| tioman virus, a novel paramyxovirus isolated from fruit bats in malaysia. | a search for the natural host of nipah virus has led to the isolation of a previously unknown member of the family paramyxoviridae. tioman virus (tiv) was isolated from the urine of fruit bats (pteropus hypomelanus) found on the island of the same name off the eastern coast of peninsular malaysia. an electron microscopic study of tiv-infected cells revealed spherical and pleomorphic-enveloped viral particles (100--500 nm in size) with a single fringe of embedded peplomers. virus morphogenesis oc ... | 2001 | 11336547 |
| emerging viral diseases of southeast asia and the western pacific. | over the past 6 years, a number of zoonotic and vectorborne viral diseases have emerged in southeast asia and the western pacific. vectorborne disease agents discussed in this article include japanese encephalitis, barmah forest, ross river, and chikungunya viruses. however, most emerging viruses have been zoonotic, with fruit bats, including flying fox species as the probable wildlife hosts, and these will be discussed as well. the first of these disease agents to emerge was hendra virus, forme ... | 2001 | 11485641 |
| full length genome sequence of tioman virus, a novel paramyxovirus in the genus rubulavirus isolated from fruit bats in malaysia. | a novel paramyxovirus in the genus rubulavirus, named tioman virus (tiv), was isolated in 1999 from a number of pooled urine samples of island flying foxes (pteropus hypomelanus) during the search for the reservoir host of nipah virus. tiv is antigenically related to menangle virus (menv) that was isolated in australia in 1997 during disease outbreak in pigs. sequence analysis of the full length genome indicated that tiv is a novel member of the genus rubulavirus within the subfamily paramyxovir ... | 2002 | 12111411 |
| managing emerging diseases borne by fruit bats (flying foxes), with particular reference to henipaviruses and australian bat lyssavirus. | since 1994, a number of novel viruses have been described from bats in australia and malaysia, particularly from fruit bats belonging to the genus pteropus (flying foxes), and it is probable that related viruses will be found in other countries across the geographical range of other members of the genus. these viruses include hendra and nipah viruses, members of a new genus, henipaviruses, within the family paramyxoviridae; menangle and tioman viruses, new members of the rubulavirus genus within ... | 2003 | 12675937 |
| pulau virus; a new member of the nelson bay orthoreovirus species isolated from fruit bats in malaysia. | after the outbreak of nipah virus (niv) in 1998-99, which resulted in 105 human deaths and the culling of more than one million pigs, a search was initiated for the natural host reservoir of niv on tioman island off the east coast of malaysia. three different syncytia-forming viruses were isolated from fruit bats on the island. they were nipah virus, tioman virus (a novel paramyxovirus related to menangle virus), and a reovirus, named pulau virus (puv), which is the subject of this study. puv di ... | 2006 | 16205863 |
| henipavirus and tioman virus antibodies in pteropodid bats, madagascar. | specimens were obtained from the 3 malagasy fruit bats, pteropus rufus, eidolon dupreanum, and rousettus madagascariensis. antibodies against nipah, hendra, and tioman viruses were detected by immunoassay in 23 and by serum neutralization tests in 3 of 427 serum samples, which suggests that related viruses have circulated in madagascar. | 2007 | 17370536 |
| tioman virus infection in experimentally infected mouse brain and its association with apoptosis. | tioman virus is a newly described bat-urine derived paramyxovirus isolated in tioman island, malaysia in 2001. hitherto, neither human nor animal infection by this virus has been reported. nonetheless, its close relationship to another paramyxovirus, the menangle virus which had caused diseases in humans and pigs [philbey, a.w., kirkland, p.d., ross, a.d., davis, r.j., gleeson, a.b., love, r.j., daniels, p.w., gould, a.r., hyatt, a.d., 1998. an apparently new virus (family paramyxoviridae) infec ... | 2007 | 17442409 |
| serological evidence of possible human infection with tioman virus, a newly described paramyxovirus of bat origin. | tioman virus, a relatively new paramyxovirus, was isolated from fruit bats (pteropus species) on tioman island, malaysia, in 2001. the objective of this study was to determine the prevalence of antibodies to t. virus in island inhabitants, by use of comparative elisa and serum neutralization assays. of the 169 human sera analyzed, 5 (approximately 3.0%) were positive for t. virus, by comparative elisa. of these 5 sera, 3 (1.8% of the total) had neutralizing antibodies against t. virus, suggestin ... | 2007 | 17703419 |
| tioman virus, a paramyxovirus of bat origin, causes mild disease in pigs and has a predilection for lymphoid tissues. | disease manifestation, pathology, and tissue tropism following infection with tioman virus (tiopv), a newly isolated, bat-derived paramyxovirus, was investigated in subcutaneously (n = 12) and oronasally (n = 4) inoculated pigs. pigs were either asymptomatic or developed pyrexia, but all of the animals produced neutralizing antibodies. the virus (viral antigen and/or genome) was detected in lymphocytes of the thymus, tonsils, spleen, lymph nodes and peyer's patches (ileum), tonsillar epithelium, ... | 2008 | 17913804 |
| viral morphogenesis and morphological changes in human neuronal cells following tioman and menangle virus infection. | tioman virus (tiopv) and menangle virus (menpv) are two antigenically and genetically related paramyxoviruses (genus: rubulavirus, family: paramyxoviridae) isolated from peninsular malaysia (2001) and australia (1997), respectively. both viruses are potential zoonotic agents. in the present study, the infectivity, growth kinetics, morphology and morphogenesis of these two paramyxoviruses in a human neuronal cell (sk-n-sh) line were investigated. sub-confluent sk-n-sh cells were infected with tio ... | 2008 | 18330496 |
| emerging and re-emerging viruses in malaysia, 1997-2007. | over the past decade, a number of unique zoonotic and non-zoonotic viruses have emerged in malaysia. several of these viruses have resulted in significant morbidity and mortality to those affected and they have imposed a tremendous public health and economic burden on the state. amongst the most devastating was the outbreak of nipah virus encephalitis in 1998, which resulted in 109 deaths. the culling of more than a million pigs, identified as the amplifying host, ultimately brought the outbreak ... | 2009 | 19010076 |
| generation of tioman virus nucleocapsid-like particles in yeast saccharomyces cerevisiae. | tioman virus (tiov) was isolated from a number of pooled urine samples of tioman island flying foxes (pteropus hypomelanus) during the search for the reservoir host of nipah virus. studies have established tiov as a new virus in the family paramyxoviridae. this novel paramyxovirus is antigenically related to menangle virus that was isolated in australia in 1997 during disease outbreak in pigs. tiov causes mild disease in pigs and has a predilection for lymphoid tissues. recent serosurvey showed ... | 2009 | 19559738 |
| novel monoclonal antibodies against menangle virus nucleocapsid protein. | menangle virus (menv) is a member of the family paramyxoviridae isolated in australia that causes a reproductive disease of pigs. there is a need for specific immunoassays for virus detection to facilitate the diagnosis of menv infection. three novel monoclonal antibodies (mabs) of the igg1 subtype were generated by immunizing mice with recombinant yeast-expressed menv nucleocapsid (n) protein self-assembled to nucleocapsid-like structures. one mab was cross-reactive with recombinant n protein o ... | 2010 | 19898771 |
| identification and complete genome analysis of three novel paramyxoviruses, tuhoko virus 1, 2 and 3, in fruit bats from china. | among 489 bats of 11 species in china, three novel paramyxoviruses [tuhokovirus 1, 2 and 3 (thkpv-1, thkpv-2 and thkpv-3)] were discovered in 15 leschenault's rousettes. phylogenetically, the three viruses are most closely related to menangle and tioman virus. genome analysis showed that their 3'-leader sequences are unique by possessing ga instead of ag at the 5th and 6th positions. unlike menangle and tioman virus, key amino acids for neuraminidase activity characteristic of rubulavirus attach ... | 2010 | 20537670 |
| completion of the full-length genome sequence of human parainfluenza virus types 4a and 4b: sequence analysis of the large protein genes and gene start, intergenic and end sequences. | we have already reported the nucleotide sequences of the np, p/v, m, f and hn genes of human parainfluenza virus type 4a (hpiv-4a) and type 4b (hpiv-4b). here, we have determined the sequences of the l protein genes as well as the gene start, intergenic and end sequences, thereby completing the full-length genome sequence of hpiv-4a and 4b. hpiv-4a and 4b have 17,052 and 17,304 nucleotides, respectively. the end sequence of hpiv-4, especially 4b, was extraordinarily long. in a comparison with me ... | 2010 | 20963613 |
| type iii ifns in pteropid bats: differential expression patterns provide evidence for distinct roles in antiviral immunity. | bats are known to harbor a number of emerging and re-emerging zoonotic viruses, many of which are highly pathogenic in other mammals but result in no clinical symptoms in bats. the ability of bats to coexist with viruses may be the result of rapid control of viral replication early in the immune response. ifns provide the first line of defense against viral infection in vertebrates. type iii ifns (ifn-?s) are a recently identified ifn family that share similar antiviral activities with type i if ... | 2011 | 21278349 |
| emerging paramyxoviruses: molecular mechanisms and antiviral strategies. | in recent years, several paramyxoviruses have emerged to infect humans, including previously unidentified zoonoses. hendra and nipah viruses (henipaviruses within this family) were first identified in the 1990s in australia, malaysia and singapore, causing epidemics with high mortality and morbidity rates in affected animals and humans. other paramyxoviruses, such as menangle virus, tioman virus, human metapneumovirus and avian paramyxovirus 1, which cause less morbidity in humans, have also bee ... | 2011 | 21345285 |
| the v protein of tioman virus is incapable of blocking type i interferon signaling in human cells. | the capacity of a virus to cross species barriers is determined by the development of bona fide interactions with cellular components of new hosts, and in particular its ability to block ifn-α/β antiviral signaling. tioman virus (tiov), a close relative of mumps virus (muv), has been isolated in giant fruit bats in southeast asia. nipah and hendra viruses, which are present in the same bat colonies, are highly pathogenic in human. despite serological evidences of close contacts between tiov and ... | 2013 | 23342031 |
| isolation of tioman virus from pteropus giganteus bat in north-east region of india. | bat-borne viral diseases are a major public health concern among newly emerging infectious diseases which includes severe acute respiratory syndrome, nipah, marburg and ebola virus disease. during the survey for nipah virus among bats at north-east region of india; tioman virus (tiov), a new member of the paramyxoviridae family was isolated from tissues of pteropus giganteus bats for the first time in india. this isolate was identified and confirmed by rt-pcr, sequence analysis and electron micr ... | 2016 | 27619056 |
| novel, potentially zoonotic paramyxoviruses from the african straw-colored fruit bat eidolon helvum. | bats carry a variety of paramyxoviruses that impact human and domestic animal health when spillover occurs. recent studies have shown a great diversity of paramyxoviruses in an urban-roosting population of straw-colored fruit bats in ghana. here, we investigate this further through virus isolation and describe two novel rubulaviruses: achimota virus 1 (achpv1) and achimota virus 2 (achpv2). the viruses form a phylogenetic cluster with each other and other bat-derived rubulaviruses, such as tuhok ... | 2013 | 23152534 |
| seroprevalence of three paramyxoviruses; hendra virus, tioman virus, cedar virus and a rhabdovirus, australian bat lyssavirus, in a range expanding fruit bat, the grey-headed flying fox (pteropus poliocephalus). | habitat-mediated global change is driving shifts in species' distributions which can alter the spatial risks associated with emerging zoonotic pathogens. many emerging infectious pathogens are transmitted by highly mobile species, including bats, which can act as spill-over hosts for pathogenic viruses. over three years, we investigated the seroepidemiology of paramyxoviruses and australian bat lyssavirus in a range-expanding fruit bat, the grey-headed flying fox (pteropus poliocephalus), in a n ... | 2020 | 32374743 |
| detection of tioman virus in pteropus vampyrus near flores, indonesia. | diverse paramyxoviruses have coevolved with their bat hosts, including fruit bats such as flying foxes (chiroptera: pteropodidae). several of these viruses are zoonotic, but the diversity and distribution of paramyxoviridae are poorly understood. we screened pooled feces samples from three pteropus vampyrus colonies and assayed tissues, rectal swabs, and oral swabs from 95 individuals of 23 pteropodid species sampled at 17 sites across the indonesian archipelago with a conventional paramyxovirus ... | 2021 | 33810446 |