| cutaneous leishmaniasis in western venezuela caused by infection with leishmania venezuelensis and l. braziliensis variants. | between 1975 and 1987, epidemiological studies were carried out in several rural and urban communities in the central part of western venezuela, especially in the state of lara. 115 positive cultures were obtained from human cases and identified by their reactivity patterns to a cross-panel of specific monoclonal antibodies using a radioimmune binding assay; 53 were leishmania venezuelensis and 62 were l. braziliensis. most of these stocks were also characterized by isoenzyme electrophoresis, wh ... | 1992 | 1440772 |
| production of a specific monoclonal antibody for the identification of leishmania (leishmania) venezuelensis. | we describe a monoclonal antibody (mab), v1, specific for leishmania (leishmania) venezuelensis. previous mabs and dna probes were not specific for this parasite, and so it was not directly possible to distinguish l. (l.) venezuelensis from other leishmania species. immunofluorescent staining using mabs may be performed on very few parasites, whereas other methods of identification usually require far greater numbers of organisms. l. (l.) venezuelensis frequently dies on subculture. mab v1 can b ... | 1990 | 2187366 |
| prolonged in vitro cultivation of leishmania mexicana venezuelensis. | | 1986 | 3798551 |
| new observations on leishmania mexicana venezuelensis. | | 1983 | 6659054 |
| 2-substituted quinoline alkaloids as potential antileishmanial drugs. | ten 2-substituted quinoline alkaloids isolated from a plant used for treatment of new world cutaneous leishmaniasis have antileishmanial in vitro activities against the extracellular forms of leishmania spp. balb/c mice infected with leishmania amazonensis ph8 or h-142 or leishmania venezuelensis were treated 1 day after the parasitic infection with a quinoline alkaloid (100 mg/kg of body weight per day) or with reference drug n-methylglucamine antimonate (glucantime) (56 mg of pentavalent antim ... | 1993 | 8494383 |
| disseminated american cutaneous leishmaniasis. | while studying cutaneous leishmaniasis in the central part of western venezuela, we found four cases of disseminated american cutaneous leishmaniasis, three from the lara state and one from portuguesa state. | 1996 | 8854152 |
| in vivo efficacy of oral and intralesional administration of 2-substituted quinolines in experimental treatment of new world cutaneous leishmaniasis caused by leishmania amazonensis. | the antileishmanial efficacies of 2-n-propylquinoline, chimanines b and d, 2-n-pentylquinoline, 2-phenylquinoline, 2-(3,4-methylenedioxyphenylethyl) quinoline, and two total alkaloidal extracts of galipea longiflora were evaluated in balb/c mice infected with leishmania amazonensis or leishmania venezuelensis. animals were treated for 4 to 6 weeks postinfection with a quinoline by the oral route at 50 mg/kg of body weight twice daily for 15 days or by five intralesional injections at intervals o ... | 1996 | 8913444 |
| polymorphism analysis of the internal transcribed spacer and small subunit of ribosomal rna genes of leishmania mexicana. | leishmania mexicana causes a wide spectrum of clinical diseases. in spite of the variety of clinical forms, no data exist regarding genetic polymorphism of l. mexicana. we analyzed the polymorphism of the internal transcribed spacer (its) and the small subunit rrna genes of 3 reference strains and 24 mexican isolates of l. mexicana, by means of polymerase chain reaction and subsequent digestion by restriction enzymes. all strains of l. mexicana had invariant patterns for both the its and the sma ... | 2002 | 12209333 |
| leishmania species identification using fta card sampling directly from patients' cutaneous lesions in the state of lara, venezuela. | a molecular epidemiological study was performed using fta card materials directly sampled from lesions of patients with cutaneous leishmaniasis (cl) in the state of lara, venezuela, where causative agents have been identified as leishmania (viannia) braziliensis and l. (leishmania) venezuelensis in previous studies. of the 17 patients diagnosed with cl, leishmania spp. were successfully identified in 16 patients based on analysis of the cytochrome b gene and rrna internal transcribed spacer sequ ... | 2011 | 21907375 |