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purification and properties of a new extracellular collagenase from aspergillus sclerotiorum. 19744375118
optimization of alpha-amylase immobilization in calcium alginate beads.alpha-amylase enzyme was produced by aspergillus sclerotiorum under ssf conditions, and immobilized in calcium alginate beads. effects of immobilization conditions, such as alginate concentration, cacl(2) concentration, amount of loading enzyme, bead size, and amount of beads, on enzymatic activity were investigated. optimum alginate and cacl(2) concentration were found to be 3% (w/v). using a loading enzyme concentration of 140 u ml(-1), and bead (diameter 3 mm) amount of 0.5 g, maximum enzyme ...200717516249
bioconversion of iodoacetophenones by marine fungi.nine marine fungi (aspergillus sclerotiorum cbmai 849, aspergillus sydowii ce19, beauveria felina cbmai 738, mucor racemosus cbmai 847, penicillium citrinum cbmai 1186, penicillium miczynskii ce16, p. miczynskii gc5, penicillium oxalicum cbmai 1185, and trichoderma sp. gc1) catalyzed the asymmetric bioconversion of iodoacetophenones 1-3 to corresponding iodophenylethanols 6-8. all the marine fungi produced exclusively (s)-ortho-iodophenylethanol 6 and (s)-meta-iodophenylethanol 7 in accordance t ...201222653656
new 1,3,4-bisthiadiazolines: synthesis, characterization and antimicrobial evaluations.the bisthiadiazolines 4a-4g have been synthesized in good yields from the cyclization reactions of bisthiosemicarbazones 3a-3g with acetic anhydride. the condensation reaction of dibenzaldehydes 2a-2g with thiosemicarbazide in alcoholic medium provided 3a-3g and former were obtained from the o-alkylation of 3-hydroxybenzaldehyde with suitable 1,ω-dibromoalkanes under alkaline conditions in the presence of dry etoh/dmf. the intermediates 3a-3g and bishetrocyclics 4a-4g were also screened for thei ...201222832010
stereoselective bioreduction of 1-(4-methoxyphenyl)ethanone by whole cells of marine-derived fungi.nine strains of marine-derived fungi (aspergillus sydowii ce15, a. sydowii ce19, aspergillus sclerotiorum cbmai 849, bionectria sp. ce5, beauveria felina cbmai 738, cladosporium cladosporioides cbmai 857, mucor racemosus cbmai 847, penicillium citrinum cbmai 1186, and penicillium miczynskii gc5) were screened, catalyzing the asymmetric bioreduction of 1-(4-methoxyphenyl)ethanone 1 to its corresponding 1-(4-methoxyphenyl)ethanol 2. a. sydowii ce15 and bionectria sp. ce5 produced the enantiopure ( ...201122160343
stereoselective bioreduction of 1-(4-methoxyphenyl)ethanone by whole cells of marine-derived fungi.nine strains of marine-derived fungi (aspergillus sydowii ce15, a. sydowii ce19, aspergillus sclerotiorum cbmai 849, bionectria sp. ce5, beauveria felina cbmai 738, cladosporium cladosporioides cbmai 857, mucor racemosus cbmai 847, penicillium citrinum cbmai 1186, and penicillium miczynskii gc5) were screened, catalyzing the asymmetric bioreduction of 1-(4-methoxyphenyl)ethanone 1 to its corresponding 1-(4-methoxyphenyl)ethanol 2. a. sydowii ce15, a. sclerotiorum cbmai 849, and bionectria sp. ce ...201121842151
cytotoxic and genotoxic potencies of single and combined spore extracts of airborne ota-producing and ota-non-producing aspergilli in human lung a549 cells.aspergillus sclerotiorum (as) is a well-known producer of ochratoxin a (ota) while aspergillus pseudoglaucus (ap) produces a wide range of extrolites with poorly investigated toxicity. these species are frequently co-occur in grain mill aeromycota. the aim of this study was to determine ota levels in spore extracts using hplc and immunoaffinity columns, and to examine the cytotoxicity of pure ota, ota-positive (as-ota(+)) and ota-negative (as-ota(-)) spore extracts, as well as of ap spore extrac ...201526086577
a case of onychomycosis caused by aspergillus sclerotiorum. 201728176686
cyclic tripeptides from the halotolerant fungus aspergillus sclerotiorum pt06-1.eleven new aspochracin-type cyclic tripeptides, sclerotiotides a-k (1-11), together with three known compounds, jbir-15 (12), aspochracin (13), and penicillic acid, were isolated from the ethyl acetate extract of the fermentation broth of the halotolerant aspergillus sclerotiorum pt06-1 in a hypersaline nutrient-rich medium. their structures were elucidated by spectroscopic analysis and chemical methods. chemical transformations of 12 and 13 proved that sclerotiotides d-k (4-11) were artifacts p ...201020503985
biological activity of the mite sancassania sp. (acari: acaridae) from bat guano associated with the pathogenic fungus histoplasma capsulatum.mites and the mammal pathogenic fungus histoplasma capsulatum are the major components of bat guano microbiota. interactions between mites and h. capsulatum were evaluated under laboratory conditions. acarid mites, mainly sancassania sp., were the most abundant microarthropod in the sampled guano of the mexican bat tadarida brasiliensis mexicana and, based on its morphology, sancassania sp. was similar to the cosmopolitan species sancassania sphaerogaster. the mycophagous and vectoring activitie ...201020428669
lovastatin analogues from the soil-derived fungus aspergillus sclerotiorum psu-rspg178.three new lovastatin analogues (1, 4, and 5) together with four known lovastatin derivatives, namely, lovastatin (2), α,β-dehydrolovastatin (3), α,β-dehydrodihydromonacolin k (6), and α,β-dehydro-4a,5-dihydromonacolin l (7), were isolated from the soil-derived fungus aspergillus sclerotiorum psu-rspg178. their structures were established using spectroscopic evidence. compound 5 exhibited the most potent activity against hmg-coa reductase, with an ic50 value of 387 μm. in addition, the present st ...201627228159
a new cytotoxic indole-3-ethenamide from the halotolerant fungus aspergillus sclerotiorum pt06-1.a new cytotoxic indole-3-ethenamide (1) and two known compounds, 7-(3-methylbut-2-enyl)-1h-indole-3-carbaldehyde (2) and emodin (3) were isolated and identified from the ethyl acetate extract of aspergillus sclerotiorum pt06-1 in a hypersaline nutrient-rich medium. on the basis of spectroscopic analysis and amino-acid analysis, the new structure of 1 was determined to be (s,e)-3-methyl-2-(n- methylacetamido)-n-(2-(7-(3-methylbut-2-enyl)-1h-indol-3-yl)vinyl)butanamide within 3:1 ratio of rotamers ...201121792207
production of penicillic acid by aspergillus sclerotiorum cgf.the production of penicillic acid by aspergillus sclerotiorum cgf for the biocontrol of phytophthora disease was investigated in submerged fermentation using media composed of different nutrients. soluble starch was found to be the most effective substrate among the carbon sources used, and produced the highest penicillic acid concentration of 2.98 mg ml(-1). when organic nitrogen sources were used, pharmamedia, yeast extract, and polypeptone-s were found to be suitable organic nitrogen sources ...200716458001
a case of otomycosis caused by aspergillus sclerotiorum. 200415729874
mycoses, bacterial infections and antibacterial activity in sandflies (psychodidae) and their possible role in the transmission of leishmaniasis.high incidence of mycoses were found in the guts and malpighian tubes of phlebotomus papatasi from the jordan valley and p. tobbi from zakinthos, greece. infections with several different bacteria were also found in the guts of female p. tobbi. fungi cultured from guts of laboratory reared p. papatasi that had similar mycoses were identified as aspergillus sclerotiorum and saccharomyces cerevisiae. fungi-infected laboratory reared p. papatasi were refractory to artificial infections with a leish ...19853982854
a new series of natural antifungals that inhibit p450 lanosterol c-14 demethylase. i. taxonomy, fermentation, isolation and structural elucidation.a new series of antifungal antibiotics, ro 09-1470 and its 6 congeners were isolated from the fermentation broth of penicillium sp. nr6564. their structures were determined as tetrahydropyran derivatives with an alkenyl side chain on the basis of their spectroscopic and physico-chemical properties. among these compounds, ro 09-1470 and ro 09-1545 possessing a glycyl n-substituted glycyl ester residue had high antifungal activity. ro 09-1469, one of the congeners, was found in the fermentation br ...19921556006
stereoselective bioreduction of α-azido ketones by whole cells of marine-derived fungi.seven strains of marine-derived fungi (aspergillus sclerotiorum cbmai 849, cladosporium cladosporioides cbmai 857, penicillium raistrickii cbmai 931, penicillium citrinum cbma 1186, mucor racemosus cbmai 847, beauveria felina cbmai 738, and penicillium oxalicum cbmai 1185) and terrestrial fungus penicillium chrysogenum cbma1199 were screened as catalysts for the asymmetric reduction of α-keto azides 5-8 to their corresponding β-azidophenylethanols 9-12. the marine fungi showed prelog and anti-pr ...201526272428
novel cyclic hexapeptides from marine-derived fungus, aspergillus sclerotiorum pt06-1.two novel cyclic hexapeptides containing both anthranilic acid and dehydroamino acid units, sclerotides a (1) and b (2), were isolated from the marine-derived halotolerant aspergillus sclerotiorum pt06-1 in a nutrient-limited hypersaline medium. both 1 and 2 are photointerconvertible and could be interconverted via a radical reaction initiated by direct photoisomerization. both compounds showed moderate antifungal activity. compound 2 also showed weak cytotoxicity and antibacterial activity.200919827766
new antifungal activity of penicillic acid against phytophthora species.penicillic acid was isolated from a culture filtrate of aspergillus sclerotiorum. it had a high in vitro antifungal activity against phytophthora spp., which has not been previously reported. mics of penicillic acid were from 1 to 25 microg ml(-1) against phytophthora spp. penicillic acid induced abnormal branch formation, apical branching, and swelling in p. capsici, in p. cactorum mycelia contained irregular branching and small spherical swelling at apices, in p. cambivora there was irregular ...200415195966
sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of aspergillus sclerotiorum.sclerotiamide (1), a new fungal natural product related to the paraherquamides, was isolated by bioassay-guided fractionation of antiinsectan organic extracts from the sclerotia of aspergillus sclerotiorum (nrrl 5167). the structure was determined primarily through 1h-nmr, 13c-nmr, hmqc, and hmbc experiments. sclerotiamide causes significant mortality and unusual physiological effects in dietary assays against the corn earworm helicoverpa zea.19968946752
γ-butenolide and furanone derivatives from the soil-derived fungus aspergillus sclerotiorum psu-rspg178.chromatographic separation of the broth extract of the soil-derived fungus aspergillus sclerotiorum psu-rspg178 resulted in isolation of four γ-butenolide-furanone dimers, aspersclerotiorones a-d, a furanone derivative, aspersclerotiorone e, and two γ-butenolide derivatives, aspersclerotiorones f and g, together with six known compounds, penicillic acid, dihydropenicillic acid, 5,6-dihydro-6-hydroxypenicillic acid, 6-methoxy-5,6-dihydropenicillic acid, coculnol and (4r,5r)-4,5-dihydroxy-3-methox ...201728228227
new cyclic peptide and bisindolyl benzenoid metabolites from the sclerotia of aspergillus sclerotiorum.scleramide (1), a new cyclic hexapeptide, and a new oxidized bisindolyl benzenoid derivative (2' '-oxoasterriquinol d methyl ether, 2) were isolated from extracts of the sclerotia of aspergillus sclerotiorum (nrrl 5167). the structures of these compounds were determined by analysis of 1d and 2d nmr experiments.200010924188
jbir-15, a new aspochracin derivative, isolated from a sponge-derived fungus, aspergillus sclerotiorum huber sp080903f04.in the course of our chemical screening program for novel metabolites by lc-ms monitoring, we isolated a new aspochracin derivative, jbir-15 (1), together with aspochracin, from the culture broth of a sponge-derived fungus, aspergillus sclerotiorum huber sp080903f04. the structure of 1 was determined to be n-demethyl aspochracin at the alanyl residue on the basis of extensive nmr and ms analyses.200919661713
comparison of some properties of free and immobilized alpha-amylase by aspergillus sclerotiorum in calcium alginate gel beads.some properties of immobilized alpha-amylase by aspergillus sclerotiorum within calcium alginate gel beads were investigated and compared with soluble enzyme. optimum ph and temperature were found to be 5.0 and 40 degrees c, respectively, for both soluble and immobilized enzymes. the immobilized enzyme had a better km value, but kcat/km values were the same for both enzymes. entrapment within calcium alginate gel beads improved, remarkably, the thermal and storage stability of alpha-amylase. the ...200818080907
marine-derived filamentous fungi and their potential application for polycyclic aromatic hydrocarbon bioremediation.eight marine-derived fungi that were previously selected for their abilities to decolorize rbbr dye were subjected to pyrene and benzo[a]pyrene degradation. the fungus aspergillus sclerotiorum cbmai 849 showed the best performance with regard to pyrene (99.7%) and benzo[a]pyrene (76.6%) depletion after 8 and 16 days, respectively. substantial amounts of benzo[a]pyrene (>50.0%) depletion were also achieved by mucor racemosus cbmai 847. therefore, these two fungal strains were subjected to metabol ...201021040933
new furanone derivatives and alkaloids from the co-culture of marine-derived fungi aspergillus sclerotiorum and penicillium citrinum.six new compounds including two furanone derivatives sclerotiorumins a and b (1 and 2), one novel oxadiazin derivative sclerotiorumin c (3), one pyrrole derivative 1-(4-benzyl-1h-pyrrol-3-yl)ethanone (4), and two complexes of neoaspergillic acid aluminiumneohydroxyaspergillin (5) and ferrineohydroxyaspergillin (6) were isolated from the co-culture of marine-derived fungi aspergillus sclerotiorum and penicillium citrinum. compound 3 was the first natural 1,2,4-oxadiazin-6-one. compound 5 showed s ...201727936301
microbial transformation of phenazines by aspergillus sclerotiorum. 19695812247
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