| [isolation and identification of active constituent of toddalia asiatica in cardiovascular system]. | the ethereal extract from the crude ethanolic extract of toddalia asiatica was chromatographed on silica gel and tested on biological activity. a crystalline was obtained and confirmed as an active constituent in cardiovascular system. the active constituent was identified as isopimpinellin on the basis of chemical method and spectral analysis. | 1998 | 12569830 |
| antimicrobial activity of some ethnomedicinal plants used by paliyar tribe from tamil nadu, india. | antimicrobial activity of 18 ethnomedicinal plant extracts were evaluated against nine bacterial strains (bacillus subtilis, staphylococcus aureus, staphylococcus epidermidis, enterococcus faecalis, escherichia coli, klebsiella pneumonia, pseudomonas aeruginosa, ervinia sp, proteus vulgaris) and one fungal strain (candida albicans). the collected ethnomedicinal plants were used in folk medicine in the treatment of skin diseases, venereal diseases, respiratory problems and nervous disorders. | 2006 | 17042964 |
| in vivo antimalarial activity of aqueous extracts from kenyan medicinal plants and their chloroquine (cq) potentiation effects against a blood-induced cq-resistant rodent parasite in mice. | hot water extracts from eight medicinal plants representing five families, used for malaria treatment in kenya were screened for their in vivo antimalarial activity in mice against a chloroquine (cq) resistant plasmodium berghei nk65, either alone or in combination with cq. extracts of three plants, toddalia asiatica (root bark), rhamnus prinoides (leaves and root bark) and vernonia lasiopus (root bark) showed high chemosuppression in the range 51%-75%. maytenus acuminata, m. heterophylla, m. se ... | 2007 | 17221829 |
| antibacterial and antifungal activity of flindersine isolated from the traditional medicinal plant, toddalia asiatica (l.) lam. | the leaves and root of toddalia asiatica (l.) lam. (rutaceae) are widely used as a folk medicine in india. hexane, chloroform, ethyl acetate, methanol and water extracts of toddalia asiatica leaves and isolated compound flindersine were tested against bacteria and fungi. | 2009 | 19481384 |
| antimicrobial activity of ulopterol isolated from toddalia asiatica (l.) lam.: a traditional medicinal plant. | aim of the study: the leaves of toddalia asiatica (l.) lam. (rutaceae) are widely used in folk medicine in india to treat various ailments. in our earlier communication we have reported the antimicrobial study on the various extracts of the leaves and the isolation and identification of flindersine, a quinolone alkaloid as the major active principle. in the present study, we report the antibacterial and antifungal activities of ulopterol, a coumarin isolated as another major active antimicrobial ... | 2012 | 22265751 |
| antimalarial activity of methanolic extracts from plants used in kenyan ethnomedicine and their interactions with chloroquine (cq) against a cq-tolerant rodent parasite, in mice. | methanolic extracts from 15 medicinal plants representing 11 families, used traditionally for malaria treatment in kenya were screened for their in vivo antimalarial activity in mice against a chloroquine (cq)-tolerant plasmodium berghei nk65, either alone or in combination with cq. the plant parts used ranged from leaves (l), stem bark (sb), root bark (rb), seeds (s) and whole plant (w). when used alone, extracts from seven plants, clerodendrum myricoides (rb), ficus sur (l/sb/rb), maytenus acu ... | 2007 | 17145149 |
| [identification of antiviral activity of toddalia asiatica against influenza type a virus]. | to identify antiviral activity of toddalia asiatica against influenza virus type a in vitro. | 2005 | 16161428 |
| [a study on anti-inflammatory and analgesic effects of alkaloids of toddalia asiatica]. | to study the pharmacological activities and toxicity of the crude alkaloids of toddalia asiatica and to provide pharmacological data for the further development of this herbal medicine. | 2004 | 15539027 |
| spasmolytic activity of toddalia asiatica var. floribunda. | the spasmolytic activity of the aerial parts of toddalia asiatica var. floribunda (family rutaceae) was evaluated. the ethanol extract exhibited significant spasmolytic activity and was then partitioned into five fractions. the activity was found to be concentrated only in the hexane and chloroform fractions. this activity was shown not to be due to the coumarins, toddalolactone and toddanone, as was previously thought. | 2002 | 12164278 |
| a new antiplasmodial coumarin from toddalia asiatica roots. | a new antiplasmodial coumarin, 5,7-dimethoxy-8-(3'-hydroxy-3'methyl-1'-butene)-coumarin (1), has been isolated from the roots of toddalia asiatica. this finding supports the traditional use of this plant for the treatment of malaria. | 2000 | 11077169 |
| potent antimalarial activity of the alkaloid nitidine, isolated from a kenyan herbal remedy. | bioassay-guided fractionation of extracts of toddalia asiatica, a plant used by the pokot tribe of kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. fractions containing nitidine have in vitro 50% inhibitory concentrations against plasmodium falciparum in the range of 9 to 108 ng/ml for a range of chloroquine-susceptible and -resistant strains. the results show a lack of cross-resistance between chloroquine and nitidine. | 1995 | 8592987 |
| isolation of active compounds from methanol extracts of toddalia asiatica against ichthyophthirius multifiliis in goldfish (carassius auratus). | the parasitic ciliate ichthyophthirius multifiliis infests all species of freshwater fish and can cause severe economic losses in fish breeding. the present study aims to evaluate the antiparasitic activity of the active components from toddalia asiatica against i. multifiliis. bioassay-guided fractionation and isolation of compounds with antiparasitic activity were performed on the methanol extract of t. asiatica yielding two bioactive compounds: chelerythrine and chloroxylonine identified by c ... | 2014 | 24295957 |
| anti-pyretic activity of some plants in female albino rats: a preliminary report. | ethanolic extracts of ailanthus exceisa (ae). toddalia asiatica (ta) and araucaria bidwilli (ab) were screened by the anti-pyretic activity in yeast induced hyperthermic test model in the laboratory. dose of ae (100), ta (60) and ab (30) mg., equivalent of the plant material per kg. body weight of the extracts were administered orally to the female albino rats. acute toxicity and preliminary phytochemical screening were conducted for all the extracts. ld 50 values on oral administration of the e ... | 1995 | 22556707 |
| molecular docking and molecular dynamics to identify a novel human immunodeficiency virus inhibitor from alkaloids of toddalia asiatica. | acquired immunodeficiency syndrome caused by human immunodeficiency virus (hiv) is an immunosuppressive disease. over the past decades, it has plagued human health due to the grave consequences in its harness. | 2015 | 26929575 |
| antiviral spirotriscoumarins a and b: two pairs of oligomeric coumarin enantiomers with a spirodienone-sesquiterpene skeleton from toddalia asiatica. | two pairs of oligomeric coumarin enantiomers, spirotriscoumarin a [(+)-1 and (-)-1] and spirotriscoumarin b [(+)-2 and (-)-2], with a spirodienone-sesquiterpene fused skeleton were isolated from toddalia asiatica. their structures were unambiguously established using spectroscopic data, x-ray diffraction analysis, and the electronic circular dichroism (ecd) method. the racemic mixtures (±)-1 and (±)-2 exhibit 3-to-6-fold stronger antiviral activity against influenza virus a (h3n2) (ic50: 3.13 an ... | 2016 | 27673343 |
| in vitro antibacterial activity of aqueous and ethanol extracts of aristolochia indica and toddalia asiatica against multidrug-resistant bacteria. | bacteria have developed multidrug resistance against available antimicrobial agents. infectious diseases caused by these multidrug-resistant bacteria are major causes of morbidity and mortality in human beings. synthetic drugs are expensive and inadequate for the treatment of diseases, causing side effects and ineffective against multidrug-resistant bacteria. the medicinal plants are promising to have effective antimicrobial property due to presence of phytochemical compounds like alkaloids, fla ... | 2017 | 26997710 |
| biosynthesis, mosquitocidal and antibacterial properties of toddalia asiatica-synthesized silver nanoparticles: do they impact predation of guppy poecilia reticulata against the filariasis mosquito culex quinquefasciatus? | mosquito-borne diseases represent a deadly threat for millions of people worldwide. furthermore, pathogens and parasites polluting water also constitute a severe plague for populations of developing countries. in this study, silver nanoparticles (agn) were biosynthesized a cheap aqueous extract of t. asiatica leaves as reducing and stabilizing agent. the formation of nanoparticle was confirmed by surface plasmon resonance band illustrated in uv-vis spectrophotometer. agn were characterized by ft ... | 2015 | 26122577 |
| screening of selected ethnomedicinal plants from south africa for larvicidal activity against the mosquito anopheles arabiensis. | this study was initiated to establish whether any south african ethnomedicinal plants (indigenous or exotic), that have been reported to be used traditionally to repel or kill mosquitoes, exhibit effective mosquito larvicidal properties. | 2012 | 22963538 |
| [studies on the chemical constituents of rutaceous plants. lxvii. the chemical constituents of toddalia asiatica (l.) lam. (t. aculeata pers). examination of coumarins using supercritical fluid and soxhlet extraction. is toddalolactone a genuine natural coumarin?]. | it is well known that toddalolactone (1) is a main component of toddalia asiatica (l.) lam. (t. aculeata pers.) (rutaceae). however, supercritical fluid (scf) extraction of the plant by using co2 showed that a main component of the extract was not 1, but aculeatin (2), a coumarin having an epoxy ring on the side chain. the same result was obtained from soxhlet extraction by using aprotic solvents. on the other hand, soxhlet extraction by using methanol yielded 13, corresponding to a methanol add ... | 2007 | 1783986 |
| tumor-selective cytotoxicity of benzo[c]phenanthridine derivatives from toddalia asiatica lam. | to develop a novel anti-cancer drug of low side effect against lung adenocarcinoma, the authors screened the bioresources of okinawa island, japan. the medicinal plant toddalia asiatica lam. contained three benzo[c]phenanthridine derivatives: dihydronitidine (dhn), nitidine (ntd) and demethylnitidine (dmn). of the three derivatives, dhn had been shown to selectively inhibit the growth of cancer cells in our previous study. because of similar molecular topology of ntd or dmn to dhn, it can be exp ... | 2010 | 19629483 |
| the tumor specific cytotoxicity of dihydronitidine from toddalia asiatica lam. | in recent years, a number of reports have shown the anticancer activity of plant extracts and phytoalkaloid. | 2006 | 16465544 |
| mitogenic activities in african traditional herbal medicines (part ii). | mitogenic activities in african traditional herbal medicines were examined on human peripheral blood lymphocytes and mouse spleen cells using protein fractions obtained from their extracts by precipitation with ammonium sulfate. target specificity for these mitogens was investigated by using isolated t cells and lymphocytes from athymic nude mice. among 20 plants investigated, potent mitogenic activities for both human and mouse lymphocytes were found in 7 plants: monanthotaxis sp. (annonaceae), ... | 1996 | 23194771 |
| phylogenetic relationships of vepris (rutaceae) inferred from chloroplast, nuclear, and morphological data. | the tribe toddalieae hook. f. (rutaceae) has been controversial since its inception by bentham and hooker. the nine taxa examined, acronychia j.r. & g.foster, diphasia pierre, diphasiopsis mendonca, fagaropsis mildbr.ex. siebenl., oricia pierre, teclea delile, toddaliopsis engl., toddalia juss. and vepris comm. ex. a. juss, have been recognized under the tribe toddalieae or tribes acronychia, phellodendron and toddalia. more recently araliopsis engl., diphasia, diphasiopsis, oricia, teclea, and ... | 2017 | 28273098 |
| therapeutic effects of extracts from radix toddaliae asiaticae on collagen-induced arthritis in balb/c mice. | radix toddaliae asiaticae (rta), also named "sanbaibang", is the dry root bark of toddalia asiatica (l.) lam. and has long been used as a traditional ethnic chinese medicine for its considerable activity to alleviate pain and inflammation for patients suffering from rheumatism. it contains coumarin, alkaloids, triterpenes and volatile oils. information regarding the anti-arthritis activity of rta in vivo or in vitro is limited yet. in the present study, the aim is to investigate the therapeutic ... | 2013 | 23337745 |
| [bioaccumulation of heavy metals by the dominant plants growing in huayuan manganese and lead/zinc mineland, xiangxi]. | heavy metal pollution is a major environmental problem of mine wasteland. finding out the tolerant plants, which can adapt to the local climate and the soil conditions, is the premise of vegetation restoration. an extensive vegetation survey and sampling were conducted in huayuan mn and pb/zn mineland, 76 species belonging to 69 genera and 39 families were recorded. the main dominant species and their associated soils were determined for heavy metal concentrations. the results showed that soil p ... | 2012 | 22946193 |
| influence of host plants on feeding, growth and reproduction of papilio polytes (the common mormon). | we studied the feeding, growth and reproductive behaviour of papilio polytes (common mormon butterfly) on five different host plants, murraya koenigii, toddalia asiatica, glycosmis pentaphylla, aegle marmelos and citrus medica. the growth rate of p. polytes was fastest on m. koenigii followed by t. asiatica, c. medica, g. pentaphylla and a. marmelos. we related this to the nutrient contexts of the five plants. the plants t. asiatica and c. medica had higher water contents, which influenced the g ... | 2010 | 20223241 |
| essential oil composition and larvicidal activity of toddalia asiatica roots against the mosquito aedes albopictus (diptera: culicidae). | the aim of this research was to determine larvicidal activity of the essential oil derived from roots of toddalia asiatica (l.) lam. and the isolated constituents against the larvae of the culicidae mosquito aedes albopictus. essential oil of t. asiatica roots was obtained by hydrodistillation and analyzed by gc and gc-ms. a total of 58 components of the essential oil of t. asiatica roots were identified. the essential oil has almost same content of (35.41 %) of sesquiterpenoids and monoterpenoi ... | 2013 | 23271568 |
| mosquito larvicidal activity of oleic and linoleic acids isolated from citrullus colocynthis (linn.) schrad. | in mosquito control programs, botanical origin may have the potential to be used successfully as larvicides. the larvicidal activity of crude acetone, hexane, ethyl acetate, methanol, and petroleum ether extracts of the leaf of centella asiatica linn., datura metal linn., mukia scabrella arn., toddalia asiatica (linn.) lam, extracts of whole plant of citrullus colocynthis (linn.) schrad, and sphaeranthus indicus linn. were assayed for their toxicity against the early fourth instar larvae of cule ... | 2008 | 18688644 |
| antimalarial and safety evaluation of extracts from toddalia asiatica (l) lam. (rutaceae). | toddalia asiatica (l) lam. (rutaceae) is a medicinal plant traditionally used in kenya by many communities for the treatment of malaria and other ailments. all parts of the plant are claimed to have medicinal value, but the root bark in particular is believed to be more potent. decoctions or infusions of the roots are taken orally to treat malaria, fever and stomach ache. | 2013 | 23207061 |
| cytotoxic coumarins from toddalia asiatica. | three new coumarins and 13 known compounds were isolated from the stem bark of toddalia asiatica. compounds 1, 3, 8, and 9 showed cytotoxicity against the nci-h187 cell line with ic50 values ranging from 6 to 9 µg/ml. compounds 4 and 9 exhibited cytotoxicity against the mcf-7 cell line with ic50 values of 3.17 and 9.79 µg/ml, respectively. compound 9 also displayed cytotoxic activity against kb cells with an ic50 value of 8.63 µg/ml. in addition, compound 14 showed antimalarial activity against ... | 2014 | 24936959 |