| ixeris dentata green sap inhibits both compound 48/80-induced aanaphylaxis-like response and ige-mediated anaphylactic response in murine model. | we studied the inhibitory effect of the green sap of ixeris dentata (ixd) on compound 48/80-induced anaphylaxis-like response in a murine model. ixd dose-dependently inhibited the anaphylaxis-like response induced by compound 48/80 in mice. ixd inhibited the anaphylaxis-like fatal response at the dose of 0.1 g/kg by 75%. ixd had a significant inhibitory effect on compound 48/80-induced ear swelling response at the doses of 0.05 and 0.1 g/kg. ixd (0.1 g/kg) also inhibited passive cutaneous anaphy ... | 2002 | 11824556 |
| nitric oxide and tumor necrosis factor-alpha production by ixeris dentata in mouse peritoneal macrophages. | using mouse peritoneal macrophages, we have examined the mechanism by which ixeris dentata (ixd) regulates nitric oxide (no) production. when ixd was used in combination with recombinant interferon-gamma (rifn-gamma), there was a marked cooperative induction of no production. however, ixd had no effect on no production by itself. the increased production of no from rifn-gamma plus ixd-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine dithiocarbamate (pdtc), an in ... | 2002 | 12241998 |
| ixeris dentata extract maintains glutathione concentrations in mouse brain tissue under oxidative stress induced by kainic acid. | the neuroprotective effects of a water fraction from the methanol extract of ixeris dentata (wfid) against oxidative stress in the brain of mice challenged with kainic acid were examined by evaluating behavioral characteristics and biochemical parameters of oxidative stress. male icr mice were divided into three groups: a control group that received no treatment and two groups challenged with kainic acid either with or without wfid (1.0 g/kg) for 4 consecutive days. on day 3 kainic acid (50 mg/k ... | 2003 | 14977444 |
| point mutation of (+)-germacrene a synthase from ixeris dentata. | sesquiterpene cyclases catalyze the conversion of common precursor, farnesyl pyrophosphate, into various terpene backbones. x-ray crystallography of tobacco epi-aristolochene synthase has previously proposed a cyclization mechanism wherein the allylic carbocation intermediate is stabilized by the main chain carbonyl oxygens of three consecutive threonine residues. alignment of amino acid sequences of plant terpene cyclases shows that the first position of the triad is almost invariably threonine ... | 2005 | 15834787 |
| cytotoxic and acat-inhibitory sesquiterpene lactones from the root of ixeris dentata forma albiflora. | ixeris dentata forma albiflora was extracted with 80% aqueous meoh, and the concentrated extract was partitioned with etoac, n-buoh and h2o. eight sesquiterpenes were isolated through repeated silica gel and octadecyl silica gel (c18, ods) column chromatography of the etoac and n-buoh fractions. physicochemical analysis using nmr, ms and ir revealed the chemical structures of the sesquiterpenes, which were zaluzanin (1), 9a-hydroxyguaian-4(15),10(14),11(13)-triene-6,12-olide (2), 3beta-o-beta-d- ... | 2006 | 17146959 |
| lactic acid bacterial fermentation increases the antiallergic effects of ixeris dentata. | ixeris dentata (id, family asteraceae), called seumbakuy in korea, was fermented with lactic acid bacteria (lab) and their antiallergic activities were investigated. fermentation of id with bifidobacterium breve or lactobacillus acidophilus increased its inhibition of degranulation in rbl-2h3 cells induced by the ige-antigen complex. oral administration of these extracts to mice inhibited the passive cutaneous anaphylaxis (pca) reaction induced by the ige-antigen complex and scratching behaviors ... | 2008 | 18309276 |
| development and characterization of microsatellite loci in ixeridium dentatum (asteraceae, lactuceae). | we isolated and characterized seven microsatellite loci for the perennial herb ixeridium dentatum ssp. dentatum, an apomictic triploid distributed throughout the lowland areas of east asia. the number of alleles ranged from two to seven in 32 screened individuals of i. dentatum ssp. dentatum from japan. the observed and expected heterozygosities were 0.000-0.950 and 0.000-0.891, respectively, calculated using genotypes of 20 individuals of i. dentatum ssp. nipponicum. one locus (msid4) deviated ... | 2009 | 19603252 |
| new guaiane sesquiterpene lactones from ixeris dentata. | three new guaiane-type sesquiterpene lactones (1-3), together with nine related sesquiterpenes (4-12), were isolated from the whole extract of ixeris dentata (asteraceae). the chemical structures of isolates 1-12 were established by spectroscopic analyses as 3 β,8 β-dihydroxy-guaia-10(14)-en-1 α,4 α,5 α,6 β,7 α,11 βh-12,6 α-olide (1), ixerin n 6'- o-acetate (2), ixerisoside a 6'- o-acetate (3), ixerin n ( 4), ixerisoside a (5), ixerin m (6), tectroside (7), 8-epidesacylcynaropicrin glucoside (8) ... | 2010 | 20890810 |