| antimalarial compounds from the aerial parts of flacourtia indica (flacourtiaceae). | in the comoros islands, the aerial parts of flacourtia indica are used in traditional medicine to treat malaria. because of the important use of this plant, the phytochemistry of the aerial parts was investigated. | 2010 | 20457242 |
| detection of anti-tuberculosis activity in some folklore plants by radiometric bactec assay. | the anti-tubercular drugs are less effective because of the emergence of multi-drug resistant (mdr) and extensively drug resistant (xdr) strains of m. tuberculosis, so plants being an alternative source of anti-microbial compounds. the aim of this study was to investigate anti-tuberculosis potential of the plants using mycobacterium smegmatis as a rapid screening model for detection of anti-mycobacterial activity and further to evaluate the active plants for anti-tuberculosis activity against m. ... | 2010 | 21114505 |
| isolation and identification of β-hematin inhibitors from flacourtia indica as promising antiplasmodial agents. | an ethanolic extract (a001) of the leaves and twigs of flacourtia indica (burm.f.) merr., was purified to give a new phenolic glycoside, 2-(2-benzoyl-β-d-glucopyranosyloxy)-7-(1α,2α,6α-trihydroxy-3-oxocyclohex-4-enoyl)-5-hydroxybenzyl alcohol (1) together with poliothrysoside (2), catechin-[5,6-e]-4β-(3,4-dihydroxyphenyl)dihydro-2(3h)-pyranone (3), 2-(6-benzoyl-β-d-glucopyranosyloxy)-7-(1α,2α,6α-trihydroxy-3-oxocyclohex-4-enoyl)-5-hydroxybenzyl alcohol (4), chrysoeriol-7-o-β-d-glucopyranoside (5 ... | 2013 | 23354072 |
| a mechanism-based pharmacological evaluation of efficacy of flacourtia indica in management of dyslipidemia and oxidative stress in hyperlipidemic rats. | flacourtia indica (burm. f.) merr. is a medicinal plant indigenous to india and is broadly used worldwide for the treatment of a variety of health ailments. the present study was experimented on hyperlipidemic charles foster rats with the aim to explore the possible mechanism responsible for the antidyslipidemic activity of the hydromethanolic extract from f. indica leaves (fil). | 2016 | 26490091 |
| methanol extract of flacourtia indica aerial parts induces apoptosis via generation of ros and activation of caspases in human colon cancer hct116 cells. | different plant parts of flacourtia indica have long been used in ayurvedic medicine. previous studies have demonstrated that the methanolic extract of f. indica possess anti-inflammatory properties. the present study was aimed at investigating the anticancer effects of methanol extract of flacourtia indica (fim) aerial parts in human colon cancer (hct116) cells. treatment of cells with fim at a concentration of 500 μg/ml for 24 hours significantly reduced cell viability and induced apoptosis, w ... | 2014 | 25227831 |
| poliothrysoside and its derivatives as novel insulin sensitizers potentially driving ampk activation and inhibiting adipogenesis. | in our efforts to develop safe and active chemical entities from nature, we first identified poliothrysoside (1), a phytoconstituent isolated from flacourtia indica, possessing antidiabetic potential. subsequently, fifteen derivatives (2-16) were synthesized to assess the activity profile of this class. all the compounds were analyzed for their glucose uptake potency in chronic insulin-induced insulin resistant 3t3-l1 adipocytes. interestingly, compound 2 exhibited strong ability to increase the ... | 2014 | 25216379 |
| phenolic glucosides from flacourtia indica. | a new phenolic glucoside, (rel)-2-(4',6' -dibenzoyl-beta-glucopyranosyloxy)-7-(1alpha-hydroxy-2alpha-ethoxy-6alpha-acetyloxy-3-oxocyclohex-4-enoyl)-benzyl alcohol (flacourticin) (1) and the known, 2-(4',6'-dibenzoyl-beta-glucopyranosyl)-5-hydroxy benzyl alcohol (4'-benzoylpoliothrysoside) (2) together with the new, (2e)-heptyl-3-(3,4-dihydroxyphenyl) acrylate (3), (+)-catechin (4) and sitosterol-beta-d-glucoside were isolated from flacourtia indica. their structures were assigned on the basis of ... | 2009 | 19413117 |