Publications

TitleAbstractYear
Filter
PMID
Filter
effects of ficus deltoidea aqueous extract on hematological and biochemical parameters in rats.aqueous extract of ficus deltoidea var. agustifolia was examined for the subchronic toxicity effects in rats. groups of 10 rats were given the extract daily by oral gavage for 90 days at 0 (control), 100 and 300mg/kg/body weight, respectively. blood samples were collected upon sacrificed and analysed for haemogram and biochemistry. the results showed there were no significant changes of the blood parameters in all treated groups compared to the control.200819025006
systematic analysis of in vitro photo-cytotoxic activity in extracts from terrestrial plants in peninsula malaysia for photodynamic therapy.one hundred and fifty-five extracts from 93 terrestrial species of plants in peninsula malaysia were screened for in vitro photo-cytotoxic activity by means of a cell viability test using a human leukaemia cell-line hl60. these plants which can be classified into 43 plant families are diverse in their type of vegetation and their natural habitat in the wild, and may therefore harbour equally diverse metabolites with potential pharmaceutical properties. of these, 29 plants, namely three from each ...200919647445
anti-inflammatory activity of aqueous extract of ficus deltoidea.ficus deltoidea (family moraceae) leaves have been used traditionally by the malays to treat ailments such as wounds, sores, and rheumatism. the aim of the present study was to determine the anti-inflammatory activity of the aqueous extract of f. deltoidea leaf (fda) using acute and chronic inflammatory models. fda, in the doses of 30, 100, and 300 mg/kg, was administered intraperitoneally in rats (n = 6) before the animals were subjected to the carrageenan-induced paw edema test, cotton pellet- ...201121278166
antimicrobial activity of ficus deltoidea jack (mas cotek).present study aimed to investigate the in vitro antimicrobial activity of the chloroform, methanol and aqueous extracts of ficus deltoidea at 10mg/ml, 20mg/ml and 50 mg/ml, respectively using the disc diffusion method against 2 gram positive {staphylococcus aureus (imr s-277), bacillus subtilis (imr k-1)}, 2 gram negative {escherichia coli (imr e-940), pseudomonas aeroginosa (imr p-84)} and 1 fungal strain, candida albicans (imr c-44). all the extracts showed inhibitory activity on the fungus, g ...201222713960
experimental and computational approaches to reveal the potential of ficus deltoidea leaves extract as α-amylase inhibitor.ficus deltoidea leaves extract are known to have good therapeutic properties such as antioxidant, anti-inflammatory and anti-diabetic. we showed that 50% ethanol-water extract of f. deltoidea leaves and its pungent compounds vitexin and isovitexin exhibited significant (p < 0.05) α-amylase inhibition with ic50 (vitexin: 4.6 μm [0.02 μg/ml]; isovitexin: 0.06 μg/ml [13.8 μm] and dpph scavenging with ic50 (vitexin: 92.5 μm [0.4 μg/ml]; isovitexin: 0.5 μg/ml [115.4 μm]). additionally, molecular dock ...201728391727
structure and principal components analyses reveal an intervarietal fusion in malaysian mistletoe fig (ficus deltoidea jack) populations.genetic structure and biodiversity of the medicinal plant ficus deltoidea have rarely been scrutinized. to fill these lacunae, five varieties, consisting of 30 f. deltoidea accessions were collected across the country and studied on the basis of molecular and morphological data. molecular analysis of the accessions was performed using nine inter simple sequence repeat (issr) markers, seven of which were detected as polymorphic markers. issr-based clustering generated four clusters supporting the ...201526114389
tongkat ali (eurycoma longifolia): a possible therapeutic candidate against blastocystis sp.in the local malaysian context, herbal plants such as eurycoma longifolia (tongkat ali), orthosiphon stamineus (misaikucing), ficus deltoidea (mas cotek), zingiber officinale (halia bara) and barringtonia racemosa (putat) are known and widely used for its therapeutic properties. the first part of this study aims to screen for the anti-protozoal activity of these herbal plant extracts against blastocystis sp. isolate subtype (st) 3. herbal extract with the highest efficacy was further fractionize ...201526082155
in-vitro effect of ficus deltoidea on the contraction of isolated rat's uteri is mediated via multiple receptors binding and is dependent on extracellular calcium.ficus deltoidea, is a perennial herb that is used to assist labor, firm the uterus post-delivery and to prevent postpartum bleeding. in view of its claimed uterotonic action, the mechanisms underlying plant's effect on uterine contraction were investigated.201324330515
genotoxicity and acute and subchronic toxicity studies of a standardized methanolic extract of ficus deltoidea leaves.ficus deltoidea leaves have been used in traditional medicine in southeast asia to treat diabetes, inflammation, diarrhea, and infections. the present study was conducted to assess the genotoxicity and acute and subchronic toxicity of a standardized methanol extract of f. deltoidea leaves.201323778480
morphological phylogenetic analysis of seven varieties of ficus deltoidea jack from the malay peninsula of malaysia.this study is the first report to suggest a morphological phylogenetic framework for the seven varieties of ficus deltoidea jack (ficus: moraceae) from the malay peninsula of malaysia. several molecular-based classifications on the genus ficus had been proposed, but neither had discussed the relationship between seven varieties of f. deltoidea to its allies nor within the varieties. the relationship between seven varieties of f. deltoidea is still debated due to the extreme morphological variabi ...201223285045
ficus deltoidea: a potential alternative medicine for diabetes mellitus.ficus deltoidea from the moraceae family has been scientifically proven to reduce hyperglycemia at different prandial states. in this study, we evaluate the mechanisms that underlie antihyperglycemic action of ficus deltoidea. the results had shown that hot aqueous extract of ficus deltoidea stimulated insulin secretion significantly with the highest magnitude of stimulation was 7.31-fold (p < 0.001). the insulin secretory actions of the hot aqueous extract involved k(+) (atp) channel-dependent ...201222701507
vitexin and isovitexin from the leaves of ficus deltoidea with in-vivo α-glucosidase inhibition.the leaves of ficus deltoidea are used as a traditional medicine by diabetes patients in malaysia.201222683902
evaluation of hypoglycemic activity and toxicity profiles of the leaves of ficus deltoidea in rodents.ficus deltoidea jack (moraceae) leaf extract is used as an antidiabetic in traditional medicine. its widespread usage is reflected by the available preparations in the present commercial market. the efficacy of other ficus species has not been entirely satisfactory and many antidiabetic herbs have demonstrated poor safety profiles. this study examined hypoglycemic and toxicity profiles of f. deltoidea leaf extract in rodent models. extracts of dried powdered leaves were obtained using methanol s ...201122754938
evaluation of the antinociceptive activity of ficus deltoidea aqueous extract.the aqueous extract of ficus deltoidea leaves was evaluated for possible antinociceptive activity in three models of nociception, namely, acetic acid-induced abdominal writhing, formalin and hot plate test. the results of the present study showed that intraperitoneal administration of the f. deltoidea leaves aqueous extract at the dose of 1, 50 and 100 mg/kg, 30 min prior to pain induction produced significant dose-dependent antinociceptive effect in all the models used, which indicating the pre ...200818672036
ficus deltoidea (mas cotek) extract exerted anti-melanogenic activity by preventing tyrosinase activity in vitro and by suppressing tyrosinase gene expression in b16f1 melanoma cells.ficus deltoidea (mas cotek) water extract has been widely used for woman health in malaysia. our investigation focused to identify anti-melanogenic efficacy of f. deltoidea since it has been known to have strong anti-oxidant activities. anti-melanogenic effect of f. deltoidea extract was analyzed using cultured b16f1 melanoma cells. cytotoxicity of the extract was measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assay and determined the highest concentration of t ...201120981431
identification of proanthocyanidin dimers and trimers, flavone c-glycosides, and antioxidants in ficus deltoidea , a malaysian herbal tea.phenolic compounds in an aqueous infusion of leaves of ficus deltoidea (moraceae), a well-known herbal tea in malaysia, were analyzed by hplc coupled to photodiode array and fluorescence detectors and an electrospray ionization tandem mass spectrometer. following chromatography of extracts on a reversed phase c(12) column, 25 flavonoids were characterized and/or tentatively identified with the main constituents being flavan-3-ol monomers, proanthocyanidins, and c-linked flavone glycosides. the p ...201121261251
anti-adipogenic effects of extracts of ficus deltoidea var. deltoidea and var. angustifolia on 3t3-l1 adipocytes.this study examined the anti-adipogenic effects of extracts of ficus deltoidea var. deltoidia and var. angustifolia, a natural slimming aid, on 3t3-l1 adipocytes.201424599694
ficus deltoidea jack: a review on its phytochemical and pharmacological importance.ficus deltoidea jack (moraceae) has had a long history of use in traditional medicine among the malays to alleviate and heal ailments such as sores, wounds, and rheumatism and as an after-birth tonic and an antidiabetic drug. modern pharmacological studies demonstrated that this plant has a wide variety of beneficial attributes for human health. despite its importance, a review of this species has not been published in the scientific literature to date. here, we review and summarize the historic ...201424772185
standardized extract of ficus deltoidea stimulates insulin secretion and blocks hepatic glucose production by regulating the expression of glucose-metabolic genes in streptozitocin-induced diabetic rats.recently, there has been increasing interest in ficus deltoidea jack. (moraceae) due to its chemical composition and the potential health benefits. the present study was undertaken to investigate the effect of extracts of f. deltoidea leaves on diabetes.201424993916
analysis of l-citrulline and l-arginine in ficus deltoidea leaf extracts by reverse phase high performance liquid chromatography.ficus deltoidea (fd) is one of the native plants widely distributed in several countries in southeast asia. previous studies have shown that fd leaf possess antinociceptive, wound healing and antioxidant properties. these beneficial effects have been attributed to the presence of primary and secondary metabolites such as polyphenols, amino acids and flavonoids.201725598632
phytochemical characteristic and uterotonic effect of aqueous extract of ficus deltoidea leaves in rats uterus.ficus deltoidea is traditionally consumed by malay woman to augment labour and hastening parturition. this study was to investigate the phytochemical present and uterotonic activity of f. deltoidea var. deltoidea (fdd) and f. deltoidea var. angustifolia (fda) leaves aqueous extract. fdd and fda were qualitatively analysed. in uterine contraction activity, adult female sprague dawley rats were pretreated with 0.2 mg kg(-1) diethylstilbestrol 24 h to induce oestrus phase. the rats then killed and ...201426031024
efficacy and safety of elaeis guineensis and ficus deltoidea leaf extracts in adults with pre-diabetes.individuals with pre-diabetes (fasting glucose 100-125 mg/dl) are at increased risk of developing diabetes; 50% of u.s. adults aged ≥65 y had pre-diabetes in 2005-08. extracts of the leaves of e. guineensis (a tropical plant producing edible oil), and f. deltoidea (a traditional tea) contain phenolic compounds that have hypoglycemic effects in vitro and in vivo. therefore, a study of the efficacy and safety of these leaf extracts was undertaken.201323547788
antidiabetic and antioxidant properties of ficus deltoidea fruit extracts and fractions.diabetes is a serious metabolic disorder affecting the metabolism of carbohydrate, protein and fat. a number of studies have shown that diabetes mellitus is associated with oxidative stress, leading to an increased production of reactive oxygen species. ficus deltoidea is traditionally used in malaysia for regulating blood sugar, blood pressure and cholesterol levels. the use of f. deltoidea as an alternative medicinal herb is increasingly gaining popularity with the sale of f. deltoidea tea bag ...201323718315
Displaying items 1 - 23 of 23