randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus.experimental studies on albino rats reported that leaf extract of ocimum sanctum and ocimum album (holy basil) had hypoglycemic effect. to explore further evidence we studied the effects of treatment with holy basil leaves on fasting and postprandial blood glucose and serum cholesterol levels in humans through randomized, placebo-controlled, crossover single blind trial. results indicated a significant decrease in fasting and postprandial blood glucose levels during treatment with holy basil lea ...19968880292
evaluation of the gastric antiulcer activity of fixed oil of ocimum sanctum (holy basil).the fixed oil of ocimum sanctum l. (labiatae) was found to possess significant antiulcer activity against aspirin-, indomethacin-, alcohol-, histamine-, reserpine-, serotonin- and stress-induced ulceration in experimental animal models. significant inhibition was also observed in gastric secretion and aspirin-induced gastric ulceration in pylorus ligated rats. the lipoxygenase inhibitory, histamine antagonistic and antisecretory effects of the oil could probably have contributed towards antiulce ...199910350365
modulation of glutathione and antioxidant enzymes by ocimum sanctum and its role in protection against radiation injury.aqueous extract (oe) of the leaves of ocimum sanctum, the indian holy basil, has been found to protect mouse against radiation lethality and chromosome damage and to possess significant antioxidant activity in vitro. therefore a study was conducted to see if oe protects against radiation induced lipid peroxidation in liver and to determine the role, if any, of the inherent antioxidant system in radioprotection by oe. adult swiss mice were injected intraperitoneally (i.p.) with 10 mg/kg of oe for ...199910641157
radiation protection of human lymphocyte chromosomes in vitro by orientin and vicenin.orientin (ot) and vicenin (vc), two water-soluble flavonoids isolated from the leaves of indian holy basil ocimum sanctum have shown significant protection against radiation lethality and chromosomal aberrations in vivo. in the present study the protective effect of ot and vc against radiation induced chromosome damage in cultured human peripheral lymphocytes was determined by micronucleus test. in order to select the most effective drug concentration, fresh whole blood was exposed to 4gy of cob ...200111673069
inhibition of lipid peroxidation by botanical extracts of ocimum sanctum: in vivo and in vitro studies.ocimum sanctum, the indian holy basil, has significant ability to scavenge highly reactive free radicals. shade dried leaf powder of the plant was extracted with water and alcohol, and then fractionated with different solvents. both extracts and their fractions have in vitro anti-lipidperoxidative activity at very low concentrations. in vivo, hypercholesterolemia-induced erythrocyte lipid peroxidation activity was inhibited by aqueous extracts of ocimum in a dose-dependent manner in male albino ...200415532130
chemopreventative strategies targeting the mgmt repair protein: augmented expression in human lymphocytes and tumor cells by ethanolic and aqueous extracts of several indian medicinal plants.o6-alkylguanines are potent mutagenic, pro-carcinogenic and cytotoxic lesions induced by exogenous and endogenous alkylating agents. a facilitated elimination of these lesions by increasing the activity of o6-methylguanine-dna methyltransferase (mgmt) is likely to be a beneficial chemoprevention strategy, which, however, has not been examined. because, a marginal enhancement of this protein may be adequate for genomic protection, we studied alterations in mgmt activity and expression in human pe ...200617016661
constituents of ocimum sanctum with antistress activity.three new compounds, ocimumosides a (1) and b (2) and ocimarin (3), were isolated from an extract of the leaves of holy basil (ocimum sanctum), together with eight known substances, apigenin, apigenin-7-o-beta-d-glucopyranoside, apigenin-7-o-beta-d-glucuronic acid ( 4), apigenin-7- o-beta- d-glucuronic acid 6''-methyl ester, luteolin-7-o-beta-d-glucuronic acid 6''-methyl ester, luteolin-7-o-beta-d-glucopyranoside, luteolin-5-o-beta-d-glucopyranoside, and 4-allyl-1-o-beta-d-glucopyronosyl-2-hydro ...200717850106
screening for alternative antibiotics: an investigation into the antimicrobial activities of medicinal food plants of mauritius.the present study was designed to evaluate the antimicrobial activities of 2 endemic medicinal plants; faujasiopsis flexuosa (asteraceae) (ff) and pittosporum senacia (pittosporaceae) (ps) and 2 exotic medicinal plants, momordica charantia (cucurbitaceae) (mc) and ocimum tenuiflorum (lamiaceae) (ot) that forms part of local pharmacopoeia of mauritius and correlate any observed activity with its phytochemical profile. aqueous and organic fractions of the leaves, fruits, and seeds of these plants ...201020492307
antimicrobial activity of tulsi (ocimum tenuiflorum) essential oil and their major constituents against three species of recent years scientists worldwide have realized that the effective life span of any antimicrobial agent is limited, due to increasing development of resistance by microorganisms. consequently, numerous studies have been conducted to find new alternative sources of antimicrobial agents, especially from plants. the aims of this project were to examine the antimicrobial properties of essential oils distilled from australian-grown ocimum tenuiflorum (tulsi), to quantify the volatile components pr ...201627242708
enterobacteriaceae resistant to third-generation cephalosporins and quinolones in fresh culinary herbs imported from southeast asia.since multidrug resistant bacteria are frequently reported from southeast asia, our study focused on the occurrence of esbl-producing enterobacteriaceae in fresh imported herbs from thailand, vietnam and malaysia. samples were collected from fresh culinary herbs imported from southeast asia in which esbl-suspected isolates were obtained by selective culturing. analysis included identification by maldi-tof mass spectrometry, susceptibility testing, xbai-pfge, microarray, pcr and sequencing of spe ...201424607424
bioactive polyketides and alkaloids from penicillium citrinum, a fungal endophyte isolated from ocimum tenuiflorum.chemical investigation of the endophytic fungus penicillium citrinum cultured on white beans or on rice led to the isolation of two new alkaloids (1 and 2), along with fourteen known polyketides (6-12, 14-20) and four known alkaloids (3-5, and 13). the structures of the isolated compounds were determined by extensive analysis of the 1d, 2d nmr, and ms data, and by comparison with the literature. compound 13, which had been previously obtained only by chemical synthesis, was isolated as a natural ...201323999155
an ethnobotanical study of indigenous knowledge on medicinal plants used by the village peoples of thoppampatti, dindigul district, tamilnadu, india.this study provides significant ethnopharmacological information, both qualitative and quantitative on medicinal plants in the thoppampatti village, dindigul district, tamilnadu, india. there is urgency in recording such data to conserve the traditional medicinal plants. this is the first ethnobotanical study which records the traditional important medicinal plants of thoppampatti village. to collect, analyze and evaluate the ethnopharmacologic knowledge in thoppampatti village in order to prote ...201424583241
hepatoprotective activity of ocimum sanctum alcoholic leaf extract against paracetamol-induced liver damage in albino rats.there is a lack of reliable hepatoprotective drugs in modern medicine to prevent and treat drug-induced liver damage. leaves of sacred/holy basil, i.e. green tulsi (ocimum sanctum), belonging to family lamiaceae are used traditionally for their hepatoprotective effect. we wanted to evaluate the hepatoprotective activity of ocimum sanctum and observe whether synergistic hepatoprotection exists with silymarin.201121731390
ethnobotanical survey of medicinal plants commonly used by kani tribals in tirunelveli hills of western ghats, india.for thousands of years, medicinal plants have played an important role throughout the world in treating and preventing a variety of diseases. kani tribal people in tirunelveli hills still depend on medicinal plants and most of them have a general knowledge of medicinal plants which are used for first aid remedies, to treat cough, cold, fever, headache, poisonous bites and some simple ailments.201121291981
potent α-amylase inhibitory activity of indian ayurvedic medicinal plants.indian medicinal plants used in the ayurvedic traditional system to treat diabetes are a valuable source of novel anti-diabetic agents. pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post-prandial hyperglycemia via control of starch breakdown. in this study, seventeen indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for α-amylase inhibition, in order to assess and evaluate their inhibitory po ...201121251279
effects of flaxseed, sardines, pearl millet, and holy basil leaves on production traits of layers and fatty acid composition of egg yolks.the effects of flaxseed, sardines, pearl millet, and holy basil (oscimum sanctum) leaf meal on single comb white leghorn (forsgate strain) layer hen production traits, fatty acid composition of egg yolks, and egg quality characteristics were studied. layer hens were allocated to 1 of 6 dietary treatments from 27 to 32 wk of age: control (treatment 1), control + 1 g of basil leaf meal (blm) (treatment 2), control + 2 g of blm (treatment 3), designer egg layer mash (delm; treatment 4), delm + 1 g ...201121177454
ursolic acid, a pentacyclin triterpene, potentiates trail-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and jnk.discovery of the molecular targets of traditional medicine and its chemical footprints can validate the use of such medicine. in the present report, we investigated the effect of ursolic acid (ua), a pentacyclic triterpenoid found in rosemary and holy basil, on apoptosis induced by trail. we found that ua potentiated trail-induced apoptosis in cancer cells. in addition, ua also sensitized trail-resistant cancer cells to the cytokine. when we investigated the mechanism, we found that ua down-regu ...201021156789
anticandidal effect of ocimum sanctum essential oil and its synergy with fluconazole and ketoconazole.holy basil, ocimum sanctum (l.) is time-honored for its medicinal properties; however its antimicrobial characteristics are used only in 'ayurvedic medicines'. attention has been drawn to antifungal activity and a possible synergistic antifungal effect of ocimum sanctum essential oil (oseo) and established azole antimycotics-fluconazole and ketoconazole. to put forward this approach, antifungal activity has been assessed in seventy four fluconazole-sensitive and sixteen fluconazole-resistant can ...201020378320
protective effect of clove oil-supplemented fish diets on experimental lactococcus garvieae infection in tilapia.the essential oils extracted from the four herbs, cinnamon (cinnamomum verum), clove (syzygium aromaticum), ginger (zingiber officinale) and holy basil (ocimum sanctum), were investigated for their antimicrobial activity and mode of action against lactococcus garvieae, a fish pathogenic bacteria causing lactococcosis. of all the tested oils, clove oil had the strongest inhibitory effect and exhibited a bactericidal mode of action against the pathogenic bacterium. when an intraperitoneal infectio ...200919734665
evaluation of anti-inflammatory activity of plant lipids containing alpha-linolenic acid.two groups of fatty acids are essential to the body, the omega6 (n6) series derived from linoleic acid (18:2, n-6) and the omega3 (n3) series derived from alpha-linolenic acid (18:3, n-3). fatty acids provide energy, are an integral part of the cell membranes and are precursors of prostaglandins, thromboxanes and leukotrienes collectively known as eicosanoids. eicosanoids participate in development and synthesis of immunological and inflammatory responses. the fixed oils (1, 2, 3 ml/kg) containi ...200818697604
evaluation of in vitro antimicrobial activity of thai basil oils and their micro-emulsion formulas against propionibacterium acnes.the aim of this study was to evaluate the efficacy of thai basil oils and their micro-emulsions, on in vitro activity against propionibacterium acnes. an agar disc diffusion method was employed for screening antimicrobial activity of the essential oils of ocimum basilicum l. (sweet basil), ocimum sanctum l. (holy basil) and ocimum americanum l. (hoary basil) against p. acnes. minimum inhibitory concentration (mic) values of the basil oils were determined using an agar dilution assay. the obtaine ...200618492147
ocimum sanctum linn. (holy basil) ethanolic leaf extract protects against 7,12-dimethylbenz(a)anthracene-induced genotoxicity, oxidative stress, and imbalance in xenobiotic-metabolizing enzymes.the present study was designed to evaluate the protective effects of ethanolic ocimum sanctum leaf extract against 7,12-dimethylbenz[a]anthracene (dmba)-induced genotoxicity, oxidative stress, and imbalance in xenobiotic-metabolizing enzymes. four different concentrations of ethanolic o. sanctum leaf extract (100, 200, 300, and 400 mg/kg of body weight) were administered to wistar rats by intragastric intubation for five consecutive days followed by intraperitoneal injection of dmba (35 mg/kg of ...200717887944
ethnomedicinal plants of kathua district, j&k, india.natural products, especially those derived from plants, continue to provide new and important leads in the drug discovery process. the first step in drug discovery is to document material traditionally used to treat an ailment. documentation of such knowledge will lead to its conservation and facilitate future research on medicinal plant safety and efficacy to validate traditional use. the present study was undertaken with an aim to document the ethnomedicinal plants of kathua district.201526023030
antioxidant activity of the ancient herb, holy basil in ccl4-induced liver injury in herbal preparation called "holy basil plus herbal powder" (hbpp) containing ocimum santum, withania somnifera, pongamia pinnata, plumbago indica, emblica officinalis and curcuma longa was investigated as an antioxidant and hepatoprotective agent. the antioxidant activity of hbpp was investigated in rats with liver injury induced by oral administration of carbon tetrachloride:olive oil (1:1). hbpp was administered orally at 500 mg/kg daily for 7 days before. hbpp exhibited statistically signif ...201526925464
ethnobotanical study of kani tribes in thoduhills of kerala, south india.india is having a rich vegetation with a wide variety of plants, because of the extreme variations in geographical and climatic conditions prevailing in the country. plants have been used since ancient times for the treatment of various ailments. especially, kani tribal communities in thodu hills of kerala meet their healthcare needs by using non-timber minor forest products and preparations based on traditional knowledge. they still depend on medicinal plants and most of them have a basic knowl ...201424393788
potential mosquito repellent compounds of ocimum species against 3n7h and 3q8i of anopheles gambiae.mosquitoes are exceptionally efficient in detecting their hosts for blood meal using odorant binding proteins, viz. 3n7h and 3q8i and spread several dreadful diseases. deet is a synthetic mosquito repellent widely used all over world for protection against mosquito bite. reports reveal that, synthetic mosquito repellents may pose health problems in considerably large population. in view of the above fact, we made an attempt to discover efficient and novel natural mosquito repellent compounds wit ...201628330095
traditional phytoremedies for the treatment of menstrual disorders in district udhampur, j&k, india.herbal remedies form an integral part of healing and are considered to be the oldest forms of health care known to mankind. the present study aims to document traditional phytoremedies for the treatment of menstrual disorders in udhampur district of j&k, india.201525479156
ethnopharmacological survey of medicinal plants used by traditional health practitioners in thanchi, bandarban hill tracts, bangladesh.there is very limited information regarding plants used by traditional healers in bandarban hill tracts (bht), bangladesh for treating general as well as complex ailments. current study provides significant ethnopharmacological information, both qualitative and quantitative on medical plants in bht. aim of the study this study aimed to collect, analyze and evaluate the rich ethnopharmacologic knowledge on medicinal plants in thanchi, bht and attempted to identify the important species used in tr ...201424892834
evaluation of holy basil mouthwash as an adjunctive plaque control agent in a four day plaque regrowth model.various antibacterial and antiplaque agents are used in chemical plaque control but none are without their shortcomings. chlorhexidine considered a gold standard, also has an array of side effects. to overcome these, numerous herbal extracts have been tried and tested and one among them is holy basil. the present study evaluated the antibacterial efficacy of holy basil in vitro against some periodontopathogens and its antiplaque effect in vivo.201425674314
bioinspired synthesis of highly stabilized silver nanoparticles using ocimum tenuiflorum leaf extract and their antibacterial activity.biosynthesis of nanoparticles is under exploration due to wide biomedical applications and research interest in nanotechnology. we herein reports bioinspired synthesis of silver nanoparticles with the aid of novel, non toxic ecofriendly biological material namely ocimum tenuiflorum leaf extract. it acts as reducing as well as stabilizing agent. an intense surface plasmon resonance band at ∼450 nm in the uv-visible spectrum clearly reveals the formation of silver nanoparticles. the photoluminesce ...201222381796
potential of native thai aromatic plant extracts in antiwrinkle body creams.antioxidant activities of 10 essential oils and 10 absolutes extracted from thai aromatic plants were evaluated and compared to thyme oil, trolox, quercetin, and kaempferol by two independent assays: the 2, 2-diphenyl-1-1-picrylhydrazyl (dpph*) radical scavenging assay and the thiobarbituric acid reactive species (tbars) assay for lipid peroxidation. we found that four essential oils including ginger oil (zingiber officinale roscoe), wan-sao-long leaf oil (amomum uliginosum koen), lemongrass oil ...201626665978
antiplasmodial potential of medicinal plant extracts from malaiyur and javadhu hills of south india.the emergence and spread of plasmodium falciparum with resistance to chloroquine (cq), the safest and cheapest anti-malarial drug, coupled with the increasing cost of alternative drugs especially in developing countries have necessitated the urgent need to tap the potential of plants for novel anti-malarials. the present study investigates the anti-malarial activity of the methanolic extracts of 13 medicinal plants from the malaiyur and javadhu hills of south india against blood stage cq-sensiti ...201121643655
evaluation of anti-oxidant and anti-microbial activity of various essential oils in fresh chicken sausages.the present study was undertaken to evaluate antimicrobial and antioxidant effect of essential oils on the quality of fresh (raw, ready to cook) chicken sausages. several preliminary trials were carried out to optimize the level of four essential oils viz., clove oil, holybasil oil, thyme oil and cassia oil and these essential oils were incorporated at 0.25, 0.125, 0.25 and 0.125%, respectively in fresh chicken sausages. quality evaluation and detailed storage stability studies were carried out ...201728242927
antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid review efficacy studies of antioxidant and antiinflammatory dietary supplements used to manage osteoarthritis (oa) and rheumatoid arthritis (ra) and make conclusions about their place in therapy. glucosamine, chondroitin, and methyl sulfonyl methane were excluded.201020232616
a comparative study of ion diffusion from calcium hydroxide with various herbal pastes through dentin.the aim of this study was to evaluate the diffusion ability of ions through dentinal tubules of different nonalcoholic calcium hydroxide-containing herbal pastes and compare it with the calcium hydroxide paste prepared with saline.201728377654
nutrigenomic evaluation of garlic (allium sativum) and holy basil (ocimum sanctum) leaf powder supplementation on growth performance and immune characteristics in this study, a planned research work was conducted to investigate the nutrigenomic aspects of supplementation of allium sativum (garlic) and ocimum sanctum (holy basil) leaf powder on the growth performance and immune characteristics of broilers.201728246456
maintenance therapy containing metformin and/or zyflamend for advanced prostate cancer: a case series.metformin is derived from galegine, a natural ingredient, and recent studies have suggested that metformin could enhance the antitumor effects of hormone ablative therapy or chemotherapy and reduce prostate cancer-specific mortality. zyflamend is a combination of herbal extracts that reduces inflammation and comprises turmeric, holy basil, green tea, oregano, ginger, rosemary, chinese goldthread, hu zhang, barberry, and basil skullcap. we propose a maintenance regimen with metformin and/or zyfla ...201525861496
traditional therapies used to manage diabetes and related complications in mauritius: a comparative ethnoreligious study.religious communities from mauritius still rely on traditional therapies (tt) for primary healthcare. nonetheless, there is still a dearth of scientific information on tt used by the different religious groups to manage diabetes and related complications (drc). this study aimed to gather ethnomedicinal knowledge on tt used by the different religious groups against drc. diabetic patients (n = 95) and traditional healers (n = 5) were interviewed. fifty-two plant species belonging to 33 families an ...201627200100
genome sequencing of herb tulsi (ocimum tenuiflorum) unravels key genes behind its strong medicinal properties.krishna tulsi, a member of lamiaceae family, is a herb well known for its spiritual, religious and medicinal importance in india. the common name of this plant is 'tulsi' (or 'tulasi' or 'thulasi') and is considered sacred by hindus. we present the draft genome of ocimum tenuiflurum l (subtype krishna tulsi) in this report. the paired-end and mate-pair sequence libraries were generated for the whole genome sequenced with the illumina hiseq 1000, resulting in an assembled genome of 374 mb, with a ...201526315624
phytotoxic activity of ocimum tenuiflorum extracts on germination and seedling growth of different plant species.phytotoxic activity of ocimum tenuiflorum (lamiaceae) plant extracts was investigated against the germination and seedling growth of cress (lepidium sativum), lettuce (lactuca sativa), alfalfa (medicago sativa), italian ryegrass (lolium multiflorum), barnyard grass (echinochloa crus-galli), and timothy (phleum pratense) at four different concentrations. the plant extracts at concentrations greater than 30 mg dry weight equivalent extract ml(-1) reduced significantly the total germination percent ...201425032234
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