| identification and characterization of the endophytic plant growth prompter bacillus cereus strain mq23 isolated from sophora alopecuroides root nodules. | endophytes mq23 and mq23r isolated from sophora alopecuroides root nodules were characterized by observing their ability to promote plant growth and employing molecular analysis techniques. results showed that mq23 and mq23r are potential n2-fixing endophytes and belong to the same species as bacillus cereus. mq23 was shown to be able to produce siderophores, iaa, and demonstrate certain antifungal activity to plant pathogenic fungi. co-inoculation with mq23+mq23ii showed a more significant effe ... | 2011 | 24031669 |
| the natural plant product sophocarpine ameliorates dextran sodium sulfate-induced colitis in mice by regulating cytokine balance. | introduction: sophora alopecuroides l., a traditional chinese herbal remedy, has been widely used for treating enteritis and bacillary dysentery for many years. sophocarpine is a major ingredient of s. alopecuroides l. and has a wide range of pharmacological effects. materials and methods: in this study, we investigated the therapeutic potential of sophocarpine for treating dextran sulfat ... | 2011 | 22083209 |
| effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in balb/c mice. | allergic contact dermatitis is a prototypic t-cell-mediated cutaneous inflammatory response. multiple cell types, inflammatory mediators and cytokines are involved in the regulation of immunologic and inflammatory processes in allergic contact dermatitis. aloperine is an isolated alkaloid found in the plant of sophora alopecuroides l. it has been clinically proved effective in china for a long time for skin inflammatory diseases such as allergic contact dermatitis. however, the mechanism of alop ... | 2010 | 20006963 |
| [antiendotoxic effects of sophora alopecuroides l]. | to investigate the effect and explore the mechanism of protective role exerted by total alkaloids of sophora alopecuroides and three kinds of pharmacoalkaloids (sophocarpine, sophoridine, oxymatrine) in mouse model with acute lung injury. | 2006 | 17326410 |
| antibacterial activity of flavanostilbenes against methicillin-resistant staphylococcus aureus. | three phytochemical compounds (alopecurone a-c), flavanostilbenes which are produced by condensation between a hydroxyflavanone and a hydroxystilbene, were isolated as major components from the root of sophora alopecuroides. they uniformly inhibited the growth of 21 strains of methicillin-resistant staphylococcus aureus with minimum inhibitory concentrations of 3.13-6.25 micrograms ml-1. | 1995 | 7576511 |
| effects of sophoramine, an alkaloid from sophora alopecuroides on isolated dog blood vessels. | in helical strips of dog mesenteric, coronary and cerebral arteries and mesenteric veins contracted with prostaglandin f2 alpha, sophoramine (10(-4) and 10(-3) m) produced a concentration-related relaxation, which was not influenced by treatment with indomethacin, atropine, aminophylline, propranolol, metoprolol, cimetidine, ouabain and methylene blue, and also not by removal of endothelium. relaxations induced by sophoramine did not differ in strips of proximal and distal coronary arteries. con ... | 1988 | 3253487 |
| [effects of seven alkaloids of sophora alopecuroides on the contractility of papillary muscles in guinea pigs]. | | 1986 | 2954365 |
| [effect of oxymatrine on beating of cultured myocardial cells in vitro]. | oxymatrine (om), extracted from sophora alopecuroides l, increased the contractility of the left heart atrium and decreased the spontaneous beating rate of right atrium of rabbit as described in our previous paper. the effect of om on the beating rate of cultured rat myocardial cells was observed in the present study by a method of recording photoelectric energy transformation. om 50 mumol/l decreased the beating rate of the myocytes by 50 +/- 27% 15 min after administration and also antagonized ... | 1989 | 2641852 |
| [anti-inflammatory and anti-allergic action of aloperine]. | aloperine, an alkaloid isolated from sophora alopecuroides l, showed a marked suppressive effect on the swelling of the rat's hind paw induced by injecting carrageenin, macostatin, pge2, histamine, 5-ht, on the rat's scald oedema induced by scalding its hind paw, and on the increased permeability of capillaries caused by histamine and the leukocytic migratory response. the swelling induced by injecting carrageenin into the hind paw of adrenolectomized rats was still significantly inhibited. noti ... | 1989 | 2533795 |
| [relationship between the positive inotropic action of matrine and extracellular calcium]. | matrine (ma) was extracted from the seed and leaves of sophora alopecuroides l. ma showed positive inotropic actions in isolated guinea pig left atrium and rat vas deferens under electric stimulation. the positive inotropic actions were markedly inhibited by verapamil (1 mumol/l). isolated rat vas deferens under the action of ma showed rhythmic contraction. high k+ (kcl 40 mmol/l) augmented the frequency of rhythmic contraction induced by ma; conversely, ma may also augment the increased tension ... | 1990 | 1964528 |
| sophocarpine displays anti-inflammatory effect via inhibiting tlr4 and tlr4 downstream pathways on lps-induced mastitis in the mammary gland of mice. | mastitis is defined as the inflammation of the mammary gland. lps, which is widely used to induce mastitis models for the study of this disease, triggers similar inflammation as escherichia coli. sophocarpine, isolated from sophora alopecuroides l., exhibits multiple biological properties. the aim of the present study was to determine the anti-inflammatory effect and mechanism of action of sophocarpine on mastitis within an lps-induced mouse model. elisa and western blotting were performed to de ... | 2016 | 27039209 |
| an investigation into the antifungal property of fabaceae using bioinformatics tools. | chemodiversity in plants provides sources of great value which might be helpful for finding new leads in drug discovery programs. fabaceae as the third largest family of flowering plants was chosen to investigate its possible antifungal activity. in order to increase the effectiveness of the result, molecular similarity methods and chemical data were used. twelve plants were selected from fabaceae and collected from the north and south of iran. percolation method with 80% ethanol was used for ex ... | 2010 | 23407751 |
| isolation and characterization of a novel lectin with antifungal and antiproliferative activities from sophora alopecuroides seeds. | sophora alopecuroides lectin (sal), a novel lectin from the seeds of sophora alopecuroides, was purified by ion-exchange chromatography on diethylaminoethyl (deae)- and carboxymethyl (cm)-sepharose columns, followed by gel filtration on a sephadex 75 10/300 gl column. sal was found to be a monomer of 39916.3 da, as determined by tricine-sodium dodecyl sulphate-polyacrylamide gel electrophoresis and high-performance liquid chromatography (hplc). the n-terminal 10-amino acid sequence of sal, kpwal ... | 2012 | 22634632 |
| anticonvulsant activity of hydroalcoholic extract and aqueous fraction of ebenus stellata in mice. | fabaceae is the third largest family of flowering plants. lack of essential oils in the plants of this family can be considered as an advantage and can favor them in search for safe and antiepileptic medicines. the effects of fabacea family plants including ebenus stellata (e. stellata), sophora alopecuroides and caesalpinia gilliiesii were evaluated in pentylenetetrazole (ptz) and maximal electroshock (mes) seizure tests. | 2012 | 23493240 |
| molecular cloning, expression, and characterization of a sophora alopecuroides lectin from escherichia coli. | sophora alopecuroides lectin (sal) has been isolated from the seeds and confirmed to have antifungal and antitumor activities, and presently the preparation of the natural lectin was cumbersome, time-consuming, and the yield was relatively low for further analysis. in this study, the signal peptide of lectin, the modification sites, and the secondary structure were analyzed, and the three-dimensional structures of sal were modeled. the gene of sal was amplified by the reverse transcription polym ... | 2014 | 25033829 |
| [effect of total alkaloid of sophora alopecuroides on sw480 cells and balb/c nude mice tumor xenograft]. | to study the anti-tumor effect of total alkaloid of sophora alopecuroides (tasa) on human colon adenocarcinoma sw480 cells and balb/c nude mice tumor xenograft. | 2011 | 22066406 |
| protective effect of total alkaloids of sophora alopecuroides on dextran sulfate sodium-induced chronic colitis. | to investigate the effect of total alkaloids of sophora alopecuroides (tasa) on dextran sulfate sodium (dss)-induced colitis in mice. | 2011 | 21826597 |
| sophocarpine administration preserves myocardial function from ischemia-reperfusion in rats via nf-?b inactivation. | sophora alopecuroides l. (the clinical usefulness of compound kudouzi injection) has been used mainly for the treatment of fever, inflammation, edema and pain. sophocarpine, a tetracyclic quinolizidine alkaloid, is one of the most abundant active ingredients in sophora alopecuroides l. sophocarpine injection (called the kangke injection) has been demonstrated to have significant antivirus effects against coxsackievirus b3 and therapeutic effects for viral myocarditis in clinical. | 2011 | 21459139 |
| diverse rhizobia associated with sophora alopecuroides grown in different regions of loess plateau in china. | a total of seventy-five symbiotic bacterial strains isolated from root nodules of wild sophora alopecuroides grown in different regions of china's loess plateau were characterized. based on the combined rflp patterns, thirty-five genotypes were defined among the rhizobia and they were classified into nine genomic species, including mesorhizobium alhagi and m. gobiense as the main groups, as well as agrobacterium tumefaciens, m. amorphae, phyllobacterium trifolii, rhizobium giardinii, r. indigofe ... | 2010 | 20965680 |
| [effects of total alkaloid of sophora alopecuroides on serum il-1beta and il-4 expression in mice with acute ulcerative colitis]. | to investigate the effects of total alkaloid of sophora alopecuroides (tasa) on expression of serum il-1beta and il-4 in mice with dss-induced acute ulcerative colitis. | 2010 | 20707078 |
| total alkaloids from sophora alopecuroides l. increase susceptibility of extended-spectrum β-lactamases producing escherichia coli isolates to cefotaxime and ceftazidime. | to evaluate the antimicrobial activity of total alkaloids extracted from sophorea alopecuroides l. (tasa) against clinical isolated extended-spectrum beta-lactamases (esbls) producing escherichia coli (e. coli) strains. | 2013 | 22528755 |
| [effect of pectins of different degree of esterification on in-vitro sophoridine release of hydrophilic matrix tablets containing total alkaloids of sophora alopecuroides]. | to prepare colon-targetting tablets of total alkaloids of sophora alopecuroides and evaluate the effect of pectins of different degree of esterification (de) on sophoridine release profiles in-vitro. | 2008 | 19166003 |
| colonization and plant growth promoting characterization of endophytic pseudomonas chlororaphis strain zong1 isolated from sophora alopecuroides root nodules. | the endophytic strain zong1 isolated from root nodules of the legume sophora alopecuroides was characterized by conducting physiological and biochemical tests employing gfp-marking, observing their plant growth promoting characteristics (pgpc) and detecting plant growth parameters of inoculation assays under greenhouse conditions. results showed that strain zong1 had an effective growth at 28 ºc after placed at 4-60 ºc for 15 min, had a wide range ph tolerance of 6.0-11.0 and salt tolerance up t ... | 2013 | 24294262 |
| matrine improves 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. | matrine is an alkaloid found in kinds of sophora plants mainly including sophora flavescens, sophora alopecuroides and sophora subprotrata. the aim of the present study was to evaluate therapeutic effects of matrine on 2,4,6-trinitrobenzene sulfonic acid (tnbs)-induced colitis in mice. two hours following colonic instillation of tnbs, matrine with several doses was given by gastric gavage once daily for 7 days. comparing with the 0.9% nacl-treated mice with tnbs-induced colitis, matrine (10 and ... | 2006 | 16332442 |
| [effects of total base of sophora alopecuroides on expression of sod, mda, no, mpo in rats with experimental colitis]. | to investigate the effects of total base of sophora alopecuroides on expression of sod, mda, no, mpo in rats with experimental colitis (uc). | 2006 | 16706026 |
| [effect of total alkaloids of kudouzi (sophora alopecuroides l.) on tolerance to anoxia in mice]. | to several anoxia mice models, total alkaloids of kudouzi (tasa) can prolong their tolerance time (ip < 1/10, 1/5ld50/kg, p < 0.05-0.01). in the experiment of myocardial ischemia induced by pituitrin, tasa decreased significantly the st change in ecg (p < 0.05). the acute ld50 of tasa by ip was found to be 130.66 +/- 22.64 mg/kg for mice. | 1993 | 8011101 |
| total alkaloids of sophora alopecuroides increases the expression of cd4+ cd25+ tregs and il-10 in rats with experimental colitis. | previous studies have demonstrated that the total alkaloids of sophora alopecuroides (tasa), which contains many different ingredients like sophocarpine, matrine, oxymatrine, sophoridine, sophoramine, aloperine and cytosine, were able to protect colon against ulcers caused by 2,4,6-trinitrobenze sulphonic acid (tnbs)/ethanol treated models. in order to elucidate the mechanisms by which tasa exerts its effect of anti-inflammation and immunoregulation on rats with colitis, dai (disease activity in ... | 2010 | 20387224 |
| total alkaloids of sophora alopecuroides inhibit growth and induce apoptosis in human cervical tumor hela cells in vitro. | uygur females of xinjiang have the higher incidence of cervical tumor in the country. alkaloids are the major active ingredients in sophora alopecuroides, and its antitumor effect was recognized by the medical profession. xinjiang is the main site of s. alopecuroides production in china so these plants are abundant in the region. studies on the antitumor properties of total alkaloids of s. alopecuroides (tasa) can take full use of the traditional folk medicine in antitumor unique utility. | 2016 | 27279716 |
| [the antiarrhythmic effect of sophoramine]. | the effects of sophoramine on experimental arrhythmias in animals and its mechanisms were studied. sopaoramine is an alkaloid isolated from sophora alopecuroides l. the iv and ip ld50 of sophoramine in mice were found to be 74.90 +/- 17.86 and 106.15 +/- 1.05 mg/kg respectively. sophoramine showed significant effects on arrhythmias induced by aconitine, bacl2 and cacl2 in rats, chcl3 in mice and chcl3-adrenatine in rabbits. the ecg of anesthetized rats was significantly changed after intravenous ... | 1989 | 2801138 |
| antiprotozoal activity of medicinal plants against ichthyophthirius multifiliis in goldfish (carassius auratus). | ichthyophthiriasis is a widespread disease in aquaculture and causes mass mortalities of fish. the development of new antiprotozoal agents for the treatment of ichthyophthirius multifiliis infections is of increasing interest. the aim of the present study was to investigate the efficacy of 30 medicinal plants against i. multifiliis. the results showed that the methanol extracts of magnolia officinalis and sophora alopecuroides displayed the highest antiprotozoal activity against theronts, with 4 ... | 2012 | 22864919 |
| effects of total alkaloids of sophora alopecuroides on biofilm formation in staphylococcus epidermidis. | staphylococcus epidermidis (s. epidermidis) is an opportunistic pathogen with low pathogenicity and a cause of the repeated outbreak of bovine mastitis in veterinary clinical settings. in this report, a biofilm model of s. epidermidis was generated and the minimal inhibitory concentration (mic) and sub-mic (smic) on bacterial cultures were assessed for the following agents: total alkaloids of sophora alopecuroides (tasa), ciprofloxacin (cip), and erythromycin (ery). the formation and characteris ... | 2016 | 27413745 |
| interconverting flavonostilbenes with antibacterial activity from sophora alopecuroides. | five flavonostilbenes (alopecurones h, i, j, k and l) and five known ones were isolated from roots of sophora alopecuroides, in addition to ten other phenolic compounds. a non-enzymatic interconversion of the lavandulyl-substituted flavonostilbenes was observed among alopecurones a, h, i, and k through a wessely-moser rearrangement reaction; this was proven by 1d and 2d nmr, hplc-cd-pda and hrms analyses. bioassay results suggested that flavonostilbenes exhibit significant antibacterial and anti ... | 2015 | 25813880 |
| separation and enrichment of major quinolizidine type alkaloids from sophora alopecuroides using macroporous resins. | matrine (mt), oxymatrine (om) and sophoridine (sp) are three bioactive alkaloids in sophora alopecuroides. in the present study, the chromatographic characteristics of six widely used macroporous resins, namely nka, nka-9, hpd-100, hpd-722, hpd-750, and ab-8, respectively, towards the separation and enrichment of the three alkaloids from the aqueous extract of s. alopecuroides are critically evaluated. the results indicated that ab-8 resin offered the best absorption and desorption capacity and ... | 2014 | 24321756 |
| [response characteristics of the field-measured spectrum for the four general types of halophyte and species recognition in the northern slope area of tianshan mountain in xinjiang]. | based on the field-measured vis-nir reflectance of four common types of halophyte (achnatherum splendens(trin.) nevski, sophora alopecuroides l., camphorosma monspeliaca l. subsp. lessingii(l.)aellen, alhagi sparsifolia shap) within given spots in the northern slope area of tianshan mountain in xinjiang, the spectral response characteristics and species recognition of these types of halophyte were analyzed. the results showed that (alhagi sparsifolia shap) had higher chlorophyll and carotenoid b ... | 2011 | 22295790 |
| anti-helicobacter pylori effect of total alkaloids of sophora alopecuroides in vivo. | helicobacter pylori (h. pylori) infection could lead to most gastroduodenal diseases and is even identified as a carcinogen of gastric cancer. total alkaloids of sophora alopecuroides (tasa) is widely used in herbal remedies to treat various infectious diseases, including stomach-associated diseases. this study is aimed at evaluating the antimicrobial activity of tasa on h. pylori-infected balb/c mice mouse gastritis. | 2014 | 24985588 |
| oral sophocarpine protects rat heart against pressure overload-induced cardiac fibrosis. | sophocarpine, a tetracyclic quinolizidine alkaloid, is one of the most abundant active ingredients in sophora alopecuroides linn. (kudouzi). sophocarpine injection was found to have significant antiviral effects against coxsackievirus b3 and therapeutic effects for viral myocarditis in the clinic. | 2014 | 24618002 |