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the inhibitory effect of the cowhage plant-mucuna pruriens-and l-dopa on chlorpromazine-induced hyperprolactinaemia in man. 1978753997
blood sugar and total cholesterol lowering effect of glycine soja (sieb and zucc.), mucuna pruriens (d.c.) and dolichos biflorus (linn.) seed diets in normal fasting albino rats. 19685732448
nutritive value of the foods cultivated and consumed by the tribals of south india.twenty five foods cultivated and consumed by the tribals of andhra pradesh, india, comprising cereals/millets, legumes, tubers and miscellaneous foods collected seasonally from 20 tribal villages were analysed for proximate composition, vitamins and minerals. the major findings of the study were as follows: protein content of cereals/millets ranged from 6.8 to 11.8 g per 100 g and that of legumes from 20 to 23.8 g per 100 g. the uncommon legume, judumulu (vigna sp.) grown by the tribals had the ...19947971787
association of l-dopa with recovery following ayurveda medication in parkinson's disease.ayurveda, the indian system of traditional medicine, uses a concoction of several spices, herbs and minerals for the treatment of diseases. in a clinical prospective study we have evaluated the efficacy of ayurveda treatment (a concoction in cow's milk of powdered mucuna pruriens and hyoscyamus reticulatus seeds and withania somnifera and sida cordifolia roots) in 18 clinically diagnosed (with a mean hoen and yahr value of 2.22) parkinsonian patients. as per ayurveda principles, 13 patients unde ...200010930594
studies on the nutritional composition and antinutritional factors of three different germplasm seed materials of an under-utilized tropical legume, mucuna pruriens var. utilis.two different germplasms of a white variety and one germplasm of a black variety of mucuna pruriens var. utilis were evaluated for their physicochemical properties as well as their nutritional and antinutritional characteristics. all germplasms had higher grain weight, density, hydration, and swelling capacity than other common legumes. the dehulled samples contained 303.2-335.5 g(-1) protein and 46.1-53.5 g x kg(-1) lipid, and these values were higher than the respective whole seeds. the levels ...200011312778
blood chemistry of rats pretreated with mucuna pruriens seed aqueous extract mp101uj after echis carinatus venom challenge.the effect of a lethal echis carinatus venom on serum enzyme levels and blood plasma coagulation parameters in rats pretreated with mucuna pruriens seed aqueous extract mp101uj (21 mg/kg body wt) 24 h and 3 wk before i.p venom injection (0.50 mg/kg rat) and rats injected with venom alone (0.50 mg/kg body wt) was investigated. the enzyme levels and coagulation parameter levels were measured 4 h after venom administration. the results showed that the increased enzymes lactate dehydrogenase (ldh), ...200111746865
medicinal plants of india with anti-diabetic potential.since ancient times, plants have been an exemplary source of medicine. ayurveda and other indian literature mention the use of plants in treatment of various human ailments. india has about 45000 plant species and among them, several thousands have been claimed to possess medicinal properties. research conducted in last few decades on plants mentioned in ancient literature or used traditionally for diabetes have shown anti-diabetic property. the present paper reviews 45 such plants and their pro ...200212020931
the effect of momordica charantia and mucuna pruriens in experimental diabetes and their effect on key metabolic enzymes involved in carbohydrate metabolism.the indian traditional system of medicine prescribed traditional plant therapies. two such plants, i.e. momordica charantia (mc) and mucuna pruriens (mp), earlier shown to reduce hyperglycaemia, were assessed for their anti hyperglycaemic effect on varying degrees of hyperglycaemia and diabetic complications. alcohol and aqueous extracts of mc (50, 100 and 200 mg/kg/day) and only an alcohol extract of mp (100, 200 and 400 mg/kg/day) were evaluated in a pilot study (plasma glucose >180 mg/dl, 21 ...200212164268
amelioration of experimental diabetic neuropathy and gastropathy in rats following oral administration of plant (eugenia jambolana, mucuna pruriens and tinospora cordifolia) extracts.extract of m. charantia (200 mg/kg), e. jambolana (200 mg/kg), m. pruriens (200 mg/kg) and t. cordifolia (400 mg/kg) was administered for 50 days in stz induced diabetic mice, the plasma glucose concentration was reduced by 24.4, 20.84, 7.45 and 9.07% respectively. tail flick latency (tfl) and gastric transit percentage were significantly higher in diabetic controls versus normal controls. m. charantia and e. jambolana modified it favorably while m. pruriens and t. cordifolia did not exert any f ...200212635695
symbiotic performance of herbaceous legumes in tropical cover cropping systems.increasing use of herbaceous legumes such as mucuna ( mucuna pruriens var. utilis [wright] bruck) and lablab ( lablab purpureus [l.] sweet) in the derived savannas of west africa can be attributed to their potential to fix atmospheric nitrogen (n2). the effects of management practices on n2 fixation in mucuna and lablab were examined using 15n isotope dilution technique. dry matter yield of both legumes at 12 weeks was two to five times more in in situ mulch (im) than live mulch (lm) systems. la ...200112805778
effects of crude extracts of mucuna pruriens (fabaceae) and carica papaya (caricaceae) against the protozoan fish parasite ichthyophthirius multifiliis.the ciliate ichthyophthirius multifiliis is among the most pathogenic parasites of fish maintained in captivity. in the present study, the effects of the crude methanolic extract of leaves of mucuna pruriens and the petroleum-ether extract of seeds of carica papaya against i. multifiliis were investigated under in vivo and in vitro conditions. goldfish (carassius auratus auratus) infected with the parasites were immersed for 72 h in baths with m. pruriens extract, and for 96 h in baths with c. p ...200414735356
preference of sheep for three forms of mucuna forage and the effect of supplementation with mucuna forage on the performance of sheep.assessment of the preference of sheep for fresh, dried or ensiled forms of mucuna (mucuna pruriens var utilis) forage was followed by investigations into the effect of supplementing straw-based diets with the forage. four sheep were offered fresh, dried and ensiled forms of the forage in a cafeteria style to assess their preference. in the second experiment, 20 sheep were randomly assigned to four dietary treatments, namely, alkali-treated straw only (m0), treated straw supplemented with mucuna ...200414998313
neuroprotective effects of the antiparkinson drug mucuna pruriens.mucuna pruriens possesses significantly higher antiparkinson activity compared with levodopa in the 6-hydroxydopamine (6-ohda) lesioned rat model of parkinson's disease. the present study evaluated the neurorestorative effect of mucuna pruriens cotyledon powder on the nigrostriatal tract of 6-ohda lesioned rats. mucuna pruriens cotyledon powder significantly increased the brain mitochondrial complex-i activity but did not affect the total monoamine oxidase activity (in vitro). unlike synthetic l ...200415478206
relationships among isoprene emission rate, photosynthesis, and isoprene synthase activity as influenced by temperature.isoprene emissions from the leaves of velvet bean (mucuna pruriens l. var utilis) plants exhibited temperature response patterns that were dependent on the plant's growth temperature. plants grown in a warm regimen (34/28 degrees c, day/night) exhibited a temperature optimum for emissions of 45 degrees c, whereas those grown in a cooler regimen (26/20 degrees c, day/night) exhibited an optimum of 40 degrees c. several previous studies have provided evidence of a linkage between isoprene emission ...199216668743
structural characterization of the n-glycans of gpmuc from mucuna pruriens seeds.mucuna pruriens seeds are used in some countries as a human prophylactic oral anti-snake remedy. aqueous extracts of m. pruriens seeds possess in vivo activity against cobra and viper venoms, and protect mice against echis carinatus venom. it was recently demonstrated that the seed immunogen generating the antibody that cross-reacts with the venom proteins is a multiform glycoprotein (gpmuc), and the immunogenic properties of gpmuc seemed to mainly reside in its glycan chains. in the present stu ...200617006651
antiparkinson drug--mucuna pruriens shows antioxidant and metal chelating activity.parkinson's disease is a neurodegenerative disorder for which no neurorestorative therapeutic treatment is currently available. oxidative stress plays an important role in the pathophysiology of parkinson's disease. the ancient indian medical system, ayurveda, traditionally uses mucuna pruriens to treat parkinson's disease. in our earlier studies, mucuna pruriens has been shown to possess antiparkinson and neuroprotective effects in animal models of parkinson's disease. the antioxidant activity ...200818064727
proteomic analysis of the pathophysiological process involved in the antisnake venom effect of mucuna pruriens extract.previously, we reported the antisnake venom properties of a mucuna pruriens seed extract (mpe) and tested its in vivo efficacy against echis carinatus venom (ev) in short- (1 injection) and long-term (three weekly injections) treatments. the aim of the present study was to investigate plasma proteome changes associated with mpe treatments and identify proteins responsible for survival of envenomated mice (challenged mice). six treatment groups were studied. three control groups: one saline, one ...200818203263
effect of mucuna pruriens on oxidative stress mediated damage in aged rat sperm.mucuna pruriens linn., a leguminous plant, has been recognized as an aphrodisiac and spermatogenic agent. protective efficacy of m. pruriens on reactive oxygen species (ros)-induced pathophysiological alterations in structural and functional integrity of epididymal sperm in aged wister albino rat was analysed. animals were grouped as groups i, ii, iii and iv, i.e. young (control), aged, aged treated with ethanolic extract (200 mg/kg b.w.) of m. pruriens and young rats treated with m. pruriens, r ...201019207619
the protective effect of mucuna pruriens seeds against snake venom poisoning.the seed, leaf and root of mucuna pruriens have been used in traditional medicine for treatments of various diseases. in nigeria, the seed is used as oral prophylactics for snakebite.200919429384
cowitch seed agar medium - a simple new medium for identification and melanin production of cryptococcus neoformans.summary a simple medium for identification and melanin production of cryptococcus neoformans was developed using cowitch (mucuna pruriens) seeds.200919895418
effect of feeding mucuna pruriens on helminth parasite infestation in lambs.mucuna pruriens is a tropical legume anecdotally reputed to have anthelmintic properties. this study was conducted to examine the validity of such claims.201019969060
nutritional and anti-nutritional potential of three accessions of itching bean (mucuna pruriens (l.) dc var. pruriens): an under-utilized tribal pulse.three accessions of the under-utilized legume itching bean (mucuna pruriens var. pruriens) were analysed for proximate composition, mineral profiles, vitamins (niacin and ascorbic acid), fatty acid profiles, amino acid profiles of total seed protein, in vitro protein digestibility and certain anti-nutritional factors. all three accessions of m. pruriens var. pruriens contained higher amounts of crude protein and crude lipid when compared with most of the commonly consumed pulses. the fatty acid ...201020128635
a water extract of mucuna pruriens provides long-term amelioration of parkinsonism with reduced risk for dyskinesias.dopaminergic anti-parkinsonian medications, such as levodopa (ld) cause drug-induced dyskinesias (did) in majority of patients with parkinson's disease (pd). mucuna pruriens, a legume extensively used in ayurveda to treat pd, is reputed to provide anti-parkinsonian benefits without inducing did. we compared the behavioral effects of chronic parenteral administration of a water extract of m. pruriens seed powder (mpe) alone without any additives, mpe combined with the peripheral dopa-decarboxylas ...201020570206
bioconversion of l: -tyrosine to l: -dopa by a novel bacterium bacillus sp. jpj.l: -dopa is an amino acid derivative and most potent drug used against parkinson's disease, generally obtained from mucuna pruriens seeds. in present communication, we have studied the in vitro production of l: -dopa from l: -tyrosine by novel bacterium bacillus sp. jpj. this bacterium produced 99.4% of l: -dopa from l: -tyrosine in buffer (ph 8) containing 1 mg ml(-1) cell mass incubated at 40°c for 60 min. the combination of cuso(4) and l: -ascorbic acid showed the inducing effect at concentra ...201020963458
effect of mucuna pruriens (linn.) on oxidative stress-induced structural alteration of corpus cavernosum in streptozotocin-induced diabetic rat.erectile dysfunction is one of the major secondary complications of diabetes. mucuna pruriens (m. pruriens), a leguminous plant identified for its antidiabetic, aphrodisiac, and fertility enhancing properties, has been the choice of indian traditional medicine.201121366877
protective effects of mucuna pruriens seed extract pretreatment against cardiovascular and respiratory depressant effects of calloselasma rhodostoma (malayan pit viper) venom in rats.the protective effects of mucuna pruriens seed extract (mpe) against the cardio-respiratory depressant and neuromuscular paralytic effects induced by injection of calloselasma rhodostoma (malayan pit viper) venom in anaesthetized rats were investigated. while mpe pretreatment did not reverse the inhibitory effect of the venom on the gastrocnemius muscle excitability, it significantly attenuated the venom-induced cardio-respiratory depressant effects (p<0.05). the protection effects may have an i ...201021399576
phytochemical analysis and antioxidant property of leaf extracts of vitex doniana and mucuna pruriens.oxidative stress and impaired antioxidant system have been implicated in the pathophysiology of diverse disease states. the phytochemical screening and antioxidant property of fresh leaves of vitex doniana and mucuna pruriens, used in the management and treatment of various diseases, were studied. the extracts (ethanol and distilled water) were screened for the presence of phytochemicals, and their inhibition of 2,2-diphenyl-1-picryl-hydrazyl (dpph) radical was used to evaluate their free radica ...201121547085
the protective effects of mucuna pruriens seed extract against histopathological changes induced by malayan cobra (naja sputatrix) venom in rats.seed of mucuna pruriens (velvet beans) has been prescribed by traditional medicine practitioners in nigeria as a prophylactic oral antisnake remedy. in the present studies, we investigated the protective effects of m. pruriens seed extract (mpe) against histopathological changes induced by intravenous injection of naja sputatrix (malayan cobra) venom in rats pretreated with the seed extract. examination by light microscope revealed that the venom induced histopathological changes in heart and bl ...200919696731
anticataleptic and antiepileptic activity of ethanolic extract of leaves of mucuna pruriens: a study on role of dopaminergic system in epilepsy in albino rats.to assess the anticataleptic and antiepileptic activity of leaves of mucuna pruriens in albino rats.201121572658
mucuna pruriens linn. seed extract pretreatment protects against cardiorespiratory and neuromuscular depressant effects of naja sputatrix (javan spitting cobra) venom in rats.mucuna pruriens has been used by native nigerians as a prophylactic for snakebite. the protective effects of m. pruriens seed extract (mpe) were investigated against the pharmacological actions of n. sputatrix (javan spitting cobra) venom in rats. the results showed that mpe-pretreatment protected against cardiorespiratory and, to a lesser extent, neuromuscular depressant effects of n. sputatrix venom. these may be explained at least in part by the neutralisation of the cobra venom toxins by ant ...201121614888
effect of mucuna pruriens seed extract pretreatment on the responses of spontaneously beating rat atria and aortic ring to naja sputatrix (javan spitting cobra) venom.mucuna pruriens linn. (velvet bean) has been used by native nigerians as a prophylactic for snakebite. rats pretreated with m. pruriens seed extract (mpe) have been shown to protect against the lethal and cardiovascular depressant effects of naja sputatrix (javan spitting cobra) venoms, and the protective effect involved immunological neutralization of the venom toxins. to investigate further the mechanism of the protective effect of mpe pretreatment against cobra venom toxicity, the actions of ...201221785646
Investigation of neuropsychopharmacological effects of a polyherbal formulation on the learning and memory process in rats.To investigate the neuropsychopharmacological effect of a polyherbal formulation (PHF) on the learning and memory processes in rats.201121731356
evaluation of the metabolizable energy value for growing lambs of the mucuna pruriens seed and the whole pod.whole pod and seeds of velvet bean (mucuna pruriens) were included in diets for growing sheep used to validate previously estimated me values of 9.7 mj and 12.6 mj for whole pod and seed respectively. twenty-four lambs, 15 females and nine males of 18.7 ± 2.4 kg average weight, were allocated in three treatments using a completely randomized block design with eight replicates per treatment. each group was given a diet with a ratio of 60% of napier grass (pennisetum purpureum) and 40% of a supple ...201121909932
evaluation of the anti-diabetic properties of mucuna pruriens seed extract.to explore the antidiabetic properties of mucuna pruriens(m. pruriens).201121914541
dose- and time-dependent effects of ethanolic extract of mucuna pruriens linn. seed on sexual behaviour of normal male rats.according to indian systems of medicine, mucuna pruriens linn., belonging to the leguminous family (papilionaceae), were used for treating male sexual disorders since ancient times. in this study, the effects of ethanolic extracts of the mucuna pruriens linn. seed on general mating behaviour, libido and potency of normal male wister albino rats were investigated and also compared with the standard reference drug, sildenafil citrate.200919429319
polyphasic approach for the characterization of rhizobial symbionts effective in fixing n(2) with common bean (phaseolus vulgaris l.).common bean (phaseolus vulgaris l.) is a legume that has been reported as highly promiscuous in nodulating with a variety of rhizobial strains, often with low effectiveness in fixing nitrogen. the aim of this work was to assess the symbiotic efficiency of rhizobial strains isolated from common bean seeds, nodules of arachis hypogaea, mucuna pruriens, and soils from various brazilian agroecosystems, followed by the characterization of elite strains identified in the first screening. forty-five el ...201122159885
assessment of symptomatic and neuroprotective efficacy of mucuna pruriens seed extract in rodent model of parkinson's disease.mucuna pruriens (mp) has long been used in indian traditional medicine as support in the treatment of parkinson's disease. however, no systematic preclinical studies that aimed at evaluating the efficacy of this substance are available to date. this study undertook an extensive evaluation of the antiparkinsonian effects of an extract of mp seeds known to contain, among other components, 12.5% l: -dihydroxyphenylalanine (l: -dopa), as compared to equivalent doses of l: -dopa. moreover, the neurop ...200919384573
bioactive compounds extracted from indian wild legume seeds: antioxidant and type ii diabetes-related enzyme inhibition properties.seven different wild legume seeds (acacia leucophloea, bauhinia variegata, canavalia gladiata, entada scandens, mucuna pruriens, sesbania bispinosa and tamarindus indica) from various parts of india were analyzed for total free phenolics, l-dopa (l-3,4 dihydroxyphenylalanine), phytic acid and their antioxidant capacity (ferric-reducing antioxidant power [frap] and 2,2-diphenyl-1-picrylhydrazyl [dpph] assay) and type ii diabetes-related enzyme inhibition activitiy (α-amylase). s. bispinosa had th ...201121970446
analysis of some biochemical and haematological parameters for mucuna pruriens (dc) seed powder in male rats.the biochemical and haematological effects of the seed powder of mucuna pruriens in male rats were evaluated to establish some biological properties of this potential biopesticide currently undergoing investigation. the result showed that mucuna pruriens seed extract produced a significant (p<0.05) increase in white blood cell (wbc) count, as well as in bilirubin concentrations, alkaline phosphatase (alp), protein and creatinine levels measured. alanine aminotransferase (alt) and aspartate amino ...201121959815
hypoglycemic effect of mucuna pruriens seed extract on normal and streptozotocin-diabetic rats.the hypoglycemic effect of the aqueous extract of the seeds of mucuna pruriens was investigated in normal, glucose load conditions and streptozotocin (stz)-induced diabetic rats. in normal rats, the aqueous extract of the seeds of mucuna pririens (100 and 200 mg/kg body weight) significantly (p<0.001) reduced the blood glucose levels after an oral glucose load from 127.5+/-3.2 to 75.6+/-4.8 mg% 2 h after oral administration of seed extract. it also significantly lowered the blood glucose in stz ...200818672037
effect of sorghum-sudangrass and velvetbean cover crops on plant-parasitic nematodes associated with potato production in florida.in a 3-year field study, population densities of belonolaimus longicaudatus and other plant-parasitic nematodes and crop yields were compared between potato (solanum tuberosum) cropping systems where either sorghum-sudangrass (sorghum bicolor x s. arundinaceum) or velvetbean (mucuna pruriens) was grown as a summer cover crop. population densities of b. longicaudatus, paratrichodorus minor, tylenchorhynchus sp., and mesocriconema sp. increased on sorghum-sudangrass. population densities of p. min ...200119265888
assessment of plant lectin antifungal potential against yeasts of major importance in medical mycology.the search for new compounds with antifungal activity is accelerating due to rising yeast and fungal resistance to commonly prescribed drugs. among the molecules being investigated, plant lectins can be highlighted. the present work shows the potential of six plant lectins which were tested in vitro against yeasts of medical importance, candida albicans, candida tropicalis, candida parapsilosis, cryptococcus gattii, cryptococcus neoformans, malassezia pachydermatis, rhodotorula sp. and trichospo ...201323161017
[evaluation of a new medium, eggplant (solanum melongena) agar as a screening medium for cryptococcus neoformans in environmental samples].cryptococcus neofomans is an encapsulated yeast-like fungus that causes life-threatening infections, especially in immunosuppresive patients. c.neoformans infection is believed to be acquired via inhalation of aerosolized particles from the environment. avian guano, decaying tree hollows and soil are the related known environmental niches. brown pigmented yeast growth from the precursors in growth media is an important step for the identification and isolation of c.neoformans. seeds of plants in ...201424819266
estimation of l-dopa from mucuna pruriens linn and formulations containing m. pruriens by hptlc method.a selective, precise, and accurate high-performance thin-layer chromatographic (hptlc) method has been developed for the analysis of l-dopa in mucuna pruriens seed extract and its formulations. the method involves densitometric evaluation of l-dopa after resolving it by hptlc on silica gel plates with n-butanol-acetic acid-water (4.0+1.0+1.0, v/v) as the mobile phase. densitometric analysis of l-dopa was carried out in the absorbance mode at 280 nm. the relationship between the concentration of ...200818310948
velvetbean (mucuna pruriens) extracts: impact on meloidogyne incognita survival and on lycopersicon esculentum and lactuca sativa germination and growth.velvetbean (mucuna spp.) is a summer annual that has been used as a cover crop to reduce erosion, fix nitrogen and suppress weeds and plant-parasitic nematodes. crude aqueous extracts (1:15 dry weight plant/volume water) were made from velvetbean plant parts, and various concentrations of the extracts were evaluated in vitro for toxicities to different stages of meloidogyne incognita (kofoid and white) chitwood and for suppression of hypocotyl and root growth and inhibition of germination of tom ...200616953489
practical use of cmc-amended rhizobial inoculant for mucuna pruriens cultivation to enhance the growth and protection against macrophomina phaseolina.in many parts of the world mucuna pruriens is used as an important medicinal, forage and green manure crop. in the present investigation the effect of the addition of cmc in carrier during development of bioformulation on shelflife, plant growth promotive and biocontrol activity against macrophomina phaseolina was screened taking m. pruriens as a test crop. ensifer meliloti rmp6(ery+kan+) and bradyrhizobium sp. bmp7(tet+kan+) (kanamycin resistance engineered by tn5 transposon mutagenesis) used i ...201222688243
appraisal on the wound healing activity of different extracts obtained from aegle marmelos and mucuna pruriens by in vivo experimental models.the use of a simple and reproducible model is inevitable for an objective statement of the effects of external factors on wound healing. hence, the present study was conducted to evaluate wound healing activities of sequential different extracts of aegle marmelos leaves (am) and mucuna pruriens seeds (mp) by in vivo experimental models.201627811447
aphrodisiac activity of polyherbal formulation in experimental models on male rats.to investigate the aphrodisiac potential of polyherbal formulations prepared from different parts of tribulus terrestris, curculigo orchioides, allium tuberosum, cucurbita pepo, elephant creeper, mucuna pruriens, and terminalia catappa in albino rats in specified ratio as suspension.201424761115
bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems.livestock and aquaculture production is under political and social pressure, especially in the european union (eu), to decrease pollution and environmental damage arising due to animal agriculture. the eu has banned the use of antibiotics and other chemicals, which have been shown to be effective in promoting growth and reducing environment pollutants because of the risk caused to humans by chemical residues in food and by antibiotic resistance being passed on to human pathogens. as a result of ...200722444893
anti-parkinson botanical mucuna pruriens prevents levodopa induced plasmid and genomic dna damage.levodopa is considered the 'gold standard' for the treatment of parkinson's disease. however, a serious concern is dyskinesia and motor fluctuation that occurs after several years of use. in vitro experiments have shown that in the presence of divalent copper ions, levodopa may induce intense dna damage. mucuna pruriens cotyledon powder (mpcp) has shown anti-parkinson and neuroprotective effects in animal models of parkinson's disease that is superior to synthetic levodopa. in the present study ...200717622977
alternative food/feed perspectives of an underutilized legume mucuna pruriens var. utilis--a review.mucuna pruriens var. utilis, an underutilized tropical legume has a nutritional quality comparable to soya beans and other conventional legumes as it contains similar proportions of protein, lipid, minerals, and other nutrients. the beans have been traditionally used as a food in a number of countries, viz., india, philippines, nigeria, ghana, brazil, and malawi. recently, the velvet beans are exploited as a protein source in the diets of fish, poultry, pig, and cattle after subjected to appropr ...200516395632
effect of antiparkinson drug hp-200 (mucuna pruriens) on the central monoaminergic neurotransmitters.hp-200, which contains mucuna pruriens endocarp, has been shown to be effective in the treatment of parkinson's disease. mucuna pruriens endocarp has also been shown to be more effective compared to synthetic levodopa in an animal model of parkinson's disease. the present study was designed to elucidate the long-term effect of mucuna pruriens endocarp in hp-200 on monoaminergic neurotransmitters and its metabolite in various regions of the rat brain. hp-200 at a dose of 2.5, 5.0 or 10.0 g/kg/day ...200415022157
in vivo inhibition of helicoverpa armigera gut pro-proteinase activation by non-host plant protease inhibitors.we evaluated 22 different host and non-host plant protease inhibitors (pis) for in vivo inhibition of helicoverpa armigera gut pro- and proteinases, and their biological activity against the pod borer, h. armigera, the most important pest of agriculture and horticultural crops worldwide. in vitro activation of h. armigera gut pro-proteinases (hagpps) in larvae fed on non-host plant pis showed significant in vivo inhibition of hagpps activation in solution as well as in gel assays. the larvae fed ...201020416317
epidemiology and treatment of parkinson's disease in india.parkinson's disease (pd) has a low prevalence in india except in the small parsi community where bharucha et al. found a high prevalence. although early onset pd and familial cases have been described from india, no genetic mutations have as yet been identified. pd has been known in india since ancient days and the powder of mucuna pruriens seeds was used for its treatment. the present day management of pd in india is similar to that in the other countries. unfortunately, lack of awareness, limi ...200312915075
prevention of experimental diabetic cataract by indian ayurvedic plant extracts.the efficacy of momordica charantia (mc), eugenia jambolana (ej), tinospora cordifolia (tc) and mucuna pruriens (mp) was assessed in the prevention of murine alloxan dibetic cataract. alloxan (120 mg/kg) was used as the diabetogenic agent. while controls and diabetic controls did not receive any plant extract, treated rats received lyophilized aqueous extract of mc and ej (200 mg/kg p.o.), alcohol extract of tc (400 mg/kg) and mp (200 mg/kg p.o.) every day until 4 months. serum glucose concentra ...200212458487
effect of the alcohol extract of the seeds of mucuna pruriens on free radicals and oxidative stress in albino rats.in vitro and in vivo studies were made with an alcohol extract of the seeds of mucuna pruriens (fabaceae) to investigate its antioxidant property. in vitro studies were carried out in rat liver homogenate to investigate the chemical interaction of various phytochemicals with different species of free radicals. the effect was also checked on iron-induced lipid peroxidation, oxidation of gsh content, and its interaction with hydroxyl and superoxide radicals. there was no change on the rate of aeri ...200212237810
effects of five ayurvedic herbs on locomotor behaviour in a drosophila melanogaster parkinson's disease model.current conventional treatments for parkinson's disease (pd) are aimed at symptom management, as there is currently no known cure or treatment that can slow down its progression. ayurveda, the ancient medical system of india, uses a combination of herbs to combat the disease. herbs commonly used for this purpose are zandopa (containing mucuna pruriens), withania somnifera, centella asiatica, sida cordifolia and bacopa monnieri. in this study, these herbs were tested for their potential ability t ...201425091506
an evidence-based approach to medicinal plants for the treatment of sperm abnormalities in traditional persian medicine.infertility is defined as inability of a sexually active couple to conceive after 1 year of regular intercourse without contraception. male factors account for 20%-50% of cases of infertility. the aim of this study was to review medicinal plants that proposed to improve sperm abnormalities in traditional persian medicine. for this purpose, pubmed, scopus, googlescholar and cochrane library were explored for medicinal plants used in traditional persian medicine for sperm abnormalities to obtain s ...201627681644
traditional indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice.the purpose of the study was to investigate the effects of daily oral feeding momordica charantia (mc) (200 mg/kg), eugenia jambolana (ej) (200 mg/kg), mucuna pruriens (mp) (200 mg/kg) and tinospora cordifolia (tc) extracts for 40 days on blood glucose concentrations and kidney functions in streptozotocin (stz)-diabetic rats. plasma glucose levels, body weight, urine volume and urinary albumin levels were monitored on every 10th day over a 40-day period while plasma creatinine levels were assess ...200111448544
effect of various domestic processing methods on antinutrients and in vitro protein and starch digestibility of two indigenous varieties of indian tribal pulse, mucuna pruriens var. utilis.the effect of various domestic processing methods on antinutrients and starch fractions and in vitro protein and starch digestibilities of white and black varieties of mucuna pruriens var. utilis was studied. cooking or autoclaving of both raw seeds and presoaked seeds in different solutions (water, tamarind extract, sodium bicarbonate, and citric acid) significantly (p < 0.05) reduced the content of total phenolics, phytic acid, trypsin inhibitor and chymotrypsin inhibitor activities, and l-dop ...200111410009
nutritional and anti-nutritional composition of velvet bean: an under-utilized food legume in south india.four accessions of the under-utilized legume, velvet bean (mucuna pruriens var. utilis (wall. ex wight) bak. ex burck), collected from three different locations of western ghats, south india were analysed for proximate composition, mineral profiles, the protein fractions, amino acid profiles of total seed protein, in vitro protein digestibility and certain anti-nutritional factors to determine their potential as an alternative source to alleviate protein-energy-malnutrition among the people of s ...200011027039
development of a neuroprotective potential algorithm for medicinal plants.medicinal plants are promising candidates for alzheimer's disease (ad) research but there is lack of systematic algorithms and procedures to guide their selection and evaluation. herein, we developed a neuroprotective potential algorithm (npa) by evaluating twenty-three standardized and chemically characterized ayurvedic medicinal plant extracts in a panel of bioassays targeting oxidative stress, carbonyl stress, protein glycation, amyloid beta (aβ) fibrillation, acetylcholinesterase (ache) inhi ...201627693453
management of parkinson's disease in ayurveda: medicinal plants and adjuvant measures.medicinal plants like mucuna pruriens l.(dc) and withania somnifera l.(dunal) have been used in traditional ayurvedic medicine to manage neurodegenerative diseases like parkinson's disease.201727544001
determination of toxic metals by icp-ms in asiatic and european medicinal plants and dietary supplements.the potentially toxic metals content was determined in selected plants, used in traditional chinese medicine (angelica sinensis, bacopa monnieri, bupleurum sinensis, curcuma longa, cola accuminata, emblica officinalis, garcinia cambogia, mucuna pruriens, ocimum sanctum, panax ginseng, pueraria lobata, salvia miltiorrhiza, schisandra sinensis, scutellaria baicalensis, siraitia grosvenorii, terminalia arjuna and terminalia chebula), and some european herbs (echinacea purpurea, hypericum perforatum ...201525467854
evaluation of raw and heated velvet beans (mucuna pruriens) as feed ingredients for broilers.velvet bean plants (mucuna pruriens) are used widely outside the u.s. as a cover crop. the beans (vb), high in protein, contain toxic substances that possibly can be destroyed by heating. few data are available on the use of vb in poultry nutrition. we examined the effects of raw and dry-roasted vb on broiler performance in two experiments. in experiment 1, 10, 20, and 30% raw vb were substituted into nutritionally balanced rations fed 0 to 42 d of age. raw vb caused progressive reductions in gr ...199910438131
effect of different post-harvest treatments on antinutritional factors in seeds of the tribal pulse, mucuna pruriens (l.) dc.the effect of soaking, cooking and autoclaving on the levels of certain antinutritional factors present in the tribal pulse, mucuna pruriens, were studied. the amount of reduction of total free phenolics was found to be greater in sodium bicarbonate solution (56%) compared to distilled water (47%); subjected to cooking and autoclaving these were further reduced to 49%. autoclaving (45 min) significantly reduced the tannin content (71%). insignificant reduction in content of l-dopa was observed i ...19968735780
mucuna pruriens (velvet bean) rescues motor, olfactory, mitochondrial and synaptic impairment in pink1b9 drosophila melanogaster genetic model of parkinson's disease.the fruit fly drosophila melanogaster (dm) mutant for pten-induced putative kinase 1 (pink1b9) gene is a powerful tool to investigate physiopathology of parkinson's disease (pd). using pink1b9 mutant dm we sought to explore the effects of mucuna pruriens methanolic extract (mpe), a l-dopa-containing herbal remedy of pd. the effects of mpe on pink1b9 mutants, supplied with standard diet to larvae and adults, were assayed on 3-6 (i), 10-15 (ii) and 20-25 (iii) days old flies. mpe 0.1% significantl ...201425340511
herbs containing l- dopa: an update.l-dopa is the drug of choice in the treatment of parkinson's disease but it has dose related adverse effects such as nausea, vomiting, orthostatic hypotension, end of dose deterioration, on off phenomena and on chronic therapy motor complications synonymous to parkinsonism. mucuna pruriens (m.p) commonly known as velvet beans or cowitch are used in case of spasms associated with parkins onism. clinical efficacy of seeds of this plant was confirmed and the efficacy was contributed to its l-dopa c ...200722557260
paralysis agitans and levodopa in "ayurveda": ancient indian medical treatise.neurologic diseases (vata rogas, sanskrit) and the pharmacologic treatment of them were described in the ancient indian medical system--ayurveda. this article explores paralysis agitans, which was described under the name kampavata. mucuna pruriens (atmagupta, sanskrit), which contains levodopa, was used in the treatment of kampavata. existence of paralysis agitans prior to the industrial revolution is not just of historical interest, but would also suggest that under the hypothesis of exposure ...19902404203
antidiabetic evaluation of mucuna pruriens, linn seeds.effects of powdered mucuna pruriens seeds on blood glucose levels were investigated in normal and alloxan-diabetic rabbits. in normal group 0.5, 1 and 2 g/kg of m. pruriens pulv significantly decreased the blood glucose levels while in alloxan-diabetic rabbits only 1 and 2 g/kg body weight caused a significant fall. the reference drug, acetohexamide in 500 mg/kg dose significantly reduced the blood glucose levels but in normal rabbits only. high levels of trace elements like manganese, zinc, and ...19902125657
l-dopa increases lignification associated with glycine max root growth-inhibition.l-3,4-dihydroxyphenylalanine (l: -dopa), an allelochemical exuded from the roots of velvet bean [mucuna pruriens (l.) dc. var. utilis], presents a highly inhibitory action to plant growth. the effects of l-dopa on phenylalanine ammonia-lyase (pal, ec 4.3.1.5) and peroxidase (pod, ec 1.11.1.7) activities, and phenolic compound and lignin content in soybean [glycine max (l.) merr.] roots were investigated to determine the possible phytotoxic mechanism. three-day-old seedlings were cultivated in ha ...200717195115
velvet bean severe mosaic virus: a distinct begomovirus species causing severe mosaic in mucuna pruriens (l.) dc.velvet bean [mucuna pruriens (l.) dc] is one of the most important medicinal plants. it is used to treat many ailments, but is widely used for the treatment especially for parkinson's disease because of the presence of 3,4-dihydroxyphenylalanine (l: -dopa) in it. it was noticed in last 5 years that the plants in the field showed severe mosaic, downward curling of the leaves, stunting, etc. this is consistently observed over the years in india. the disease was transmitted by whiteflies and by gra ...201121556742
mucuna pruriens attenuates haloperidol-induced orofacial dyskinesia in rats.neuroleptic-induced tardive dyskinesia (td) is a motor disorder of the orofacial region resulting from chronic neuroleptic treatment. the agents improving dopaminergic transmission improve td. mucuna pruriens seed contains levodopa and amino acids. the effect of methanolic extract of m. pruriens seeds (memp) was studied on haloperidol-induced td, alongside the changes in lipid peroxidation, reduced glutathione, superoxide dismutase (sod) and catalase levels. the effect of memp was also evaluated ...201120635303
studies on the incorporation of velvet bean (mucuna pruriens var. utilis) as an alternative protein source in poultry feed and its effect on growth performance of broiler chickens.the effect of replacement of soybean meal by the velvet bean meal as an alternative protein ingredient on the growth performance of broiler chickens was investigated. the raw seeds of velvet bean [mucuna pruriens (l.) dc. var. utilis (wall. ex wight) baker ex burck], an under-utilized food legume collected from south india, was found to contain appreciable levels of crude protein (273.2 g/kg dm), lipid (60.61 g/kg dm), neutral detergent fiber (84.3 g/kg dm), and ash content (56.04 g/kg dm). soak ...201020509048
effect of mucuna pruriens (linn.) on sexual behavior and sperm parameters in streptozotocin-induced diabetic male rat.introduction.  sexual dysfunction is one of the major secondary complications in the diabetic. mucuna pruriens, a leguminous plant identified for its antidiabetic, aphrodisiac, and improving fertility properties, has been the choice of indian traditional medicine. aim.  objective of the present study was to analyze the efficacy of m. pruriens on male sexual behavior and sperm parameters in long-term hyperglycemic male rats. methods.  male albino rats were divided as group i control, group ii dia ...201020456630
identification and optimization of tyrosine hydroxylase activity in mucuna pruriens dc. var. utilis.tyrosine hydroxylase, an iron containing tetrahydrobiopterin dependent monooxygenase (tyrosine 3-monooxygenase; ec 1.14.16.2), catalyzes the rate-limiting step in which l: -dopa is formed from the substrate l-tyrosine. l-dopa concentration and activity of l-tyrosine hydroxylase enzyme were measured in roots, stem, leaves, pods, and immature seeds of mucuna pruriens. immature seeds contained maximum l-dopa content and mature leaves possessed maximum catalytic activity of tyrosine hydroxylase. tyr ...201020300771
nutrient digestibility of mucuna (mucuna pruriens var. utilis) bean in guinea fowl (numida meleagris, l): effects of heat treatment and levels of incorporation in diets.1. mucuna pruriens var. utilis is a legume, the seeds of which are scarcely used in animal diets owing to their high content of 3,4-dihydroxy-l-phenylalanine (l-dopa). 2. experiments were conducted on guinea fowl to assess the effects of two types of heat processing (cooking and toasting) on chemical composition and nutrient digestibility of mucuna seeds offered alone or incorporated at three concentrations (40, 120 or 200 g/kg) in complete diets. 3. diets containing 200 g/kg seeds had more crud ...200919904635
effects of the hydroethanolic extract of mucuna pruriens (l.) dc (fabaceae) on haematological profile in normal and haloperidol treated rats.mucuna pruriens (l.) dc (fabaceae) is a climbing plant claimed in traditional medicine to possess anti-anaemic effect.201121913505
microneurography of pruritus.microneurography of human skin nerves has recently contributed detailed information on the peripheral input leading to itch sensations. in this context it has been demonstrated that itch induced by different agents activates different neuronal populations in the pns. histamine acts on a specific subgroup of mechano-insensitive c-fibers which are also sensitive to other endogenous mediators, e.g. prostaglandine e2 and acetylcholine, and to capsaicin. since these agents can also provoke pain, a "s ...201019576959
a role for nociceptive, myelinated nerve fibers in itch sensation.despite its clinical importance, the underlying neural mechanisms of itch sensation are poorly understood. in many diseases, pruritus is not effectively treated with antihistamines, indicating the involvement of nonhistaminergic mechanisms. to investigate the role of small myelinated afferents in nonhistaminergic itch, we tested, in psychophysical studies in humans, the effect of a differential nerve block on itch produced by intradermal insertion of spicules from the pods of a cowhage plant (mu ...201122016517
quantitative determination of l-dopa in seeds of mucuna pruriens germplasm by high performance thin layer chromatography.mucuna pruriens linn. is an important medicinal plant used for treatment of parkinson's disease and many others in ancient indian medical system. l-dopa extracted from seeds of mucuna is a constituent of more than 200 indigenous drug formulations and is more effective as drug than the synthetic counterpart. a densitometric high performance thin-layer chromatographic (hptlc) method was developed for quantification of l-dopa content present in the seeds extract. the method involves separation of l ...201122707835
potential of leguminous cover crops in management of a mixed population of root-knot nematodes (meloidogyne spp.).root-knot nematode is an important pest in agricultural production worldwide. crop rotation is the only management strategy in some production systems, especially for resource poor farmers in developing countries. a series of experiments was conducted in the laboratory with several leguminous cover crops to investigate their potential for managing a mixture of root-knot nematodes (meloidogyne arenaria, m. incognita, m. javanica). the root-knot nematode mixture failed to multiply on mucuna prurie ...201022736854
microarray analysis of arabidopsis plants in response to allelochemical l-dopa.velvetbean (mucuna pruriens) plants impede the growth of neighboring plants. one compound, 3-(3',4'-dihydroxyphenyl)-l-alanine (l-dopa), is responsible for the allelopathic capacity of velvetbean. this compound is an active allelochemical that decreases root growth of several plant species. in mammals, l-dopa is a well-known therapeutic agent for the symptomatic relief of parkinson's disease. however, its mode of action in plants is still not well understood. to address such issues, gene express ...201120978802
efficacy of aphrodisiac plants towards improvement in semen quality and motility in infertile males.infertility is the inability to conceive after one year of unprotected intercourse. in the present study, herbal composition prepared by using medicinal plants having aphrodisiac potentials was administered orally to the albino rats for 40 days and to the oligospermic patients for 90 days in order to prove the efficacy of herbal composition. herbal composition was the mixture (powder form) of the medicinal plants namely, mucuna pruriens (linn), chlorophytum borivillianum (sant and fernand), and ...201222499723
effect of hydro-alcoholic root extract of plumbago zeylanica l alone and its combination with aqueous leaf extract of camellia sinensis on haloperidol induced parkinsonism in wistar rats.herbal medicines have been used to treat pd in ancient medical systems in asian countries such as india, china, japan and korea based on their own anecdotal or experience-based theories. mucuna pruriens commonly known asvelvet beans, or cow itch, are used in case of spasms associated with parkinsonism.201425206060
nutritional and antinutritional characteristics of seven south indian wild legumes.seeds from seven species of wild legumes of the south india were analyzed for proximate composition, mineral profiles, amino acid profiles of total seed protein, in vitro protein digestibility, and certain antinutritional factors to assess their potential as alternative sources of protein crops. the major findings of the study were as follows: crude protein ranged from 20.3 to 35.0%, crude lipid 3.1-9.6%, crude fiber 5.9-12.1%, ash 2.7-5.1%, and carbohydrates 49.2-61.8%. minerals viz., sodium, p ...200516021834
oligosaccharides in several philippine indigenous food legumes: determination, localization and removal.the oligosaccharide profile of raw mature seeds of seven different legumes indigenous to the philippines was measured in 70% ethanol extracts of the seeds by thin layer chromatography using hptlc plates and quantified by a densitometer. based on the results, the legumes could be ranked according to decreasing oligosaccharide content or flatulence potential as follows: sam-samping (clitoria ternatea) greater than hyacinth bean (dolichos lablab) greater than sabawel (mucuna pruriens) greater than ...19902345736
indian herbs for the treatment of neurodegenerative disease.ayurveda, an ancient system of medicine that is indigenous to india, is believed to be the world's oldest comprehensive health-care system and is now one of the most recognized and widely practiced disciplines of alternative medicine in the world. medicinal herbs have been in use for treating diseases since ancient times in india. ayurvedic therapies with medicinal herbs and herbomineral products generally provide relief without much adverse effects even after prolonged administration. neurodege ...201627651261
screening for rho-kinase 2 inhibitory potential of indian medicinal plants used in management of erectile dysfunction.activation of rho-kinase 2 (rock-ii) results in contraction of corpus cavernosum smooth muscle and rock-ii inhibitors relax corpus cavernosum in vitro and in vivo hence, plant extracts capable of inhibiting rock-ii enzyme may be useful in management of erectile dysfunction (ed). the aim of the study was to screen selected indian medicinal plants, having similar ethnopharmacological use for rock-ii inhibition.201223043981
a blend of chlorophytum borivilianum and velvet bean increases serum growth hormone in exercise-trained men.several isolated ingredients have been proposed to increase growth hormone (gh) release, including chlorophytum borivilianum and velvet bean. a combination of these two ingredients has been packaged within an investigational dietary supplement. it was the purpose of the present investigation to determine the impact of acute ingestion of this supplement on circulating gh in healthy, exercise-trained men.201123946662
mucuna pruriens seed powder feeding influences reproductive conditions and development in japanese quail coturnix coturnix japonica.this study was designed to test whether mucuna pruriens, a natural source of l-dihydroxyphenylalanine (l-dopa, a dopamine precursor) feeding, can influence development and reproductive conditions in the high food value bird, japanese quail, coturnix coturnix japonica. experiments were performed in both male and female japanese quail. one-week-old quail chicks were divided into three groups of 36 birds each. group i was provided with normal diet and served as control. group ii was provided with f ...200922444229
an alternative medicine treatment for parkinson's disease: results of a multicenter clinical trial. hp-200 in parkinson's disease study group.the natural occurrence of antiparkinsonian drugs in plants--anticholinergics in datura stramonium, levodopa in mucuna pruriens and vicia faba, dopamine agonist activity in claviceps purpura, and mao inhibitor activity in banisteria caapi-are known. our study examined the efficacy and tolerability of hp-200, derived from mucuna prurient, in patients with parkinson's disease. sixty patients with parkinson's disease (46 male and 14 female) with a mean (+/- sd) age of 59 +/- 9 years were treated in ...19959395621
differential effects of phytotherapic preparations in the hsod1 drosophila melanogaster model of als.the present study was aimed at characterizing the effects of withania somnifera (wse) and mucuna pruriens (mpe) on a drosophila melanogaster model for amyotrophic lateral sclerosis (als). in particular, the effects of wse and mpe were assessed following feeding the flies selectively overexpressing the wild human copper, zinc-superoxide dismutase (hsod1-gain-of-function) in drosophila motoneurons. although als-hsod1 mutants showed no impairment in life span, with respect to gal4 controls, the res ...201728102336
effects of soybean ingestion on pharmacokinetics of levodopa and motor symptoms of parkinson's disease--in relation to the effects of mucuna pruriens.mucuna pruriens is a levodopa-containing legume and its favorable effects on motor complications in parkinson disease patients have been reported. the aim of this study was to investigate the effects of another legume, soybeans, on the pharmacokinetics and metabolism of levodopa. seven parkinsonian patients with the wearing-off phenomenon and dyskinesia and five healthy volunteers participated in this study. we conducted a crossover study of the clinical effects on the participants before and af ...201626810548
the effects of dopamine on root growth and enzyme activity in soybean seedlings.in the present study, we investigated the effects of dopamine, an allelochemical exuded from the velvetbean (mucuna pruriens l dc. var utilis), on the growth and cell viability of soybean (glycine max l. merrill) roots. we analyzed the effects of dopamine on superoxide dismutase, phenylalanine ammonia-lyase and cell wall-bound peroxidase activities as well as its effects on lignin contents in the roots. three-day-old seedlings were cultivated in half-strength hoagland nutrient solution (ph 6.0), ...201323838960
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