| flavin-dependent monooxygenases as a detoxification mechanism in insects: new insights from the arctiids (lepidoptera). | insects experience a wide array of chemical pressures from plant allelochemicals and pesticides and have developed several effective counterstrategies to cope with such toxins. among these, cytochrome p450 monooxygenases are crucial in plant-insect interactions. flavin-dependent monooxygenases (fmos) seem not to play a central role in xenobiotic detoxification in insects, in contrast to mammals. however, the previously identified senecionine n-oxygenase of the arctiid moth tyria jacobaeae (lepid ... | 2010 | 20454663 |
| evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-acquired pyrrolizidine alkaloids in the alkaloid-defended arctiid moth tyria jacobaeae. | larvae of tyria jacobaeae feed solely upon the pyrrolizidine alkaloid-containing plant senecio jacobaea. ingested pyrrolizidine alkaloids (pas), which are toxic to unspecialized insects and vertebrates, are efficiently n-oxidized in the hemolymph of t. jacobaeae by senecionine n-oxygenase (sno), a flavin-dependent monooxygenase (fmo) with a high substrate specificity for pas. peptide microsequences obtained from purified t. jacobaeae sno were used to clone the corresponding cdna, which was expre ... | 2002 | 11972041 |
| nosema tyriae n.sp. and nosema sp., microsporidian parasites of cinnabar moth tyria jacobaeae. | nosema tyriae n.sp. was found in 63% of a population of cinnabar moth larvae (tyria jacobaeae). the infection was found in the gut wall, silk glands, and fat body and was probably generalized but appeared to be of low pathogenicity. merogony and sporogony were by binary fission of diplokaryotic stages. fresh spores were elongate, slightly pointed at the anterior end, and measured 4.7 x 2.0 microm. ultrastructural features of special interest were 20-nm tubules connecting the surface of sporonts ... | 1999 | 10388544 |