| [polysaccharides in fungi. xxv. biological activities of two galactomannans from the insect-body portion of chán hua (fungus: cordyceps cicadae)]. | biological activities of two galactomannans (ci-p and ci-a) isolated from the insectbody portion of chán hua (fungus: cordyceps cicadae) were studied. ci-p having low affinity for concanavalin a (con a) exhibited potent carbon-clearance activity in mouse, although both polysaccharides had little antitumor activity against sarcoma 180 in mice. furthermore, ci-p and ci-a was found to have potent hypoglycemic activity in normal mice, and ci-a having high affinity for con a showed slightly higher ac ... | 1990 | 2376822 |
| immunomodulatory functions of extracts from the chinese medicinal fungus cordyceps cicadae. | the effects of cordyceps cicadae extracted fractions on human mononuclear cells (hmnc) proliferation were determined by tritiated thymidine uptake. the results indicated that aqueous methanol (50%) extracts of c. cicadae ascocarps portion (cc-1-2) enhanced hmnc proliferation activated with phytohemagglutinin (pha) with an ec(50) of 13.8+/-4.6 micro g/ml. by contrast, the methanol (100%) extracts of c. cicadae insect-body portion (cc-2-1) suppressed hmnc proliferation stimulated by pha with an ic ... | 2002 | 12413710 |
| activation and proliferation signals in primary human t lymphocytes inhibited by ergosterol peroxide isolated from cordyceps cicadae. | effects of ergosterol peroxide (c28h44o3; cpd 6a) from cordyceps cicadae on phytohemagglutinin (pha)-stimulated cell proliferation were studied in primary human t cells. the results showed that cpd 6a suppressed t-cell proliferation for about 24 h after stimulation with pha. cell cycle analysis indicated that cpd 6a arrested the cell cycle progression of activated t cells from the g1 transition to the s phase. to localize the point in the cell cycle where arrest occurred, a set of key regulatory ... | 2003 | 14504132 |
| the liquid culture filtrates of paecilomyces tenuipes (peck) samson (=isaria japonica yasuda) and paecilomyces cicadae (miquel) samson (=isaria sinclairii (berk.) llond) regulate th1 and th2 cytokine response in murine peyer's patch cells in vitro and ex vivo. | the effects of liquid culture filtrates of medicinal entomogenous fungi, paecilomyces tenuipes (peck) samson (=isaria japonica yasuda or isaria tenuipes) (ptcf) and paecilomyces cicadae (miquel) samson (=isaria sinclairii (berk.) llond) (pccf), on cytokine productions in cultured peyer's patches (pp) from c57bl/6j mice were investigated in vitro and ex vivo. in an in vitro experiment, ptcf (100 and 10 microg/ml) enhanced the production of t helper 1 (th1) cytokines, interleukin (il)-2 and interf ... | 2005 | 15778126 |
| [regulating effects of paecilomyces cicadae polysaccharides on immunity of aged rats]. | to investigate the effects of paecilomyces cicadae polysaccharide (pcps) on the immunological function of aged rats in vivo. | 2008 | 18536469 |
| a beauvericin hot spot in the genus isaria. | beauvericin is a naturally occurring cyclohexadepsipeptide originally described from beauveria bassiana but also reported from several fusarium species as well as members of the genus isaria. twenty-six isolates of isaria species and its cordyceps teleomorph, and ten taxonomically close strains including beauveria, nomuraea and paecilomyces species were sequenced and tested for beauvericin production. trees using its rdna and beta-tubulin sequence data were constructed and used to infer the phyl ... | 2009 | 19766720 |
| phenotypic and functional maturation of dendritic cells induced by polysaccharide isolated from paecilomyces cicadae. | abstract paecilomyces cicadae miquel samson is the anamorph of cordyceps cicadae shing and is used in functional foods for the prevention and treatment of various diseases. in the present study, we examined the effects of p. cicadae polysaccharide (pcp) on dendritic cell (dc) maturation. phenotypic maturation of dcs by pcp was confirmed by the elevated expressions of cd80, cd86, major histocompatibility complex (mhc)-i, and mhc-ii molecules and functional maturation by increased expression of in ... | 2011 | 21631358 |
| Cordyceps cicadae extracts ameliorate renal malfunction in a remnant kidney model. | Background and Objectives: Chronic kidney disease (CKD) is a growing public health problem with an urgent need for new pharmacological agents. Cordyceps cicadae is widely used in traditional Chinese medicine (TCM) and has potential renoprotective benefits. The current study aimed to determine any scientific evidence to support its clinical use. Methods: We analyzed the potential of two kinds of C. cicadae extract, total extract (TE) and acetic ether extract (AE), in treating kidney disease simul ... | 2011 | 22135152 |
| polysaccharides purified from cordyceps cicadae protects pc12 cells against glutamate-induced oxidative damage. | two polysaccharides cpa-1 and cpb-2 were isolated purified from cordyceps cicadae by hot water extraction, ethanol precipitation and purification using anion exchange and gel filtration chromatography. preliminary structural characterization of cpa-1 and cpb-2 were performed. the protective effect of cpa-1 and cpb-2 against glutamate-induced oxidative toxicity in pc12 cells was analyzed. the results indicated that pretreatment of pc12 cells with cpa-1 and cpb-2 significantly increased cell survi ... | 2016 | 27561486 |
| cordycepin protects pc12 cells against 6-hydroxydopamine induced neurotoxicity via its antioxidant properties. | parkinson's disease (pd) is a progressive neurodegenerative disorder that is characterized by degeneration and loss of dopaminergic neurons of the substantia nigra. increasing evidence has indicated that oxidative stress plays a pivotal role in the pathogenesis of parkinson's disease (pd). therapeutic options that target the antioxidant machinery may have potential in the treatment of pd. cordycepin, a nucleoside isolated from cordyceps species displayed potent antioxidant, anti-inflammatory and ... | 2016 | 27261571 |
| neuroprotective effects of adenosine isolated from cordyceps cicadae against oxidative and er stress damages induced by glutamate in pc12 cells. | glutamate has been proven to induce oxidative stress through the formation of reactive oxygen species (ros) and increased calcium overload which results in neuronal injury, development of neurodegenerative diseases and death. adenosine is one of the bioactive nucleosides found in cordyceps cicadae and it has displayed several pharmacological activities including neuroprotection. in this study, the protective effects of adenosine from c. cicadae against glutamate-induce oxidative stress in pc12 c ... | 2016 | 27114365 |
| chemical constituents of cordyceps cicadae. | one new bifuran derivative (1), together with fourteen known compounds, were isolated from cordyceps cicadae x. q. shing. the known compounds included nine nucleosides, uracil (2), uridine (3), 2'-deoxyuridine (4), 2'-deoxyinosine (5), guanosine (6), 2'-deoxyguanosine (7), thymidine (8), adenosine (9), and 2'-deoxyadenosine (10); three amino acids tryptophan (11), phenylalanine (12), and tyrosine (13); and two dopamine analogues n-acetylnoradrenaline (14) and its dimer, trans-2-(3',4'-dihydroxyp ... | 2015 | 26882686 |
| optimized extraction, composition, antioxidant and antimicrobial activities of exo and intracellular polysaccharides from submerged culture of cordyceps cicadae. | cordyceps cicadae is known as jin chan hua in traditional chinese medicine and known to possess different pharmacological activities. presently, it was collected from the wild and isolated. mycelial culture was optimized for extraction of polysaccharides under submerged culture conditions. besides antioxidant, antibacterial activities of extracted polysaccharides were tested for first time. | 2015 | 26694071 |
| structure and chain conformation of a neutral intracellular heteropolysaccharide from mycelium of paecilomyces cicadae. | a neutral heteropolysaccharide (pcips2) was isolated and purified from mycelium of paecilomyces cicadae, which was investigated to be mainly composed of d-mannose, l-rhamnose, 3-o-methyl-d-galactose, d-glucose and d-galactose with a molar ratio of 47.9:3.1:6.4:0.9:0.8. it had a backbone of 1,4-linked α-l-rhap residues and 1,6-linked α-d-manp residues with branches at o-3 of α-d-manp residues. its side chain was comprised of minor terminal β-d-glucose and 1,4-linked α-3-o-me-d-galp residues termi ... | 2016 | 26572406 |
| a 90-day subchronic toxicity study of submerged mycelial culture of cordyceps cicadae (ascomycetes) in rats. | cordyceps cicadae is a parasitic fungus that hibernates inside a host (cicada flammata dist.) and then grows its fruiting body on the surface of the insect. the complete insect/fungus combination of c. cicadae has been widely applied in chinese traditional medicine. recent studies have demonstrated that the medicinal benefits of cultured mycelia are as effective as those found in the wild. however, toxicological information regarding the chronic consumption of c. cicadae mycelia culture is not a ... | 2015 | 26559863 |
| n(6)-(2-hydroxyethyl)adenosine in the medicinal mushroom cordyceps cicadae attenuates lipopolysaccharide-stimulated pro-inflammatory responses by suppressing tlr4-mediated nf-κb signaling pathways. | natural products play an important role in promoting health with relation to the prevention of chronic inflammation. n(6)-(2-hydroxyethyl)adenosine (hea), a physiologically active compound in the medicinal mushroom cordyceps cicadae, has been identified as a ca(2+) antagonist and shown to control circulation and possess sedative activity in pharmacological tests. the fruiting body of c. cicadae has been widely applied in chinese medicine. however, neither the anti-inflammatory activities of hea ... | 2015 | 26394068 |
| cordyceps cicadae induces g2/m cell cycle arrest in mhcc97h human hepatocellular carcinoma cells: a proteomic study. | cordyceps cicadae is a medicinal fungus that is often used for treating cancer. however, the anticancer mechanisms of c. cicadae are largely unknown. this study aims to investigate the anticancer mechanisms of c. cicadae against hepatocellular carcinoma cells in vitro using a proteomic approach. | 2014 | 24872842 |
| cyclodepsipeptides from the ascocarps and insect-body portions of fungus cordyceps cicadae. | a new cyclodepsipeptide cordycecin a (1), together with four known ones beauvericin e (2), beauvericin j (3), beauvericin (4), and beauvericin a (5) was isolated from the ascocarps and insect-body portions of fungus cordyceps cicadae. their structures were identified by nmr and ms analyses. the absolute configuration of 1 was confirmed by crystal x-ray diffraction. compounds 2-5 exhibited a significant inhibitory effect on hepg2 and hepg2/adm cells with ic50 values ranging from 2.40±0.37 to 14.4 ... | 2014 | 24862062 |
| distribution of nucleosides in populations of cordyceps cicadae. | a rapid hplc method had been developed and used for the simultaneous determination of 10 nucleosides (uracil, uridine, 2'-deoxyuridine, inosine, guanosine, thymidine, adenine, adenosine, 2'-deoxyadenosine and cordycepin) in 10 populations of cordyceps cicadae, in order to compare four populations of ophicordyceps sinensis and one population of cordyceps militaris. statistical analysis system (sas) 8.1 was used to analyze the nucleoside data. the pattern of nucleoside distribution was analyzed in ... | 2014 | 24830714 |
| optimization of the solid-state fermentation and properties of a polysaccharide from paecilomyces cicadae (miquel) samson and its antioxidant activities in vitro. | the culture conditions for the yield of a polysaccharide (pcps) produced by paecilomyces cicadae (miquel) samson on solid-state fermentation were investigated using response surface methodology (rsm). plackett-burman design (pbd) was applied to screen out significant factors, followed by the paths of steepest ascent to move to the nearest region of maximum response. then box-behnken design (bbd) was conducted to optimize the final levels of the culture conditions. after analyzing the regression ... | 2014 | 24498337 |
| ergosterol peroxide from cordyceps cicadae ameliorates tgf-β1-induced activation of kidney fibroblasts. | chronic kidney disease is a growing public health problem with an urgent need for new pharmacological agents. ergosterol peroxide (ep) is the major sterol produced by cordyceps cicadae shing (c. cicadae), a widely used traditional chinese medicine. c. cicadae has been used to treat many kinds of diseases and has a potential benefit on renoprotection. this study aimed to investigate the anti-fibrotic effects of ep as well as the underlying mechanisms. a normal rat kidney fibroblast cell line (nrk ... | 2014 | 24095053 |
| optimization of fermentation process for the production of intracellular polysaccharide from paecilomyces cicadae and the immuno-stimulating activity of intracellular polysaccharide. | optimization of fermentation process for the production of intracellular polysaccharide (ips) from the fungus paecilomyces cicadae and the immuno-stimulating activity of ips were carried out. the quantitative effects of initial ph, fermentation temperature and time on the yield of ips content produced by p. cicadae in submerged fermentation were investigated separately using response surface methodology (rsm). the three factors chosen for the present investigation were based on the results of a ... | 2012 | 22864602 |
| activation of macrophages by polysaccharide isolated from paecilomyces cicadae through toll-like receptor 4. | paecilomyces cicadae have been reported to have immunomodulatory properties. in this study, we investigated the effect of polysaccharide (pcp) isolated from p. cicadae on the macrophages. pcp increased the production of nitric oxide (no) and the gene expression of il-1β, il-6, and tnf-α in raw 264.7 cells. to investigate the membrane receptor, we examined the effect of pcp on primary macrophages isolated from wild type c3h/hen and c3h/hej mice having mutant-tlr4. pcp induced no production and cy ... | 2012 | 22687552 |
| characterizations of a new cordyceps cicadae isolate and production of adenosine and cordycepin. | cordyceps is a fastidious pathogenic fungus infecting insects, and recent years have witnessed rapid progress in its medical properties. in this study, a wild isolate, c. cicadae mp12, was characterized through in vitro cultivation and its nuclear small-subunit (ssu) ribosomal dna (rdna) data. in vitro culture of c. cicadae mp12 was established by growing its fruiting bodies in a solid matrix. c. cicadae mp12 was inoculated into cryptotympana atrata cicada pupae for in vivo culture, where the fu ... | 2012 | 24031851 |
| [artificial culturing of cordyceps cicadidae on living silkworm]. | to culture silkworm cordyceps cicadidae artificially. | 2009 | 19943471 |
| determination of myriocin in natural and cultured cordyceps cicadae using 9-fluorenylmethyl chloroformate derivatization and high-performance liquid chromatography with uv-detection. | a simple and sensitive reversed-phase liquid chromatographic method, based on the precolumn derivatization with 9-fluorenylmethyl chloroformate, was developed for the determination of myriocin. the derivatization reaction was performed in organic solvents of pyridine and tetrahydrofuran at 40 degrees c. several factors influencing the derivative yield were investigated and optimized. the formed derivative was stable for more than 24 h at room temperature. the detection wavelength was 262 nm. the ... | 2009 | 19609022 |
| cyclopentenone and furan derivative from the mycelia of cordyceps cicadae. | a new cyclopentenone derivative, named as 2-(3-carboxy-2-hydroxypropyl)-3-methyl-2-cyclopentenone, and a new furan derivative, named as 5-(2-hydroxyethyl)-2-furanacetic acid, were isolated from the cultivated cordyceps cicadae mycelia. their structures were determined by spectroscopic methods, including 2d nmr analyses. | 2008 | 18305360 |
| [isolation and fermentation culture of fungi from cordyceps soofifera]. | to study the fungi isolated from cordyceps sobolifera and its fermentation culture. | 2006 | 16617773 |
| polysaccharides in fungi. xiii. antitumor activity of various polysaccharides isolated from dictyophora indusiata, ganoderma japonicum, cordyceps cicadae, auricularia auricula-judae, and auricularia species. | | 1983 | 6883594 |