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dissemination of the phage-associated novel superantigen gene spel in recent invasive and noninvasive streptococcus pyogenes m3/t3 isolates in japan.in japan, more than 10% of streptococcal toxic shock-like syndrome (tsls) cases have been caused by streptococcus pyogenes m3/t3 isolates since the first reported tsls case in 1992. most m3/t3 isolates from tsls or severe invasive infection cases during 1992 to 2001 and those from noninvasive cases during this period are indistinguishable in pulsed-field gel electropherograms. the longest fragments of these recent isolates were 300 kb in size, whereas those of isolates recovered during or before ...200212011018
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