| myodegeneration in rats fed melia azedarach. | | 1992 | 1632727 |
| meliacine, an antiviral compound from melia azedarach l., inhibits interferon production. | a glycopeptide isolated from the high plant melia azedarach l. (meliacine) inhibits the in vitro replication of several rna and dna animal viruses. interferon (ifn) production was depressed greatly in meliacine treated l929 cells and primary mouse embryo fibroblast cultures (mef) induced with newcastle disease virus (ndv) or poly(ri).poly(rc). this action was observed when meliacine was added before, simultaneously or early after induction with poly(ri).poly(rc) or ndv. in addition, accumulation ... | 1990 | 1703195 |
| antifertility effects of leaf extracts of some plants in male rats. | ethanolic leaf extracts of different local folklore plants (azadirachta indica, beaumontia grandiflora, chordia dichotoma, casiarea tomentosa, diospyros embryopteris, milletia auriculata and melia azedarach) were investigated for antifertility effects on male rats in oral doses of 100 mg/kg daily for 21 days. though, none of these extracts interfered with spermatogenesis, anti-implantational and abortifacient effects were observed in females mated by the males fed with leaf extracts of a. indica ... | 1990 | 2253961 |
| [inhibition of the pseudorabies virus (suis herpesvirus 1) by an antiviral agent isolated from the leaves of melia azedarach]. | a partially purified extract from fresh green leaves of melia azedarach l prevents the replication of pseudorabies virus (suid herpesvirus, (prv)) in vero cells. monolayers of vero cells were fully protected against prv cpe when an appropriate concentration of the antiviral compound was added to the culture medium after virus adsorption and remained during 72 h. by contrast, if cells were pretreated with the same amount of antiviral during 18 h before infection, cpe produced by prv was only slig ... | 1989 | 2562074 |
| [assays of cytotoxicity and antiviral activity of crude and semipurified extracts of green leaves of melia azedarach l]. | crude extracts from fresh green leaves of melia azedarach l contain an antiviral factor (fav) able to inhibit the replication of several animal viruses, e.g. polio, vsv, hsv, fmdv, sindbis, junín, pichinde and tacaribe in vero or bhk-21 cells. crude preparations were subjected to different steps of purification like chromatography on sephadex g-100 and deae-sephadex. the antiviral activity of g-100 and deae fractions was fully conserved, whereas contaminating proteins were lost. two types of cyt ... | 1985 | 2825236 |
| pollinosis: some immunologic and regional considerations and the description of melia azedarach respiratory allergy. | pollens constitute one of the most allergenic groups for man. their prevalence make them an important factor when studying antigens that induce allergical diseases such as rhinitis, asthma, conjunctivitis, etc., wherein immunological mechanisms play a fundamental role. it is believed that genetic factors are involved in pollinosis and this could probably explain the enhanced susceptibility of certain individuals to acquire this type of allergy. here we mention the hla system, among others involv ... | 1987 | 2895575 |
| antiviral effects of melia azedarach l. leaves extracts on sindbis virus-infected cells. | partially purified extracts from leaves of melia azedarach l. (ma) exert a broad range of antiviral effects on dna and rna viruses. the effect of ma on different stages of sindbis virus replicative cycle in bhk cells was investigated. under one-step growth conditions ma afforded a greater than 90% inhibition in virus yield if added to the cell cultures 2 h before or after infection, and when added 4 h after infection ma still caused a greater than 80% inhibition. analysis of early events followi ... | 1987 | 3688841 |
| poisoning by melia azedarach in pigs. | | 1974 | 4451337 |
| effect of melia azedarach fruits on gipsing-restraint stress-induced ulcers in rats. | a study was undertaken on the antiulcer effect of some active ingredients present in the lipid part of the fruits of m. azedarach administered p.o. to male rats. acute gastric ulcers were induced by gipsing the rats for 22 hr preceded by 24 hr starvation to obtain the maximum stress. the free hcl, total hcl and total acidity were also measured. the total lipid (tlp), 1.0, 2.5 and 5.0 g/kg, reduced the ulcer index by 25-41.8% and 50-58% when given daily for 5 and 10 days, respectively. the saponi ... | 1984 | 6543233 |
| [susceptibility of picornaviruses++ to an antiviral of plant origin (meliacin)]. | meliacine, a peptide associated with antiviral activity isolated from the high plant melia azedarach l (ma) inhibits the replication of different strains of foot and mouth disease virus (fmdv) and poliovirus in bhk-21 or vero cells, respectively, infected at a multiplicity of infection (m.o.i.) of 1. a leaf extract of ma, containing meliacine was added to the culture medium after virus adsorption and maintained up to virus harvest (18 hs). fmdv o1 campos and o69 strains showed 60% and 52% inhibi ... | 1995 | 7568867 |
| in vitro antiphagocytic effect of melia azedarach leaf extracts on mouse peritoneal exudate cells. | the effect of melia azedarach l. (meliaceae) leaf extract on the phagocytic capability and respiratory burst of mouse peritoneal exudate cells was studied. the extract inhibited the phagocytosis of opsonized sheep erythrocytes. this inhibition was both dose- and time-dependent and reverted 48 h after removing the extract from the culture medium. furthermore, chemiluminescence in treated cells was also impaired using either receptor (opsonized zymosan) or post-receptor (pma) stimuli. | 1994 | 7967653 |
| effect of melia azedarach l. leaf extracts on human complement and polymorphonuclear leukocytes. | the effect of the water extract of melia azedarach l. (meliaceae) leaves on human complement and polymorphonuclear leukocytes was investigated. this extract showed a strong anticomplementary activity, which was more pronounced in the classical pathway assay. the extract did not affect the phagocytic activity of polymorphonuclear leukocytes, nor the respiratory burst of these cells as measured by the nitro blue tetrazolium reduction assay. | 1994 | 8170159 |
| lignanes from the brazilian melia azedarach, and their activity in rhodnius prolixus (hemiptera, reduviidae). | a study of the phagoinhibitor and anti-moulting activities of the brazilian melia azedarach, collected in the state of rio de janeiro, brazil, allowed the isolation of four lignanes identified as pinoresinol (1), bis-epi-pinoresinol (2), the hemicetal (3) and the diacid (4). these substances are devoid of anti-moulting activity. | 1995 | 8731373 |
| chinaberry poisoning in two dogs. | two young dogs became acutely ill following ingestion of fallen fruit from a chinaberry tree (melia azedarach). clinical signs of poisoning developed within hours and were characteristic of gastrointestinal and cns disturbances. despite prompt and aggressive emergency treatment, neither dog survived longer than 36 hours after the onset of clinical signs of poisoning. necropsy of 1 dog revealed severe renal congestion, moderate hepatic congestion, and a moderate amount of serosanguineous fluid in ... | 1997 | 9170094 |
| inhibition of foot and mouth disease virus (fmdv) uncoating by a plant-derived peptide isolated from melia azedarach l leaves. | meliacine (ma), a peptide isolated from leaves of the high plant melia azedarach l inhibited the multiplication of foot and mouth disease virus (fmdv) in bhk-21 cells. in this report, we establish that the ma-inhibitable process takes place within the first hour of the viral reproductive cycle. ma had no virucidal effect and did not affect adsorption and penetration of the virus in cells. in experiments with neutral red-labeled virus, it was found that ma significantly suppressed the development ... | 1998 | 9572558 |
| in vitro anti-junin virus activity of a peptide isolated from melia azedarach l. leaves. | meliacine, a peptide isolated from leaves of melia azedarach l. inhibited the multiplication of junin virus in vero cells treated with the compound before infection (pre-treatment) or immediately after virus adsorption. analysis of early events following infection demonstrated that meliacine blocks virus penetration by preventing the uncoating step. the addition of meliacine at different times after infection indicated that meliacine also interferes with the release of infectious particles to th ... | 1998 | 9624546 |
| [molluscacidal activity of paraiso (melia azedarach l.) (meliaceae) on lymnaea cubensis, host snail of fascioliasis]. | fasciolosis is a source of serious economic loss in various regions of brazil and when control measures of its host (molluscs) are not taken under favorable ecological conditions, isolated cases of human fasciolosis may occur. among the alternative measures for its control is the use of vegetable extracts and the purpose of this project is the assessment of the use of juice extracted from the fruit and seeds of the paraiso plant (melia azedarach l.) in the control of lymnaea cubensis, the main v ... | 1998 | 9778861 |
| activity and biological effects of neem products against arthropods of medical and veterinary importance. | botanical insecticides are relatively safe and degradable, and are readily available sources of biopesticides. the most prominent phytochemical pesticides in recent years are those derived from neem trees, which have been studied extensively in the fields of entomology and phytochemistry, and have uses for medicinal and cosmetic purposes. the neem products have been obtained from several species of neem trees in the family meliaceae. six species in this family have been the subject of botanical ... | 1999 | 10412110 |
| inducible nitric oxide synthase inhibitors from melia azedarach var. japonica. | in bioassay-guided search for inducible nitric oxide synthase (inos) inhibitory compounds from higher plants of south korea, two beta-carboline alkaloids, 4-methoxy-1-vinyl-beta-carboline (1) and 4,8-dimethoxy-l-vinyl-beta-carboline (2) have been isolated from the cortex of melia azedarach var. japonica. the structures of these compounds were elucidated on the basis of spectroscopic data. compounds 1 and 2 showed marked inhibitory activity of inos on lps- and interferon-gamma-stimulated raw 264. ... | 1999 | 10489883 |
| [action of crude extracts of melia azedarach l on the multiplication of chlamydia in distinct cellular systems]. | | 1999 | 10509404 |
| antiviral effects of 28-deacetylsendanin on herpes simplex virus-1 replication. | the compound purified from the fruit of melia azedarach exerted an antiviral effect on herpes simplex virus-1 (hsv-1) in vero cells. it was identified as 28-deacetylsendanin (28-das). the 50% inhibitory concentration (ic50) of 28-das was 1.46 microg/ml without cytotoxicity at 400 microg/ml on vero cells. electron microscopy showed that low electron-dense cores of newly synthesized nucleocapsids remained in swollen nuclei and no extracellular virus particles were observed at 15 h p.i. consistent ... | 1999 | 10517312 |
| relationship between foliar chemical parameters measured in melia azedarach l. and environmental conditions in urban areas. | a diagnostic study was done on melia azedarach l. in relation to atmospheric pollutants in córdoba city, argentina. the study area receives regional pollutants, and it was categorized taking into account traffic level, industrial level, location of the sample point in relation to the corner, treeless condition, building type, topographic level and distance to the river. water content and specific leaf area (sla) were calculated; and concentrations of soluble proteins, sulphur, hydroperoxy conjug ... | 1999 | 10635592 |
| growth inhibitory effects on fall armyworm spodoptera frugiperda of some limonoids isolated from cedrela spp. (meliaceae). | dichloromethane extracts of cedrela salvadorensis and cedrela dugessi afforded a photogedunin epimeric mixture, gedunin and cedrelanolide. these compounds and the photogedunin epimeric acetates 3 and 4 at the 23-oh position were evaluated against spodoptera frugiperda. toosendanin, isolated from melia azedarach, was used as a positive control. when tested for activity on neonate larvae into the no-choice bioassays, gedunin, photogedunin epimeric mixture, and photogedunin acetates mixture caused ... | 2000 | 10820113 |
| treatment with meliacine, a plant derived antiviral, prevents the development of herpetic stromal keratitis in mice. | herpetic stromal keratitis is caused by ocular infection with herpes simplex virus type 1 (hsv-1) and constitutes a leading cause of human blindness. the effect of meliacine, an antiviral compound isolated from leaves of melia azedarach l. that inhibits hsv-1 replication in vitro, was examined on experimental corneal hsv-1 inoculation in balb/c mice. mice were inoculated with hsv-1 strain kos at their corneas after abrasion. meliacine was administered topically 3 times a day for 4 days beginning ... | 2000 | 10897066 |
| suppression of inducible nitric oxide synthase expression in raw 264. 7 macrophages by two beta-carboline alkaloids extracted from melia azedarach. | we investigated the mechanism of suppression of inducible nitric oxide synthase (inos) by two beta-carboline alkaloids isolated from melia azedarach, 4,8-dimethoxy-1-vinyl-beta-carboline (compound 1, c-1) and 4-methoxy-1-vinyl-beta-carboline (compound 2, c-2). inos activity in a cell-free extract of lipopolysaccharide/interferon-gamma-stimulated raw 264.7 cells was found to be markedly increased, and this increase was prevented by c-1 and c-2, accompanied by the parallel reduction in nitrite acc ... | 2000 | 11040335 |
| insect growth regulatory activity of some extracts and compounds from parthenium argentatum on fall armyworm spodoptera frugiperda. | the methanolic extract from aerial parts of parthenium argentatum, afforded argentatin a and b. these compounds were evaluated for their effect on the fall armyworm (spodoptera frugiperda). toosendanin, a commercial insecticide derived from melia azedarach was used as positive control. when tested for activity, using neonate larvae into the no-choice artificial diet bioassays, argentatin a, argentatin b and methanol extract caused significant growth inhibitory activity with gc50 of 17.8, 36.1 an ... | 2001 | 11302221 |
| insect growth regulator and insecticidal activity of beta-dihydroagarofurans from maytenus spp. (celastraceae). | from the aerial parts of maytenus disticha, we have isolated 9beta-benzoyloxy-1alpha,2alpha,6beta,8alpha,15penta-acetoxy-dihydro-beta-agarofuran (1) and from seeds of maytenus boaria 9beta-furoyloxy-1alpha,6beta,8alpha-triacetoxy-dihydro-beta-agarofuran (2). these compounds and their meoh and hexane/ethyl acetate (1:1 v/v) extracts were evaluated for their effects on the fall armyworm (spodoptera frugiperda). toosendanin, a commercial insecticide derived from melia azedarach was used as a positi ... | 2001 | 11531097 |
| antimycotic activities of selected plant flora, growing wild in lebanon, against phytopathogenic fungi. | petroleum ether (pe) and methanolic extracts of nine wild plant species were tested in vitro for their antimycotic activity against eight phytopathogenic fungi. the efficacy of pe extracts against all pathogens tested was higher than that of methanolic extracts. wild marjoram (origanum syriacum) pe extract showed the highest and widest range of activity. it resulted in complete inhibition of mycelial growth of six of eight fungi tested and also gave nearly complete inhibition of spore germinatio ... | 2002 | 12009988 |
| intoxication of cattle by the fruits of melia azedarach. | melia azedarach fruits were administered at single doses ranging from 5 to 30 g/kg bw to 10 calves. the animals dosed with 25 g/kg bw and 30 g/ kg bw died, as well as 1/2 cattle that received 15 g/kg bw. clinical signs were depression, ruminal stasis, anorexia, diarrhea, incoordination, muscle tremors, difficulty to stand, sternal recumbence, hypothermia and dyspnea. serum ast and cpk were increased. signs appeared 4 to 24 h after dosing and the clinical manifestations continued for 20 to 72 h. ... | 2002 | 12046965 |
| an antiviral principle present in a purified fraction from melia azedarach l. leaf aqueous extract restrains herpes simplex virus type 1 propagation. | meliacine (ma), an antiviral principle isolated from leaves of melia azedarach l., exhibits potent antiviral activity against herpes simplex virus type 1 (hsv-1) by inhibiting specific infected-cell polypeptides (icps) produced late in infection. some of these are involved in dna synthesis and in the assembly of nucleocapsids. the present report provides additional evidence to elucidate the mode of action of ma against hsv-1. time-of-addition experiments confirmed that ma affects a late event in ... | 2002 | 12112291 |
| in vitro antimalarial activity of extracts of albizia gummifera, aspilia mossambicensis, melia azedarach and azadirachta indica against plasmodium falciparum. | since chemotherapy is presently the primary strategy of malaria control in the world, and some malaria parasites are developing resistance to the commonly used antimalarial drugs, new antimalarial compounds are required. therefore, it is important to test antimalarial activities of medicinal plant extracts which most herbalists claim to cure malaria. we evaluated the antimalarial activities of extracts of albizia gummiffera, aspilia mossambicensis, melia azedar and azadirahchta indica against la ... | 1995 | 12160442 |
| potent limonoid insect antifeedant from melia azedarach. | systematic fractionation of a fruit extract from argentine melia azedarach l., which was monitored by an insect antifeedant bioassay, led to the isolation of meliartenin, a limonoid antifeedant, which existed as a mixture of two interchangeable isomers. at 4 microg/cm2 and 1 microg/cm2, the isomeric mixture was as active as azadirachtin in strongly inhibiting the larval feeding of epilachna paenulata germ. (coleoptera: coccinellidae) and the polyphagous pest, spodoptera eridania (lepidoptera: no ... | 2002 | 12353636 |
| therapeutic action of meliacine, a plant-derived antiviral, on hsv-induced ocular disease in mice. | ocular herpes simplex virus type-1 (hsv-1) infections remain an important cause of corneal disease which may result in a loss of vision. meliacine (ma), an antiviral activity present in crude leaf extracts of melia azedarach l. that inhibits hsv-1 multiplication in vitro, was studied in a murine herpetic stromal keratitis experimental model. adult balb/c mice were inoculated with hsv-1 at their corneas after abrasion. ma was administered topically three times a day for 3 consecutive days, beginn ... | 2002 | 12384095 |
| meroterpenes from penicillium sp found in association with melia azedarach. | a penicillium sp was isolated from the root bark of melia azedarach and cultivated over sterilized rice. after chromatographic procedures, two meroterpenes, named preaustinoid a and b, were obtained in addition to the known alkaloid verruculogen. their structures were identified by extensive spectroscopic studies, and they exhibited moderate bacteriostatic effects on escherichia coli, staphylococcus aureus, pseudomonas aeruginosa and bacillus sp. | 2002 | 12453515 |
| antibacterial effect of melia azedarach flowers on rabbits. | a methanol extract of melia azedarach flowers showed potent antibacterial action in rabbits suffering from a skin infection produced by stapyhlococcus aureus. the healing effects were found comparable to neomycin. | 2002 | 12458483 |
| antifungal effects of different organic extracts from melia azedarach l. on phytopathogenic fungi and their isolated active components. | extracts from different parts of melia azedarach l. were studied as potential antifungal agents for selected phytopathogenic fungi. in a serial agar dilution method, hexanic and ethanolic extracts from fruit, seed kernels, and senescent leaves exhibited fungistatic activity against aspergillus flavus,diaporthe phaseolorum var. meridionales, fusarium oxysporum, fusarium solani, fusarium verticillioides, and sclerotinia sclerotiorum. both hexanic extract from senescent leaves and ethanolic extract ... | 2003 | 12696928 |
| an antiviral meliacarpin from leaves of melia azedarach l. | bioassay guided purification of the ethyl acetate extract of leaves of melia azedarach led to the isolation of the limonoid 1-cinnamoyl-3,11-dihydroxymeliacarpin, which showed ic50 values of 6 microm and 20 microm for vesicular stomatitis (vsv) and herpes simplex (hsv-1) viruses, respectively. its structure was established by spectroscopic methods. | 2003 | 12710731 |
| pregnancy interceptive activity of melia azedarach linn. in adult female sprague-dawley rats. | ethanolic extract of the root of melia azedarach linn. (family: meliaceae) collected from the institute campus intercepted pregnancy in 60% and 75% adult female rats when administered at 250 and 500 mg/kg daily doses, respectively, on days 1-10 post-coitum by the oral route. on fractionation, the activity was localized in the chloroform fraction of the ethanolic extract, which showed 80-100% activity at 250 mg/kg daily dose in repeat tests. in animals that became pregnant, there was also a signi ... | 2003 | 14572895 |
| further meroterpenes produced by penicillium sp., an endophyte obtained from melia azedarach. | from the methanol extract of penicillium sp. cultivated on sterilized rice for three weeks we isolated three new meroterpenes preaustinoid a1, a2 and b1. the fungus was isolated from the root bark of melia azedarach after surface sterilization. the structures of these compounds were identified by intensive spectroscopic studies. | 2003 | 14577628 |
| the anthelmintic efficacy of five plant products against gastrointestinal trichostrongylids in artificially infected lambs. | forty-eight helminth-free lambs were divided into eight groups (a-h) of six animals. groups a-g were infected artificially with 10,000 third stage larvae of haemonchus contortus and 20,000 third stage larvae of trichostrongylus colubriformis, whereas group h remained uninfected. thirty days post-infection the lambs were treated orally with a single dosage of one of the following products: group a with 3 mg/kg body weight (bw) of an aqueous ethanol extract (70%, v/v) of the seeds of azadirachta i ... | 2003 | 14597279 |
| block of vesicular stomatitis virus endocytic and exocytic pathways by 1-cinnamoyl-3,11-dihydroxymeliacarpin, a tetranortriterpenoid of natural origin. | previously, it has been shown that 1-cinnamoyl-3,11-dihydroxymeliacarpin (cdm), a natural compound isolated from leaf extracts of melia azedarach l., inhibits the vesicular stomatitis virus (vsv) multiplication cycle when added before or after infection. here, we have established that the lack of vsv protein synthesis in cdm pre-treated vero cells is ascribed to the inhibition of an initial step during virus multiplication, although indirect immunofluorescence (ifi) studies confirmed that the bi ... | 2004 | 14769906 |
| role of energy metabolism in the pregnancy interceptive action of ferula assafoetida and melia azedarach extracts in rat. | ethanolic extract of ferula assafoetida and chloroform fraction of melia azedarach, both devoid of estrogenic activity, were examined for their pregnancy interceptive property. treatment of rats from days 1 to 7 of pregnancy with either of the plant extracts resulted in pregnancy failure in about 65-85% of the animals. the possible role of energy metabolism in the antifertility action was investigated by measuring changes in activities of the key enzymes of carbohydrate metabolism in uterus on d ... | 2004 | 15504384 |
| effects of azadirachta indica and melia azedarach (meliaceae) extracts from leaves on trypanosoma cruzi growth and ultrastructure. | the chloroformic extracts from dried fresh leaves ofazadirachta indica a. juss. and melia azedarach l. (meliaceae) showed marked inhibitory activity on epimastigotes growth of trypanosoma cruzi, evidenced by 96-wells microtiter plate bioassay and radioactive thymidine incorporation experiment. each chloroformic extract was separated using silica gel and alumina column. in transmission electron microscopy the bioactive chromatographic fractions caused ultrastructural changes in epimastigotes such ... | 2004 | 15554501 |
| isoprene emission from tropical tree species. | foliar emission of isoprene was measured in nine commonly growing tree species of delhi, india. dynamic flow enclosure technique was used and gas samples were collected onto tenax-gc/carboseive cartridges, which were then attached to the sample injection system in the gas chromatograph (gc). eluting compounds were analysed using a flame ionisation detector (fid). out of the nine tree species, isoprene emission was found in six species (eucalyptus sp., ficus benghalensis, ficus religiosa, mangife ... | 2005 | 15701397 |
| antifungal synergistic effect of scopoletin, a hydroxycoumarin isolated from melia azedarach l. fruits. | in the continuous search for antifungal compounds from plants, the hydroxycoumarin scopoletin (1) was isolated from seed kernels of melia azedarach l. from which three other compounds, vanillin (2), 4-hydroxy-3-methoxycinnamaldehyde (3), and (+/-) pinoresinol (4), have also been isolated. guided fractionation through autobiography on tlc using fusarium verticillioides (saccardo) nirenberg as test organism led to the isolation of 1, which exhibited a minimum inhibitory concentration (mic) of 1.50 ... | 2005 | 15826040 |
| extracts of azadirachta indica and melia azedarach seeds inhibit folliculogenesis in albino rats. | the seed oil of azadirachta indica a. juss (neem) is used in traditional medicine for its antidiabetic, spermicidal, antifertility, antibacterial, and wound healing properties. the present study was undertaken to investigate the quantitative aspects of follicular development in cyclic female albino rats (135 +/- 10 g; 8 groups with 6 animals in each group) after oral administration of polar (pf) and non-polar (npf) fractions of a. indica seed extract at 3 and 6 mg kg body weight-1 day-1 and meli ... | 2005 | 15933789 |
| complete 1h and 13c nmr assignments of aurasperone a and fonsecinone a, two bis-naphthopyrones produced by aspergillus aculeatus. | complete assignments of 1h and 13c nmr chemical shifts of the polyketides aurasperone a and fonsecinone a were made by means of nuclear overhauser enhancement and heteronuclear nmr correlation experiments. these compounds were isolated for the first time from aspergillus aculeatus, an endophytic fungus obtained from leaves of melia azedarach(meliaceae). | 2005 | 16155971 |
| toxicological studies of melia azedarach l. (flowers and berries). | toxicological evaluation of media azedarach linn. was carried out in lower laboratory animals, i.e. rats and mice by oral and intravenous routes. aqueous and alcoholic extracts were found to be non-toxic uptil a dose of 1500 mg/kg orally in mice and rats. when injected aqueous extract intravenously, ld50 was 395, 580 mg/kg (flowers) and 700, 925 mg/kg (berries) respectively in mice and rats. it was also observed that alcoholic and aqueous extracts of melia azedarach have a mild cns sedative effe ... | 1991 | 16414695 |
| ovicidal and larvicidal activity of melia azedarach extracts on haemonchus contortus. | haemonchus contortus is responsible for severe economic losses in sheep and goat breeding in the northeast of brazil. however, the effectiveness of control is compromised due to anthelmintic resistance and misuse. in the search for natural anthelmintics, melia azedarach l., a plant indigenous to india but now distributed throughout brazil, was selected due to the reported anthelmintic properties of its seeds. the aim of this study was to evaluate the anthelmintic activity of the seed and leaf ex ... | 2006 | 16621294 |
| 1-cinnamoyl-3,11-dihydroxymeliacarpin is a natural bioactive compound with antiviral and nuclear factor-kappab modulating properties. | we have reported the isolation of the tetranortriterpenoid 1-cinnamoyl-3,11-dihydroxymeliacarpin (cdm) from partially purified leaf extracts of melia azedarach l. (ma) that reduced both, vesicular stomatitis virus (vsv) and herpes simplex virus type 1 (hsv-1) multiplication. cdm blocks vsv entry and the intracellular transport of vsv-g protein, confining it to the golgi apparatus, by pre- or post-treatment, respectively. here, we report that hsv-1 glycoproteins were also confined to the golgi ap ... | 2006 | 16631615 |
| accumulation of alpha-tocopherol in senescing organs as related to chlorophyll degradation. | alpha-tocopherol (alpha-t) has been identified, using gas chromatography-mass spectroscopy and (1)h- and (13)c-nuclear magnetic resonance, in senescing leaves of melia azedarach l. the content of alpha-t increased concomitantly with the breakdown of chlorophyll in senescing vinca and melia leaves. an increase in alpha-t was found also in detached melia leaves, senescing in either light or darkness and in senescing, ethylene-treated orange leaves and fruit. the possibility that phytol, which is r ... | 1989 | 16666657 |
| in vitro anthelmintic activity of melia azedarach naturalized in argentina. | the anthelmintic activity of the drupe extracts of melia azedarach l. (meliaceae) growing in argentina was tested against tapeworms, hookworms, nodular worms and earthworms, and was shown to be better than the standards piperazine phosphate and hexylresorcinol against tapeworms and hookworms, respectively. | 2006 | 16941610 |
| in vitro pediculicidal and ovicidal activity of an extract and oil from fruits of melia azedarach l. | head louse infestation is difficult to control because of increasing lice resistance to synthetic pediculicidal drugs. | 2007 | 17147968 |
| larvicide and oviposition deterrent effects of fruit and leaf extracts from melia azedarach l. on aedes aegypti (l.) (diptera: culicidae). | aedes aegypti (l.) (diptera: culicidae), the main urban vector of dengue, has developed resistance to various insecticides, making its control increasingly difficult. we explored the effects of argentine melia azedarach l. (meliaceae) fruit and senescent leaf extracts on ae. aegypti larval development and survival, by rearing cohorts of first instar mosquitoes in water with different extract concentrations. we also analysed oviposition deterrent activity in choice tests with extract-treated ovit ... | 2008 | 17669645 |
| antifertility effect of melia azedarach linn. (dharek) seed extract in female albino rats. | in the present study, the effect of oral administration of melia azedarach linn. (dharek) seed extract on fertility index, uterine weight and various histological and biochemical parameters of uterus were studied in the adult cyclic wistar rats. average number of embryos and implantation losses in the pregnant animals treated with dharek seed extract was also studied. the extract was prepared using a flash evaporator at 35 degrees c and dissolved in olive oil to prepare doses on per kg body weig ... | 2007 | 17948733 |
| poisoning in ostriches following ingestion of toxic plants--field observations. | data from post-mortem and field studies were obtained that discussed poisoning in ostriches following ingestion of toxic plants. from the notes, all plants studied caused death in ostriches and there was systemic organ damage. poisoning from sarcostemma viminale (melktou) resulted in beak patting, muscular tremors and head flopping, followed by collapse and violent kicking before death. ingestion of combretum oatesii (red wings) seeds from plants in free grazing pastures resulted in vomiting, re ... | 2007 | 17966275 |
| [evaluation of efficacy of ripe and unripe fruit oil extracts of melia azedarach against rhipicephalus (boophilus) microplus (acari: ixodidae)]. | hexanic extracts gotten of the fruits of cinamomo (melia azedarach) were tested on engorged females and larvae of rhipicephalus (boophilus) microplus. four extracts were produced: one of unripe fruits and three of ripe fruits, being one with the fruits immediately processed, another one with fruits stored for five months and one tested after storage of the extract for 2 (two) years at 4 degrees c. the tests were made in triplicate, in 0.25% - 0.0156% dilutions. the effectiveness of extracts was ... | 2008 | 18554439 |
| antiviral activity of meliacine on the replication of a thymidine kinase-deficient mutant of herpes simplex virus type 1 alone and in combination with acyclovir. | the anti-hsv-1 activity of meliacine (ma), a peptide isolated from leaves of melia azedarach l., alone and in combination with acyclovir (acv), was assayed against thymidine kinase-deficient (tk(-)) virus yields in vitro. ma alone proved to inhibit significantly tk(-) viral replication, whereas acv was more potent than ma as an inhibitor of tk(+) replication. tk(-) and tk(+) synergistic inhibition by the combination of both agents was observed at concentrations that did not alter cell viability. ... | 1997 | 18611819 |
| human melia azedarach poisoning. | in traditional chinese medicine, melia azedarach (ku-lian) is used orally and topically as an antiparasitic and antifungal agent. although toxicity of this plant has been widely described in veterinary literature, human poisoning is rarely reported. we describe five patients with m. azedarach poisoning who recovered with supportive care. | 2008 | 18763152 |
| a natural tetranortriterpenoid with immunomodulating properties as a potential anti-hsv agent. | meliacine (ma), an antiviral principle present in partially purified leaf extracts of melia azedarach l., prevents the development of herpetic stromal keratitis (hsk) in mice by diminishing the viral load in the eye and the severity of lesions caused by a virus-induced immunopathological reaction. the tetranortriterpenoid 1-cinnamoyl-3,11-dihydroxymeliacarpin (cdm), obtained from ma purification, displays anti-herpetic activity and impedes nuclear factor kappab (nf-kappab) activation in hsv-1 in ... | 2009 | 19162100 |
| steroids from the leaves of chinese melia azedarach and their cytotoxic effects on human cancer cell lines. | three new (1-3) and several known (4-6) steroids were isolated from the leaves of chinese melia azedarach. the structures of the new compounds were elucidated by means of spectroscopic methods including 2d nmr techniques and mass spectrometry to be (20s)-5,24(28)-ergostadiene-3beta,7alpha,16beta,20-tetrol (1), (20s)-5-ergostene-3beta,7alpha,16beta,20-tetrol (2), and 2alpha,3beta-dihydro-5-pregnen-16-one (3). the cytotoxicities of the isolated compounds against three human cancer cell lines (a549 ... | 2009 | 19379765 |
| therapeutic effect of meliacine, an antiviral derived from melia azedarach l., in mice genital herpetic infection. | since natural products are considered powerful sources of novel drug discovery, a partially purified extract (meliacine) from the leaves of melia azedarach l., a plant used in traditional medicine in india for the treatment of several diseases, has been studied. meliacine exhibits a potent antiviral effect against several viruses without displaying cytotoxicity. the purpose of the present study was to evaluate the therapeutic effect of intravaginal administration of meliacine in a mouse model of ... | 2009 | 19441066 |
| structural features of a new heteropolysaccharide from the fruit bodies of melia azedarach and its effect on cytotoxic activity. | water-soluble polysaccharides were extracted from the fruit pulps of melia azedarach and some columns were undertaken to isolate the major polysaccharide (mps-iii). its structural features were elucidated by ir analysis, carbohydrate analysis, periodate oxidation, smith degradation, methylation analysis and nmr spectroscopy. then it was evaluated for the cytotoxic activity in vitro against four human cell lines, using the sulphorhodamine b assay. the data obtained indicated that mps-iii contains ... | 2009 | 19463921 |
| natural products-based insecticidal agents 4. semisynthesis and insecticidal activity of novel esters of 2-chloropodophyllotoxin against mythimna separata walker in vivo. | by using podophyllotoxin as a lead compound, eight novel esters of 2-chloropodophyllotoxin were designed, semisynthesized, and preliminarily evaluated for their insecticidal activity against the pre-third-instar larvae of mythimna separata walker in vivo for the first time. among all the tested compounds, especially three esters of 2-chloropodophyllotoxin 8a, 8c, and 8g, and one intermediate 6 showed more promising and pronounced insecticidal activity than toosendanin, a commercial insecticide d ... | 2009 | 19665895 |
| semisynthesis and quantitative structure-activity relationship (qsar) study of novel aromatic esters of 4'-demethyl-4-deoxypodophyllotoxin as insecticidal agents. | by using podophyllotoxin as a phytoinsecticidal lead compound, 15 novel aromatic esters of 4'-demethyl-4-deoxypodophyllotoxin were semisynthesized and preliminarily tested for their insecticidal activity against the pre-third-instar larvae of mythimna separata walker in vivo for the first time. among all of the tested compounds, especially two compounds, 4m and 4o, containing a pyridinyl group, for which final corrected mortality rates against m. separata at 1 mg/ml were 62.9 and 59.2%, respecti ... | 2009 | 19689137 |
| potential plant poisonings in dogs and cats in southern africa. | plant poisoning occurs less commonly in dogs and cats than in herbivorous livestock, but numerous cases have been documented worldwide, most of them caused by common and internationally widely cultivated ornamental garden and house plants. few cases of poisoning of cats and dogs have been reported in southern africa, but many of the plants that have caused poisoning in these species elsewhere are widely available in the subregion and are briefly reviewed in terms of toxic principles, toxicity, s ... | 2009 | 19831265 |
| laboratory and field evaluation of neem (azadirachta indica a. juss) and chinaberry (melia azedarach l.) oils as repellents against phlebotomus orientalis and p. bergeroti (diptera: psychodidae) in ethiopia. | the study evaluated the efficacy of neem (azadirachta indica a. juss.) and chinaberry (melia azedarach l.) seed oils as repellents against laboratory and field populations of some sandflies in ethiopia. in the laboratory, concentrations of 2% and 5% neem oil in coconut oil tested against phlebotomus orientalis (vector of visceral leishmaniasis) provided 96.28% (95% ci=95.60-96.97) protection up to a mean time of 7h and 20 min and 98.26% (95% ci=93.46-104. 07) protection up to 9h, respectively. s ... | 2010 | 19854142 |
| repellent activity of plant-derived compounds against amblyomma cajennense (acari: ixodidae) nymphs. | repellence responses of amblyomma cajennense nymphs to callicarpenal, intermedeol, hyptis suaveolens essential oil, extract of melia azedarach, cymbopogon nardus, spiranthera odoratissima, chenopodium ambrosioides, ageratum conyzoides, mentha pulegium, ruta graveolens, and memora nodosa were studied. among these the extract of c. nardus stood out because of the long-lasting repellence, maintaining, in the highest concentration, 35h of protection against 90% of the nymphs. the essential oil of h. ... | 2010 | 19897309 |
| 1-cinnamoyl-3,11-dihydroxymeliacarpin delays glycoprotein transport restraining virus multiplication without cytotoxicity. | the 1-cinnamoyl-3,11-dihydroxymeliacarpin (cdm), isolated from extracts of melia azedarach l., displays antiviral and immunomodulating properties. cdm is the first reported tetranortriterpenoid responsible for the alkalinization of intracellular compartments affecting both, viral endocytic and exocytic pathways. considering that viral glycoprotein synthesis is completely dependent upon cellular membrane trafficking, we questioned whether cdm might also interfere with the normal transport of cell ... | 2010 | 20097166 |
| ethnopharmacological application of medicinal plants to cure skin diseases and in folk cosmetics among the tribal communities of north-west frontier province, pakistan. | the present investigation is an attempt to find out ethnopharmacological application of medicinal plants to cure skin diseases and in folk cosmetics. | 2010 | 20138210 |
| ovicidal and larvicidal activity of crude extracts of melia azedarach against haemonchus contortus (strongylida). | the rapid development of anthelmintic resistance, associated with the high cost of the available anthelmintic drugs, has limited the success of gastrointestinal nematodiosis control in sheep and goats and thus created interest in studying medicinal plants as an alternative source of anthelmintics. the aim of this study was carried out to evaluate the anthelmintic activity of the leaves and seed aqueous and hydro-alcoholic extracts of melia azedarach l. (meliaceae) were tested for in vitro ovicid ... | 2010 | 20177909 |
| chinaberry tree (melia azedarach) poisoning in dog: a case report. | this article describes a case of chinaberry tree poisoning diagnosed in a dog. the initial clinical signs were variable and included tremors (muscular seizures) and a moderate limp in the dog's back leg, which evolved to a more severe condition in the following hours. abdominal radiographic evaluation was requested, and abundant small, foreign, radio-dense bodies were detected, which were associated with chinaberry tree fruits after surgical extraction. adequate treatment was established, and th ... | 2010 | 20188341 |
| natural products-based insecticidal agents 5. design, semisynthesis and insecticidal activity of novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against mythimna separata walker in vivo. | in an attempt to find the effective phytopesticides, eight novel 4'-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin were synthesized and preliminarily tested against the pre-third-instar larvae of mythimna separata walker in vivo at the concentration of 1mg/ml. among all of the tested analogs, compounds 5a, 5c, 5d, and 5h showed the higher insecticidal activity than 4-deoxypodophyllotoxin. especially 5a exhibited the most potent insecticidal activity compared with toosendanin, ... | 2010 | 20346661 |
| determination of antibacterial and antioxidant potential of some medicinal plants from saurashtra region, india. | many plants used in saurashtra folk medicine have been reported to exhibit high antibacterial and antioxidant activities. in the present study, some parts of five plants, guazuma ulmifolia l., manilkara zapota l., melia azedarach l., syzygium cumini l. and wrightia tomentosa r.& s., were evaluated for their antibacterial activity, total phenol content, flavonoid content, 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity and phytochemical analysis, using successive extraction by cold ... | 2009 | 20502546 |
| natural products-based insecticidal agents 6. design, semisynthesis, and insecticidal activity of novel monomethyl phthalate derivatives of podophyllotoxin against mythimna separata walker in vivo. | to discover the more potent analogs, 12 novel monomethyl phthalate derivatives of podophyllotoxin were synthesized and preliminarily tested against the pre-third-instar larvae of mythimna separata walker in vivo at the concentration of 1mg/ml. compounds 8e-i showed the higher insecticidal activity than podophyllotoxin. especially 8g exhibited the most potent insecticidal activity compared with toosendanin, a commercially available insecticide derived from melia azedarach. the structure-activity ... | 2010 | 20584606 |
| antifungal compounds from melia azedarach leaves for management of ascochyta rabiei, the cause of chickpea blight. | the antifungal activity of melia azedarach l. leaves was investigated against ascochyta rabiei (pass.) lab., the cause of destructive blight disease of chickpea (cicer arietinum l.). bioassay guided fractionation revealed that the chloroform fraction of the methanolic extract of m. azedarach leaves was highly effective against a. rabiei. six compounds, namely β-sitosterol (1), β-amyrin (2), ursolic acid (3), benzoic acid (4), 3,5 dimethoxybenzoic acid (5) and maesol (6) were isolated from the ch ... | 2011 | 20628965 |
| natural products-based insecticidal agents 7. semisynthesis and insecticidal activity of novel 4alpha-alkyloxy-2-chloropodophyllotoxin derivatives against mythimna separata walker in vivo. | in continuation of our program aimed at the discovery and development of natural products-based insecticidal agents, 16 novel 4alpha-alkyloxy-2-chloropodophyllotoxin derivatives were semisynthesized from podophyllotoxin, and preliminarily evaluated for their insecticidal activity against the pre-third-instar larvae of mythimna separata walker in vivo. among all the tested derivatives, especially compounds 4b, 4e, 4g, and 4p exhibited more promising and pronounced insecticidal activity than toose ... | 2010 | 20678933 |
| cytotoxic tirucallane triterpenoids from melia azedarach fruits. | the phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of melia azedarach afforded one new tirucallane-type triterpene, 3-alpha-tigloylmelianol and three known tirucallanes, melianone, 21-beta-acetoxy-melianone, and methyl kulonate. the structure of the isolated compounds was mainly determined by 1d and 2d nmr experiments as well as hplc-q-tof mass spectrometry. the cytotoxicity of the isolated compounds toward the human lung adenocar ... | 2010 | 20802401 |
| potential synergistic effect of melia azedarach fruit extract and beauveria bassiana in the control of rhipicephalus (boophilus) microplus (acari: ixodidae) in cattle infestations. | the use of a concentrate emulsion of melia azedarach green fruits and a suspension of the fungus beauveria bassiana was evaluated in the control of rhipicephalus microplus on artificially infested cattle. the evaluation was conducted following the protocol established by the brazilian agriculture ministry. five groups of 4 or 5 animals were allocated to one of the following treatments: emulsion concentrate of m. azedarach at 0.25% (t azed 0.25%), emulsion concentrate of m. azedarach at 0.5% (t a ... | 2010 | 21055878 |
| [effects of tomato genotypes and aqueous extracts of melia azedarach leaves and azadirachta indica seeds on tuta absoluta (meyrick) (lepidoptera: gelechiidae)]. | insecticide plants are an important tool among the new alternatives for pest control in ipm systems because they reduce the use of synthetic insecticides, preserving human health and the environment. we investigated the effects of aqueous extracts of melia azedarach leaves and azadirachta indica seeds and three tomato genotypes, 'santa clara', 'ipa-5'--solanum lycopersicum (=lycopersicon esculentum mill), and la444-1--s. peruvianum (=l. peruvianum), on the development, reproduction and longevity ... | 2010 | 21120389 |
| cytotoxic triterpenoids and steroids from the bark of melia azedarach. | two new triterpenoids (1, 2) and two new steroids (3, 4) along with twelve related known compounds (5-16) were isolated from the bark of melia azedarach. the new structures were elucidated by means of spectroscopic methods and molecular modeling studies and found to be 21,24-cycloeupha-7-ene-3 β,16 β,21 α,25-tetrol (1), 3 β-acetoxy-12 β-hydroxy-eupha-7,24-dien-21,16 β-olide (2), 29-hydroperoxy-stigmasta-7,24(28) e-dien-3 β-ol (3), and 24 ξ-hydroperoxy-24-vinyl-lathosterol (4). all isolated compo ... | 2011 | 21243584 |
| ethnobotanical survey of medicinal plants commonly used by kani tribals in tirunelveli hills of western ghats, india. | for thousands of years, medicinal plants have played an important role throughout the world in treating and preventing a variety of diseases. kani tribal people in tirunelveli hills still depend on medicinal plants and most of them have a general knowledge of medicinal plants which are used for first aid remedies, to treat cough, cold, fever, headache, poisonous bites and some simple ailments. | 2011 | 21291981 |
| toxic polyketides produced by fusarium sp., an endophytic fungus isolated from melia azedarach. | a new isocoumarin derivative named fusariumin (1), together with two known related resorcylic acid lactones aigialomycin d (2) and pochonin n (3), has been isolated from the cultures of fusarium sp. ln-10, an endophytic fungus originated from the leaves of melia azedarach. their structures were established on the basis of extensive spectroscopic analyzes including 1d- and 2d- nmr ((1)h-(1)h cosy, hsqc, hmbc, and noesy) experiments. compounds 1-3 displayed significant growth inhibitory activity a ... | 2010 | 21353539 |
| antifungal activity of plant extracts against candida species from oral lesions. | seventy five patients with oral lesions attending the different departments of rajah muthiah medical college and hospital, annamalai university were screened for candida. forty six (61.3%) candida strains were isolated from the oral lesions. of the 46 candida strains, candida albicans accounted for 35 (76.08%), candida glabrata for 5 (10.86%), candida tropicalis and candida krusei for 2 (4.34%) each and candida parapsilosis and candida guilliermondii for one (2.17%) each. antifungal activity of ... | 2008 | 21369447 |
| natural products-based insecticidal agents 9. design, semisynthesis and insecticidal activity of 28-acyloxy derivatives of toosendanin against mythimna separata walker in vivo. | in continuation of our program aimed at the discovery and development of natural products-based insecticidal agents, twelve 28-acyloxy derivatives of toosendanin (2a-l) were semisynthesized and preliminarily evaluated their activity against the pre-third-instar larvae of mythimna separata walker in vivo at the concentration of 1mg/ml. some compounds exhibited the potent insecticidal activity. especially compounds 2c and 2j displayed the more promising insecticidal activity than their natural pre ... | 2011 | 21376589 |
| larvicidal effects of chinaberry (melia azederach) powder on anopheles arabiensis in ethiopia. | abstract: | 2011 | 21569263 |
| hepatoprotective action of ethanolic extracts of melia azedarach linn. and piper longum linn and their combination on ccl4 induced hepatotoxicity in rats. | a comparison of analysis in evaluating the hepatoprotective action of ethanolic extract of m. azedarach (mae) and p. longum (ple) with their combination biherbal extract (bhe) against carbon tetrachloride (ccl4) induced hepatic damage is reported in albino rats. there was a marked elevation of serum marker enzyme levels in ccl4 treated rats, which were restored towards normalization in the drug (mae and/or ple:50 mg/kg body weight po, once daily for 14 days) treated animals. the biochemical para ... | 2011 | 21614891 |
| natural products-based insecticidal agents 11. synthesis and insecticidal activity of novel 4+¦-arylsulfonyloxybenzyloxy-2+¦-chloropodophyllotoxin derivatives against mythimna separata walker in vivo. | in continuation of our program aimed at the discovery and development of natural products-based insecticidal agents, 14 novel 4+¦-arylsulfonyloxybenzyloxy-2+¦-chloropodophyllotoxin derivatives were stereoselectively semisynthesized from podophyllotoxin, and preliminarily evaluated for their insecticidal activity against the pre-third-instar larvae of mythimna separata walker in vivo. especially compounds 9c' and 9g' exhibited the most promising and pronounced insecticidal activity than toosendan ... | 2011 | 21835617 |
| [Complete sequence of a full-length DNA and molecular characterization of one plasmid from chinaberry (Melia azedarach Z) witches'-broom phytoplasma]. | To clone plasmid from chinaberry witches'-broom phytoplasma and analyse its molecular characterization. | 2011 | 22126070 |
| In vitro Anthelmintic effect of Melia azedarach L. and Trichilia claussenii C. against sheep gastrointestinal nematodes. | The control of parasitic diseases in small ruminants is mainly done with the use of synthetic anthelmintics. However, incorrect and indiscriminate use of these products has caused the emergence of parasite resistance. Plants with anthelmintic activity are used in folk veterinary medicine, but it is necessary to investigate and scientifically validate low-cost phytotherapeutic alternatives for future use to control gastrointestinal nematodes in small ruminants by family farmers. Thus, the aim of ... | 2011 | 22209941 |
| an investigation of phenolic compounds from plant sources as trypsin inhibitors. | in the search of new trypsin inhibitors caffeic acid (1), cinnamic acid (2), gallic acid (3) and eugenol (4) from cinnamomum zeylanicum, ferulic acid (5) from impatiens bicolor, vanillin (6) from melia azedarach and catechol (7) from allium cepa were isolated through bioassay guided fractionation of the plant extracts. ic (50) values of the compounds 1, 2 and 5 were found to be 0.35 ± 0.02 mm, 0.96 ± 0.05 mm and 1.22 ± 0.06 mm, respectively. lineweaver-burk and dixon plots and their secondary re ... | 2011 | 22011193 |
| Assessment of antimicrobial, insecticidal and genotoxic effects of Melia azedarach L. (chinaberry) naturalized in Anatolia. | In this study, antibacterial, antifungal, insecticidal and genotoxic activities of the fruit and leaf extracts of Melia azedarach of Turkish origin were evaluated for the first time. The antimicrobial activity was assessed against Gram (+) and ( - ) bacteria, four Candida species and three dermatophytic fungus (Trichophyton rubrum, Epidermophyton floccosum and Microsporum gypseum). The insecticidal activity of the methanolic fruit extract was performed against the larvae of Aedes aegpyti, Culex ... | 2011 | 22149768 |
| Screening of allelopathic trees for their antifungal potential against Alternaria alternata strains isolated from dying-back Eucalyptus spp. | Antifungal activity of methanolic extracts of leaves of three tree species, namely Azadirachta indica L., Syzygium cumini (L.) Skeels. and Melia azedarach L. was evaluated against two strains of Alternaria alternata, isolated from dying-back trees of two Eucalyptus spp., namely Eucalyptus citriodora and Eucalyptus globulus. All the concentrations (1,?2,?…?,?5% w/v) of the methanolic extracts of the three tree species significantly reduced the fungal biomass. There were reductions in the ranges 8 ... | 2011 | 22007991 |
| fusaroside, a unique glycolipid from fusarium sp., an endophytic fungus isolated from melia azedarach. | fusaroside (1), a unique trehalose-containing glycolipid composed of the 4-hydroxyl group of a trehalose unit attached to the carboxylic carbon of a long-chain fatty acid, was isolated from the organic extract of fermentation broths of an endophytic fungus, fusarium sp. ln-11 isolated from the leaves of melia azedarach. six known compounds, phalluside (2), (9r*,10r*,7e)-6, 9,10-trihydroxyoctadec-7-enoic acid (3), porrigenic acid (4), (9z)-2,3-dihydroxypropyl octadeca-9-enoate (5), cerevisterol ( ... | 2012 | 22124543 |
| limonoids from melia azedarach fruits as inhibitors of flaviviruses and mycobacterium tubercolosis. | the biological diversity of nature is the source of a wide range of bioactive molecules. the natural products, either as pure compounds or as standardized plant extracts, have been a successful source of inspiration for the development of new drugs. the present work was carried out to investigate the cytotoxicity, antiviral and antimycobacterial activity of the methanol extract and of four identified limonoids from the fruits of melia azedarach (meliaceae). the extract and purified limonoids wer ... | 2015 | 26485025 |
| repellent efficacy of deet, mygga, neem (azedirachta indica) oil and chinaberry (melia azedarach) oil against anopheles arabiensis, the principal malaria vector in ethiopia. | in ethiopia, anopheles arabiensis is the main vector responsible for the transmission of malaria in the country and its control mainly involves application of indoor residual spraying (irs) and use of insecticide-treated bed nets (itns). | 2015 | 25935845 |
| evaluation of some plant fruit extracts for the control of west nile virus vector culex pipiens (diptera: culicidae). | the extracts of different parts of plants were found very effective against various pests. the aim of this research was to determine the insecticidal activity of fruit methanol extracts obtained from melia azedarach (meliaceae), phoenix theophrasti (arecaceae), styphnolobium japonicum (fabaceae) and pyracantha coccinea (rosaceae) against the larvae of culex pipiens (diptera: culicidae). | 2016 | 28032112 |
| metabolites from aspergillus fumigatus, an endophytic fungus associated with melia azedarach, and their antifungal, antifeedant, and toxic activities. | thirty-nine fungal metabolites 1-39, including two new alkaloids, 12β-hydroxy-13α-methoxyverruculogen tr-2 (6) and 3-hydroxyfumiquinazoline a (16), were isolated from the fermentation broth of aspergillus fumigatus ln-4, an endophytic fungus isolated from the stem bark of melia azedarach. their structures were elucidated on the basis of detailed spectroscopic analysis (mass spectrometry and one- and two-dimensional nmr experiments) and by comparison of their nmr data with those reported in the l ... | 2012 | 22409377 |
| potential allelopathic indole diketopiperazines produced by the plant endophytic aspergillus fumigatus using the one strain-many compounds method. | on the basis of the osmac (one strain-many compounds) strategy, 14 indole diketopiperazine (dkp) alkaloids, including spirotryprostatins (1-3), tryprostatins (4-6), and cyclotryprostatins (7-14), were isolated from the endophyte aspergillus fumigatus associated with melia azedarach l. their structures were identified by nuclear magnetic resonance and electrospray ionization mass spectrometry data. all the indole dkps were evaluated for plant growth regulation using the lettuce (lactuca sativa) s ... | 2013 | 24188331 |
| antifungal and antibacterial metabolites from an endophytic aspergillus sp. associated with melia azedarach. | seven known metabolites, dianhydro-aurasperone c (1), isoaurasperone a (2), fonsecinone a (3), asperpyrone a (4), asperazine (5), rubrofusarin b (6) and (r)-3-hydroxybutanonitrile (7), were isolated from the culture of aspergillus sp. kj-9, a fungal endophyte isolated from melia azedarach and identified by spectroscopic methods. all isolates were evaluated in vitro against several phytopathogenic fungi (gibberella saubinetti, magnaporthe grisea, botrytis cinerea, colletotrichum gloeosporioides a ... | 2014 | 24708541 |