| unique loss of the pyhin gene family in bats amongst mammals: implications for inflammasome sensing. | recent genomic analysis of two bat species (pteropus alecto and myotis davidii) revealed the absence of the pyhin gene family. this family is recognized as important immune sensors of intracellular self and foreign dna and activators of the inflammasome and/or interferon pathways. further assessment of a wider range of bat genomes was necessary to determine if this is a universal pattern for this large mammalian group. here we expanded genomic analysis of this gene family to include ten bat spec ... | 2016 | 26906452 |
| adaptive evolution of the hox gene family for development in bats and dolphins. | bats and cetaceans (i.e., whales, dolphins, porpoises) are two kinds of mammals with unique locomotive styles and occupy novel niches. bats are the only mammals capable of sustained flight in the sky, while cetaceans have returned to the aquatic environment and are specialized for swimming. associated with these novel adaptations to their environment, various development changes have occurred to their body plans and associated structures. given the importance of hox genes in many aspects of embr ... | 2013 | 23825528 |
| two recently sequenced vertebrate genomes are contaminated with apicomplexan species of the sarcocystidae family. | this paper highlights a general problem, namely that host genome sequences can easily be contaminated with parasite sequences, thus careful isolation of genetic material and careful bioinformatics analysis are needed in all cases. two recently published genomes are shown here to be contaminated with sequences of apicomplexan parasites which belong to the sarcocystidae family. sequences of the characteristic apicomplexan organelle, the apicoplast, were used as queries in blastn searches against n ... | 2015 | 26264549 |
| cloning, expression, and antiviral activity of interferon β from the chinese microbat, myotis davidii. | bats are natural reservoir hosts for many viruses that produce no clinical symptoms in bats. therefore, bats may have evolved effective mechanisms to control viral replication. however, little information is available on bat immune responses to viral infection. type i interferon (ifn) plays a key role in controlling viral infections. in this study, we report the cloning, expression, and biological activity of interferon β (ifnβ) from the chinese microbat species, myotis davidii. we demonstrated ... | 2015 | 26645237 |
| gene structure and evolution of transthyretin in the order chiroptera. | bats are mammals in the order chiroptera. although many extensive morphologic and molecular genetics analyses have been attempted, phylogenetic relationships of bats has not been completely resolved. the paraphyly of microbats is of particular controversy that needs to be confirmed. in this study, we attempted to use the nucleotide sequence of transthyretin (ttr) intron 1 to resolve the relationship among bats. to explore its utility, the complete sequences of ttr gene and intron 1 region of bat ... | 2016 | 26681450 |
| detection and genome characterization of four novel bat hepadnaviruses and a hepevirus in china. | in recent years, novel hepadnaviruses, hepeviruses, hepatoviruses, and hepaciviruses have been discovered in various species of bat around the world, indicating that bats may act as natural reservoirs for these hepatitis viruses. in order to further assess the distribution of hepatitis viruses in bat populations in china, we tested the presence of these hepatitis viruses in our archived bat liver samples that originated from several bat species and various geographical regions in china. | 2017 | 28222808 |
| the complete mitochondrial genome of david's myotis, myotis davidii (myotis, vespertilionidae). | in this study, we report the complete mitochondrial genome sequence of david's myotis, myotis davidii. the genome is found to be 17,531 bp in length and has a base composition of a (33.8%), g (13.2%), c (23.2%), and t (29.8%). similar to other bats, it contains a typically conserved structure including 13 protein-coding genes, 22 transfer rna genes, 2 ribosomal rna genes, and 1 control region (d-loop). most of the genes are encoded on h-strand, except for the nd6 subunit gene and 8 trna genes. a ... | 2016 | 25208182 |
| sensory rewiring in an echolocator: genome-wide modification of retinogenic and auditory genes in the bat myotis davidii. | bats comprise 20% of all mammalian species and display a number of characteristics, including true flight, echolocation, and a heightened ability to resist viral load that uniquely position this group for comparative genomic studies. here we searched for evidence of genomic variation consistent with sensory rewiring through bat evolution. we focused on two species with divergent sensory preferences. myotis davidii is a bat species that echolocates and possesses dim- but not daylight-adapted visi ... | 2014 | 25096539 |
| comparative analysis of bat genomes provides insight into the evolution of flight and immunity. | bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including nipah, hendra, ebola, and severe acute respiratory syndrome (sars). to identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related species, fruit bat pteropus alecto and insectivorous bat myotis davidii. we discovered an unexpected concen ... | 2013 | 23258410 |
| [a long distance colonization event of chinese endemic bat myotis davidii]. | in order to reveal the population phylogenetic relationships and colonization history of chinese endemic bat species myotis davidii, a total of 126 samples from 14 populations in nationwide were collected in 2001-2009, taking the mitochondrial control region as the molecular marker. based on the tcs network diagram of the mitochondrial dna control region sequences, the 14 geographical populations were divided into three geographical regions, i.e., mid-east plain region, southwest plateau region, ... | 2011 | 21657037 |
| pleistocene glacial cycle effects on the phylogeography of the chinese endemic bat species, myotis davidii. | global climatic oscillations, glaciation cycles and the unique geographic topology of china have profoundly influenced species population distributions. in most species, contemporary distributions of populations cannot be fully understood, except in a historical context. complex patterns of pleistocene glaciations, as well as other physiographic changes have influenced the distribution of bat species in china. until this study, there had been no phylogeographical research on myotis davidii, an e ... | 2010 | 20618977 |
| complementary regulation of caspase-1 and il-1β reveals additional mechanisms of dampened inflammation in bats. | bats have emerged as unique mammalian vectors harboring a diverse range of highly lethal zoonotic viruses with minimal clinical disease. despite having sustained complete genomic loss of aim2, regulation of the downstream inflammasome response in bats is unknown. aim2 sensing of cytoplasmic dna triggers asc aggregation and recruits caspase-1, the central inflammasome effector enzyme, triggering cleavage of cytokines such as il-1β and inducing gsdmd-mediated pyroptotic cell death. restoration of ... | 2020 | 33106404 |
| detection and identification of the bat circovirus btcv-ds13. | the bat circovirus has been detected from different bat species and regions after detection in rousettus leschenaultia. to enrich the epidemiologic data of the bat circovirus, a complete sequence named "btcv-ds13" was obtained by nested polymerase chain reaction and genome walking? based on the intestines of myotis davidii from zhoushan island (zhejiang province, china). the complete length of btcv-ds13 was 1873nt, and it had the typical gene structure of a circovirus according to sequencing ana ... | 2017 | 30702826 |
| incomer, a dd36e family of tc1/mariner transposons newly discovered in animals. | the tc1/mariner superfamily might represent the most diverse and widely distributed group of dna transposons. several families have been identified; however, exploring the diversity of this superfamily and updating its classification is still ongoing in the life sciences. | 2019 | 31788035 |
| new data on david's myotis, myotis davidii (peters, 1869) (mammalia, chiroptera, vespertilionidae), in siberia and the urals. | david's myotis, myotis davidii, is a vespertilionid bat inhabiting the wide spaces of the palearctic region. although previously registered in the north of mongolia (50° n.l.) and the southern urals (52° n.l.), data on the ecology of the species on the northern periphery of the range was missing. | 2019 | 31105443 |
| structure of interferon-stimulated gene product 15 (isg15) from the bat species myotis davidii and the impact of interdomain isg15 interactions on viral protein engagement. | bats have long been observed to be the hosts and the origin of numerous human diseases. bats, like all mammals, rely on a number of innate immune mechanisms to combat invading pathogens, including the interferon type i, ii and iii responses. ubiquitin-like interferon-stimulated gene product 15 (isg15) is a key modulator of these interferon responses. within these pathways, isg15 can serve to stabilize host proteins modulating innate immune responses and act as a cytokine. post-translational modi ... | 2019 | 30644842 |
| lineage-specific duplication and adaptive evolution of bitter taste receptor genes in bats. | by generating raw genetic material and diverse biological functions, gene duplication represents a major evolutionary mechanism that is of fundamental importance in ecological adaptation. the lineage-specific duplication events of bitter taste receptor genes (tas2rs) have been identified in a number of vertebrates, but functional evolution of new tas2r copies after duplication remains largely unknown. here, we present the largest data set of bat tas2rs to date, identified from existing genome se ... | 2018 | 30230081 |