| a preliminary study of the pharmacological actions and toxicity of "cerbera odollam". | | 1970 | 5447219 |
| antiproliferative and phytochemical analyses of leaf extracts of ten apocynaceae species. | the anticancer properties of apocynaceae species are well known in barks and roots but less so in leaves. | 2011 | 21772753 |
| cardiotoxic effects of cerbera odollam. | | 1965 | 5829508 |
| a preliminary report on the neurological manifestations of cerbera odollam poisoning. | | 1975 | 1213727 |
| detection of cerbera odollam by thin-layer chromatography. | | 1978 | 659549 |
| [the separation and identification of cardiac glycosides in the kernal of cerbera odollam (author's transl)]. | | 1981 | 7246182 |
| toxicity and effects on the central nervous system of a cerbera odollam leaf extract. | the immediate and delayed toxicity of cerbera odollam leaf extract was studied in mice. under the experimental conditions adopted, using macroscopic and microscopic examinations, cerbera odollam leaves appeared to be relatively devoid of the marked toxicity found in seeds, a common source of poisoning. at doses smaller than the maximal dose never lethal (14.5 g/kg i.p.), the leaf extract decreased mice spontaneous motor activity significantly, increased the reaction time to a thermal stimulus, r ... | 1991 | 1795524 |
| bis[14beta-hydroxy-3beta-o-(l-thevetosyl)-5beta-card-20(22)-enolide] methanol solvate monohydrate and 3beta-o-(l-2'-o-acetylthevetosyl)-14beta-hydroxy-5beta-card-20(22)-enolide. | the title compounds, 2c(30)h(46)o(8).ch(3)oh.h(2)o, (i), and c(32)h(48)o(9), (ii), respectively, are cardenolide glycosides which were isolated from the seeds of cerbera odollam. there are two crystallographically independent cardenolide molecules in (i), together with one methanol and one water solvate molecule. in both (i) and (ii), the steroid nuclei are in cis/trans/cis configurations, with the cyclopentane rings showing conformational flexibility, viz. an envelope conformation in (i) and a ... | 2003 | 12574657 |
| cerbera odollam: a 'suicide tree' and cause of death in the state of kerala, india. | cerbera odollam is a tree belonging to the poisonous apocynaceae family, which includes the yellow and common oleanders. the seeds are excessively toxic, containing cerberin as the main active cardenolide. cerbera venenifera, a related species found in madagascar, has a long history as an ordeal poison, and was responsible for the death of 3000 people per year in previous centuries. the odollam tree is responsible for about 50% of the plant poisoning cases and 10% of the total poisoning cases in ... | 2004 | 15507323 |
| an unusual case of cardiac glycoside toxicity. | | 2014 | 24315350 |
| cytotoxicity studies of semi-synthetic derivatives of theveside derived from the aqueous extract of leaves of 'suicide tree' cerbera odollam. | we report the isolation of two known iridoid glucosides theviridoside (1) and theveside (2) from the aqueous extract of leaves of cerbera odollam and semi-synthetic derivatisation of theveside prepared in a single step under protection group-free conditions. derivatives 2a-j were evaluated for cytotoxicity towards five human cancer cell lines of different origins, namely skbr3 (breast), hela (cervical), a375 (skin), hepg2 (liver) and hct-116 (colon), and ic50 values were determined. derivatives ... | 2014 | 24805359 |
| clinical profile and management of poisoning with suicide tree: an observational study. | the clinical features, management, and the associations of dosage in poisoning with the cardiotoxic plant cerbera odollam (suicide tree), responsible for more than half of plant poisoning deaths in the south indian state of kerala alone, have not been evaluated. there are only few studies on its clinical features and none on the usage of cardiac pacing in its management, given its rarity in the western world. we depend on data for similar toxins to form our management protocols. | 2017 | 28400936 |
| cytotoxic cardenolide glycoside from the seeds of cerbera odollam. | a cardenolide glycoside, 3 beta-o-(2'-o-acetyl-l- thevetosyl)-15(14-->8)-abeo-5 beta-(8r)-14-oxo-card-20(22)-enolide (2'-o-acetyl cerleaside a), was isolated from a methylene chloride extract of the seeds of cerbera odollam, together with four known compounds: cerleaside a, 17 alpha-neriifolin, 17 beta- neriifolin and cerberin. their structures were elucidated by spectroscopic methods. all compounds except cerleaside a exhibited cytotoxic activities against oral human epidermoid carcinoma (kb), ... | 2004 | 14759549 |