| expansion of intestinal prevotella copri correlates with enhanced susceptibility to arthritis. | rheumatoid arthritis (ra) is a prevalent systemic autoimmune disease, caused by a combination of genetic and environmental factors. animal models suggest a role for intestinal bacteria in supporting the systemic immune response required for joint inflammation. here we performed 16s sequencing on 114 stool samples from rheumatoid arthritis patients and controls, and shotgun sequencing on a subset of 44 such samples. we identified the presence of prevotella copri as strongly correlated with diseas ... | 2013 | 24192039 |
| gut dendritic cell activation links an altered colonic microbiome to mucosal and systemic t-cell activation in untreated hiv-1 infection. | hiv-1-associated disruption of intestinal homeostasis is a major factor contributing to chronic immune activation and inflammation. dendritic cells (dcs) are crucial in maintaining intestinal homeostasis, but the impact of hiv-1 infection on intestinal dc number and function has not been extensively studied. we compared the frequency and activation/maturation status of colonic myeloid dc (mdc) subsets (cd1c(+) and cd1c(neg)) and plasmacytoid dcs in untreated hiv-1-infected subjects with uninfect ... | 2016 | 25921339 |
| prevotella copri and the microbial pathogenesis of rheumatoid arthritis. | | 2016 | 25555460 |
| rheumatoid arthritis: prevotella copri associated with new-onset untreated ra. | | 2014 | 24275964 |
| microbial strain-level population structure and genetic diversity from metagenomes. | among the human health conditions linked to microbial communities, phenotypes are often associated with only a subset of strains within causal microbial groups. although it has been critical for decades in microbial physiology to characterize individual strains, this has been challenging when using culture-independent high-throughput metagenomics. we introduce strainphlan, a novel metagenomic strain identification approach, and apply it to characterize the genetic structure of thousands of strai ... | 2017 | 28167665 |
| the gut microbiome. | since the discovery and use of the microscope in the 17(th) century, we know that we host trillions of micro-organisms mostly in the form of bacteria indwelling the "barrier organs" skin, gut, and airways. they exert regulatory functions, are in a continuous dialogue with the intestinal epithelia, influence energy handling, produce nutrients, and may cause diabetes and obesity. the human microbiome has developed by modulating or avoiding inflammatory responses; the host senses bacterial presence ... | 2014 | 24953716 |
| role of the gut microbiota of children in diarrhea due to the protozoan parasite entamoeba histolytica. | an estimated 1 million children die each year before their fifth birthday from diarrhea. previous population-based surveys of pediatric diarrheal diseases have identified the protozoan parasite entamoeba histolytica, the etiological agent of amebiasis, as one of the causes of moderate-to-severe diarrhea in sub-saharan africa and south asia. | 2016 | 26712950 |
| human gut microbes impact host serum metabolome and insulin sensitivity. | insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic danish individuals. the serum metabolome of insulin-resistant individuals is characterized by increased levels of branched-chain amino acids (bcaas), which correlate with a gut microbiome that has an enriched biosynthetic potential for bcaas and is deprived of genes encod ... | 2016 | 27409811 |
| microbial community of healthy thai vegetarians and non-vegetarians, their core gut microbiota, and pathogen risk. | pyrosequencing analysis of intestinal microflora from healthy thai vegetarians and non-vegetarians exhibited 893 otus covering 189 species. the strong species indicators of vegetarians and non-vegetarians were prevotella copri and bacteroides vulgatus as well as bacteria close to escherichia hermanii with % relative abundance of 16.9 and 4.5-4.7, respectively. core gut microbiota of the vegetarian and non-vegetarian groups consisted of 11 and 20 different bacterial species, respectively, belongi ... | 2016 | 27381339 |
| senior thai fecal microbiota comparison between vegetarians and non-vegetarians using pcr-dgge and real-time pcr. | the fecal microbiotas were investigated in 13 healthy thai subjects using polymerase chain reaction denaturing gradient gel electrophoresis (pcr-dgge). among the 186 dna bands detected on the polyacrylamide gel, 37 bands were identified as representing 11 species: bacteroides thetaiotaomicron, bacteroides ovatus, bacteroides uniformis, bacteroides vulgatus, clostridium colicanis, eubacterium eligenes, e. rectale, faecalibacterium prausnitzii, megamonas funiformis, prevotella copri, and roseburia ... | 2014 | 24743571 |
| prevotella copri sp. nov. and prevotella stercorea sp. nov., isolated from human faeces. | six strains (cb7(t), cb18, cb23, cb26, cb28 and cb35(t)) were isolated from human faeces. based on phylogenetic analysis, phenotypic characteristics, cellular fatty acid profiles and menaquinone profiles, these strains could be included within the genus prevotella and made up two clusters. 16s rrna gene sequence analysis indicated that five strains were most closely related to prevotella veroralis, sharing about 92 % sequence similarity; the remaining strain was most closely related to prevotell ... | 2007 | 17473237 |
| functional implications of microbial and viral gut metagenome changes in early stage l-dopa-naïve parkinson's disease patients. | parkinson's disease (pd) presently is conceptualized as a protein aggregation disease in which pathology involves both the enteric and the central nervous system, possibly spreading from one to another via the vagus nerves. as gastrointestinal dysfunction often precedes or parallels motor symptoms, the enteric system with its vast diversity of microorganisms may be involved in pd pathogenesis. alterations in the enteric microbial taxonomic level of l-dopa-naïve pd patients might also serve as a ... | 2017 | 28449715 |
| the impact of the bovine fecal microbiome on escherichia coli o157:h7 prevalence and enumeration in naturally infected cattle. | the objective of this study was to determine if the fecal microbiome has an association with e. coli o157:h7 prevalence and enumeration. | 2017 | 28736954 |
| gene expression and molecular characterization of a xylanase from chicken cecum metagenome. | a xylanase gene xynamg1 with a 1,116-bp open reading frame, encoding an endo-β-1,4-xylanase, was cloned from a chicken cecum metagenome. the translated xynamg1 protein consisted of 372 amino acids including a putative signal peptide of 23 amino acids. the calculated molecular mass of the mature xynamg1 was 40,013 da, with a theoretical pi value of 5.76. the amino acid sequence of xynamg1 showed 59% identity to endo-β-1,4-xylanase from prevotella bryantii and prevotella ruminicola and 58% identit ... | 2017 | 28751915 |
| analysis of gut microbiota in patients with parkinson's disease. | gut microbiota of patients with parkinson's disease and healthy volunteers was analyzed by the method of high throughput 16s rrna sequencing of bacterial genomes. in patients with parkinson's diseases, changes in the content of 9 genera and 15 species of microorganisms were revealed: reduced content of dorea, bacteroides, prevotella, faecalibacterium, bacteroides massiliensis, stoquefichus massiliensis, bacteroides coprocola, blautia glucerasea, dorea longicatena, bacteroides dorei, bacteroides ... | 2017 | 28429209 |
| distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. | to characterize the gut bacterial microbiota of patients with primary sclerosing cholangitis (psc) and ulcerative colitis (uc). | 2017 | 28740343 |
| quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitis. | the assessment and characterization of the gut microbiome has become a focus of research in the area of human autoimmune diseases. ankylosing spondylitis is an inflammatory autoimmune disease and evidence showed that ankylosing spondylitis may be a microbiome-driven disease. | 2017 | 28750650 |
| differential susceptibility to colorectal cancer due to naturally occurring gut microbiota. | recent studies investigating the human microbiome have identified particular bacterial species that correlate with the presence of colorectal cancer. to evaluate the role of qualitatively different but naturally occurring gut microbiota and the relationship with colorectal cancer development, genetically identical embryos from the polyposis in rat colon (pirc) rat model of colorectal cancer were transferred into recipients of three different genetic backgrounds (f344/nhsd, lew/ssnhsd, and crl:sd ... | 2015 | 26378041 |
| dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of prevotella. | the gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (bkb) with those who responded least to this dietary intervention. the prevotella/bacteroides ratio was higher in responders than non-responders after bkb. metagenomi ... | 2015 | 26552345 |
| gut microbiota in 2015: prevotella in the gut: choose carefully. | gut microbial communities often contain many bacteroides or their close relatives, prevotella, but not both. prevotella strains are associated with plant-rich diets but are also linked with chronic inflammatory conditions. in 2015, papers probed the genomic diversity of prevotella strains and interactions of prevotella copri with its host and other bacteria. | 2016 | 26828918 |
| microbiota-produced succinate improves glucose homeostasis via intestinal gluconeogenesis. | beneficial effects of dietary fiber on glucose and energy homeostasis have long been described, focusing mostly on the production of short-chain fatty acids by the gut commensal bacteria. however, bacterial fermentation of dietary fiber also produces large amounts of succinate and, to date, no study has focused on the role of succinate on host metabolism. here, we fed mice a fiber-rich diet and found that succinate was the most abundant carboxylic acid in the cecum. dietary succinate was identif ... | 2016 | 27411015 |
| dysbiosis contributes to arthritis development via activation of autoreactive t cells in the intestine. | the intestinal microbiota is involved in the pathogenesis of arthritis. altered microbiota composition has been demonstrated in patients with rheumatoid arthritis (ra). however, it remains unclear how dysbiosis contributes to the development of arthritis. the aim of this study was to investigate whether altered composition of human intestinal microbiota in ra patients contributes to the development of arthritis. | 2016 | 27333153 |
| editorial: can prevotella copri be a causative pathobiont in rheumatoid arthritis? | | 2016 | 27390139 |
| evidence of the immune relevance of prevotella copri, a gut microbe, in patients with rheumatoid arthritis. | prevotella copri, an intestinal microbe, may overexpand in stool samples from patients with new-onset rheumatoid arthritis (ra), but it is not yet clear whether the organism has immune relevance in ra pathogenesis. | 2016 | 27863183 |
| the microbiome: a revolution in treatment for rheumatic diseases? | the microbiome is the term that describes the microbial ecosystem that cohabits an organism such as humans. the microbiome has been implicated in a long list of immune-mediated diseases which include rheumatoid arthritis, ankylosing spondylitis, and even gout. the mechanisms to account for this effect are multiple. the clinical implications from observations on the microbiome and disease are broad. | 2016 | 27641915 |
| role of gut microbiota in rheumatoid arthritis. | rheumatoid arthritis (ra) is a systemic autoimmune disease, caused by both genetic and environmental factors. recently, investigators have focused on the gut microbiota, which is thought to be an environmental agent affecting the development of ra. here we review the evidence from animal and human studies that supports the role of the gut microbiota in ra. we and others have demonstrated that the abundance of prevotella copri is increased in some early ra. we have also used gnotobiotic experimen ... | 2017 | 28598360 |