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plasmodium falciparum and plasmodium coatneyi: immunogenicity of "knob-like protrusions" on infected erythrocyte membranes. 1977405234
plasmodium coatneyi-infected rhesus monkeys: a primate model for human cerebral malaria.although several animal models for human cerebral malaria have been proposed in the past, none have shown pathological findings that are similar to those seen in humans. in order to develop an animal model for human cerebral malaria, we studied the pathology of brains of plasmodium coatneyi (primate malaria parasite)-infected rhesus monkeys. our study demonstrated parasitized erythrocyte (prbc) sequestration and cytoadherence of knobs on prbc to endothelial cells in cerebral microvessels of thes ...19921343725
susceptibility of macaca fascicularis monkeys from mauritius to different species of plasmodium.macaca fascicularis monkeys from mauritius were shown to be susceptible via sporozoite inoculation to 7 species of plasmodium (p. fragile, p. coatneyi, p. gonderi, p. inui, p. cynomolgi, p. knowlesi, and p. fieldi), indigenous to macaques in southeastern asia. four monkeys were sequentially infected with different species of plasmodium to determine maximum and course of parasitemia. in 2 nonsplenectomized monkeys, p. fragile developed maximum parasite counts of only 134 and 155/microliters. for ...19921597796
enhancement of in vitro infectivity of simian malaria sporozoites to hepatocytes by centrifugation.sporozoites of plasmodium cynomolgi, plasmodium knowlesi, and plasmodium coatneyi were deposited onto monolayers of hepatocytes from rhesus monkeys (macaca mulatta). when sporozoites were centrifuged (1,600 g for 5 min), 4-13-fold more schizonts were observed than were found in noncentrifuged control cultures. centrifugation of hepatocyte monolayers before adding sporozoites did not modify the number of parasites.19892614610
plasmodium coatneyi: alterations of transcapillary escape rate and capillary permeability to fibrinogen in rhesus monkeys.the transcapillary escape rate and plasma clearance of fibrinogen were studied in six rhesus monkeys infected with plasmodium coatneyi as well as in six control monkeys using 131i-fibrinogen as a tracer. the mean transcapillary escape rate of fibrinogen in the infected group was significantly higher than that of the control group. both plasma volume and plasma fibrinogen concentration were also elevated in the infected group, these resulting in a significantly higher intravascular fibrinogen mas ...19863709748
comparative studies on the pathology and host physiology of malarias. iv. serum protein alterations in plasmodium coatneyi malaria: a comparison of cellulose acetate and polyacrylamide disc electrophoretic patterns. 19684178555
decreased deformability of plasmodium coatneyi-infected red cells and its possible relation to cerebral malaria. 19724621952
studies on intravascular haemolysis in monkeys infected with plasmodium coatneyi. 19724622656
fate of labelled haemoglobin in normal and plasmodium coatneyi-infected monkeys. 19724623924
the fine structure of trophozoites and gametocytes in plasmodium coatneyi. 19684966879
comparative studies on the pathology and host physiology of malarias. v. hypovolaemia in plasmodium coatneyi malaria. 19684973798
the sites of deep vascular schizogony in plasmodium coatneyi malaria. 19694978466
further studies on the effects of antipantothenates on malaria parasites (plasmodium coatneyi and p. falciparum) in vitro. 19714997036
a new method for intraerythrocytic cultivation of malaria parasites (plasmodium coatneyi and p. falciparum). 19714997037
mechanism of haemolysis in monkeys infected with plasmodium coatneyi. 19715002826
density distribution of red cells infected by plasmodium knowlesi and plasmodium coatneyi. 19715003357
metabolism of 131 i-labelled fibrinogen in monkeys infected with plasmodium coatneyi. 19715004139
comparative studies on the pathology and host physiology of malarias. i. plasmodium coatneyi. 19675004333
studies of the exoerythrocytic stages of simian malaria. ii. plasmodium coatneyi. 19676062074
studies on the transmission of simian malaria. 3. infection and transmission of plasmodium coatneyi with anopheles freeborni and a. balabacensis balabacensis mosquitoes. 19676078599
blood parasites of wild and domestic animals from south kalimantan (borneo), indonesia.wild and domestic animals trapped from forests, villages, and rice fields in south kalimantan (3 degrees 20' s, 115 degrees 02' e, 25 m) were examined for blood parasites using giemsa stained thick and thin blood films and nuclepore filter preparations of peripheral vein and heart puncture blood. presbytis cristatus (silvered leaf monkey) (25%) and felis catus (domestic cat) (7%) were infected with brugia malayi and b. pahangi. in addition, p. cristatus was infected with wuchereria kalimantani ( ...19816789456
a nonhuman primate model for human cerebral malaria: rhesus monkeys experimentally infected with plasmodium fragile.we studied the brains of rhesus monkeys infected with the primate malaria parasite plasmodium fragile. electron microscopy showed that, in these animals, erythrocytes infected with p. fragile undergo sequestration and that parasitized red blood cells adhere to endothelial cells in the cerebral microvessels by means of knobs. cerebral microvessels with sequestered parasitized red blood cells were shown by immunohistochemical analysis to possess the platelet glycoprotein cd36, thrombospondin, and ...19947515825
rosette formation by plasmodium coatneyi-infected erythrocytes of the japanese macaque (macaca fuscata).we studied in vitro the spontaneous rosette formation by red blood cells of a japanese macaque infected with plasmodium coatneyi, which occurred after 30 hr of incubation. rosette formation involved 88% of parasitized red blood cells (prbcs). spontaneous rosettes were formed when the ring-stage parasites developed into late trophozoites or schizonts. a rosette usually consisted of a prbc surrounded by three or more uninfected erythrocytes. electron microscopic examination revealed that interacti ...19957573716
ultrastructure of rosette formation by plasmodium coatneyi-infected erythrocytes of rhesus. 19938278346
a correlation of the sequestration rate of plasmodium coatneyi-infected erythrocytes in cerebral and subcutaneous tissues of a rhesus monkey.parasitized red blood cells (prbcs) were sequestered in microvessels of cerebral and subcutaneous tissues of a rhesus monkey infected with plasmodium coatneyi. a similar sequestration rate (approximately 80%) was observed in both cerebral and subcutaneous microvessels. electron microscopy showed knobs of the sequestrated prbcs cytoadhered to endothelial cells. these results are consistent with the finding of prbc sequestration in subcutaneous tissues in a comatose patient with cerebral malaria. ...19968842121
malaria infection induces rapid elevation of the soluble fas ligand level in serum and subsequent t lymphocytopenia: possible factors responsible for the differences in susceptibility of two species of macaca monkeys to plasmodium coatneyi infection.the intraerythrocytic stage of the simian malaria parasite plasmodium coatneyi (cdc strain) was intravenously inoculated into two species of macaques with different susceptibilities to infection with this parasite, including four japanese macaques (macaca fuscata) and three cynomolgus macaques (m. fascicularis). the japanese macaques infected with p. coatneyi developed severe clinical manifestations similar to those of severe human malaria and eventually became moribund, while the infected cynom ...200010678924
placental changes associated with fetal outcome in the plasmodium coatneyi/rhesus monkey model of malaria in pregnancy.term placentas collected surgically from seven plasmodium coatneyi-infected rhesus monkeys, one abortion, and five controls were evaluated histopathologically. the placentas from plasmodium-infected dams had more significant pathologic changes than those from controls for six parameters (p < 0.05) and higher numbers of activated (ln5 + zymed) macrophages in the intervillous space (ivs) (p = 0.0173). total parasite load (tpl) was defined as the sum of all weekly peripheral infected red blood cell ...200011388509
plasmodium coatneyi: observations on periodicity, mosquito infection, and transmission to macaca mulatta monkeys.plasmodium coatneyi has adapted well to experimental studies with macaca mulatta monkeys and anopheles dirus mosquitoes. studies were made to determine 1) the course of asexual parasitemia, 2) periods when infective gametocytes were produced, 3) the laboratory-reared mosquitoes susceptible to infection, 4) the mosquito most capable of transmitting the infection to monkeys via bite, 5) the pattern of recrudescence, and 6) the prepatent periods following the bites of infected an. dirus mosquitoes. ...200111442203
plasmodium coatneyi-infected erythrocytes bind to c32 amelanotic melanoma cells under static and flow conditions.the ability of plasmodium coatneyi-infected red blood cells (irbcs) to bind to c32 amelanotic melanoma cells was examined under static and physiologic flow conditions in vitro. six blood samples obtained from p. coatneyi-infected japanese macaques (macaca fuscata) with severe manifestations of disease were used in the static adhesion assay. all blood samples constantly exhibited binding of irbcs to c32 cells under static conditions. immunofluorescence staining with anti-cd36 mab revealed a posit ...200312679569
phylogenetic analysis of csp and msp-9 gene sequences demonstrates the close relationship of plasmodium coatneyi to plasmodium knowlesi.plasmodium coatneyi is a simian malaria parasite with various biological features similar to the human malaria p. falciparum and potential as a model for severe cases of malaria. we have characterized two single-copy genes from p. coatneyi, the circumsporozoite protein and merozoite surface protein-9 genes, and determined its phylogenetic relationship among plasmodium species. this study demonstrates that while it has similarities to p. falciparum, p. coatneyi belongs to a distant clade includin ...200312797974
increased plasma levels of soluble intercellular adhesion molecule-1 (sicam-1) and soluble vascular cell molecule-1 (svcam-1) associated with disease severity in a primate model for severe human malaria: plasmodium coatneyi-infected japanese macaques (macaca fuscata).in the present study, we investigated plasma levels of soluble intercellular adhesion molecule-1 (sicam-1) and vascular cell adhesion molecule-1 (svcam-1) in seven japanese macaques (macaca fuscata) infected with plasmodium coatneyi. concentrations of sicam-1 and svcam-1 were significantly elevated in the severe phase; the levels were maximally increased up to six times and three times those before infection, respectively. we subsequently examined kinetic profiles of sicam-1 and svcam-1 concentr ...200312808217
plasmodium coatneyi from the philippines. 196314084189
alterations in the profile of blood cell types during malaria in previously unexposed primigravid monkeys.malaria in nonimmune, primigravid women threatens both mother and fetus. we used the plasmodium coatneyi/rhesus monkey model to examine factors associated with this. clinical and immunologic responses during the blood stage of chronic malaria (4 months) were evaluated in 8 malaria-naive primigravid (pmi) and 8 age-matched nulligravid (nmi) infected monkeys, compared with those in 8 primigravid, noninfected control monkeys. although parasitemia levels were similar, recrudescence was more frequent ...200515871129
infection of saimiri boliviensis monkeys with plasmodium coatneyi.abundant, apparently normally developing, liver-stage parasites of plasmodium coatneyi were demonstrated following injection of sporozoites dissected from the salivary glands of anopheles dirus mosquitoes. erythrocytic development was not demonstrated.200515986634
enhancement of splenic glucose metabolism during acute malarial infection: correlation of findings of fdg-pet imaging with pathological changes in a primate model of severe human malaria.in the current study, to elucidate the clinical features of severe malaria, we performed whole-body positron emission tomography (pet) with (18)f-fluorodeoxyglucose (fdg) of plasmodium coatneyi-infected acute-phase japanese macaques. the infected monkeys clearly exhibited increase in splenic fdg uptake indicating marked enhancement of glucose metabolism. the standardized uptake values (suvs) of the spleen in the infected monkeys were significantly higher than those in the uninfected monkey. at a ...200616525091
factors shaping genetic variation in the mhc of natural non-human primate populations.across a large distribution range, population-specific factors as well as pathogen-mediated selection may shape species genetic diversity in the major histocompatibility complex (mhc). we have studied genetic diversity and population differentiation in the mhc region of the southeast asian cynomolgus macaque (macaca fascicularis fascicularis), a species with large and discontinuous range, in order to investigate the role of demography vs selection. genetic variation was assessed at seven mhc mic ...200717854428
imaging analysis of the brain in a primate model of cerebral malaria.this paper reviews our studies concerning imaging analysis of the brain in a primate model of cerebral malaria. to elucidate the clinical features of cerebral malaria, we performed positron emission tomography with (18)f-fluorodeoxyglucose (fdg-pet) scanning and magnetic resonance imaging (mri) of the brain in japanese macaques (macaca fuscata) infected with plasmodium coatneyi, a primate model of severe human malaria with cerebral involvement. on fdg-pet scanning, we observed diffuse and hetero ...201019467218
evolutionary analysis of circumsporozoite surface protein and merozoite surface protein-1 (csp and msp-1) sequences of malaria parasites.malaria, one of the world's most common diseases, is caused by the intracellular protozoan parasite known as plasmodium. in this study, we have determined the evolutionary relationship of two single-copy proteins, circumsporozoite protein (csp) and merozoite surface protein-1 (msp-1), among plasmodium species using various bioinformatics tools and softwares. these two proteins are major blood stage antigens of plasmodium species. this study demonstrates that the circumsporozoite protein of plasm ...201121769195
the evolution and diversity of a low complexity vaccine candidate, merozoite surface protein 9 (msp-9), in plasmodium vivax and closely related species.the merozoite surface protein-9 (msp-9) has been considered a target for an anti-malarial vaccine since it is one of many proteins involved in the erythrocyte invasion, a critical step in the parasite life cycle. orthologs encoding this antigen have been found in all known species of plasmodium parasitic to primates. in order to characterize and investigate the extent and maintenance of msp-9 genetic diversity, we analyzed dna sequences of the following malaria parasite species: plasmodium falci ...201324044894
distribution and prevalence of malaria parasites among long-tailed macaques (macaca fascicularis) in regional populations across southeast asia.plasmodium knowlesi and plasmodium cynomolgi are two malaria parasites naturally transmissible between humans and wild macaque through mosquito vectors, while plasmodium inui can be experimentally transmitted from macaques to humans. one of their major natural hosts, the long-tailed macaque (macaca fascicularis), is host to two other species of plasmodium (plasmodium fieldi and plasmodium coatneyi) and is widely distributed in southeast asia. this study aims to determine the distribution of wild ...201627590474
high-quality genome assembly and annotation for plasmodium coatneyi, generated using single-molecule real-time pacbio technology.plasmodium coatneyi is a protozoan parasite species that causes simian malaria and is an excellent model for studying disease caused by the human malaria parasite, p. falciparum here we report the complete (nontelomeric) genome sequence of p. coatneyi hackeri generated by the application of only pacific biosciences rs ii (pacbio rs ii) single-molecule real-time (smrt) high-resolution sequence technology and assembly using the hierarchical genome assembly process (hgap). this is the first plasmod ...201627587810
quantifying the removal of red blood cells in macaca mulatta during a plasmodium coatneyi infection.malaria is the most deadly parasitic disease in humans globally, and the long-time coexistence with malaria has left indelible marks in the human genome that are the causes of a variety of genetic disorders. although anaemia is a common clinical complication of malaria, the root causes and mechanisms involved in the pathogenesis of malarial anaemia are unclear and difficult to study in humans. non-human primate (nhp) model systems enable the mechanistic study and quantification of underlying cau ...201627520455
simian malaria in wild macaques: first report from hulu selangor district, selangor, malaysia.malaria is a vector-borne parasitic disease which is prevalent in many developing countries. recently, it has been found that plasmodium knowlesi, a simian malaria parasite can be life-threatening to humans. long-tailed macaques, which are widely distributed in malaysia, are the natural hosts for simian malaria, including p. knowlesi. the aim of the present study was to determine the prevalence of simian malaria parasites in long-tailed macaques in the district of hulu selangor, selangor, malays ...201526437652
a review of plasmodium coatneyi-macaque models of severe malaria.malaria remains one of the most significant public health concerns in the world today. approximately half the human population is at risk for infection, with children and pregnant women being most vulnerable. more than 90% of the total human malaria burden, which numbers in excess of 200 million annually, is due to plasmodium falciparum. lack of an effective vaccine and a dwindling stockpile of antimalarial drugs due to increased plasmodial resistance underscore the critical need for valid anima ...201526077782
disseminated intravascular coagulation complicated by peripheral gangrene in a rhesus macaque (macaca mulatta) experimentally infected with plasmodium coatneyi.we report the first case of disseminated intravascular coagulation (dic) complicated by peripheral gangrene induced by plasmodium coatneyi in rhesus monkeys. ten days after experimental challenge, numerous petechiae were noted over the trunk and extremities, with polychromasia, severe anemia, thrombocytopenia, and moderate parasitemia. these changes were accompanied by elevated serum activity of blood urea nitrogen, creatinine, transaminases, and creatinine phosphokinase. the animal received int ...200717426164
the role of soluble tumor necrosis factor receptor types i and ii and tumor necrosis factor-alpha in malaria during pregnancy.in a prospective study of rhesus monkeys inoculated with plasmodium coatneyi or saline on an infection/gestational timeline, we determined the serum levels of tumor necrosis factor-alpha (tnf-alpha), soluble tumor necrosis factor receptor type i (stnfr-i), and soluble tumor necrosis factor receptor type ii (stnfr-ii) in peripheral blood throughout primigravid pregnancy, malaria infection, and a combination of the two. our goal was to determine the association between levels of tnf-alpha and of i ...200616741891
evolutionary relationships between 15 plasmodium species from new and old world primates (including humans): an 18s rdna cladistic analysis.we present a new phylogenetic analysis of 15 primate plasmodium species based on 18s rdna sequences including new sequences of plasmodium coatneyi, p. fieldi, p. gonderi, p. hylobati and p. simium. the results are discussed in the context of the parasite host species and their geographical distribution. contrary to other phylogenies constructed with this 18s rdna molecule, we observed that the topology of phylogenetic trees was not affected either by the quality of the nucleotide matrices, or by ...200415648690
cerebral metabolic reduction in severe malaria: fluorodeoxyglucose-positron emission tomography imaging in a primate model of severe human malaria with cerebral involvement.cerebral metabolic changes in japanese macaques (macaca fuscata) infected with plasmodium coatneyi, a primate model of severe human malaria with cerebral involvement, were directly evaluated by fluorodeoxyglucose-positron emission tomography (fdg-pet). we observed diffuse and heterogeneous reduction of metabolism in the cerebral cortex in the acute phase of malaria infection. neuropathologic examination showed preferential sequestration of parasitized red blood cells in the cerebral microvascula ...200415569780
expression of proinflammatory cytokines in four regions of the brain in macaque mulatta (rhesus) monkeys infected with plasmodium coatneyi.we have characterized brain cytokine expression profiles in the plasmodium coatneyi/rhesus (macaque mulatta) malaria model. eight rhesus monkeys were included in the study; four were infected with p. coatneyi, and four were used as uninfected controls. all inoculated animals became infected. eleven days after parasite inoculation, the rhesus monkeys were killed and tissue samples from 4 regions of the brain (cortex and white matter of the cerebrum, cerebellum, and midbrain) were collected for qu ...200011220773
cytokine production in rhesus monkeys infected with plasmodium coatneyi.plasmodium coatneyi infection in rhesus monkeys has been used as a model for studying human malaria. cytokine production in this model, however, has so far not been examined. in this study, four rhesus monkeys were infected with p. coatneyi, with another four animals serving as uninfected controls. blood samples were taken for the determination of daily parasitemia, and cytokine and prostaglandin e2 (pge2) levels at days 0, 3, 5, 7, and 10. all inoculated animals became infected, with synchroniz ...199910463671
plasmodium coatneyi: differential clinical and immune responses of two populations of macaca fascicularis from different origins.two species of macaques, including two macaca fascicularis from the philippines, two m. fascicularis from mauritius, and one macaca mulatta, were experimentally infected with blood stages of plasmodium coatneyi and followed during their clinical, parasitological, biological, and immunological evolution. plasma cytokine (tnf-alpha, il-1beta, il-6, ifn-gamma) production peaked for all monkeys 11 days after inoculation, concomitantly with peaks of parasitemia. only the m. fascicularis from the phil ...19999920040
plasmodium coatneyi in the rhesus monkey (macaca mulatta) as a model of malaria in pregnancy.pregnant women with plasmodium falciparum infection are at increased risk for complications such as anemia and cerebral malaria. in addition, the infants of these women suffer intrauterine growth retardation (iugr), low birth weight (lbw), congenital infection, and high infant mortality. although much has been learned from studies of malaria during human pregnancy, progress has been limited by the lack of a suitable animal model. nonhuman primates are of particular interest because, other than t ...19989715932
multi-organ erythrocyte sequestration and ligand expression in rhesus monkeys infected with plasmodium coatneyi malaria.the pathogenesis of human cerebral malaria is suspected to be caused by blockage of cerebral microvessels by the sequestration of parasitized human red blood cells (prbc). examination of infected tissues indicate prbc sequestration in microvessels is the result of prbc knob attachment to endothelial cell surface cytoadherence receptors such as cd36, thrombospondin (tsp), and intercellular adhesion molecule-1 (icam-1). in lieu of fresh human tissue, several animal models for human cerebral malari ...19968916792
a primate model for severe human malaria with cerebral involvement: plasmodium coatneyi-infected macaca fuscata.to develop an animal model for severe human malaria, we carried out clinical and pathologic observations of japanese monkeys (macaca fuscata) infected with plasmodium coatneyi. two monkeys, eight and nine months of age, were used in this experiment. after inoculation with the parasite, both monkeys developed a fulminating acute infection with high parasitemia (20-28.2%) and became moribund with typical signs of severe malaria. in the splenectomized japanese monkey, sequestered infected erythrocy ...19938517481
plasmodium coatneyi ring-infected erythrocyte surface antigens.plasmodium coatneyi produced ring-infected erythrocyte surface antigen (resa) during infection of the rhesus monkey. this antigen was immunogenic and elicited an antibody response that was not persistent but was boosted by repeated infections in a manner similar to that seen in p. falciparum infections in humans. preliminary data showed that the appearance and increasing titer of antibodies to p. coatneyi resa-like antigen were associated with prolongation of intervals from inoculation to patenc ...19938352385
metabolic disturbances in plasmodium coatneyi-infected rhesus monkeys.to investigate metabolic disturbances in an animal model of human malaria, four rhesus monkeys (macaca mulatta) were infected with plasmodium coatneyi, a parasite which induces cytoadherence of infected erythrocytes. when moribund or the parasitaemia had plateaued, the monkeys were sacrificed (3 animals) or treated with chloroquine (1 animal). blood and cerebrospinal fluid (csf) were sampled at intervals between inoculation and sacrifice or treatment. arterial and csf glucose and lactate rose du ...19938225757
sequestration pattern of parasitized erythrocytes in cerebrum, mid-brain, and cerebellum of plasmodium coatneyi-infected rhesus monkeys (macaca mulatta).six rhesus monkeys (macaca mulatta) infected with plasmodium coatneyi were studied for parasitized red blood cell (prbc) sequestration in microvessels of the brain. the degree of prbc sequestration is different in the cerebral, mid-brain, and cerebellar microvessels, with sequestration occurring preferentially in the cerebellum. this pattern resembles that of prbc sequestration in cerebral and cerebellar microvessels in human falciparum malaria. the morphologic appearance of sequestered cells un ...19938214282
malaria-induced increase of splenic gamma delta t cells in humans, monkeys, and mice.the number and distribution of gamma delta t cells in spleens from patients who died of cerebral malaria and from rhesus monkeys severely infected with plasmodium coatneyi were examined by immunocytochemistry. gamma delta t cells were significantly increased in these spleens. in a rodent malaria model using plasmodium chabaudi adami, an avirulent strain of murine malaria parasites, the degree of parasitemia appears to be modulated by the number of gamma delta t cells in the spleen. as parasitemi ...19947957758
a nonhuman primate model for human cerebral malaria: effects of artesunate (qinghaosu derivative) on rhesus monkeys experimentally infected with plasmodium coatneyi.we studied the effects of artesunate on rhesus monkeys infected with plasmodium coatneyi. sixteen rhesus monkeys were divided in four groups. group i consisted of three monkeys that were splenectomized and were treated with three doses (loading dose: 3.3 mg/kg, maintenance doses: 1.7 mg/kg) of artesunate, group ii consisted of three monkeys that were treated with three doses of artesunate (same as group i), group iii consisted of two monkeys that were treated with one dose (3.3 mg/kg) of artesun ...19937506497
rosette formation by plasmodium coatneyi-infected red blood cells.animal models are needed for the study of cytoadherence in falciparum malaria. red blood cell (rbc) rosette formation is one type of cytoadherence and appears to be associated with knob formation, endothelial cell adhesion and sequestration of plasmodium-infected rbcs. since plasmodium coatneyi-infected rbcs develop knobs and sequester, we hypothesized that they also form rosettes. rbcs from p. coatneyi-infected rhesus monkeys (macaca-mulatta) were collected, allowed to mature overnight in vitro ...19911904195
the infective efficiency of intradermally inoculated plasmodium coatneyi sporozoites. 19921417212
a primate model for human cerebral malaria: plasmodium coatneyi-infected rhesus monkeys.a major factor in the pathogenesis of human cerebral malaria is blockage of cerebral microvessels by the sequestration of parasitized human red blood cells (prbc). in vitro studies indicate that sequestration of prbc in the microvessels is mediated by the attachment of knobs on prbc to receptors on the endothelial cell surface such as cd36, thrombospondin (tsp), and intercellular adhesion molecule-1 (icam-1). however, it is difficult to test this theory in vivo because fresh human brain tissues ...19921374220
serum complement and immunity in experimental simian malaria. i. cyclical alterations in c4 related to schizont rupture.previous studies indicated that the level of whole serum complement (c') falls during malaria, and that the fall in c' is linked to schizont rupture and the appearance of humoral antibody. for a more detailed study of the role of c' in malaria, levels of c4 were monitored in rhesus monkeys infected with plasmodium coatneyi. after one to two weeks of infection, significant and abrupt declines in c4 levels occurred, and these were temporally related to the process of schizont rupture. the level of ...19751089126
plasmodium coatneyi in rhesus macaques replicates the multisystemic dysfunction of severe malaria in humans.severe malaria, a leading cause of mortality among children and nonimmune adults, is a multisystemic disorder characterized by complex clinical syndromes that are mechanistically poorly understood. the interplay of various parasite and host factors is critical in the pathophysiology of severe malaria. however, knowledge regarding the pathophysiological mechanisms and pathways leading to the multisystemic disorders of severe malaria in humans is limited. here, we systematically investigate infect ...201323509137
comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated plasmodium coatneyi-infected rhesus monkey model.the us army designed artelinate/lysine salt (al) to overcome the instability of sodium artesunate in aqueous solution (as). to select the most efficacious artemisinin treatment, direct comparison was performed in an uncomplicated non-human primate malaria model.201627599723
schistosoma mansoni infection impairs antimalaria treatment and immune responses of rhesus macaques infected with mosquito-borne plasmodium coatneyi.malaria and schistosomiasis are the world's two most important parasitic infections in terms of distribution, morbidity, and mortality. in areas where plasmodium and schistosoma species are both endemic, coinfections are commonplace. mouse models demonstrate that schistosomiasis worsens a malaria infection; however, just as mice and humans differ greatly, the murine-infecting plasmodium species differ as much from those that infect humans. research into human coinfections (schistosoma haematobiu ...201222907811
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