Publications

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noninvasive, quantitative determination of muscle blood flow in man by a combination of venous-occlusion plethysmography and computed tomography.because of the lack of non-invasive methods for measuring muscle blood flow, quantitative investigations of blood flow in the skeletal muscle of hypertensive subjects are rare. we therefore developed a new method for the determination of muscle blood flow noninvasively and quantitatively by a combination of computed tomography and venous occlusion plethysmography (strain-gauge method). at two sites on one forearm (p = site of the largest diameter, d = 1 cm proximal to the epicondyle lat.) the vo ...19883415636
cyclic analogues of thr6-bradykinin, n epsilon-lys-bradykinin and endo-lys8a-vespulakinin 1.syntheses are described of the endo-lys8a-vespulakinin 1 and of cyclo-thr6- and cyclo-n epsilon-lys-bradykinin. the linear peptides covering the entire sequences of endo-lys8a-vsk-1 and thr6-bk, and the decapeptide containing all residues constituting lys-bk, with a arg-lys peptide bond involving the epsilon-amino function of lysine, were prepared by the solid-phase procedure based on fmoc chemistry. cyclization was carried out by the diphenylphosphorazide method. the amino-terminal octapeptide ...19957591485
cyclic analogues of wasp kinins from vespa analis and vespa tropica.syntheses are described of two bradykinin-like kinins isolated from vespa analis (g-r-p-p-g-f-s-p-f-r-v-i, vsk-a) and vespa tropica (g-r-p-hyp-g-f-s-p-f-r-v-v, vsk-t) and of their cyclic analogues. linear dodecapeptides were prepared by the solid-phase procedure based on fmoc-chemistry, and cyclization was carried out by the diphenyl-phosphorylazide method. peptide were characterized by amino acid analysis, optical rotation, analytical hplc and fab-ms. the conformational features of the cyclic a ...19957775021
synthesis and biological activity of some linear and cyclic kinin analogues.syntheses are described of some linear and cyclic kinin analogues. cyclization, by the diphenyl-phosphorazide method, of linear peptides prepared by the solid-phase procedure based on fmoc chemistry, was used for preparing cyclo-bradykinin and cyclo-kallidin (cyclo-lys-bradykinin). removal of the protecting group from the lysine side chain of cyclo-kallidin followed by acylation with the n-terminal sequence of vespulakinin 1 (vsk 1), fmoc-thr(tbu)-ala-thr(tbu)-thr(tbu)-arg(pmc)-arg(pmc)-gly-oh, ...19947960398
integration of the dna of a novel filamentous bacteriophage vsk from vibrio cholerae 0139 into the host chromosomal dna.an unusual filamentous bacteriophage, vsk, containing single-stranded, circular dna as its genome was isolated from vibrio cholerae 0139 strains p07 and b04. unlike other single-stranded dna phages, vsk can integrate its genome into the chromosome of the host and enter into a lysogenic state. the double-stranded replicative form (rf) of the single-stranded phage dna was isolated. a restriction map of the vsk rf dna was constructed using haeii, avaii, clai and xbai. by southern blot analysis of t ...19968931321
quantitative analysis using the star volume method applied to skeleton patterns extracted with a morphological filter.in this study, a morphological filter was combined with star volume analysis and applied to digital images to determine its potential usefulness in assessing trabecular structure. three digital "geometric" test patterns (square, rectangle, circle) were created on a crt (cathode ray tube). each shape was arranged into five groups by size to yield 15 final "skeletal" patterns that were subsequently assessed with star volume analysis. also, three digital x-ray images (background, soft tissue, bone ...200010959616
a low-cost, accurate method of producing large quantities of digitally filtered images.we demonstrate how to produce complex image transformations of bitmap files for vision experiments using the cogimatic vision starter kit (vsk) library of mathematical routines along with visual basic, c++, or the delphi pascal compiler. implementing this system on an ibm-compatible pc running windows 95, 98, or nt4 enables researchers to quickly and economically manipulate images for vision research. the vsk includes a simple stand-alone image-processing application. in addition, vsk has the ab ...200011029820
results of tv imaging of phobos (experiment vsk-fregat).from february to march 1989 the phobos 2 spacecraft took 37 tv images of phobos at a distance of 190-1100 km. these images complement mariner-9 and viking data by providing higher-resolution coverage of a large region west of the crater stickney (40-160 degrees w) and by providing disk-resolved measurements of surface brightness at a greater range of wavelengths and additional phase angles. these images have supported updated mapping and characterization of large craters and grooves, and have ...199111538495
assessment of bone feature parameters from lumbar trabecular skeletal patterns using mathematical morphology image processing.in this study, bone feature parameters were obtained from digital lumbar vertebral images to determine their potential usefulness in assessing binary trabecular skeletal patterns. the system consisted of a magnification radiographic technique, computed radiography (cr), microfocused x-ray computed tomography (mu-ct), and mathematical morphology image processing. a digital cr image was produced, using a ten-times magnified lumbar vertebral cancellous bone block (1.5 x 1.5 x 1.5 cm(3)). the inform ...200212115065
early detection of radiation-induced structural changes in rat trabecular bone.early detection of bone changes following radiotherapy is very important. the aim of this study is to establish a radiographic image analysis method for early detection of radiation-induced trabecular bone changes.200312820851
immunophenotypic and viral (human papillomavirus) correlates of vulvar seborrheic keratosis.human papillomavirus (hpv) infections of the genital mucosa classically present as warts (condylomata) and are traditionally defined by the presence of viral cytopathic effect (koilocytosis). in recent years, hpv has been detected in vulvar epithelial changes lacking koilocytosis, including squamous papillomas and lesions closely resembling seborrheic keratosis (sk). the purpose of this study was to determine the frequency and type of hpv associated with vulvar sk (vsk) and to compare expression ...200312827609
videostrobokymographic analysis of benign vocal fold lesions.videostrobokymography (vsk) has recently been introduced. the aim of this study was to analyze vibratory patterns and objective parameters in various benign vocal fold lesions using vsk and to examine the efficacy of vsk in clinical applications.200314710916
overexpression of defense response genes in transgenic wheat enhances resistance to fusarium head blight.fusarium head blight (fhb) of wheat, caused by fusarium graminearum and other fusarium species, is a major disease problem for wheat production worldwide. to combat this problem, large-scale breeding efforts have been established. although progress has been made through standard breeding approaches, the level of resistance attained is insufficient to withstand epidemic conditions. genetic engineering provides an alternative approach to enhance the level of resistance. many defense response genes ...200717103001
transgenic wheat expressing a barley class ii chitinase gene has enhanced resistance against fusarium graminearum.fusarium head blight (fhb; scab), primarily caused by fusarium graminearum, is a devastating disease of wheat worldwide. fhb causes yield reductions and contamination of grains with trichothecene mycotoxins such as deoxynivalenol (don). the genetic variation in existing wheat germplasm pools for fhb resistance is low and may not provide sufficient resistance to develop cultivars through traditional breeding approaches. thus, genetic engineering provides an additional approach to enhance fhb resi ...200818467324
autism spectrum disorders in children and adolescents with moebius sequence.moebius sequence is a rare congenital disorder usually defined as a combination of facial weakness with impairment of ocular abduction. a strong association of moebius sequence with autism spectrum disorders (asds) has been suggested in earlier studies with heterogenous age groups. the primary caregivers of all children and adolescents with moebius sequence aged 6-17 years known to the german moebius foundation were anonymously asked to complete two screening measures of asd [behavior and commun ...200919255803
vej{phi}, a novel filamentous phage of vibrio cholerae able to transduce the cholera toxin genes.a novel filamentous bacteriophage, designated vejphi, was isolated from strain mo45 of vibrio cholerae of the o139 serogroup. a molecular characterization of the phage was carried out, which included sequencing of its whole genome, study of the genomic structure, identification of the phage receptor, and determination of the function of some of the genes, such as those encoding the major capsid protein and the single-stranded dna-binding protein. the genome nucleotide sequence of vejphi, which c ...201019833774
moebius sequence and autism spectrum disorders--less frequently associated than formerly thought.moebius sequence is a rare congenital disorder usually defined as a combination of facial weakness with impairment of ocular abduction. it is questionable, whether there is a strong association of the sequence with autism spectrum disorders (asds) as suggested in some earlier case reports and studies. twenty-two participants with möbius sequence aged 6-16 years followed a request of the german moebius foundation to participate in a nationwide study. all patients had a physical examination and in ...201020621443
impact of moisture, host genetics and fusarium graminearum isolates on fusarium head blight development and trichothecene accumulation in spring wheat.the impact of moisture on the development of fusarium head blight (fhb) and accumulation of deoxynivalenol (don) in fusarium-infected wheat was examined. the field experiments were designed as split-split-plot with five replicates. main plots were durations of mist-irrigation [14, 21, 28 and 35 days after inoculation (dai)]; sub-plots were wheat cultivar; and sub-sub-plots were f. graminearum isolates differing in aggressiveness and don production capacity. the wheat cultivars 'alsen' (moderatel ...201123605982
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