| extract of solanum muricatum (pepino/csg) inhibits tumor growth by inducing apoptosis. | apoptosis, or programmed cell death, is characterized by certain distinct morphological and biochemical features. most chemotherapeutic drugs exert their anti-tumor effects by inducing apoptosis. therefore, an effective compound inducing apoptosis appears to be a relevant strategy to suppress various human tumors. in a search for tumor inhibitors from various kinds of plants, we found that extracts from solanum muricatum (csg) can inhibit tumor growth both in vivo and in vitro by inducing apopto ... | 1999 | 10226574 |
| occurrence of colombian datura virus in brugmansia hybrids, physalis peruviana l. and solanum muricatum ait. in hungary. | colombian datura virus (cdv) has been found to infect angel trumpets (brugmansia spp.) frequently and cape gooseberry (physalis peruviana) and pepino (solanum muricatum) sporadically in hungary. a cdv brg/h isolate was characterized. it had flexuous thread-like virions of about 750 x 12 nm in size. host range and symptomathological studies revealed its great similarity to authentic cdv isolates. nicotiana tabacum cultivars and lines resistant to potato virus y (pvyn) either genically or transgen ... | 2005 | 16047739 |
| [complete sequence analysis on potato virus m infecting solanum muricatum]. | the complete sequence of potato virus m from solanum muricatum was determined. the liner, single-strand and positive sense genomic rna was 8526 nucleotides long and six open reading frames were identified. the genome organization was typical feature of genus carlavirus. sequence analysis showed that pvm isolates shared 62.5% - 97.2% nucleotide and 60.9% - 97.4% amino acid identities. the coat protein gene was most conserved and tgb3 gene was greatly variable. phylogenetic tree analysis suggested ... | 2003 | 16279199 |
| molecular characterization of two pepino mosaic virus variants from imported tomato seed reveals high levels of sequence identity between chilean and us isolates. | pepino mosaic virus (pepmv), a member of the genus potexvirus, was first described in south america on pepino (solanum muricatum a.). only in recent years, it was reported to infect greenhouse-grown tomatoes. genome nucleotide sequences from several european isolates showed extensive sequence identity (>99%). recent genome nucleotide sequences from two us isolates (us1 and us2) however showed much greater sequence divergence from that of the european pepmv isolates. my interest in characterizing ... | 2007 | 16927118 |
| genetic structure of the population of pepino mosaic virus infecting tomato crops in spain. | abstract the population structure of pepino mosaic virus (pepmv), which has caused severe epidemics in tomato in spain since 2000, was analyzed. isolates were characterized by the nucleotide sequence of the triple gene block and coat protein gene and, for a subset of isolates, a part of the rna-dependent rna polymerase gene. the full-length sequence of the genomic rna of a solanum muricatum isolate from peru also was determined. in spite of high symptom diversity, the spanish population of pepmv ... | 2006 | 18944442 |
| pepino mosaic virus: a successful pathogen that rapidly evolved from emerging to endemic in tomato crops. | taxonomy: pepino mosaic virus (pepmv) belongs to the potexvirus genus of the flexiviridae family. physical properties: pepmv virions are nonenveloped flexuous rods that contain a monopartite, positive-sense, single-stranded rna genome of 6.4 kb with a 3' poly-a tail. the genome contains five major open reading frames (orfs) encoding a 164-kda rna-dependent rna polymerase (rdrp), three triple gene block proteins of 26, 14 and 9 kda, and a 25-kda coat protein. genome diversity: four pepmv genotype ... | 2010 | 20447268 |
| protective effects of an aqueous extract from pepino (solanum muricatum ait.) in diabetic mice. | this study analysed the content of ascorbic acid, phenolic acids and flavonoids in aqueous and ethanol extracts of pepino (solanum muricatum ait.), and examined the protective effects of pepino aqueous extract (pae) in a mouse model of diabetes. pae at 1, 2 and 4% was supplied for 5 weeks. | 2011 | 21445856 |
| agrobacterium-mediated transformation of pepino and regeneration of transgenic plants. | regeneration of pepino (solanum muricatum ait.) shoots was achieved both by organogenesis and by embryogenesis. shoots derived via organogenesis were easily rooted and most regenerated plants appeared phenotypically normal. transgenic plants were obtained using the binary vector pkiwi110 in the avirulent agrobacterium tumefaciens strain lba4404. optimization of transformation protocols was rapidly achieved by monitoring early expression of the gus (β-d-glucuronidase) reporter gene carried on pki ... | 1991 | 24221548 |
| pepino mosaic virus and tomato torrado virus: two emerging viruses affecting tomato crops in the mediterranean basin. | the molecular biology, epidemiology, and evolutionary dynamics of pepino mosaic virus (pepmv) are much better understood than those of tomato torrado virus (totv). the earliest descriptions of pepmv suggest a recent jump from nontomato species (e.g., pepino; solanum muricatum) to tomato (solanum lycopersicum). its stability in contaminated plant tissues, its transmission through seeds, and the global trade of tomato seeds and fruits may have facilitated the global spread of pepmv. stability and ... | 2012 | 22682177 |
| in vitro anti-inflammatory properties of fermented pepino (solanum muricatum) milk by γ-aminobutyric acid-producing lactobacillus brevis and an in vivo animal model for evaluating its effects on hypertension. | the objectives of this study were to determine the in vitro anti-inflammatory and in vivo antihypertensive effects of fermented pepino (solanum muricatum) milk by lactobacillus brevis with the goal of developing functional healthy products. the inflammatory factors of fermented pepino milk with l. brevis were assessed in raw 264.7 macrophages, including nitric oxide (no) production. inflammatory factor genes of cyclooxygenase (cox)-1 and -2, and tumor necrosis factor (tnf)-α were also assayed by ... | 2016 | 25582456 |
| genetic variation in potato virus m isolates infecting pepino (solanum muricatum) in china. | potato virus m (pvm, genus carlavirus, family betaflexviridae) is considered to be one of most economically important pathogens of pepino in china. however, the details and the mechanisms underlying pvm evolution are unknown. in this study, we determined and analyzed 40 tgb 1 gene sequences, 67 tgb 2 and tgb 3 gene sequences, and 88 cp and nabp gene sequences from viruses isolated from 19 samples of pepino (solanum muricatum) and one sample of tomato (s. lycopersicum) collected from different ar ... | 2014 | 25233939 |