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antinephritis and radical scavenging activity of prenylflavonoids.antinephritis activity of 5 prenylflavonoids similar to glabridin (1-5), isolated from morus alba, artocarpus communis, glycyrrhiza uralensis and g. inflata, was evaluated in mice with glomerular disease (masugi-nephritis). oral administrations of artonin e (2) or licochalcone a (4) for 10 days (30 mg kg(-1) day(-1)) reduced the amount of urinary protein excretion compared to nephritic mice. esr spectroscopy demonstrated that morusin (1) and licorisoflavan a (5) increased the radical intensity o ...200314630182
[nutrition in french guiana; breeding of swine and raising of breadfruit]. 195513303493
new prenylflavonoids from artocarpus communis.five new prenylflavonoids, artocommunols ca (1), cb (2), cc (3), cd (4), and ce (5), were isolated from the cortex of the roots of artocarpus communis, along with the known compound cyclomorusin. the structures of 1-5 were determined by spectral methods.200312662107
population pressure on coral atolls: trends and approaching limits.trends and approaching limits of population pressure on coral atolls is discussed by examining the atoll environment in terms of the physical geography, the production systems, and resource distribution. atoll populations are grouped as dependent and independent, and demographic trends in population growth, migraiton, urbanization, and political dependency are reviewed. examination of the carrying capacity includes a dynamic model, the influences of the west, and philopsophical considerations. ...199012284705
a new dimeric dihydrochalcone and a new prenylated flavone from the bud covers of artocarpus altilis: potent inhibitors of cathepsin k.a meoh/ch(2)cl(2) extract of the bud covers of artocarpus altilis collected in micronesia showed activity in a cathepsin k inhibition assay. in addition to the three known flavonoids isolated from the bud covers of this species, two new compounds have been identified whose structures were determined on the basis of spectral data. these compounds include a dimeric dihydrochalcone, cycloaltilisin 6 (2), and a new prenylated flavone, cycloaltilisin 7 (3). novel compounds 2 and 3 have ic(50) values ...200211975520
urticaria and rhinitis to shrubs of ficus benjamina and breadfruit in a banana-allergic road worker: evidence for a cross-sensitization between moracea, banana and latex.we report the case of a road worker with a food allergy to banana, who developed urticaria and rhinitis when cutting shrubs of ficus benjamina and breadfruit. he did not develop an allergy to latex of hevea brasiliensis.200111435736
amino acid, fatty acid, and carbohydrate content of artocarpus altilis (breadfruit).a study is conducted to determine the amino acid, fatty acid, and carbohydrate content of breadfruit using high-performance liquid chromatography (hplc) and gas chromatography (gc). an hplc method is used for the determination of amino acids and fatty acids in breadfruit. representative amino acid samples are derivatized with phenylisothiocianate and the resulting phenylthiocarbamyl derivatives are separated on a reversed-phase column by gradient elution with a 0.05m ammonium acetate buffer and ...200111396689
effect of heat processing on in vitro protein digestibility and some chemical properties of african breadfruit (treculia africana decne) seeds.the effects of dry heat (roasting) and moist heat (boiling) on in vitro protein digestibility, protein fractions and other chemical properties of african breadfruit (treculia africana decne) seed that affect their utilization as a source of human food were investigated. chemical analyses showed that the crude protein and fat contents of the unprocessed (raw) seeds were 20. 1% and 13.7%, respectively. the level of phytic acid in the raw seed (1.19 mg/g) was lower than the levels found in some com ...200111318500
influence of ph and sodium chloride on selected functional and physical properties of african breadfruit (treculia africana decne) kernel flour.african breadfruit seeds were cleaned, parboiled (98 degrees c) for 15 min, drained and dehulled. the kernels were sun-dried, then milled and sieved into flour. nitrogen solubility (ns), water absorption capacity (wac), emulsion activity (ea), viscosity, foaming and emulsifying properties of the flour were determined as functions of ph and nacl concentration. the ns was ph dependent with a minimum at ph 4 and maximum at ph 10. the flour also exhibited minimum and maximum foam capacity at ph 4 an ...200111318499
chromosome numbers and pollen stainability of three species of pacific island breadfruit (artocarpus, moraceae).chromosome numbers were determined for 48 accessions of breadfruit (artocarpus altilis, a. mariannensis, and a. camansi [moraceae]) from 16 pacific island groups, indonesia, and the philippines: artocarpus camansi and a. mariannensis exhibit counts of 2n = 56; 2n = 56 (diploidy) and 2n = 84 (triploidy) were observed for a. altilis. most diploid cultivars of a. altilis were seeded, but two cultivars with reduced seed number were observed. micronesian accessions included putative interspecific hyb ...200111302856
alterations of igf-binding proteins in patients with alcoholic liver cirrhosis.the protein synthetic activity of the liver is diminished in cirrhosis. the aim of this study was to investigate possible changes in the serum igf-igfbp system among patients with alcoholic liver cirrhosis (alc). the results obtained demonstrated that serum igf-i and igf-ii concentrations were significantly lower in patients with alc than in healthy persons (p=0.0008 for igf-i and 0.0002 for igf-ii). the igfbp profile was markedly altered and the 34 kda igfbp from patients had higher affinity to ...200011091025
ethnomedicines used in trinidad and tobago for urinary problems and diabetes mellitus.this paper is based on ethnobotanical interviews conducted from 1996-2000 in trinidad and tobago with thirty male and female respondents.200617040567
compositional, functional and storage properties of flours from raw and heat processed african breadfruit (treculia africana decne) seeds.african breadfruit (treculia africana decne) seeds were either boiled or roasted and then milled into flour. chemical composition, functional properties and storage characteristics of raw and treated flours and the effect of partial proteolysis on selected functional properties of the raw flour were determined. raw flour contained 20.1% crude protein, 2.5% total ash and 13.7% fat. heat processing significantly (p < 0.05) improved in vitro protein digestibility, and water and fat absorption capac ...200011086878
production of african breadfruit (treculia africana) and soybean (glycine max) seed based food formulations, 2: effects of germination and fermentation on microbiological and physical properties.the effects of germination (g) and naturally fermented (f) on the bacterial flora, viscosities and moisture sorption isotherms of soybean (s) and african breadfruit (b) seed based food products were investigated. bacillus, enterobacter, enterobacteriaceae, proteus, serratia and staphylococcus species dominated in the nonfermented products. lactobacillus, leuconostoc, pediococcus and yeast species dominated in the fermented products whose gruels also inhibited growth of coagulase positive staphyl ...199910716402
production of african breadfruit (treculia africana) and soybean (glycine max) seed based food formulations, 1: effects of germination and fermentation on nutritional and organoleptic quality.germination and fermentation were investigated as methods of improving the nutritional and organoleptic properties of soybean and african breadfruit seed based food formulations. four products consisting of germinated-fermented soy-breadfruit seeds (gfsb), nongerminated-fermented soy-breadfruit seeds (ngfsb), germinated-nonfermented soy-breadfruit seeds (gnfsb) and nongerminated-nonfermented soy-breadfruit seeds (ngnfsb) were prepared. phytic acid contents, in vitro protein digestibilities, prot ...199910716401
proximate composition and selected functional properties of african breadfruit and sweet potato flour blends.full-fat african breadfruit flour was used to replace 30, 40, 50, 60 and 70% of sweet potato flour. the chemical composition and functional properties of composite flours showed that they contain more protein, fat, and ash and less carbohydrate than sweet potato flour. with increasing level of supplementation of breadfruit, ash, protein and fat contents increased while carbohydrate decreased. the composite flours possessed higher water absorption than sweet potato flour. the water absorption cap ...19979498694
oral allergy syndrome to a jackfruit (artocarpus integrifolia).a 30-year-old man from the philippines with pollen allergy noted the appearance of oral allergy syndrome (oas) after eating raw apple, raw peach, raw celery, and recently, jackfruit (artocarpus integrifolia), a tropical fruit which belongs to the moraceae family (mulberry) and to the genus artocarpus (breadfruit tree). despite the patient's multiple sensitization in skin prick tests and in the pharmacia cap system to birch, grass, mugwort pollen, related fruits and vegetables, and jackfruit, in ...19979188925
traps and baits for flies (diptera) on pacific islands.studies conducted on oahu, hi, and on islands of the kwajalein atoll, marshall islands, demonstrated that adult house flies, musca domestica l., were attracted to a mixture of cooked rice and chicken and to a commercial bait, whereas adults of chrysomya megacephala f. and musca sorbens wiedemann were attracted to shark fluids or to ripe breadfruit. m. domestica and m. sorbens could be captured in standard inverted-cone traps, whereas c. megacephala could be captured in traps fitted with horizont ...19947815393
studies on the baking properties of non-wheat flours--i. breadfruit (artocarpus artilis).the possibility of producing bread from wheat (wf)/breadfruit (bf), composite flour has been examined. wheat flour was supplemented with up to 50% breadfruit flour. chemical analysis of the breadfruit flour indicated a high starch content (80.9 +/- 0.9%), a fairly high crude fibre and ash contents (1.6 +/- 0.3; 4.2 +/- 0.3%) respectively and a low protein content (4.0 +/- 0.5%). brabender amylograph pasting viscosity of the various flour and flour blends indicated that apart from the 100% wf, 10 ...19957584166
falls from trees and tree associated injuries in rural melanesians.falls from trees and other tree related injuries are the most common cause of trauma in some parts of rural melanesia. a four year review of all admissions for trauma to the provincial hospital at alotau, milne bay province, papua new guinea, showed that 27% were due to falls from trees, and a further 10% were due to related injuries, such as being struck by a falling branch or a coconut. a questionnaire distributed to rural health centres showed that during the study period at least 28 villager ...19846440619
a new 5-lipoxygenase selective inhibitor derived from artocarpus communis strongly inhibits arachidonic acid-induced ear edema.natural compounds isolated from the indonesian plant, artocarpus communis, inhibit 5-lipoxygenase of cultured mastocytoma cells. one of five compounds, ac-5-1, strongly inhibits 5-lipoxygenase with a half-inhibition dose of 5 +/- 0.12 x 10(-8) m. however, prostaglandin synthesizing activity is not inhibited until 10(-5) m. ac-5-1 is a highly selective inhibitor for 5-lipoxygenase. the ac-5-1 at 10(-5) m inhibits 96% of leukotriene c4 synthesis of mouse peritoneal cells facilitated by calcium-ion ...19883132172
effect of alkaline treatment ('akanwu') and supplementary value of corn or crayfish on the protein quality of breadfruit (treculia africana).the effect of treatment and supplementary value of corn (c) or crayfish (cr) on the protein quality of breadfruit (treculia africana) flours were studied in eighteen young rats. the 70:30 or 70:15:15 (protein basis) combinations of breadfruit flours and corn or crayfish or both provided 1.6 g n/100 g diet for the 35 day study. the addition of 'akanwu' to the cooking water reduced cooking time and crude protein and saved fuel. the addition of 'akanwu' and replacement of cr with c was not benefici ...19902385577
structural and functional similarities of breadfruit seed lectin and jacalin.aquous extracts from seeds of artocarpus altilis (breadfruit) and artocarpus heterophyllus (jackfruit) were compared by polyacrylamide gel electrophoresis. two bands of the same size (12 and 15 kd) as the jacalin subunits were the major components in breadfruit seed extract. they strongly reacted with anti-jacalin antibodies by western blotting. the breadfruit lectin displayed the same igal and igd precipitation specificity as jacalin in gel double diffusion experiments. it also stimulated in vi ...19902111454
inactivation of strongyloides stercoralis filariform larvae in vitro by six jamaican plant extracts and three commercial anthelmintics.in vitro bioassay of (a) aqueous methanol extracts (ame) of the green leaves of mimosa (mimosa pudica), love weed (cuscuta americana), vervine (stachytarpheta jamaicensis), chicken weed (salvia serotina) and breadfruit (artocarpus altilis); (b) methanol-water fraction (mwf) of breadfruit leaves, and (c) commercially available drugs albendazole, thiabendazole and levamisole were assayed for nematode inactivating potential, using filariform larvae of strongyloides stercoralis. test larvae were obt ...19902082565
carbohydrate-rich foods: glycaemic indices and the effect of constituent macronutrients.the glycaemic index (gi) ranks foods according to their acute glycaemic impact and is used in planning meals for patients invoking glycaemic control through diet. kurakkan (eleusine coracana) flour roti, rice flour roti, atta flour roti, boiled breadfruit (artocarpus altilis/artocarpus communis) and boiled legumes (mungbean, cowpea and chickpea) were categorized as low-gi foods (relative to white bread; prima crust top), and the corresponding gi (+/- standard error of the mean) values were 70+/- ...200919418327
[the anticestodal activity of preparations made from the breadfruit].breadfruit tree (artocarpus tonkinensis) is used in laotian folk medicine for the treatment of taeniasis. breadfruit tree preparations impair in vitro the motility of the cestodes hymenolepis nana causing their motor excitation, contracture and death. the latter is observed when fairly high concentrations of the preparations (10(-2) = 2.10(-3)) are used. in mice experimentally invaded by h. nana it was shown that the water extraction of breadfruit tree substance is rather less effective than its ...19911758366
studies on weaning diets in nigeria: 2 protein sources.protein isolates were extracted from melon, groundnut, and soybean cakes in an aqueous system that could potentially yield both oil and protein from oilseeds quantitatively. protein isolates obtained were 91.2, 78.6 and 79.5% of the total protein content of melon, groundnut and soybean cakes respectively. both cakes and isolates were assessed in a rat bioassay while breadfruit, cassava, and corn starch were also investigated as sources of carbohydrate. results showed that there were no significa ...19921574484
factors to consider in micronesian food-based interventions: a case study of preventing vitamin a deficiency.many factors need to be considered in a food-based intervention. vitamin a deficiency and chronic diseases, such as diabetes, heart disease and cancer, have become serious problems in the federated states of micronesia (fsm) following the decreased production and consumption of locally grown foods. however, agricultural and social conditions are still favourable for local food production.200415153273
glycaemic index of selected staples commonly eaten in the caribbean and the effects of boiling v. crushing.integrating information about the glycaemic index (gi) of foods into the caribbean diet is limited by the lack of data. therefore, we determined the gi of eight staple foods eaten in the caribbean and the effect on gi of crushing selected tubers. groups of eight to ten healthy volunteers participated in three studies at two sites. gi was determined using a standard method with white bread and adjusted relative to glucose. the mean area under the glucose response curve elicited by white bread was ...200415182400
food of paradise: tahitian breadfruit and the autocritique of european consumption.in many ways, tahiti was central to european colonialism, for it was there that european visitors forged a model of primitive nature that served as a comparison to, and sometimes critique of, european civilization. tahiti was also the place from which a unique plant, the breadfruit, was brought to european colonies and to england and france during the late 18th century, at the behest of naturalists. with the breadfruit travelled contrasting perceptions of the tahitian way of life. the autocritiq ...200415183025
antiinflammatory flavonoids from artocarpus heterophyllus and artocarpus communis.the antiinflammatory activities of the isolated flavonoids, including cycloartomunin (1), cyclomorusin (2), dihydrocycloartomunin (3), dihydroisocycloartomunin (4), cudraflavone a (5), cyclocommunin (6), and artomunoxanthone (7), and cycloheterohyllin (8), artonins a (9) and b (10), artocarpanone (11), artocarpanone a (12), and heteroflavanones a (13), b (14), and c (15) from artocarpus communis and a. heterophyllus, were assessed in vitro by determining their inhibitory effects on the chemical ...200515884809
physicochemical properties of venezuelan breadfruit (artocarpus altilis) starch.artocarpus altilis, seedless variety, is a fruit-producing plant which is cultived in margarita island, venezuela, and is consumed by the inhabitants of the region. its chemical composition and physical characteristics were determined. the chemical (aoac and aacc methods), physicochemical, morphometric characteristics, viscoamylographic properties and digestibility in vitro of starch from artocarpus were studied. the starch yield was 18.5 g/100 g (dw)w with a purity of 98.86%, 27.68 and 72.32% o ...200415969272
structural characterization of novel chitin-binding lectins from the genus artocarpus and their antifungal activity.two novel chitin-binding lectins from seeds of artocarpus genus were described in this paper, one from a. integrifolia (jackfruit) and one from a. incisa (breadfruit). they were purified from saline crude extract of seeds using affinity chromatography on chitin column, size-exclusion chromatography and reverse-phase chromatography on the c-18 column. both are 14 kda proteins, made up of 3 chains linked by disulfide bonds. the partial amino acid sequences of the two lectins showed they are homolo ...200616257591
antiplatelet prenylflavonoids from artocarpus communis.four flavonoids, dihydroartomunoxanthone (1), artomunoisoxanthone (2), cyclocomunomethonol (3) and artomunoflavanone (4), together with three known compounds, artochamins b (5), d and artocommunol cc (6) were isolated from the cortex of the roots of artocarpus communis. the structures of 1-4 were determined by spectroscopic methods. the antiplatelet effects of the flavonoids, 1-3, 5 and 6 on human platelet-rich plasma (prp) were evaluated. of the compounds tested in human prp, compounds 1, 5 and ...200616516939
prenylated flavonoids from the heartwood of artocarpus communis with inhibitory activity on lipopolysaccharide-induced nitric oxide production.a new prenylated chalcone, 3' ',3' '-dimethylpyrano[3',4']2,4,2'-trihydroxychalcone (1), was isolated from the heartwood of artocarpus communis. two flavonoid derivatives, (-)-cycloartocarpin (9) and (-)-cudraflavone a (10), were isolated as new isomers. in addition, eight known flavonoids, isobacachalcone (2), morachalcone a (3), gemichalcones b (4) and c (5), artocarpin (6), cudraflavone c (7), licoflavone c (8), and (2s)-euchrenone a(7) (11), were isolated and identified from this plant for t ...200616643064
food processing methods influence the glycaemic indices of some commonly eaten west indian carbohydrate-rich foods.glycaemic index (gi) values for fourteen commonly eaten carbohydrate-rich foods processed by various methods were determined using ten healthy subjects. the foods studied were round leaf yellow yam (dioscorea cayenensis), negro and lucea yams (dioscorea rotundata), white and sweet yams (dioscorea alata), sweet potato (solanum tuberosum), irish potato (ipomoea batatas), coco yam (xanthosoma spp.), dasheen (colocasia esculenta), pumpkin (cucurbita moschata), breadfruit (artocarpus altilis), green ...200616925852
bioassay-guided isolation of antiatherosclerotic phytochemicals from artocarpus altilis.the cytoprotective effects of various solvent extracts of artocarpus altilis (parkinson) fosberg were evaluated. the cytoprotective effects were determined in human u937 cells incubated with oxidized ldl (oxldl) using the 4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2h-5-tetrazolio]-1, 3-benzene disulfonate (wst-1) assay. the results demonstrated that the ethyl acetate extract showed cytoprotective activities. to identify the main cytoprotective components, a bioassay guided isolation of the ethyl acet ...200617006973
Cytotoxic Effects of Native and Recombinant Frutalin, a Plant Galactose-Binding Lectin, on HeLa Cervical Cancer Cells.Frutalin is the a-D-galactose-binding lectin isolated from breadfruit seeds. Frutalin was obtained from two different sources: native frutalin was purified from its natural origin, and recombinant frutalin was produced and purified from Pichia pastoris. This work aimed to study and compare the effect of native and recombinant frutalin on HeLa cervical cancer cells proliferation and apoptosis. Furthermore, the interaction between frutalin and the HeLa cells was investigated by confocal microscopy ...201122131813
geranyl flavonoids from the leaves of artocarpus altilis.five geranyl dihydrochalcones, 1-(2,4-dihydroxyphenyl)-3-{4-hydroxy-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6h-dibenzo[b,d]pyran-5-yl}-1-propanone (2), 1-(2,4-dihydroxyphenyl)-3-[3,4-dihydro-3,8-dihydroxy-2-methyl-2-(4-methyl-3-pentenyl)-2h-1-benzopyran-5-yl]-1-propanone (4), 1-(2,4-dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(3,4-epoxy-4-methyl-1-pentenyl)-2h-1-benzopyran-5-yl]-1-propanone (5), 1-(2,4-dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(4-hydroxy-4-methyl-2-pentenyl)-2h-1-benzopyran-5-yl]-1-pr ...200717363017
two-dimensional counter-current chromatography for the preparative separation of prenylflavonoids from artocarpus altilis.a two-dimensional counter-current chromatographic system (2d-ccc) for preparative isolation and purification of three prenylflavonoids from artocarpus altilis is presented. an upright ccc instrument (ccc1, total capacity: 1600 ml) was used as the first dimension. effluent of interest from ccc1 was collected on-line into a 30 ml sample loop by a laboratory-prepared column-switching interface and introduced into a high-speed ccc instrument (ccc2, total capacity: 210 ml) for the second dimension se ...200717376457
in vitro conservation and sustained production of breadfruit (artocarpus altilis, moraceae): modern technologies for a traditional tropical crop.breadfruit (artocarpus altilis, moraceae) is a traditionally cultivated, high-energy, high-yield crop, but widespread use of the plant for food is limited by poor quality and poor storage properties of the fruit. a unique field genebank of breadfruit species and cultivars exists at the national tropical botanical garden in the hawaiian islands and is an important global resource for conservation and sustainable use of breadfruit. however, this plant collection could be damaged by a random natura ...200817710379
effect of hormone on root formation in artocarpus communis. 194817749206
the name of the breadfruit. 190317757657
breadfruit in the marquesas. 192417801245
isolation and identification of mosquito (aedes aegypti ) biting deterrent fatty acids from male inflorescences of breadfruit (artocarpus altilis (parkinson) fosberg).dried male inflorescences of breadfruit ( artocarpus altilis , moraceae) are burned in communities throughout oceania to repel flying insects, including mosquitoes. this study was conducted to identify chemicals responsible for mosquito deterrence. various crude extracts were evaluated, and the most active, the hydrodistillate, was used for bioassay-guided fractionation. the hydrodistillate and all fractions displayed significant deterrent activity. exploratory gc-ms analysis revealed more than ...201222420541
hyperglycaemic effect of artocarpus communis forst (moraceae) root bark aqueous extract in wistar rats.decoctions and infusions of artocarpus communis (forst) (family: moraceae) root bark are traditionally used among the yoruba-speaking people of western nigeria as folk remedies for the management, control and treatment of an array of human diseases, including type 2 diabetes mellitus. although numerous bioactive prenylflavonoids have been isolated from the roots, stem bark and leaves of a communis, to the best of our knowledge, the effects of the plant's root bark extract on animal models of dia ...200717940666
[effect of acetylation and oxidation on some properties of breadfruit (artocarpus altilis) seed starch].starch extracted from seeds of artocarpus altilis (breadfruit) was chemically modified by acetylation and oxidation, and its functional properties were evaluated and compared with these of native starch. analysis of the chemical composition showed that moisture content was higher for modified starches. ash, protein, crude fiber and amylose contents were reduced by the modifications, but did not alter the native starch granules' irregularity, oval shape and smooth surface. acetylation produced ch ...200718271408
evaluation of the effect of thai breadfruit's heartwood extract on melanogenesis-inhibitory and antioxidation activities.the aim of this study was to clarify the melanogenesis-inhibitory and antioxidant activity of thai breadfruit's heartwood extract for application as a skin-lightening agent. the heartwood of breadfruit (artocarpus incisus ) grown in phitsanulok province, thailand, was extracted by using diethyl ether or methanol. the amount of artocarpin, a major component of a. incisus extract, was determined by using the hplc method. the artocarpin content found in ether extract was 45.19 +/- 0.45% w/w, wherea ...200818350234
sea-level-rise disaster in micronesia: sentinel event for climate change?to describe the impact of an acute-onset sea-level-rise disaster in 2 coral atoll populations and to generate hypotheses for further investigation of the association between climate change and public health.201020389200
prenylated flavones from artocarpus altilis.six prenylated flavones, including one new compound, were isolated and identified from the stem bark extracts of artocarpus altilis. the new prenylated flavone hydroxyartocarpin (1) was characterized as 3-(gamma,gamma-dimethylallyl)-6-isopentenyl-5,8,2',4'-tetrahydroxy-7-methoxyflavone and the known compounds were artocarpin (2), morusin (3), cycloartobiloxanthone (4), cycloartocarpin a (5) and artoindonesianin v (6). the structures of the compounds were determined by spectroscopic methods (ir, ...201020526745
evaluation of the effect of thai breadfruit's heartwood extract on the biological functions of fibroblasts from wrinkles.in previous studies, extract from artocarpus incisus's heartwood (breadfruit tree) had antioxidant and antimelanogenic activities. here, we investigated the extract's action on facial skin fibroblasts from wrinkled skin and nonwrinkled skin biopsies, particularly in the production of type i procollagen and metalloproteinase- 1 (mmp-1) and in the reorganization of collagen fibers. we found that the extract at a concentration of 50 microg/ml significantly enhanced percent viability and proliferati ...201020716439
new development and validation of 50 ssr markers in breadfruit (artocarpus altilis, moraceae) by next-generation sequencing.using next-generation sequencing technology, new microsatellite loci were characterized in artocarpus altilis (moraceae) and two congeners to increase the number of available markers for genotyping breadfruit cultivars.201627610273
low-coverage, whole-genome sequencing of artocarpus camansi (moraceae) for phylogenetic marker development and gene discovery.we used moderately low-coverage (17×) whole-genome sequencing of artocarpus camansi (moraceae) to develop genomic resources for artocarpus and moraceae.201627437173
rheological, baking, and sensory properties of composite bread dough with breadfruit (artocarpus communis forst) and wheat flours.the rheological (pasting, farinograph, and alveograph) properties of wheat flour (wf) replaced with breadfruit four (05-40%) was analyzed. baking and sensory qualities of the resulting bread were evaluated. differences in baking properties of loaves produced under laboratory and industrial conditions were analyzed with t-test, whereas anova was used for other analyses. peak and final viscosities in the composite blends (cb) ranged from 109.20 to 114.06 rvu and 111.86 to 134.40 rvu, respectively. ...201627386107
modulatory effects of methanol extract of artocarpus altilis (moraceae) on cadmium-induced hepatic and renal toxicity in male wistar rats.cadmium (cd) is an environmental risk factor with an established toxicity in animals. therefore, natural antioxidants may be protective against cd-toxicity. the study was designed to investigate the modulatory effects of methanol extract of artocarpus altilis (aa) on oxidant-antioxidant balance and lipid profile in liver and kidney of cd-exposed rats while quercetin (qe) served as standard.201626905312
evaluation of a "traditional food for health" intervention in pohnpei, federated states of micronesia.federated states of micronesia (fsm) faces increasing rates of non-communicable diseases related to the neglect of the traditional food system and the shift to consumption of imported food and adoption of sedentary lifestyles. to reverse this trend, a two-year, food-based intervention in one pohnpeian community in fsm promoted local food production and consumption using a variety of approaches including education, training, agriculture and social marketing following a "go local" message. foods p ...201020968237
anti-inflammatory effect of the 5,7,4'-trihydroxy-6-geranylflavanone isolated from the fruit of artocarpus communis in s100b-induced human monocytes.the fruit of artocarpus communis moraceae, a traditional starch crop, is a rich source of phytochemicals, such as flavonoids and their derivatives. the aim of this study was to investigate whether 5,7,4'-trihydroxy-6-geranylflavanone (ac-gf), a geranyl flavonoid derivative isolated from the fruits of a. communis, could decrease the activation of inflammatory mediators induced by s100b (ligand of receptor for advanced glycation end products, rage) in thp-1 monocytes. according to the results, low ...201021126004
thermal and rheological properties of breadfruit starch.the thermal and rheological properties of breadfruit starch were studied using dsc and 2 different rheometers. it was found that the gelatinization temperature of starch with excess moisture content (>70%) was at approximately 75 °c. a new endotherm was detected at about 173 °c when the moisture content was lower than required for full gelatinization of the starch. a detailed examination revealed that this endotherm represented the melting of amylose-lipid complexes. breadfruit starch paste exhi ...201121535676
antimicrobial activities of the methanol extract and compounds from artocarpus communis (moraceae).abstract: background: artocarpus communis is used traditionally in cameroon to treat several ailments, including infectious and associated diseases. this work was therefore designed to investigate the antimicrobial activities of the methanol extract (acb) and compounds isolated from the bark of this plant, namely peruvianursenyl acetate c (1), alpha-amyrenol or viminalol (2), artonin e (4) and 2-[(3,5-dihydroxy)-(z)-4-(3-methylbut-1-enyl)phenyl]benzofuran-6-ol (5). methods: the liquid microdilut ...201121612612
prenylated dihydrochalcones from artocarpus altilis as antiausterity agents.human pancreatic cancer cell lines have remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. a novel antiausterity strategy in anticancer drug discovery led to the discovery of agents that preferentially inhibit the survival of cancer cells under low nutrient conditions. artocarpus altilis (family: moraceae) is commonly referred to as breadfruit, traditionally for the treatment of many diseases. many prenylated flavonoid and prenylated chalo ...201526298457
protective effects of artocarpus altilis (moraceae) on cadmium-induced changes in sperm characteristics and testicular oxidative damage in rats.cadmium (cd) is a major environmental toxicant and an endocrine disruptor. we investigated the protective effects of methanol extract of artocarpus altilis (aa) against cd-induced testicular damage in rats while quercetin (que) served as standard. the total flavonoids and phenolic contents (tfc and tpc), 2, 2-diphenyl-1-picrylhydrazyl (dpph) and hydroxyl (oh) radicals scavenging activities of aa were determined. in vivo, thirty male wistar rats were assigned to six groups and orally treated with ...201625912632
complex origins of breadfruit (artocarpus altilis, moraceae): implications for human migrations in oceania.breadfruit (artocarpus altilis, moraceae), a traditional starch crop in oceania, has enjoyed legendary status ever since its role in the infamous mutiny aboard the h.m.s. bounty in 1789, yet its origins remain unclear. breadfruit's closest relatives are a. camansi and a. mariannensis. dna fingerprinting data (aflp, amplified fragment length polymorphisms) from over 200 breadfruit cultivars, 30 a. camansi, and 24 a. mariannensis individuals were used to investigate the relationships among these s ...200421653430
hemostatic potential of latex proteases from tabernaemontana divaricata (l.) r. br. ex. roem. and schult. and artocarpus altilis (parkinson ex. f.a. zorn) forsberg.pharmacological properties exhibited by latex of plants are due to various biologically active compounds including several proteolytic enzymes. present study evaluates hemostatic potential of tabernaemontana divaricata and artocarpus altilis from apocynaceae and moraceae families respectively. the latex of these plants were initially subjected to dialysis and crude extracts were estimated for proteolytic activity using casein as the substrate. mean caseinolytic activity for 100 μg of latex prote ...201525603786
breadfruit (artocarpus altilis): a source of high-quality protein for food security and novel food products.protein deficiency has been observed as a leading cause of malnutrition and child death in the tropics. the current study evaluated the protein quality of 49 important breadfruit cultivars (41 artocarpus altilis and 8 hybrids of a. altilis × a. mariannensis). while significant differences were found between cultivars, all varieties contained a full spectrum of the essential amino acids and are especially rich in phenylalanine, leucine, isoleucine, and valine. the cultivar ma'afala contained sign ...201525588988
Mutualism breakdown in breadfruit domestication.During the process of plant domestication, below-ground communities are rarely considered. Some studies have attempted to understand the changes in root symbionts owing to domestication, but little is known about how it influences mycorrhizal response in domesticated crops. We hypothesized that selection for above-ground traits may also result in decreased mycorrhizal abundance in roots. Breadfruit (Artocarpus sp.) has a long domestication history, with a strong geographical movement of cultivar ...201121920983
flow injection assessment of nitrate contents in fresh and cooked fruits and vegetables grown in fiji.nitrates form part of the essential chemistry of soils and plants. thus, plant roots are able to absorb nitrate directly from the soil. it has been discovered that human nitrate intake is mainly from vegetables. vegetables play an important role in human nutrition since they are an outstanding source for vitamins, minerals, and biologically active compounds. in risk assessment of nitrate contents, this study reports the nitrate levels of 8 commonly consumed fruits and vegetables grown in fiji, t ...201122417577
two jacalin-related lectins from seeds of the african breadfruit (treculia africana l.).two jacalin-related lectins (jrls) were purified by mannose-agarose and melibiose-agarose from seeds of treculia africana. one is galactose-recognizing jrl (gjrl), named t. africana agglutinin-g (taa-g), and another one is mannose-recognizing jrl (mjrl), taa-m. the yields of the two lectins from the seed flour were approximately 7.0 mg/g for gjrl and 7.2 mg/g for mjrl. the primary structure of taa-g was determined by protein sequencing of lysyl endopeptic peptides and chymotryptic peptides. the ...201425155899
adaptation and evaluation of the willtry tool among children in guam.fruit and vegetable consumption may reduce risk for chronic disease and obesity. children's fruit and vegetable intake is mediated by a preference or willingness to try them. this study's primary objective was to adapt the previously validated willtry tool and to evaluate the adapted version among children in guam.201425144677
evaluation of antioxidant, total phenol and flavonoid content and antimicrobial activities of artocarpus altilis (breadfruit) of underutilized tropical fruit extracts.artocarpus altilis (breadfruit) pulp, peel and whole fruit were extracted with various solvents such as hexane, dichloromethane (dcm) and methanol. the antioxidant activity of these extracts were examined using the stable 2,2-diphenyl-1-picrylhydrazyl (dpph) radical scavenging test. ic50 was 55 ± 5.89 μg/ml for the pulp part of methanol extract. in the β-carotene bleaching assay, the antioxidant activity was 90.02 ± 1.51 % for the positive control (trolox) and 88.34 ± 1.31 % for the pulp part of ...201525649443
recombinant production of plant lectins in microbial systems for biomedical application - the frutalin case study.frutalin is a homotetrameric partly glycosylated α-d-galactose-binding lectin of biomedical interest from artocarpus incisa (breadfruit) seeds, belonging to the jacalin-related lectins family. as other plant lectins, frutalin is a heterogeneous mixture of several isoforms possibly with distinct biological activities. the main problem of using such lectins as biomedical tools is that "batch-to-batch" variation in isoforms content may lead to inconstant results. the production of lectins by recomb ...201425152749
fermentation by amylolytic lactic acid bacteria and consequences for starch digestibility of plantain, breadfruit, and sweet potato flours.the potential of tropical starchy plants such as plantain (musa paradisiaca), breadfruit (artocarpus communis), and sweet potato (ipomoea batatas) for the development of new fermented foods was investigated by exploiting the capacity of some lactic acid bacteria to hydrolyze starch. the amylolytic lactic acid bacteria (alab) lactobacillus plantarum a6 and lactobacillus fermentum ogi e1 were able to change the consistency of thick sticky gelatinized slurries of these starchy fruits and tubers int ...201222860595
in vivo antiplasmodial potentials of the combinations of four nigerian antimalarial plants.various combinations of nauclea latifolia root, artocarpus altilis stem bark, murraya koenigii leaf and enantia chlorantha stem bark used in african ethnomedicine as decoctions for malaria and fevers, and combinations with standard drugs, were investigated for antiplasmodial activities using plasmodium berghei berghei-infected mice. the respective prophylactic and curative ed50 values of 189.4 and 174.5 mg/kg for n. latifolia and chemosuppressive ed50 value of 227.2 mg/kg for a. altilis showed t ...201425162955
expression of frutalin, an alpha-d-galactose-binding jacalin-related lectin, in the yeast pichia pastoris.frutalin is an alpha-d-galactose-binding lectin expressed in breadfruit seeds. its isolation from plant is time-consuming and results in a heterogeneous mixture of different lectin isoforms. in order to improve and facilitate the availability of the breadfruit lectin, we cloned an optimised codifying frutalin mature sequence into the ppiczalphaa expression vector. this expression vector, designed for protein expression in the methylotrophic yeast pichia pastoris, contains the saccharomyces alpha ...200818534865
cytotoxic effects of new geranyl chalcone derivatives isolated from the leaves of artocarpus communis in sw 872 human liposarcoma cells.breadfruit (artocarpus communis moraceae) is cultivated in tropical and subtropical regions as a traditional starch crop and also has potential medicinal properties. the aim of this work was to study the in vitro anticancer activity of compounds isolated from the leaves of artocarpus communis. three new geranyl chalcone derivatives including isolespeol (1), 5'-geranyl-2',4',4-trihydroxychalcone (2), and 3,4,2',4'-tetrahydroxy-3'-geranyldihydrochalcone (3), together with two known compounds lespe ...200818767861
diet and social status on taumako, a polynesian outlier in the southeastern solomon islands.stable isotopes (δ(13)c, δ(15)n, and δ(34)s) are used to characterize the diet of the adult individuals (n = 99) interred in the namu burial ground located on the polynesian outlier of taumako (∼300-750 bp). polynesian outliers are islands on the fringe of remote oceania that were inhabited by a back migration of populations from polynesia during prehistory. as a result of admixture with nearby island communities, little is known about the social structure and social diversity of the prehistoric ...201323868172
development of microsatellite loci in artocarpus altilis (moraceae) and cross-amplification in congeneric species. 201325202565
identification of cytotoxic compound from artocarpus communis leaves against p-388 cells.in the course of continuing research for finding bioactive compounds from indonesian plants, the leaves of artocarpus communis was extracted by ethanol. this extract partitioned with n-hexane-water (1:4) and then water extract was partitioned with dichloromethane. dichloromethane extract was purified by column chromatography techniques on silica gel to afford yellow crystal (f-1). based on lc-ms, 1h-nmr and 13c-nmr (1d and 2d) spectra and compared with previous spectral data, it was identified a ...200819205275
cdna cloning and functional expression of the alpha-d-galactose-binding lectin frutalin in escherichia coli.cdna clones encoding frutalin, the alpha-d-galactose-binding lectin expressed in breadfruit seeds (artocarpus incisa), were isolated and sequenced. the deduced amino acid sequences indicated that frutalin may be encoded by a family of genes. the ncbi database searches revealed that the frutalin sequence is highly homologous with jacalin and mornigag sequences. frutalin cdna was re-amplified and cloned into the commercial expression vector pet-25b(+) for frutalin production in escherichia coli. a ...200919521795
hypoglycemic effect of treculia africana decne root bark in normal and alloxan-induced diabetic rats.the solvent partitioned purified fractions of the hydro-acetone root bark extract of the african breadfruit (treculia africana decne) were evaluated for hypoglycemic activities in normal and diabetic albino rats. fasting blood glucose levels were estimated by the use of a glucometer at pre-determined intervals after oral administration of the test extracts/fractions. results revealed that the test fractions have only a slight effect on blood sugar level of normal rats. on short term and chronic ...200720161906
artocarpus communis forst. root-bark aqueous extract- and streptozotocin-induced ultrastructural and metabolic changes in hepatic tissues of wistar rats.decoctions and infusions of artocarpus communis (forst.) (family: moraceae) root-bark are commonly used traditionally among the yoruba-speaking people of western nigeria as folk remedies for the management, control and/or treatment of an array of human diseases, including type 2, adult-onset diabetes mellitus. although numerous bioactive flavonoids have been isolated from the roots, stem-bark and leaves of a. communis, to the best of our knowledge, the effects of the plant's root-bark extract on ...200720161908
effect of heat-moisture treatment on multi-scale structures and physicochemical properties of breadfruit starch.breadfruit starch was subjected to heat-moisture treatment (hmt) at different moisture content (mc). hmt did not apparently change the starch granule morphology but decreased the molecular weight and increased the amylose content. with increased mc, hmt transformed the crystalline structure (b→a+b→a) and decreased the relative crystallinity. with ≥25% mc, the scattering peak at ca. 0.6nm(-1) disappeared, suggesting the lamellar structure was damaged. compared with native starch, hmt-modified sam ...201728189241
out of borneo: biogeography, phylogeny and divergence date estimates of artocarpus (moraceae).the breadfruit genus ( artocarpus , moraceae) includes valuable underutilized fruit tree crops with a centre of diversity in southeast asia. it belongs to the monophyletic tribe artocarpeae, whose only other members include two small neotropical genera. this study aimed to reconstruct the phylogeny, estimate divergence dates and infer ancestral ranges of artocarpeae, especially artocarpus , to better understand spatial and temporal evolutionary relationships and dispersal patterns in a geologica ...201728073771
breadfruit (artocarpus altilis) gibberellin 2-oxidase genes in stem elongation and abiotic stress response.breadfruit (artocarpus altilis) is a traditional staple tree crop in the oceania. susceptibility to windstorm damage is a primary constraint on breadfruit cultivation. significant tree loss due to intense tropical windstorm in the past decades has driven a widespread interest in developing breadfruit with dwarf stature. gibberellin (ga) is one of the most important determinants of plant height. ga 2-oxidase is a key enzyme regulating the flux of ga through deactivating biologically active gas in ...201626646240
artocarpus altilis cg-901 alters critical nodes in the jh1-kinase domain of janus kinase 2 affecting upstream jak/stat3 signaling.as a key step in achieving low-cost, easily accessible anti-cancer therapy for low- and middle-income countries, we recently established the scientific basis for the folkloric use of artocarpus altilis for the treatment of cancer by investigating the geranyl dihydrochalcone (cg-901) content and its interference with signal transducer and activator of transcription 3 (stat3) phosphorylation and blockage of further downstream signaling. in the current study, the cg-901 upstream target was queried ...201526442513
chloroplast microsatellite markers for artocarpus (moraceae) developed from transcriptome sequences.chloroplast microsatellite loci were characterized from transcriptomes of artocarpus altilis (breadfruit) and a. camansi (breadnut). they were tested in a. odoratissimus (terap) and a. altilis and evaluated in silico for two congeners.201526421253
artocarpus altilis heartwood extract protects skin against uvb in vitro and in vivo.artocarpus altilis (moreceae) has been widely used as a traditional folk medicine in southeast asia for the treatment of many diseases, including skin disorders, such as ulcers and dermatitis.201526387741
artocarpus altilis (parkinson) fosberg extracts and geranyl dihydrochalcone inhibit stat3 activity in prostate cancer du145 cells.artocarpus altilis (parkinson) fosberg has traditionally been used in indonesia for the treatment of liver cirrhosis, hypertension, and diabetes. in many other countries, it is used for the treatment of malaria, yellow fever, and dengue fever. it has been reported that a. altilis extracts have antiatherosclerotic and cytoprotective effects, but its molecular targets in tumor cells are not yet fully understood. the a. altilis extracts and the partially purified fraction have been shown to inhibit ...201525682949
phytochemical screening and evaluation of in vitro angiotensin-converting enzyme inhibitory activity of artocarpus altilis leaf.this study investigates the effect of artocarpus altilis leaf extracts on angiotensin-converting enzyme (ace) activity. among the extracts tested, hot ethanol extract exhibited a potent ace-inhibitory activity with an ic(50) value of 54.08?±?0.29?µg?ml(-1) followed by cold ethyl acetate extract (ic(50) of 85.44?±?0.85?µg?ml(-1)). in contrast, the hot aqueous extracts showed minimum inhibition with the ic(50) value of 765.52?±?11.97?µg?ml(-1) at the maximum concentration tested. further, the phyt ...201121756104
enhancing adsorption capacity of toxic malachite green dye through chemically modified breadnut peel: equilibrium, thermodynamics, kinetics and regeneration studies.breadnut skin, in both its unmodified (ks) and base-modified (bm-ks) forms, was investigated for its potential use as a low-cost adsorbent for the removal of toxic dye, malachite green (mg). characterization of the adsorbents was carried out using scanning electron microscope, x-ray fluorescence and fourier transform infra-red spectroscopy. batch adsorption experiments, carried out under optimized conditions, for the adsorption of mg were fitted using five isotherm models (langmuir, freundlich, ...201425409587
in vitro studies to assess the antioxidative, radical scavenging and arginase inhibitory potentials of extracts from artocarpus altilis, ficus exasperate and kigelia africana.to justify the use of artocarpus altilis (a. altilis), ficus exasperata (f. exasperata) and kigelia africana (k. africana) in ethnomedicine for the treatment of several ailments and to evaluate the in vitro antioxidant, radical scavenging and arginase inhibitory potentials of these herbs and compared with catechin (standard).201425183137
safety evaluation of artocarpus altilis as pharmaceutical agent in wistar rats.this study was designed to elucidate the acute toxicity of artocarpus altilis leaf and bark extracts. in acute toxicity study, no mortality or any toxic reaction was recorded in any group after 14 days of administering the extracts (2000 mg kg(-1) bw). the extracts (ala, aba, alm, and abm) did not cause any behavioural or physical changes in experimental rats. there was no significant (p ≤ 0.05) difference in the biochemical parameters analysed between the groups. slight elevation in activities ...201424803928
effects of methanol extract of breadfruit (artocarpus altilis) on atherogenic indices and redox status of cellular system of hypercholesterolemic male rats.we investigated the effects of methanol extract of artocarpus altilis (aa) on atherogenic indices and redox status of cellular system of rats fed with dietary cholesterol while questran (que) served as standard. biochemical indices such as total cholesterol (tc), triglycerides (tg), low- and high-density lipoproteins-cholesterol (ldl-c and hdl-c), aspartate and alanine aminotransferases (ast and alt), lactate dehydrogenase (ldh), reduced glutathione, glutathione-s-transferase, glutathione peroxi ...201424592277
geranyl dihydrochalcones from artocarpus altilis and their antiausteric activity.human pancreatic cancer cell lines have remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. the search for agents that preferentially inhibit the survival of cancer cells under low nutrient conditions is a novel antiausterity strategy in anticancer drug discovery. in this study, the methanolic extract of the leaves of artocarpus altilis showed 100 % preferential cytotoxicity against panc-1 human pancreatic cancer cells under nutrient-depriv ...201424431013
taxonomy, distribution, and natural history of flying foxes (chiroptera, pteropodidae) in the mortlock islands and chuuk state, caroline islands.the taxonomy, biology, and population status of flying foxes (pteropus spp.) remain little investigated in the caroline islands, micronesia, where multiple endemic taxa occur. our study evaluated the taxonomic relationships between the flying foxes of the mortlock islands (a subgroup of the carolines) and two closely related taxa from elsewhere in the region, and involved the first ever field study of the mortlock population. through a review of historical literature, the name pteropus pelagicus ...201324194666
food security. botanists spread the gospel that breadfruit can be manna. 201324136946
dietary intake of boiled breadfruit (treculia africana) seeds did not improve hyperglycemia in streptozotocin induced diabetic rats: effect on the oral glucose tolerance of normoglycemic rats.although african breadfruit (treculia africana) is said to be useful in the dietary management of diabetes, the effect of cooking on its glycemic index has not been reported. hence this study has investi- gated the effect of a dietary intake of boiled breadfruit on the serum glucose, glucose tolerance, body weights and relative organ weights of streptozotocin (stz) induced diabetic rats.201728362476
aqueous extract from leaf of artocarpus altilis provides cardio-protection from isoproterenol induced myocardial damage in rats: negative chronotropic and inotropic effects.the leaves of artocarpus altilis (parkinson ex f.a.zorn, fosberg) (moraceae) are used in the management of hypertension; this study assessed the cardio-protective effects of the leaf extract on isoproterenol (iso) induced myocardial damage in rats.201728342858
n-hexane insoluble fraction of plantago lanceolata exerts anti-inflammatory activity in mice by inhibiting cyclooxygenase-2 and reducing chemokines levels.inflammation is involved in the progression of many disorders, such as tumors, arthritis, gastritis, and atherosclerosis. thus, the development of new agents targeting inflammation is still challenging. medicinal plants have been used traditionally to treat various diseases including inflammation. a previous study has indicated that dichloromethane extract of p. lanceolata leaves exerts anti-inflammatory activity in an in vitro model. here, we examined the in vivo anti-inflammatory activities of ...201728335408
preparation of a breadfruit flour bar.breadfruit is a nutritious, high energy food with a low quantity of protein but excellent protein quality. it has the potential to be developed into desired products which will help increase its utilization and add value to the crop. the overall purposes of this investigation were to develop a portable, nutritious, ready-to-eat breadfruit product (bar), test the sensory qualities of the product, and evaluate the nutritional properties of the product. flour made from the micronesian variety, mein ...201628231132
the preventive role of breadfruit against inflammation-associated epithelial carcinogenesis in mice.artocarpus communis has been identified as a rich source of flavonoids and has been gaining attention for its potential chemopreventive abilities. in this study, methanol extracts from the fruit of a. communis (mefa) and leaf of a. communis (mela) were prepared, and their effects on inflammation-associated skin tumorigenesis were assessed using mouse models, including 12-o-tetradecanoylphorbol-13-acetate (tpa) induced cutaneous inflammation as well as 7,12-dimethylbenz[α]anthracene (dmba) initia ...201423983093
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