hbeag and hbv dna around 45%, similar to that of ifn-alpha. the anti-inflammatory compound, stronger neominophagen c (snmc), is a japanese preparation of glycerrhi ... | 2000 | 10921385 |
| the ameliorating effects of the cognitive-enhancing chinese herbs on scopolamine-induced amnesia in rats. | ameliorating effects were investigated of the cognitive-enhancing chinese herbs administered orally for 1 week-panax ginseng (pg), panax notoginseng (png), dioscorea opposita (do), gastrodia elata (ge), salvia miltiorrhiza (sm), acorus gramineus (ag), coptis chinensis (cc), polygonum multiflorum (pm), cyperus rotundus (cr) and psoralea corylifolia (pc)-on the scopolamine (scop)-induced amnesia by using a passive avoidance task in rats. of ten chinese herbs, only pg, png, ge and cc prolonged the ... | 2000 | 10925408 |
| potential use of medicinal plants in the treatment of alcoholism. | the present paper briefly reviews the most relevant experimental data on the reducing effect of some medicinal herbs on voluntary alcohol intake in animal models of alcoholism. pueraria lobata, tabernanthe iboga, panax ginseng, salvia miltiorrhiza and hypericum perforatum proved to be effective in decreasing alcohol consumption. reduction of alcohol absorption from the gastrointestinal system appears to be a common feature among most of the above plants. these data suggest that medicinal plants ... | 2000 | 10930711 |
| inhibition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from salvia miltiorrhiza. | pharmacological control of interleukin-12 (il-12) and interferon-gamma (ifn-gamma) production may be a key therapeutic strategy for modulating immunological diseases dominated by th1-derived cytokine responses. in this study, we investigated the effects of three different tanshinone pigments from salvia miltiorrhiza (tanshinone i, dihydrotanshinone, and cryptotanshinone) on il-12 production in mouse macrophages and on ifn-gamma production in lymph node cells. all tested tanshinones significantly ... | 2000 | 10996033 |
| [a comparative study on the chemical components of salvia miltiorrhiza bge. collected from zhongjiang of sichuan and from other habitats]. | in this paper, the chemical components in the root of salvia miltiorrhiza from three habitats (zhongjiang of sichuan, henan and shandong) were comparatively studied. the results show that the tlc chromatogram and contents of tanshinone iia in the crude drugs are about the same, the sodium content appears to be lower in the sample from sichuan, but the contents of other metallic elements are about the same in the samples from different habitats. | 1997 | 11038938 |
| [the plant regeneration of salvia miltiorrhiza bge. transformed by agrobacterium]. | the hairy roots and crown galls of salvia miltiorrhiza were obtained by infecting plant with a. rhizogenes (strain 15834, lba 9402) and a. tumefaciens (strain c58). the transformed plants were regenerated light and transplanted form cultural medium into soil successfully. the plants transformed by a. rhizogenes have characteristics of short stems and develop hairy roots, those and trans formed by a. tumefaciens grow vigorously featuring, longer stems and well developed roots. both biomass produc ... | 1997 | 11038957 |
| the effect of yeast elicitor on the growth and secondary metabolism of hairy root cultures of salvia miltiorrhiza. | hairy root cultures of salvia miltiorrhiza transformed with agrobacterium rhizogenes atcc 15834 produced a tiny amount of tanshinones and a constituent level of phenolic acids under normal growth conditions. upon elicitation with yeast elicitor, the production of both phenolic acids and tanshinones was enhanced. for example, the contents of two phenolic acids, rosmarinic acid and lithospermic acid b were elevated from 1.24% and 2.59% to 2.89% and 2.98% of dry wt, respectively while the intracell ... | 2001 | 11118603 |
| a salvianolic acid b-rich fraction of salvia miltiorrhiza induces neointimal cell apoptosis in rabbit angioplasty model. | apoptosis has been suggested to participate in stabilizing cell number in restenosis. salvia miltiorrhiza (sm) bunge which is a chinese herb widely used for the treatment of cardiovascular disorders contains a potent antioxidant, salvianolic acid b. to determine whether the antioxidant affects vascular apoptosis, the present study examined the frequency of apoptotic cell death in atherosclerotic plaques and in restenotic lesions of cholesterol-fed rabbits. new zealand white rabbits were treated ... | 2001 | 11193193 |
| [the studies on protective effects of sm against myocardial hypoxia/reoxygenation injury]. | to assess the myocardial effects of salvia miltiorrhiza (sm) injection against hypoxia-reoxygenation injury, 31p nmr was used to trace the time courses of high energy phosphates (hep) content and intracellular ph (phi) of the isolated perfused rat hearts under hypoxia (30 min) and subsequent reoxygenation (40 min). | 2000 | 11236689 |
| anti-fibrotic effects of a hot-water extract from salvia miltiorrhiza roots on liver fibrosis induced by biliary obstruction in rats. | the anti-fibrotic effects of a hot-water extract form the traditional chinese medicinal herb salvia miltiorrhiza (labiatae) on liver fibrosis induced by biliary obstruction was studied in rats. liver fibrosis was induced in male sprague-dawley rats by bile duct ligation and scission (bdl). after surgery, the hot-water extract of s. miltiorrhiza roots (100 mg kg(-1), p.o.) was administered daily for 28 days. the concentrations of aspartate transaminase, alanine transaminase, alkaline phosphatase, ... | 2001 | 11273016 |
| interaction between warfarin and danshen (salvia miltiorrhiza). | to discuss the potential for an adverse interaction between the chinese herb danshen, the dry root and rhizome of salvia miltiorrhiza bge, and warfarin. | 2001 | 11302416 |
| cancer chemopreventive activities of s-3-1, a synthetic derivative of danshinone. | salvia miltiorrhiza is a traditional chinese medicine which has been well documented for its anti-cancer effects. based on the structure of danshinone, one of the active compounds derived from salvia miltiorrhiza, we synthesized a simplified phenolic analog, s-3-1, and tried to explore its possible actions in preventing the development of cancer. with the ames test, s-3-1 was found to efficiently suppress the mutagenicity of benzo[alpha]pyrene. this result is consistent with the inhibitory effec ... | 2001 | 11355772 |
| [experimental study of hirudo and salvia miltiorrhiza on smooth muscle cell hyperplasia after balloon angioplasty]. | to find the preventive method of restenosis after transluminal angioplasty (ta). | 1998 | 11367667 |
| two new fatty diterpenoids from salvia miltiorrhiza. | two new fatty abietane diterpenoids, oleoyl neocryptotanshinone (1) and oleoyl danshenxinkun a (2), were isolated as minor components from the roots of salvia miltiorrhiza. their structures were established on the basis of spectral evidence. in preliminary tests, they selectively inhibited rabbit platelet aggregation induced by arachidonic acid. | 2001 | 11374966 |
| protection of salvia miltiorrhiza against aflatoxin-b1-induced hepatocarcinogenesis in fischer 344 rats dual mechanisms involved. | extract of salvia miltiorrhiza (sm) has been widely used in traditional chinese medicine for treating liver diseases. recent experimental evidence indicates that it has anti-tumor potential. in this study, the effect of sm on alfatoxin b1 (afb1)-induced hepatocarcinogenesis was investigated in male fischer 344 rats. afb1 (40 microg/100 g body wt, by gavage) was administered once a week for 24 weeks. in sm treatment group, rats were given sm (0.25g/100g body wt, 5 days/week by gavage) for a total ... | 2001 | 11441922 |
| [effect of salvia miltiorrhiza injection on umbilical artery hemodynamics during fetal distress in ewe]. | to study the effect of salvia miltiorrhiza injection (smi) on umbilical artery hemodynamics during fetal distress in ewe. | 1998 | 11475732 |
| hemodynamic effects of salvia miltiorrhiza on cirrhotic rats. | salvia miltiorrhiza (sm) administration has been shown to reduce hepatic fibrosis in rats. we investigated the hemodynamic effects of sm on bile duct ligated (bdl) rats. hemodynamic, histological, and vascular contractile studies were conducted in rats 4 weeks after bile duct ligation. an aqueous extract of sm (0.2 g twice per day) or vehicle was administered for 4 weeks to bdl rats. sm treatment in bdl rats significantly reduced histological grades of fibrosis and ameliorated the portal hyperte ... | 2001 | 11478589 |
| salvianolic acid b attenuates vcam-1 and icam-1 expression in tnf-alpha-treated human aortic endothelial cells. | attachment to, and migration of leukocytes into the vessel wall is an early event in atherogenesis. expression of cell adhesion molecules by the arterial endothelium may play a major role in atherosclerosis. it has been suggested that antioxidants inhibit the expression of adhesion molecules and may thus attenuate the processes leading to atherosclerosis. in the present study, the effects of a potent water-soluble antioxidant, salvianolic acid b (sal b), and an aqueous ethanolic extract (sme), b ... | 2001 | 11500927 |
| effects of salvianolic acid-a on rat hepatic stellate cell proliferation and collagen production in culture. | to investigate the effects of salvionolic acid-a (sa-a), one of main effective components of salvia miltiorrhiza for its antifibrotic action, on the cell proliferation and collagen production in cultured hepatic stellate cells (hsc). | 2000 | 11501181 |
| salvia miltiorrhiza inhibits intimal hyperplasia and monocyte chemotactic protein-1 expression after balloon injury in cholesterol-fed rabbits. | antioxidants that prevent low density lipoproteins (ldl) from oxidation may inhibit atherosclerosis and post-angioplasty restenosis. salvia miltiorrhiza (sm) has been shown to inhibit ldl oxidation and reduce atherosclerosis in cholesterol-fed rabbits. the effects of sm on neointimal hyperplasia and monocyte chemotactic protein-1 (mcp-1) expression after balloon injury were studied. male new zealand white rabbits were fed a 2% cholesterol diet together with daily sm (4.8 gm/kg body wt.) treatmen ... | 2001 | 11596116 |
| role of intracellular thiol depletion, mitochondrial dysfunction and reactive oxygen species in salvia miltiorrhiza-induced apoptosis in human hepatoma hepg2 cells. | recent studies have demonstrated that induction of apoptosis is related to the cell growth inhibition potential of salvia miltiorrhiza (sm), a traditional herbal medicine. in the present study, we further explore the mechanistic pathway involved in sm-induced apoptosis in human hepatoma hepg2 cells. a rapid decline of intracellular glutathione (gsh) and protein thiol content was found in sm-treated cells. moreover. sm exposure resulted in mitochondrial dysfunction as demonstrated by: (i) the ons ... | 2001 | 11693264 |
| determination of danshensu, a major active compound of radix salvia miltiorrhiza in dog plasma by hplc with fluorescence detection. | a simple and sensitive high performance liquid chromatography method has been developed for the determination of danshensu (3, 4-dihydroxyphenyllactic acid) in dog plasma. plasma samples were extracted with ethyl acetate. analysis of the extracts was performed on a reversed-phase column with an aqueous phosphate buffer-acetonitrile (93:7, v/v) mobile phase, and 4-hydroxybenzoic acid was used as the internal standard. fluorescence detection at 285 nm (excitation) and 320 nm (emission) was employe ... | 2001 | 11748681 |
| effect of salvia miltiorrhiza bunge injection on anticardiolipin antibody production induced by beta2 glycoprotein. | to explore the therapeutic effect and the mechanism of chinese herbs on antiphospholipid syndrome (aps) by observing the effect of salvia miltiorrhiza bunge injectio (smbi) on anticardiolipin antibody (acl) induced by beta2 glycoprotein i (beta2-gp i). | 2001 | 11749813 |
| [the therapeutic effect of ligustrazin and salvia miltiorrhiza on the gene expression of alpha1 (i) and alpha1 (iii) procollagen in rat pulmonary fibrosis]. | to evaluate the effect of ligustrazin and salvia miltiorrhiza on collagen gene expression in rat pulmonary fibrosis (pf). | 1999 | 11812356 |