| bioactive acridone alkaloids from swinglea glutinosa. | a new prenylated acridone alkaloid, 1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone (1), was isolated from the stembark of swinglea glutinosa, along with three known acridone alkaloids, 5-hydroxynoracronycine (2), 1,3,5-trihydroxy-4-methoxy-2-(3-methylbut-2-enyl)-10-methyl-9-acridone (3), and 1,3,5-trihydroxy-4-methoxy-10-methylacridone (4). the isolated alkaloids were assessed in vitro against chloroquine-sensitive and -resistant plasmodium falciparum strains and for cytotoxic ... | 2001 | 11575960 |
| antiprotozoal activities of colombian plants. | in our search for therapeutical alternatives for antiprotozoal chemotherapy, we collected a selection of 44 plants from western colombia upon ethnopharmacological and chemotaxonomic considerations. polar and apolar extracts of these species were examined for antimalarial activity using in vitro tests with two clones of plasmodium falciparum. leishmanicidal and trypanocidal activity were determined in vitro using promastigote and amastigote forms of several strains of leishmania sp. and epimastig ... | 2001 | 11694364 |
| in vitro cytotoxicity activity on several cancer cell lines of acridone alkaloids and n-phenylethyl-benzamide derivatives from swinglea glutinosa (bl.) merr. | the methanol extract from the stems and fruits of swinglea glutinosa (rutaceae) afforded 11 known acridone alkaloids and three n-phenylethyl-benzamide derivatives, glycocitrine-iv, 1,3,5-trihydroxy-4-methoxy-10-methyl-2,8-bis(3-methylbut-2-enyl)acridin-9(10h)-one, 1,3,5- trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-methyl-9-acridone, citbrasine, citrusinine-ii, citrusinine-i, 5-dihydroxyacronycine, pyranofoline, 3,4-dihydro-3,5,8-trihydroxy-6-methoxy-2,2,7-trimethyl-2h-pyrano[2,3-a]acridin-12(7h)-o ... | 2007 | 17365689 |
| anti-tubercular activity of eleven aromatic and medicinal plants occurring in colombia. | human tuberculosis is a contagious-infectious disease mainly caused by mycobacterium tuberculosis. although regimens exist for treating tuberculosis, they are far from ideal. development of effective strategies for treatment of human tuberculosis has posed a challenge, considering the increase in infections associated with the human immunodeficiency virus and immunocompromised patients. essential oils--volatile, aromatic oil extracts from plants--have been used in traditional treatment of many d ... | 2009 | 19753839 |
| algicide constituents from swinglea glutinosa. | oscillatoria perornata, a cyanobacterium (blue-green alga), common in catfish production ponds in the southeastern united states, produces the monoterpene 2-methylisoborneol (mib), which is absorbed into catfish flesh and imparts a "musty" taste, rendering them unpalatable and unmarketable. algicides that are currently in the commercial market to control o. perornata have broad-spectrum toxicity toward other beneficial phytoplankton, such as the green alga selenastrum capricornutum, as well as l ... | 2009 | 19877680 |
| acridone alkaloids as potent inhibitors of cathepsin v. | cathepsin v is a lysosomal cysteine peptidase highly expressed in thymus, testis and corneal epithelium. eleven acridone alkaloids were isolated from swinglea glutinosa (bl.) merr. (rutaceae), with eight of them being identified as potent and reversible inhibitors of cathepsin v (ic(50) values ranging from 1.2 to 3.9 µm). detailed mechanistic characterization of the effects of these compounds on the cathepsin v-catalyzed reaction showed clear competitive inhibition with respect to substrate, wit ... | 2011 | 21277783 |
| anti-quorum sensing activity of essential oils from colombian plants. | essential oils from colombian plants were characterised by gc-ms, and assayed for anti-quorum sensing activity in bacteria sensor strains. two major chemotypes were found for lippia alba, the limonene-carvone and the citral (geranial-neral). for other species, the main components included α-pinene (ocotea sp.), β-pinene (swinglea glutinosa), cineol (elettaria cardamomun), α-zingiberene (zingiber officinale) and pulegone (minthostachys mollis). several essential oils presented promising inhibitor ... | 2011 | 21936639 |
| repellent and anti-quorum sensing activity of six aromatic plants occurring in colombia. | essential oils (eos) are widely used as biopesticides and to control bacterial infections. this study describes the ability of six eos isolated from plants cultivated in colombia to perform as repellents against ulomoides dermestoides and as quorum sensing (qs) inhibitors. eos from aloysia triphylla, cymbopogon nardus, lippia origanoides, hyptis suaveolens, swinglea glutinosa and eucalyptus globulus were repellents classified as class iv, iv, iv, iii, ii, and ii, respectively, whereas the commer ... | 2015 | 26669119 |
| insecticidal and repellent activity of several plant-derived essential oils against aedes aegypti. | we examined the pupicidal, adulticidal, repellent, and oviposition-deterrent activities of essential oils (eos) from lippia alba, l. origanoides, eucalyptus citriodora, cymbopogon citratus, cymbopogon flexuosus, citrus sinensis , cananga odorata , swinglea glutinosa, and tagetes lucida plants against aedes aegypti under laboratory conditions. pupicidal and adulticidal activities were assessed at exploratory concentrations of 250, 310, and 390 parts per million (ppm); and 30, 300, and 1,000 ppm, ... | 2017 | 28388322 |
| essential oils with insecticidal activity against larvae of aedes aegypti (diptera: culicidae). | insecticidal activity of the essential oils (eos) isolated from tagetes lucida, lippia alba, lippia origanoides, eucalyptus citriodora, cymbopogon citratus, cymbopogon flexuosus, citrus sinensis, swinglea glutinosa, and cananga odorata aromatic plants, grown in colombia (bucaramanga, santander), and of a mixture of l. alba and l. origanoides eos were evaluated on aedes (stegomyia) aegypti rockefeller larvae. the eos were extracted by microwave-assisted hydrodistillation and characterized by gas ... | 2014 | 24781026 |
| acridone alkaloids from swinglea glutinosa (rutaceae) and their effects on photosynthesis. | continuing our search for herbicide models based on natural products, we investigated the action mechanisms of five alkaloids isolated from swinglea glutinosa (rutaceae): citrusinine-i (1), glycocitrine-iv (2), 1,3,5-trihydroxy-10-methyl- 2,8-bis(3-methylbut-2-en-1-yl)-9(10h)-acridinone (3), (2r)-2-tert-butyl-3,10-dihydro-4,9-dihydroxy-11-methoxy-10-methylfuro[3,2-b]acridin-5(2h)-one (4), and (3r)-2,3,4,7-tetrahydro-3,5,8-trihydroxy-6-methoxy-2,2,7-trimethyl-12h-pyrano[2,3-a]acridin-12-one (5) o ... | 2016 | 26765357 |