| evolutionary relationships among aspergillus terreus isolates and their relatives. | aspergillus terreus is a ubiquitous fungus in our environment. it is an opportunistic human pathogen and economically important as the main producer of lovastatin, a cholesterol lowering drug. our aim was to examine the genetic variability of a. terreus and closely related species using molecular and analytical techniques. lovastatin production was examined by hplc. lovastatin was produced by seven isolates belonging to the species a. terreus. rapd analyses were carried out using 25 different ra ... | 2005 | 16096690 |
| photoinduced synthesis of new diisochromenochromen-4-ones and their antimicrobial activities. | the diisochromenochromen-4-one 3a-3b, 4a-4c, 5a-6a & 7 have been prepared from the photocyclization reaction of bischromen-4-one 2a-2e. the later compounds are obtained from the o-alkylation of the suitable 3-hydroxy-2-aryl-4h-chromen-4-one 1a-1e with 4,4'-bischloromethyl-diphenyl in dry acetone, anhydrous k₂co₃, and ptc (bu₄n⁺i⁻) under refluxing conditions. the structures of compounds 2a-2e, 3a-3b, 4a-4c, 5a-6a & 7 have been characterized from the rigorous analysis of their ir, ¹h-nmr, ¹³c-nm ... | 2012 | 22666175 |
| total synthesis of an oxepine natural product, (±)-janoxepin. | the total synthesis of (±)-janoxepin, a novel antiplasmodial d-leucine derived oxepine-pyrimidinone-ketopiperazine isolated from the fungus aspergillus janus, is described. the cornerstones of the synthetic route are pyrimidinone preparation, ring-closing metathesis, aldol introduction of the enamide, and dihydro-oxepine elaboration. this synthetic route proved very efficient for the formation of a number of janoxepin analogues, including dihydro-janoxepin and tetrahydro-janoxepin. | 2012 | 22288766 |